{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:25:41Z","timestamp":1761168341232,"version":"build-2065373602"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["397484323-TRR259"],"award-info":[{"award-number":["397484323-TRR259"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sex-related differences play a pivotal role in disease manifestation and outcome in patients with cardiovascular disease, including aortic valve stenosis (AS). However, data regarding sex-related hormonal differences in AS patients undergoing transcatheter aortic valve replacement (TAVR) is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to assess sex-related hormonal variances in patients with severe symptomatic AS and to evaluate the impact of these hormonal differences on the clinical outcomes after TAVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a total of 361 TAVR patients, we assessed the hormonal status, including cortisol, parathormone (PTH), insulin-like growth factor 1 (IGF-1), dehydroepiandrosterone sulfate (DHEAs), estradiol, progesterone and testosterone prior to TAVR. We compared baseline characteristics and outcome data according to sex and hormonal parameters. The primary endpoint was 1-year all-cause mortality according to sex; secondary endpoints included the risk of 1-year all-cause mortality in conjunction with hormone levels, with pre-specified cut-off values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Rates of 1-year all-cause mortality were comparable between the sexes (p\u2009=\u20090.285). Cox regression analysis revealed significant associations between 1-year mortality and levels of cortisol (HR 2.30; p\u2009=\u20090.007), PTH (HR 2.09; p\u2009=\u20090.019), DHEA-S (HR 0.47; p\u2009=\u20090.016), and IGF-1 (HR 0.42; p\u2009=\u20090.004) in the overall cohort. Elevated cortisol levels (p\u2009=\u20090.011), decreased DHEA-S levels (p\u2009=\u20090.007), and lower IGF-1 levels (p\u2009=\u20090.017) were significantly associated with higher rates of 1-year all-cause mortality in males. Conversely, higher PTH levels were significantly associated with an increased risk of 1-year mortality in females (p\u2009=\u20090.012).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sex-specific hormonal differences significantly impact the prognosis of severe AS patients undergoing TAVR. Elevated cortisol levels and decreased DHEA-S and IGF-1 levels in males, as well as higher levels of PTH in females, were associated with an increased mortality risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-025-02623-6","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T10:33:49Z","timestamp":1740393229000},"page":"1527-1536","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex-related hormonal variances and clinical outcomes in TAVR patients"],"prefix":"10.1007","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2225-4532","authenticated-orcid":false,"given":"Mustafa","family":"Mousa Basha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baravan","family":"Al-Kassou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Beiert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Bakhtiary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip Roger","family":"Goody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmin","family":"Shamekhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"issue":"13","key":"2623_CR1","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/s0195-668x(03)00201-x","volume":"24","author":"B Iung","year":"2003","unstructured":"Iung B, Baron G, Butchart EG, Delahaye F, Gohlke-B\u00e4rwolf C, Levang OW, Tornos P, Vanoverschelde JL, Vermeer F, Boersma E, Ravaud P, Vahanian A (2003) A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on Valvular Heart Disease. Eur Heart J 24(13):1231\u20131243. https:\/\/doi.org\/10.1016\/s0195-668x(03)00201-x. (PMID: 12831818)","journal-title":"Eur Heart