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However, whole-body vibration (WBV) exercise could offer a novel approach to improve exercise capacity and quality of life, though its effects remain unclear in this population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Thirty patients with AS scheduled for TAVI were prospectively and randomly assigned to either the WBV group (12 sessions, 30\u00a0min each over 4\u00a0weeks) or a control group. Assessments of cardiopulmonary exercise testing (CPET), 6-min walking distance (6MWD) and health-related quality of life (HRQoL) questionnaires were conducted at baseline (V1), one day before TAVI (V2) and at short-term follow-up (V3). WBV was conducted between V1 and V2.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>For the analysis at V1 and V2 16 patients in the WBV group and 14 in the control group were included. Mean age was 79.7\u2009\u00b1\u20095.22\u00a0years, with a mean aortic valve area of 0.75\u2009\u00b1\u20090.21 cm<jats:sup>2<\/jats:sup>. Peak V\u2019O<jats:sub>2<\/jats:sub> increased by 0.3\u00a0mL*min<jats:sup>-1<\/jats:sup>*kg<jats:sup>-1<\/jats:sup> in the WBV group versus a decrease of\u2009\u2212\u20091.4\u00a0mL*min<jats:sup>-1<\/jats:sup>*kg<jats:sup>-1<\/jats:sup> in the control group (difference, 1.7\u00a0mL*min<jats:sup>-1<\/jats:sup>*kg<jats:sup>-1<\/jats:sup>; 95% CI, [0.2 to 3.2], <jats:italic>p<\/jats:italic>\u2009=\u20090.03). Peak power improved by 5.1 W in the WBV group compared to a decline of\u2009\u2212\u20094.5 W in the control group (difference, 9.6 W; 95% CI, [2.1 to 17.1], <jats:italic>p<\/jats:italic>\u2009=\u20090.01). The WBV group also showed a non-significant improvement in 6MWD (34\u00a0m vs.\u2009\u2212\u20098\u00a0m in the control group; difference, 42\u00a0m; 95% CI, [-10 to 93], <jats:italic>p<\/jats:italic>\u2009=\u20090.11). No serious adverse events occurred in the WBV group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This pilot study demonstrated that a WBV exercise program is feasible, safe, and showed potential to preserve exercise capacity as well as physical performance in AS patients scheduled for TAVI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical Abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s00392-025-02744-y","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T09:52:39Z","timestamp":1758534759000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and effectiveness of oscillatory whole-body vibration training on exercise capacity and physical performance in aortic valve stenosis patients prior to transcatheter aortic valve implantation: a randomized clinical trial"],"prefix":"10.1007","author":[{"given":"Johannes","family":"Klaus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Gerhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Nienaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Mauri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"M\u00f6llenhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Nies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elmar","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Gerfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilija","family":"Djordjevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Guthoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Iliadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Hohmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Adam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5810-2868","authenticated-orcid":false,"given":"Hendrik","family":"Wienemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"2744_CR1","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1136\/heartjnl-2012-302265","volume":"99","author":"GW Eveborn","year":"2013","unstructured":"Eveborn GW, Schirmer H, Heggelund G et al (2013) The evolving epidemiology of valvular aortic stenosis. 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Kuhn reports consultancy and personal fees from Medtronic, Edwards Lifesciences, Boston Scientific, and Abbott. S. Baldus reports lecture fees from Abbott, Edwards Lifesciences, AstraZeneca, and JenaValve Technology; he received research grants from Abbott and AstraZeneca; and participates as a principal investigator in clinical trials sponsored by AstraZeneca and Abbott. C. Hohmann reports lecture\/consultancy fees and\/or travel grants\u00a0from\u00a0Bayer, Daiichi Sankyo, Edwards Lifesciences,\u00a0Johnson & Johnson,\u00a0MSD, and Pfizer. M. Adam reports grants and personal fees from Medtronic, and personal fees from Abbott, JenaValve Technology, Edwards Lifesciences, Boston Scientific, and Meril. H. Wienemann reports consultancy fees and travel grants from JenaValve Technology. All other authors declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest\/disclosures"}}]}}