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Transcatheter tricuspid valve annuloplasty (TTVA) offers a promising approach due to minimal interaction with leaflets and transvalvular CIEDs, though real-world evidence is limited.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This bi-center, retrospective study includes 204 consecutive patients who underwent TTVA with the Cardioband (Edwards Lifesciences) for severe symptomatic TR. Patients were divided into CIED carriers and non-CIED carriers. CIED carriers were further classified into those with lead-associated TR (LTR-A) and those with TR unrelated to CIED leads (LTR-B).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Among the 204 patients, 41 (20%) were CIED carriers. Of these, 24% had mixed TR etiology (functional and LTR-A), while 76% had predominantly functional TR (LTR-B). Compared to non-CIED-carriers, CIED carriers were more symptomatic (NYHA-FC\u2009&gt;\u2009II; 93% vs. 89%; <jats:italic>p<\/jats:italic>\u2009=\u20090.026) with comparable TR severity at baseline. Intraprocedural success according to the Tricuspid Valve Academic Research Consortium was 68% in CIED carriers and 70% in non-CIED carriers (<jats:italic>p<\/jats:italic>\u2009=\u20090.851). LTR-A was associated with poorer TR reduction immediately after TTVA (<jats:italic>p<\/jats:italic>\u2009=\u20090.022). Overall safety was comparable, with right ventricular lead dislodgement occurring in one patient. Beyond that, CIED function remained unimpaired.<\/jats:p>\n            <jats:p>At 30\u00a0days, echocardiographic follow-up showed comparable TR reduction (TR\u2009\u2264\u2009II: 56% vs. 68%; <jats:italic>p<\/jats:italic>\u2009=\u20090.219) and NYHA-FU\u2009\u2264\u2009II (63% vs. 70%; <jats:italic>p<\/jats:italic>\u2009=\u20090.524) in CIED-and non-CIED carriers, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>TTVA achieves significant TR reduction, providing a safe and effective therapeutic option for TR treatment in CIED carriers.<jats:disp-quote>\n                <jats:p>\n                  <jats:bold>What is known?<\/jats:bold>\n                <\/jats:p>\n                <jats:p>TTVA using the Cardioband has been approved for severe, symptomatic TR patients, however data on the safety and efficacy in CIED carriers is lacking.<\/jats:p>\n                <jats:p>\n                  <jats:bold>What the study adds?<\/jats:bold>\n                <\/jats:p>\n                <jats:p>\n                  <jats:list list-type=\"bullet\">\n                    <jats:list-item>\n                      <jats:p>Intraprocedural success and safety were comparable in CIED and non-CIED carriers treated with TTVA.<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Subgroup analyses showed a trend towards worse outcome and efficiency of TTVA in patients with LTR-A.<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Postinterventional CIED interrogations did not show critical technical issues.<\/jats:p>\n                    <\/jats:list-item>\n                  <\/jats:list>\n                <\/jats:p>\n              <\/jats:disp-quote>\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical abstract<\/jats:title>\n            <jats:p>Intraprocedural success and TR reduction following TTVA in CIED- and non-CIED-carriers. Blue arrows indicate CIED lead trajectory through tricuspid valve.<\/jats:p>\n            <jats:p>\n              <jats:italic>BL<\/jats:italic>\u2009Baseline, <jats:italic>FU<\/jats:italic>\u2009=\u200930-day Follow Up, <jats:italic>LTR-A<\/jats:italic>\u2009 Lead-associated Tricuspid Regurgitation, type A, <jats:italic>LTR-B<\/jats:italic>\u2009 Lead-associated Tricuspid Regurgitation, type B, <jats:italic>TR<\/jats:italic>\u2009Tricuspid Regurgitation, <jats:italic>TTVA<\/jats:italic>\u2009Transcatheter Tricuspid Valve Annuloplasty<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00392-025-02616-5","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T13:32:23Z","timestamp":1749216743000},"page":"878-891","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiac implantable electronic device carriers undergoing transcatheter tricuspid valve annuloplasty: real-world insights"],"prefix":"10.1007","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1637-3413","authenticated-orcid":false,"given":"Jan M.","family":"Wrobel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kirchner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Friedrichs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Gietzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Althoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Hasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"von Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"W\u00f6rmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"von Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Curio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ivannikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Iliadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Steven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Ger\u00e7ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Koerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"2616_CR1","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.jcmg.2018.09.028","volume":"12","author":"K Addetia","year":"2019","unstructured":"Addetia K, Harb SC, Hahn RT, Kapadia S, Lang RM (2019) Cardiac implantable electronic device lead-induced tricuspid regurgitation. 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MI Koerber has received travel support and consultant honoraria by Abbott Medical, Edwards Lifesciences and JenaValve. Mohammed Ger\u00e7ek has received travel support and consultant honoraria by Edwards Lifesciences; Advanced clinician scientist grant Ruhr-University Bochum. All other authors declare they have no financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}