J"},{"issue":"13","key":"2623_CR2","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.jacc.2007.06.024","volume":"50","author":"SH Goldbarg","year":"2007","unstructured":"Goldbarg SH, Elmariah S, Miller MA, Fuster V (2007) Insights into degenerative aortic valve disease. J Am Coll Cardiol 50(13):1205\u20131213. https:\/\/doi.org\/10.1016\/j.jacc.2007.06.024. (Epub 2007 Sep 10 PMID: 17888836)","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"2623_CR3","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jjcc.2017.11.007","volume":"71","author":"H Akahori","year":"2018","unstructured":"Akahori H, Tsujino T, Masuyama T, Ishihara M (2018) Mechanisms of aortic stenosis. J Cardiol 71(3):215\u2013220. https:\/\/doi.org\/10.1016\/j.jjcc.2017.11.007. (Epub 2017 Dec 16 PMID: 29258711)","journal-title":"J Cardiol"},{"issue":"21","key":"2623_CR4","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1136\/heartjnl-2016-310894","volume":"103","author":"P Andell","year":"2017","unstructured":"Andell P, Li X, Martinsson A, Andersson C, Stagmo M, Z\u00f6ller B, Sundquist K, Smith JG (2017) Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study. Hear 103(21):1696\u20131703. https:\/\/doi.org\/10.1136\/heartjnl-2016-310894","journal-title":"Hear"},{"issue":"8","key":"2623_CR5","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1093\/eurheartj\/ehv560","volume":"37","author":"JJ Thaden","year":"2016","unstructured":"Thaden JJ, Nkomo VT, Suri RM, Maleszewski JJ, Soderberg DJ, Clavel MA, Pislaru SV, Malouf JF, Foley TA, Oh JK, Miller JD, Edwards WD, Enriquez-Sarano M (2016) Sex-related differences in calcific aortic stenosis: correlating clinical and echocardiographic characteristics and computed tomography aortic valve calcium score to excised aortic valve weight. Eur Heart J 37(8):693\u2013699. https:\/\/doi.org\/10.1093\/eurheartj\/ehv560","journal-title":"Eur Heart J"},{"issue":"4","key":"2623_CR6","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1161\/01.cir.86.4.1099","volume":"86","author":"JD Carroll","year":"1992","unstructured":"Carroll JD, Carroll EP, Feldman T, Ward DM, Lang RM, McGaughey D, Karp RB (1992) Sex-associated differences in left ventricular function in aortic stenosis of the elderly. Circulation 86(4):1099\u20131107. https:\/\/doi.org\/10.1161\/01.cir.86.4.1099. (PMID: 1394918)","journal-title":"Circulation"},{"issue":"16","key":"2623_CR7","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15433","volume":"10","author":"MA Fleury","year":"2022","unstructured":"Fleury MA, Annabi MS, Voisine M, Hervault M, Boilard AJ, Shen M, Marette A, C\u00f4t\u00e9 N, Clavel MA (2022) Impact of sex and sex hormones on pathophysiology and progression of aortic stenosis in a murine model. Physiol Rep 10(16):e15433. https:\/\/doi.org\/10.14814\/phy2.15433","journal-title":"Physiol Rep"},{"issue":"Suppl 1","key":"2623_CR8","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.1007\/s11739-013-0914-1","volume":"8","author":"G Tirabassi","year":"2013","unstructured":"Tirabassi G, Gioia A, Giovannini L, Boscaro M, Corona G, Carpi A, Maggi M, Balercia G (2013) Testosterone and cardiovascular risk. Intern Emerg Med 8(Suppl 1):S65\u2013S69. https:\/\/doi.org\/10.1007\/s11739-013-0914-1. (PMID: 23475207)","journal-title":"Intern Emerg Med"},{"issue":"455","key":"2623_CR9","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.cca.2016.01.034","volume":"1","author":"B Yang","year":"2016","unstructured":"Yang B, Lu C, Wu Q, Zhang J, Zhao H, Cao Y (2016) Parathyroid hormone, cardiovascular and all-cause mortality: a meta-analysis. Clin Chim Acta 1(455):154\u2013160. https:\/\/doi.org\/10.1016\/j.cca.2016.01.034. (Epub 2016 Feb 4 PMID: 26835752)","journal-title":"Clin Chim Acta"},{"issue":"1","key":"2623_CR10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1093\/aje\/kwf160","volume":"157","author":"AW Van den Beld","year":"2003","unstructured":"Van