{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:07:43Z","timestamp":1788433663860,"version":"build-2803163510"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005970","name":"Deutsche Stiftung f\u00fcr Herzforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005970","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e4ts-Herzzentrum Freiburg - Bad Krozingen GmbH"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Advances in pediatric cardiology and congenital heart surgery have increased the adult population with congenital heart disease (CHD), now facing long-term complications like atrial arrhythmias. Given the limited data and safety concerns in this unique and vulnerable patient group, this study analyzes in-hospital outcomes of atrial catheter ablation in CHD patients versus non-CHD patients from a German nationwide real-world registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using health records, all atrial catheter ablation procedures in Germany from 2008 to 2021 were analyzed. After adjustment for confounders, safety performance endpoints were compared between patients with and without CHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 2008 to 2021, 790,896 patients underwent right or left atrial catheter ablation in Germany. Of these, 1004 patients were classified as simple CHD, 1,054 patients as moderate CHD and 843 patients as complex CHD. Age at time of procedure was lower with increasing complexity of the CHD. Atypical atrial flutter (5.5% vs. 21.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and other atrial tachycardias (21.2% vs. 42.2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) occurred more often in patients with complex CHD compared to patients without. Combined ablation in both atria was more often performed in complex CHD. Despite higher complexity, in-hospital mortality (&lt;\u20090.2%) and other investigated complications were rare. After adjustment for baseline characteristics, type of arrhythmia and ablation location, the relative risk for serious adverse events (combination of mortality, stroke, intracerebral bleeding or pericardiocentesis) did not show a significant difference for patients with CHD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Even in patients with CHD, complications are rare and after adjustment, no differences were identified concerning serious adverse events. Therefore, an ablation should not be generally avoided in patients with CHD due to concerns about complications although an individualized evaluation of the anatomy must be taken into account.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-025-02614-7","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T10:21:54Z","timestamp":1740392514000},"page":"507-515","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["In-hospital outcomes of catheter ablation in atrial arrhythmias: a nationwide analysis of 2,901 patients with adult congenital heart disease compared to 787,995 without"],"prefix":"10.1007","volume":"114","author":[{"given":"Sebastian","family":"Grundmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Kaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Rilinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Steinfurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Stiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Westermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"von zur M\u00fchlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8638-5228","authenticated-orcid":false,"given":"Markus","family":"J\u00e4ckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"2614_CR1","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1161\/CIRCULATIONAHA.106.627224","volume":"115","author":"AJ Marelli","year":"2007","unstructured":"Marelli AJ, Mackie AS, Ionescu-Ittu R, Rahme E, Pilote L (2007) Congenital heart disease in the general population: changing prevalence and age distribution. Circulation 115:163\u2013172. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.627224","journal-title":"Circulation"},{"key":"2614_CR2","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1161\/CIRCULATIONAHA.109.866319","volume":"120","author":"J Bouchardy","year":"2009","unstructured":"Bouchardy J, Therrien J, Pilote L, Ionescu-Ittu R, Martucci G, Bottega N, Marelli AJ (2009) Atrial arrhythmias in adults with congenital heart disease. Circulation 120:1679\u20131686. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.866319","journal-title":"Circulation"},{"key":"2614_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9020039","author":"V Waldmann","year":"2022","unstructured":"Waldmann V, Guichard J-B, Marijon E, Khairy P (2022) Tachyarrhythmias in Congenital Heart Diseases: From Ion Channels to Catheter Ablation. J Cardiovasc Dev Dis. https:\/\/doi.org\/10.3390\/jcdd9020039","journal-title":"J Cardiovasc Dev Dis"},{"key":"2614_CR4","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1093\/eurheartj\/ehaa554","volume":"42","author":"H Baumgartner","year":"2021","unstructured":"Baumgartner H, de Backer J, Babu-Narayan SV, Budts W, Chessa M, Diller G-P, Lung B, Kluin J, Lang IM, Meijboom F, Moons P, Mulder BJM, Oechslin E, Roos-Hesselink JW, Schwerzmann M, Sondergaard L, Zeppenfeld K (2021) 2020 ESC Guidelines for the management of adult congenital heart disease. Eur Heart J 42:563\u2013645. https:\/\/doi.org\/10.1093\/eurheartj\/ehaa554","journal-title":"Eur Heart J"},{"key":"2614_CR5","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.acvd.2020.12.005","volume":"114","author":"V Waldmann","year":"2021","unstructured":"Waldmann V, Amet D, Zhao A, Ladouceur M, Otmani A, Karsenty C, Maltret A, Ollitrault J, Pontnau F, Legendre A, Florens E, Munte L, Soulat G, Mousseaux E, Du Puy-Montbrun L, Lavergne T, Bonnet D, Vouh\u00e9 P, Jouven X, Marijon E, Iserin L (2021) Catheter ablation in adults with congenital heart disease: A 15-year perspective from a tertiary centre. Arch Cardiovasc Dis 114:455\u2013464. https:\/\/doi.org\/10.1016\/j.acvd.2020.12.005","journal-title":"Arch Cardiovasc Dis"},{"key":"2614_CR6","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.acvd.2017.01.007","volume":"110","author":"N Combes","year":"2017","unstructured":"Combes N, Derval N, Hasco\u00ebt S, Zhao A, Amet D, Le Bloa M, Maltret A, Heitz F, Thambo J-B, Marijon E (2017) Ablation of supraventricular arrhythmias in adult congenital heart disease: A contemporary review. Arch Cardiovasc Dis 110:334\u2013345. https:\/\/doi.org\/10.1016\/j.acvd.2017.01.007","journal-title":"Arch Cardiovasc Dis"},{"key":"2614_CR7","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.ijcard.2019.01.079","volume":"287","author":"V Waldmann","year":"2019","unstructured":"Waldmann V, Laredo M, Abadir S, Mond\u00e9sert B, Khairy P (2019) Atrial fibrillation in adults with congenital heart disease. Int J Cardiol 287:148\u2013154. https:\/\/doi.org\/10.1016\/j.ijcard.2019.01.079","journal-title":"Int J Cardiol"},{"key":"2614_CR8","unstructured":"Webb G, Williams, R. 2000. Care of the Adult with Congenital Heart Disease. In: Proceedings of the 32nd Bethesda Conference, Bethesda, ML, USA. pp. 1161\u20131198."},{"key":"2614_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10215071","author":"M Maser","year":"2021","unstructured":"Maser M, Freisinger E, Bronstein L, K\u00f6ppe J, Orwat S, Kaleschke G, Baumgartner H, Diller G-P, Lammers A (2021) Frequency, mortality, and predictors of adverse outcomes for endocarditis in patients with congenital heart disease: results of a nationwide analysis including 2512 Endocarditis Cases. J Clin Med. https:\/\/doi.org\/10.3390\/jcm10215071","journal-title":"J Clin Med"},{"key":"2614_CR10","doi-asserted-by":"crossref","unstructured":"Belloni A, Chernozhukov V, Wei Y (2013) Post-Selection Inference for Generalized Linear Models with Many Controls. arXiv","DOI":"10.1920\/wp.cem.2013.2413"},{"key":"2614_CR11","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1198\/016214506000000735","volume":"101","author":"H Zou","year":"2006","unstructured":"Zou H (2006) The adaptive lasso and its oracle properties. J Am Stat Assoc 101:1418\u20131429. https:\/\/doi.org\/10.1198\/016214506000000735","journal-title":"J Am Stat Assoc"},{"key":"2614_CR12","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1136\/heartjnl-2021-320676","volume":"108","author":"KP Ramlakhan","year":"2022","unstructured":"Ramlakhan KP, van der Bie M, den Uil CA, Dubois EA, Roos-Hesselink JW (2022) Adult patients with congenital heart disease in the intensive care unit. Heart 108:1452\u20131460. https:\/\/doi.org\/10.1136\/heartjnl-2021-320676","journal-title":"Heart"},{"key":"2614_CR13","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1161\/CIRCULATIONAHA.109.899310","volume":"120","author":"MJ Landzberg","year":"2009","unstructured":"Landzberg MJ, Cecchin F (2009) Atrial arrhythmias: a \u201ccall to arms\u201d for congenital heart disease caregivers. Circulation 120:1649\u20131650. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.899310","journal-title":"Circulation"},{"key":"2614_CR14","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1093\/europace\/eux380","volume":"20","author":"A Hern\u00e1ndez-Madrid","year":"2018","unstructured":"Hern\u00e1ndez-Madrid A, Paul T, Abrams D, Aziz PF, Blom NA, Chen J, Chessa M, Combes N, Dagres N, Diller G, Ernst S, Giamberti A, Hebe J, Janousek J, Kriebel T, Moltedo J, Moreno J, Peinado R, Pison L, Rosenthal E, Skinner JR, Zeppenfeld K (2018) Arrhythmias in congenital heart disease: a position paper of the European heart rhythm association (EHRA), association for european paediatric and congenital cardiology (AEPC), and the European society of cardiology (ESC) Working group on grown-up congenital heart disease, endorsed by HRS, PACES, APHRS, and SOLAECE. Europace 20:1719\u20131753. https:\/\/doi.org\/10.1093\/europace\/eux380","journal-title":"Europace"},{"key":"2614_CR15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.122.010954","volume":"15","author":"JR Griffiths","year":"2022","unstructured":"Griffiths JR, Nussinovitch U, Liang JJ, Sims R, Yoneda ZT, Bernstein HM, Viswanathan MN, Khairy P, Srivatsa UN, Frankel DS, Marchlinski FE, Sandhu A, Shoemaker MB, Mohanty S, Burkhardt JD, Natale A, Lakireddy D, de Groot NMS, Gerstenfeld EP, Moore JP, \u00c1vila P, Ernst S, Nguyen DT (2022) Catheter ablation for atrial fibrillation in adult congenital heart disease: an international multicenter registry study. Circ Arrhythm Electrophysiol 15:e010954. https:\/\/doi.org\/10.1161\/CIRCEP.122.010954","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2614_CR16","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/j.jacep.2018.08.012","volume":"4","author":"BM Moore","year":"2018","unstructured":"Moore BM, Anderson R, Nisbet AM, Kalla M, Du Plessis K, d\u2019Udekem Y, Bullock A, Cordina RL, Grigg L, Celermajer DS, Kalman J, McGuire MA (2018) Ablation of atrial arrhythmias after the atriopulmonary fontan procedure: mechanisms of arrhythmia and outcomes. JACC Clin Electrophysiol 4:1338\u20131346. https:\/\/doi.org\/10.1016\/j.jacep.2018.08.012","journal-title":"JACC Clin Electrophysiol"},{"key":"2614_CR17","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad275","author":"V Waldmann","year":"2023","unstructured":"Waldmann V, Bessi\u00e8re F, Gardey K, Hasco\u00ebt S, Henaine R, Iserin L, Ladouceur M, Bonnet D, Marijon E, Maltret A, Combes N, de Groot N (2023) Catheter ablation of atrial tachyarrhythmias in patients with atrioventricular septal defect. Europace. https:\/\/doi.org\/10.1093\/europace\/euad275","journal-title":"Europace"},{"key":"2614_CR18","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1111\/aor.14364","volume":"46","author":"M J\u00e4ckel","year":"2022","unstructured":"J\u00e4ckel M, Kaier K, Rilinger J, Bemtgen X, Zotzmann V, Zehender M, zur M\u00fchlen C von, Stachon P, Bode C, Wengenmayer T, Staudacher DL, (2022) Annual hospital procedural volume and outcome in extracorporeal membrane oxygenation for respiratory failure. Artif Organs 46:2469\u20132477. https:\/\/doi.org\/10.1111\/aor.14364","journal-title":"Artif Organs"},{"key":"2614_CR19","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007378","author":"A Khan","year":"2018","unstructured":"Khan A, Ramsey K, Ballard C, Armstrong E, Burchill LJ, Menashe V, Pantely G, Broberg CS (2018) Limited accuracy of administrative data for the identification and classification of adult congenital heart disease. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.117.007378","journal-title":"J Am Heart Assoc"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-025-02614-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00392-025-02614-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-025-02614-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T10:56:24Z","timestamp":1743245784000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00392-025-02614-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["2614"],"URL":"https:\/\/doi.org\/10.1007\/s00392-025-02614-7","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"20 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All other authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Approval by an ethics committee and informed consent were not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}