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Patients with QRS duration\u2009\u2265\u2009120\u00a0ms were compared to patients with QRS duration\u2009&lt;\u2009120\u00a0ms, further risk stratification was performed comparing patients with left and right bundle branch block (LBBB vs. RBBB). The primary endpoint was all-cause mortality at 30\u00a0months, secondary endpoints comprised the risk of HF-related rehospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 1627 patients with HFmrEF were included with a median QRS duration of 90\u00a0ms (i.e., QRS duration\u2009\u2265\u2009120\u00a0ms: 15%). Although the risk of long-term all-cause mortality was not affected by a prolonged QRS duration (35.1% vs. 28.7%; p\u2009=\u20090.057; HR\u2009=\u20091.254; 95% CI 0.993\u20131.583), patients with QRS duration\u2009\u2265\u2009120\u00a0ms had a higher risk of HF-related rehospitalization (18.2% vs. 11.9%; p\u2009=\u20090.008; HR\u2009=\u20091.574; 95% CI 1.124\u20132.204). A QRS duration\u2009\u2265\u2009120\u00a0ms was associated with long-term HF-related rehospitalization even after multivariable adjustment (HR 1.420, 95% CI 1.008\u20132.002, p\u2009=\u20090.045). Finally, the risks of long-term all-cause mortality and HF-related rehospitalization did not differ among patients with LBBB and RBBB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A prolonged native QRS duration is independently associated with a higher risk of HF-related rehospitalization in HFmrEF, but not long-term all-cause mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-025-02667-8","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T05:58:23Z","timestamp":1747029503000},"page":"1498-1511","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Native QRS duration and outcomes in heart failure with mildly reduced ejection fraction: results from a large-scaled registry"],"prefix":"10.1007","volume":"115","author":[{"given":"Finn Ole","family":"Kronberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Behnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielen","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Abel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bertsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning Johann","family":"Steffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Weidner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Abumayyaleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Kuschyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Schupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"issue":"4","key":"2667_CR1","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1007\/s00059-021-05062-x","volume":"47","author":"J Wintrich","year":"2022","unstructured":"Wintrich J, Berger AK, Bewarder Y, Emrich I, Slawik J, Bohm M (2022) Update on diagnostics and treatment of heart failure. 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