{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T09:10:57Z","timestamp":1778490657694,"version":"3.51.4"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00392-025-02668-7","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T05:33:18Z","timestamp":1747027998000},"page":"946-954","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ischemic outcomes after left atrial appendage closure following intracerebral hemorrhage: a retrospective inverse probability weighting analysis from the HANSE-LAAC registry"],"prefix":"10.1007","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7440-4986","authenticated-orcid":false,"given":"Dominik","family":"Jurczyk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Mezger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicitas","family":"Lemmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Fatum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"Gradaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nele-Kristin","family":"Drochner-Brocks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roza","family":"Saraei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Frerker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Stiermaier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Paitazoglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Eitel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"issue":"9921","key":"2668_CR1","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","volume":"383","author":"CT Ruff","year":"2014","unstructured":"Ruff CT, Giugliano RP, Braunwald E, Hoffman EB, Deenadayalu N, Ezekowitz MD et al (2014) Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. The Lancet 383(9921):955\u2013962","journal-title":"The Lancet"},{"key":"2668_CR2","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1056\/NEJMoa2408308","volume":"392","author":"OM Wazni","year":"2025","unstructured":"Wazni OM, Saliba WI, Nair DG, Marijon E, Schmidt B, Hounshell T et al (2025) (2024) Left atrial appendage closure after ablation for atrial fibrillation. N Engl J Med 392:1277\u20131287. https:\/\/doi.org\/10.1056\/NEJMoa2408308","journal-title":"N Engl J Med"},{"issue":"36","key":"2668_CR3","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","volume":"45","author":"IC Van Gelder","year":"2024","unstructured":"Van Gelder IC, Rienstra M, Bunting KV, Casado-Arroyo R, Caso V, Crijns HJGM et al (2024) 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): Developed by the task force for the management of atrial fibrillation of the European Society of Cardiology (ESC), with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Endorsed by the European Stroke Organisation (ESO). Eur Heart J 45(36):3314\u20133414","journal-title":"Eur Heart J"},{"key":"2668_CR4","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1007\/s00415-021-10448-2","volume":"269","author":"T Wu","year":"2022","unstructured":"Wu T, Lv C, Wu L, Chen W, Lv M, Jiang S et al (2022) Risk of intracranial hemorrhage with direct oral anticoagulants: a systematic review and meta-analysis of randomized controlled trials. J Neurol 269:664\u2013675","journal-title":"J Neurol"},{"key":"2668_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.961000","volume":"9","author":"X Liu","year":"2022","unstructured":"Liu X, Guo S, Xu Z (2022) Meta-analysis of oral anticoagulants and adverse outcomes in atrial fibrillation patients after intracranial hemorrhage. Front Cardiovasc Med 9:961000. https:\/\/doi.org\/10.3389\/fcvm.2022.961000","journal-title":"Front Cardiovasc Med"},{"issue":"24","key":"2668_CR6","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1016\/j.jacc.2017.10.021","volume":"70","author":"VY Reddy","year":"2017","unstructured":"Reddy VY, Doshi SK, Kar S, Gibson DN, Price MJ, Huber K et al (2017) 5-year outcomes after left atrial appendage closure: from the PREVAIL and PROTECT AF trials. J Am Coll Cardiol 70(24):2964\u20132975","journal-title":"J Am Coll Cardiol"},{"issue":"25","key":"2668_CR7","doi-asserted-by":"publisher","first-page":"3122","DOI":"10.1016\/j.jacc.2020.04.067","volume":"75","author":"P Osmancik","year":"2020","unstructured":"Osmancik P, Herman D, Neuzil P, Hala P, Taborsky M, Kala P et al (2020) Left Atrial Appendage Closure Versus Direct Oral Anticoagulants in High-Risk Patients With Atrial Fibrillation. J Am Coll Cardiol 75(25):3122\u20133135","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"2668_CR8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.118.006841","volume":"12","author":"LV Boersma","year":"2019","unstructured":"Boersma LV, Ince H, Kische S, Pokushalov E, Schmitz T, Schmidt B et al (2019) Evaluating real-world clinical outcomes in atrial fibrillation patients receiving the WATCHMAN left atrial appendage closure technology. Circ Arrhyth Electrophysiol 12(4):e006841","journal-title":"Circ Arrhyth Electrophysiol"},{"issue":"5","key":"2668_CR9","doi-asserted-by":"publisher","first-page":"e590","DOI":"10.4244\/EIJ-D-18-00344","volume":"14","author":"U Landmesser","year":"2018","unstructured":"Landmesser U, Tondo C, Camm J, Diener H-C, Paul V, Schmidt B et al (2018) Left atrial appendage occlusion with the AMPLATZER Amulet device: one-year follow-up from the prospective global Amulet observational registry. EuroIntervention 14(5):e590\u2013e597","journal-title":"EuroIntervention"},{"issue":"10","key":"2668_CR10","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.4244\/EIJY15M01_06","volume":"11","author":"A Tzikas","year":"2016","unstructured":"Tzikas A, Shakir S, Gafoor S, Omran H, Berti S, Santoro G et al (2016) Left atrial appendage occlusion for stroke prevention in atrial fibrillation: multicentre experience with