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While EuroSCORE II is well established for surgical risks, it is less effective for TAVR, and the newer STS\/ACC TAVR score has so far been validated mainly for in-hospital and 30-day mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Aims<\/jats:title>\n            <jats:p>This study aims to improve risk stratification for TAVR patients by identifying real-time predictors of 30-day and 1-year mortality that incorporate comprehensive, procedure-specific factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Five-year data from 2256 transfemoral TAVR procedures performed at two German Heart Centers (2017\u20132022) were retrospectively analyzed. Predictors of 1-year and 30-day mortality were assessed using multivariable logistic and LASSO regression, considering a broad spectrum of patient demographics, comorbidities, and peri-procedural factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The analyses revealed a predictor model (PRE-TAVR predictors) for 1-year mortality (AUC 0.770; 95% CI 0.731\u20130.809), including age (&gt;\u200981.5\u00a0years), NYHA stage IV, COPD (GOLD\u2009\u2265\u20092), atrial fibrillation, previous stroke or malignancy, elevated C-reactive protein (\u2265\u20099.5\u00a0mg\/L), aortic valve \u0394P mean\u2009\u2265\u200948.5\u00a0mmHg, peripheral arterial disease (&gt;\u2009stage 2) and low platelet count (\u2264\u2009228.5\u00a0g\/L). The accuracy of the model exceeded the EuroSCORE II (AUC 0.645; 95% CI 0.599\u20130.691) and the STS\/ACC TAVR score (AUC 0.714; 95% CI 0.670\u20130.758). For 30-day mortality, NYHA class IV was the only significant predictor in the bivariate analyses. However, additional LASSO analyses identified pre-existing renal insufficiency (KDIGO stage\u2009\u2265\u20093) and pre-TAVR sodium levels as further significant predictors. The AUC was 0.699 (95% CI 0.611\u20130.788) compared to an AUC of 0.680 (95% CI 0.604\u20130.756) for EuroSCORE II and 0.7129 (95% CI 0.633\u20130.793) for the STS\/ACC TAVR score.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The PRE-TAVR study developed a robust model, particularly for predicting 1-year mortality. This model outperformed the EuroSCORE II and STS\/ACC TAVR scores, despite requiring fewer variables. It provides a solid basis for future risk scores and enables more precise patient selection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical Abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s00392-025-02704-6","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T07:06:48Z","timestamp":1751872008000},"page":"1574-1584","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patient risk evaluation for transcatheter aortic valve replacement (PRE-TAVR) \u2014 identification of real-time predictors of short- and long-term mortality"],"prefix":"10.1007","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9498-9558","authenticated-orcid":false,"given":"Julian","family":"Kreutz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Lauten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Chatzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Nabrotzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Patsalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Styliani","family":"Syntila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Lapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Schieffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Markus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"issue":"10","key":"2704_CR1","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1001\/jamacardio.2022.2695","volume":"7","author":"NM Van Mieghem","year":"2022","unstructured":"Van Mieghem NM, Deeb GM, S\u00f8ndergaard L et al (2022) Self-expanding transcatheter vs surgical aortic valve replacement in intermediate-risk patients: 5-year outcomes of the SURTAVI randomized clinical trial. 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