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We aim to investigate the impact of sex-specific differences on defibrillation-capable cardiac devices\u2019 implantation and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The German DEVICE registry is a prospective, multicentre database of ICD and CRT device implantation. A total of 5330 patients receiving a defibrillation-capable device were prospectively enrolled in 44 centres between March 2007 and February 2014 and followed for 17 (13, 23) months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A minority of patients in this registry was female 1017 (19.1%). The rate of CRT-D use among the defibrillator recipients was higher in women (32.4% vs. 28.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). The incidence of major periprocedural complications and in-hospital complications were higher in women (3.3% vs. 1.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001 and 5.5% vs. 3.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017, respectively). The 1-year all-cause mortality was 5.5% for women and 7.4% for men (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039), while the 1-year cardiovascular mortality was 4.1% and 6.2%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). Less women received device shocks during 1-year follow-up (10.7% vs. 13.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023). Women receiving CRT-D had a lower non-device-related cardiovascular hospitalization rate than men.\n                    <\/jats:p>\n                    <jats:p>System revision until discharge, in-hospital death and non-fatal complications during follow-up were comparable for men and women. Similar rates of all-cause and cardiac rehospitalizations were found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real-life patient cohort only a minority of patients was female. Female patients had a higher risk of major periprocedural complications and in-hospital complications but a lower all-cause and cardiovascular mortality. Less women experienced device-shocks during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                    <jats:p>Overview of the results<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-025-02792-4","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T09:39:12Z","timestamp":1764581952000},"page":"622-633","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of sex on the utilization of defibrillation-capable cardiac implantable devices and outcome: results from the German device registry"],"prefix":"10.1007","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5469-8833","authenticated-orcid":false,"given":"Sorin \u0218tefan","family":"Popescu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Gasperetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Brachmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Eckardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Heinz","family":"Kuck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Willems","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3886-0930","authenticated-orcid":false,"given":"Patrick","family":"Lugenbiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1974-6147","authenticated-orcid":false,"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Schmidtke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3256-0726","authenticated-orcid":false,"given":"Steffen","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0499-704X","authenticated-orcid":false,"given":"Matthias","family":"Hochadel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3547-2126","authenticated-orcid":false,"given":"Jochen","family":"Senges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0122-7130","authenticated-orcid":false,"given":"Roland Richard","family":"Tilz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"2792_CR1","doi-asserted-by":"publisher","unstructured":"Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators (1997) A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias. 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Approval was granted by the Ethics Committee of Landesaerztekammer Rheinland-Pfalz.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"RRT has received honoraria for lectures from Pfizer, Abbott, Biosense Webster, Boston Scientific, Doctrina Med, cme4u, Medtronic, Radcliff Cardiology, and Wikonect. He has received honoraria for advisory board participation and consulting from Boston Scientific, Biosense Webster, Capvision, Guidepoint, Haemonetics, Medtronic, Philips, and Abbott. His institution has received research funding or participated in clinical trials sponsored by Biotronik, Abbott, Boston Scientific, Medtronic, Lifetech, and Johnson & Johnson. He has also received travel grants from Biosense Webster, Abbott, Boston Scientific, Medtronic, and Philips.\u00a0SSP is a medical consultant by Active Health and has received travel grants and congress grants from Lifetech and educational grants and speaker grants from Abbott Medical.\u00a0KHK reports grants and personal fees from Abbott Vascular, Medtronic, and Biosense Webster outside the submitted work.\u00a0All other authors have declared that no competing interests exist.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}