the AMPLATZER Cardiac Plug. EuroIntervention 11(10):1170\u20131179","journal-title":"EuroIntervention"},{"issue":"3","key":"2668_CR11","doi-asserted-by":"publisher","first-page":"371","DOI":"10.4244\/EIJ-D-17-00201","volume":"13","author":"JE Nielsen-Kudsk","year":"2017","unstructured":"Nielsen-Kudsk JE, Johnsen SP, Wester P, Damgaard D, Airaksinen JKE, Lund J et al (2017) Left atrial appendage occlusion versus standard medical care in patients with atrial fibrillation and intracerebral haemorrhage: a propensity score-matched follow-up study. EuroIntervention 13(3):371\u2013378","journal-title":"EuroIntervention"},{"issue":"7","key":"2668_CR12","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1001\/jamaneurol.2021.0925","volume":"78","author":"SB Murthy","year":"2021","unstructured":"Murthy SB, Zhang C, Diaz I, Levitan EB, Koton S, Bartz TM et al (2021) Association Between Intracerebral Hemorrhage and Subsequent Arterial Ischemic Events in Participants From 4 Population-Based Cohort Studies. JAMA Neurol 78(7):809\u2013816","journal-title":"JAMA Neurol"},{"issue":"6","key":"2668_CR13","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1161\/01.STR.17.6.1078","volume":"17","author":"T Brott","year":"1986","unstructured":"Brott T, Thalinger K, Hertzberg V (1986) Hypertension as a risk factor for spontaneous intracerebral hemorrhage. Stroke 17(6):1078\u20131083","journal-title":"Stroke"},{"issue":"1","key":"2668_CR14","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1177\/2396987321994296","volume":"6","author":"R Stanton","year":"2021","unstructured":"Stanton R, Demel SL, Flaherty ML et al (2021) Risk of intracerebral haemorrhage from hypertension is greatest at an early age. Eur Stroke J 6(1):28\u201335. https:\/\/doi.org\/10.1177\/2396987321994296","journal-title":"Eur Stroke J"},{"issue":"11","key":"2668_CR15","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1161\/01.STR.27.11.2020","volume":"27","author":"AG Thrift","year":"1996","unstructured":"Thrift AG, McNeil JJ, Forbes A, Donnan GA (1996) Risk Factors for Cerebral Hemorrhage in the Era of Well-Controlled Hypertension. Stroke 27(11):2020\u20132025","journal-title":"Stroke"},{"issue":"5","key":"2668_CR16","doi-asserted-by":"publisher","first-page":"E348","DOI":"10.25270\/jic\/21.00240","volume":"34","author":"C Paitazoglou","year":"2022","unstructured":"Paitazoglou C, Fau-Bergmann MW, Bergmann MW, Ince H, Fau-Kische S, Kische S, Fau-Romanov A, Fau-Schmitz Romanov A, Schmitz T, Fau-Schmidt B et al (2022) True efficacy of LAA closure: patient outcomes on long-term single-antiplatelet or no therapy: insights from the EWOLUTION Registry. J Invasive Cardiol 34(5):E348\u2013E355. https:\/\/doi.org\/10.25270\/jic\/21.00240","journal-title":"J Invasive Cardiol"},{"issue":"4","key":"2668_CR17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.jacc.2021.04.098","volume":"78","author":"T Simard","year":"2021","unstructured":"Simard T, Jung RG, Lehenbauer K, Piayda K, Praco\u0144 R, Jackson GG et al (2021) Predictors of device-related thrombus following percutaneous left atrial appendage occlusion. J Am Coll Cardiol 78(4):297\u2013313","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"2668_CR18","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.hrthm.2022.02.011","volume":"19","author":"C Paitazoglou","year":"2022","unstructured":"Paitazoglou C, Meincke F, Bergmann MW, Eitel I, Fink T, Vireca E et al (2022) The ALSTER-FLX Registry: 3-Month outcomes after left atrial appendage occlusion using a next-generation device, a matched-pair analysis to EWOLUTION. Heart Rhythm 19(6):917\u2013926","journal-title":"Heart Rhythm"},{"key":"2668_CR19","doi-asserted-by":"crossref","unstructured":"CLEARANCE Study (2024) [Available from: https:\/\/www.uniklinikum-jena.de\/clearance\/Clearance.html. Accessed 10 Mar 2025","DOI":"10.1515\/9780228020783-007"},{"issue":"3","key":"2668_CR20","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1177\/2396987320932069","volume":"5","author":"EH Svensson","year":"2020","unstructured":"Svensson EH, Abul-Kasim K, Engstr\u00f6m G, S\u00f6derholm M (2020) Risk factors for intracerebral haemorrhage \u2013 Results from a prospective population-based study. Eur Stroke J 5(3):278\u2013285","journal-title":"Eur Stroke J"},{"issue":"9","key":"2668_CR21","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1161\/01.STR.26.9.1558","volume":"26","author":"S Juvela","year":"1995","unstructured":"Juvela S, Hillbom M, Palom\u00e4ki H (1995) Risk factors for spontaneous intracerebral hemorrhage. Stroke 26(9):1558\u20131564","journal-title":"Stroke"},{"issue":"1","key":"2668_CR22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.5853\/jos.2016.00864","volume":"19","author":"SJ An","year":"2017","unstructured":"An SJ, Kim TJ, Yoon B-W (2017) Epidemiology, risk factors, and clinical features of intracerebral hemorrhage: an update. J Stroke 19(1):3\u201310","journal-title":"J Stroke"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-025-02668-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00392-025-02668-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-025-02668-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T08:40:16Z","timestamp":1778488816000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00392-025-02668-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,12]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["2668"],"URL":"https:\/\/doi.org\/10.1007\/s00392-025-02668-7","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,12]]},"assertion":[{"value":"20 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors declared that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}