den Beld AW, Bots ML, Janssen JA, Pols HA, Lamberts SW, Grobbee DE (2003) Endogenous hormones and carotid atherosclerosis in elderly men. Am J Epidemiol 157(1):25\u201331. https:\/\/doi.org\/10.1093\/aje\/kwf160. (PMID: 1250588)","journal-title":"Am J Epidemiol"},{"issue":"Suppl 4","key":"2623_CR11","doi-asserted-by":"publisher","first-page":"iv44","DOI":"10.1136\/heartjnl-2012-302401","volume":"98","author":"S Stortecky","year":"2012","unstructured":"Stortecky S, Buellesfeld L, Wenaweser P, Windecker S (2012) Transcatheter aortic valve implantation: the procedure. Heart 98(Suppl 4):iv44-51. https:\/\/doi.org\/10.1136\/heartjnl-2012-302401","journal-title":"Heart"},{"issue":"11","key":"2623_CR12","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.jcin.2010.09.009","volume":"3","author":"JM Sinning","year":"2010","unstructured":"Sinning JM, Ghanem A, Steinh\u00e4user H, Adenauer V, Hammerstingl C, Nickenig G, Werner N (2010) Renal function as predictor of mortality in patients after percutaneous transcatheter aortic valve implantation. JACC Cardiovasc Interv 3(11):1141\u20131149. https:\/\/doi.org\/10.1016\/j.jcin.2010.09.009. (PMID: 21087750)","journal-title":"JACC Cardiovasc Interv"},{"issue":"4480","key":"2623_CR13","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/176503a0","volume":"176","author":"LL Sparks","year":"1955","unstructured":"Sparks LL, Rosenau W, Macalpin RN, Daane TA, Li CH (1955) Production of dystrophic calcification of cardiac muscle in mice by hydrocortisone. Nature 176(4480):503\u2013504. https:\/\/doi.org\/10.1038\/176503a0. (PMID: 13253600)","journal-title":"Nature"},{"key":"2623_CR14","doi-asserted-by":"publisher","first-page":"107194","DOI":"10.1016\/j.carpath.2019.107194","volume":"46","author":"KA Vaidya","year":"2020","unstructured":"Vaidya KA, Donnelly MP, Gee TW, Ibrahim Aibo MA, Byers S, Butcher JT (2020) Induction of aortic valve calcification by celecoxib and its COX-2 independent derivatives is glucocorticoid-dependent. Cardiovasc Pathol 46:107194. https:\/\/doi.org\/10.1016\/j.carpath.2019.107194","journal-title":"Cardiovasc Pathol"},{"issue":"1","key":"2623_CR15","doi-asserted-by":"publisher","first-page":"43","DOI":"10.21037\/gs.2019.11.03","volume":"9","author":"D Li","year":"2020","unstructured":"Li D, El Kawkgi OM, Henriquez AF, Bancos I (2020) Cardiovascular risk and mortality in patients with active and treated hypercortisolism. Gland Surg 9(1):43\u201358. https:\/\/doi.org\/10.21037\/gs.2019.11.03","journal-title":"Gland Surg"},{"issue":"2","key":"2623_CR16","doi-asserted-by":"publisher","first-page":"676","DOI":"10.3390\/ijerph18020676","volume":"18","author":"NAS Mohd Azmi","year":"2021","unstructured":"Mohd Azmi NAS, Juliana N, Azmani S, Mohd Effendy N, Abu IF, Mohd Fahmi Teng NI, Das S (2021) Cortisol on circadian rhythm and its effect on cardiovascular system. Int J Environ Res Public Health 18(2):676. https:\/\/doi.org\/10.3390\/ijerph18020676","journal-title":"Int J Environ Res Public Health"},{"issue":"7","key":"2623_CR17","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S2213-8587(22)00100-0","volume":"10","author":"T Deutschbein","year":"2022","unstructured":"Deutschbein T, Reimondo G, Di Dalmazi G, Bancos I, Patrova J, Vassiliadi DA, Neki\u0107 AB, Debono M, Lardo P, Ceccato F, Petramala L, Prete A, Chiodini I, Ivovi\u0107 M, Pazaitou-Panayiotou K, Alexandraki KI, Hanzu FA, Loli P, Yener S, Langton K, Spyroglou A, Kocjan T, Zacharieva S, Vald\u00e9s N, Ambroziak U, Suzuki M, Detomas M, Puglisi S, Tucci L, Delivanis DA, Margaritopoulos D, Dusek T, Maggio R, Scaroni C, Concistr\u00e8 A, Ronchi CL, Altieri B, Mosconi C, Diamantopoulos A, I\u00f1iguez-Ariza NM, Vicennati V, Pia A, Kroiss M, Kaltsas G, Chrisoulidou A, Marina LV, Morelli V, Arlt W, Letizia C, Boscaro M, Stigliano A, Kastelan D, Tsagarakis S, Athimulam S, Pagotto U, Maeder U, Falhammar H, Newell-Price