{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:08:24Z","timestamp":1789027704209,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fractional flow reserve (FFR) for non-culprit lesions (NCLs) in patients with ST-elevation myocardial infarction (STEMI) can be influenced by temporary changes in microvascular resistance. Angiography-derived vessel fractional flow reserve (vFFR) has been tested as a less-invasive alternative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The FAST STEMI II study aimed to assess the diagnostic performance of acute-setting vFFR vs. FFR for intermediate NCLs in STEMI patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>FAST STEMI II is a prospective two-center cohort study including STEMI patients with\u2009\u2265\u20091 intermediate NCL (50\u201390% diameter stenosis). Patients with cardiogenic shock, prior revascularization of the non-culprit vessel, or aorta-ostial lesions were excluded. Following primary percutaneous coronary intervention (PCI), vFFR, FFR, resting full-cycle ratio (RFR), coronary flow reserve (CFR), and index of microcirculatory resistance (IMR) measurements of the NCL were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 111 patients were included. Median [25th\u201375th percentile] vFFR and FFR were 0.83 [0.74\u20130.88] and 0.83 [0.80\u20130.90], respectively. vFFR had a moderate to good discriminative ability to predict FFR\u2009\u2264\u20090.80 (AUC: 0.78; 95% CI: 0.68\u20130.89; p\u2009&lt;\u20090.001) with a moderate correlation (r\u2009=\u20090.54; p\u2009&lt;\u20090.001). Diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of vFFR to predict FFR\u2009\u2264\u20090.80 were 72%, 76%, 70%, 53%, and 87%, respectively. Microvascular dysfunction (CFR\u2009&lt;\u20092.0 and IMR\u2009\u2265\u200925) was observed in 33 (31%) patients. In patients with microvascular dysfunction, median vFFR and FFR values were 0.76 [0.71\u20130.86] and 0.85 [0.77\u20130.90], respectively (p\u2009=\u20090.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found moderate correlation between vFFR and FFR in NCLs of patients undergoing primary PCI. Discordance between vFFR and FFR was associated with the presence of microvascular dysfunction.<\/jats:p>\n                    <jats:p>The study was conducted in accordance with Good Clinical Practice and the Declaration of Helsinki and was registered at 22-jun-2023 on clinicaltrials.gov under the identifier NCT05698719.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-025-02729-x","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T10:11:10Z","timestamp":1757412670000},"page":"1775-1784","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Validation of angiography-based FFR in non-culprit vessels of patients presenting with STEMI"],"prefix":"10.1007","volume":"115","author":[{"given":"Jari A.","family":"van der Eijk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik T. 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NvM has received institutional research grants from Abbott, Boston Scientific, Edwards Lifesciences, Medtronic, Meril, Pie Medical, PulseCath BV, Teleflex and consultancy fees from Abbott, Abiomed, Alleviant Medical Inc., AncorValve, Anteris, Approxima Srl, Bolt Medical, Boston Scientific, Daiichi Sankyo, LUMA Vision, Materialise, Medtronic, Pie Medical, Polares, PulseCath BV, Siemens. JD received institutional grant\/research support from Abbott Vascular, Boston Scientific, ACIST Medical, Medtronic, Pie Medical, and ReCor medical, and consultancy and speaker fees from Abbott Vascular, ACIST medical, Boston Scientific, Cardialysis BV, CardiacBooster, Kaminari Medical, ReCor Medical, Pie Medical, Sanofi, Siemens Health Care and Medtronic. The remaining authors report to have no disclosures.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}