J, Terzolo M, Fassnacht M (2022) Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study. Lancet Diabetes Endocrinol 10(7):499\u2013508. https:\/\/doi.org\/10.1016\/S2213-8587(22)00100-0","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"2623_CR18","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1210\/jc.2011-2107","volume":"97","author":"S Iwata","year":"2012","unstructured":"Iwata S, Walker MD, Di Tullio MR, Hyodo E, Jin Z, Liu R, Sacco RL, Homma S, Silverberg SJ (2012) Aortic valve calcification in mild primary hyperparathyroidism. J Clin Endocrinol Metab 97(1):132\u2013137. https:\/\/doi.org\/10.1210\/jc.2011-2107","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2623_CR19","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.ijcard.2011.06.025","volume":"163","author":"S Iwata","year":"2013","unstructured":"Iwata S, Hyodo E, Yanagi S, Hayashi Y, Nishiyama H, Kamimori K, Ota T, Matsumura Y, Homma S, Yoshiyama M (2013) Parathyroid hormone and systolic blood pressure accelerate the progression of aortic valve stenosis in chronic hemodialysis patients. Int J Cardiol 163(3):256\u2013259. https:\/\/doi.org\/10.1016\/j.ijcard.2011.06.025. (Epub 2011 Jun 25 PMID: 21705098)","journal-title":"Int J Cardiol"},{"issue":"7","key":"2623_CR20","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.3390\/ijms23073776","volume":"23","author":"M Vadana","year":"2022","unstructured":"Vadana M, Cecoltan S, Ciortan L, Macarie RD, Mihaila AC, Tucureanu MM, Gan AM, Simionescu M, Manduteanu I, Droc I, Butoi E (2022) Parathyroid hormone induces human valvular endothelial cells dysfunction that impacts the osteogenic phenotype of valvular interstitial cells. Int J Mol Sci 23(7):3776. https:\/\/doi.org\/10.3390\/ijms23073776","journal-title":"Int J Mol Sci"},{"issue":"5","key":"2623_CR21","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.ahj.2013.02.014","volume":"165","author":"AJ van Ballegooijen","year":"2013","unstructured":"van Ballegooijen AJ, Reinders I, Visser M, Brouwer IA (2013) Parathyroid hormone and cardiovascular disease events: a systematic review and meta-analysis of prospective studies. Am Heart J 165(5):655\u2013664. https:\/\/doi.org\/10.1016\/j.ahj.2013.02.014","journal-title":"Am Heart J"},{"issue":"4","key":"2623_CR22","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/MCA.0000000000000089","volume":"25","author":"S Shekarkhar","year":"2014","unstructured":"Shekarkhar S, Foroughi M, Moatamedi M, Gachkar L (2014) The association of serum parathyroid hormone and severity of coronary artery diseases. Coron Artery Dis 25(4):339\u2013342. https:\/\/doi.org\/10.1097\/MCA.0000000000000089. (PMID: 24487940)","journal-title":"Coron Artery Dis"},{"key":"2623_CR23","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.jsbmb.2015.12.001","volume":"164","author":"J El Hilali","year":"2016","unstructured":"El Hilali J, de Koning EJ, van Ballegooijen AJ, Lips P, Sohl E, van Marwijk HWJ, Visser M, van Schoor NM (2016) Vitamin D, PTH and the risk of overall and disease-specific mortality: results of the longitudinal aging study Amsterdam. J Steroid Biochem Mol Biol 164:386\u2013394. https:\/\/doi.org\/10.1016\/j.jsbmb.2015.12.001. (Epub 2015 Dec 8 PMID: 26678328)","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"2623_CR24","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004896","volume":"6","author":"TT Wu","year":"2017","unstructured":"Wu TT, Chen Y, Zhou Y, Adi D, Zheng YY, Liu F, Ma YT, Xie X (2017) Prognostic value of dehydroepiandrosterone sulfate for patients with cardiovascular disease: a systematic review and meta-analysis. J Am Heart Assoc 6(5):e004896. https:\/\/doi.org\/10.1161\/JAHA.116.004896","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"2623_CR25","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.21037\/apm-20-441","volume":"9","author":"REL Li","year":"2020","unstructured":"Li REL, Zha N (2020) Circulating dehydroepiandrosterone sulfate level and cardiovascular or all-cause mortality in the elderly population: a meta-analysis. Ann Palliat Med 9(5):3537\u20133545","journal-title":"Ann Palliat Med"},{"key":"2623_CR26","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.jsbmb.2014.03.006","volume":"145","author":"C Ohlsson","year":"2015","unstructured":"Ohlsson C, Vandenput L, Tivesten A (2015) DHEA and mortality: what is the nature of the association? J Steroid Biochem Mol Biol 145:248\u2013253. https:\/\/doi.org\/10.1016\/j.jsbmb.2014.03.006. (Epub 2014 Apr 2 PMID: 24704256)","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"8","key":"2623_CR27","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1172\/JCI119730","volume":"100","author":"Q Li","year":"1997","unstructured":"Li Q, Li B, Wang X, Leri A, Jana KP, Liu Y, Kajstura J, Baserga R, Anversa P (1997) Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest 100(8):1991\u20131999. https:\/\/doi.org\/10.1172\/JCI119730","journal-title":"J Clin Invest"},{"issue":"2","key":"2623_CR28","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.cbpb.2004.02.022","volume":"138","author":"LB Esberg","year":"2004","unstructured":"Esberg LB, Zhang X, Scott GI, Culver B, Ren J (2004) Impact of gender on basal and insulin-like growth factor I-regulated nitric oxide synthase activity in adult rat left ventricular myocytes. Comp Biochem Physiol A Mol Integr Physiol 138(2):141\u2013146. https:\/\/doi.org\/10.1016\/j.cbpb.2004.02.022. (PMID: 15275648)","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"issue":"11","key":"2623_CR29","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3390\/jcdd10110454","volume":"10","author":"JA Laukkanen","year":"2023","unstructured":"Laukkanen JA, Lavie CJ, Kunutsor SK (2023) Association between serum testosterone and aortic valve stenosis: a prospective cohort study. J Cardiovasc Dev Dis 10(11):454. https:\/\/doi.org\/10.3390\/jcdd10110454","journal-title":"J Cardiovasc Dev Dis"},{"issue":"6","key":"2623_CR30","doi-asserted-by":"publisher","first-page":"768","DOI":"10.7326\/M23-2781","volume":"177","author":"BB Yeap","year":"2024","unstructured":"Yeap BB, Marriott RJ, Dwivedi G, Adams RJ, Antonio L, Ballantyne CM, Bauer DC, Bhasin S, Biggs ML, Cawthon PM, Couper DJ, Dobs AS, Flicker L, Handelsman DJ, Hankey GJ, Hannemann A, Haring R, Hsu B, Martin SA, Matsumoto AM, Mellstr\u00f6m D, Ohlsson C, O\u2019Neill TW, Orwoll ES, Quartagno M, Shores MM, Steveling A, Tivesten \u00c5, Travison TG, Vanderschueren D, Wittert GA, Wu FCW, Murray K (2024) Associations of testosterone and related hormones with all-cause and cardiovascular mortality and incident cardiovascular disease in men\u202f: individual participant data meta-analyses. Ann Intern Med 177(6):768\u2013781. https:\/\/doi.org\/10.7326\/M23-2781. (Epub 2024 May 14 PMID: 38739921)","journal-title":"Ann Intern Med"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-025-02623-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00392-025-02623-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-025-02623-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:02:50Z","timestamp":1761091370000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00392-025-02623-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["2623"],"URL":"https:\/\/doi.org\/10.1007\/s00392-025-02623-6","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"type":"print","value":"1861-0684"},{"type":"electronic","value":"1861-0692"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"16 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Drs. G. Nickenig and S. Zimmer have received speaker honoraria from Abbott, Abiomed, AstraZeneca, Bayer, Boehringer Ingelheim, Daiichi, Novartis, Pfizer, Medtronic, Boston Scientific, and Edwards Lifesciences. The other authors report no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}