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The purpose of this study was the CMR-based quantification of PWV and AD in the context of cardiovascular risk factors (CVRF) and\/or diseases (CVD) in the Hamburg City Health Study (HCHS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The HCHS is a prospective, population-based cohort study. 2D-phase-contrast-flow CMR measurements were performed to quantify PWV and AD in the ascending (AD AoAsc) and descending aorta (AD AoDesc).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The CMR cohort consisted of 2270 participants (41.5% females, median age 66.5\u00a0years). PWV was 5.80 [4.91, 7.19] m\/s, AD AoAsc 0.54 [0.34, 0.78] [1\/(10^3*kPa)], and AD AoDesc 0.61 [0.39, 0.84] [1\/(10^3*kPa)] in participants without any CVRF and\/or CVD. In participants with at least one CVRF and\/or CVD PWV was significantly higher, AD AoAsc and AD AoDesc significantly lower. After adjustment for age and sex, PWV was significantly associated with smoking (OR 1.05), CAD (OR 0.932), and hypertension (OR 1.118); AD AoAsc with hypertension (OR 0.448); and AD AoDesc with hypertension (OR 0.343), BMI\u2009&gt;\u200930\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (OR 0.575), CAD (OR 2.17), and history of myocardial infarction (OR 2.413).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The presence of CVRF and\/or CVD is related to significantly higher PWV and lower AD values. However, hypertension is the only CVRF\/CVD consistently associated with higher PWV and lower AD after adjustment for age and sex. Our findings do not indicate a predictive value of abnormal PWV and AD values for prevalent CAD and MI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-026-02866-x","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T10:05:28Z","timestamp":1770631528000},"page":"1389-1399","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Associations between cardiovascular risk factors and diseases with aortic pulse wave velocity and aortic distensibility: magnetic resonance imaging in the Hamburg city health study"],"prefix":"10.1007","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5956-0051","authenticated-orcid":false,"given":"Katharina A.","family":"Riedl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Di Carluccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Huellebrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Hennemuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Frye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Hazizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersin","family":"Cavus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan N.","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enver","family":"Tahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Erley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern P.","family":"Schoennagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulus","family":"Kirchhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Muellerleile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"2866_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jash.2015.11.012","volume":"10","author":"H Smulyan","year":"2016","unstructured":"Smulyan H, Mookherjee S, Safar ME (2016) The two faces of hypertension: role of aortic stiffness. 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PK is listed as inventor on two issued patents held by the University of Hamburg (Atrial Fibrillation Therapy WO 2015140571, Markers for Atrial Fibrillation WO 2016012783). AZ is listed as co-inventor of an international patent on the use of a computing device to estimate the probability of myocardial infarction (International Publication Number WO2022043229A1) and is scientific director and CEO of Cardio-CARE, a program by the K\u00fchne Foundation and shareholder of the ART-EMIS Hamburg GmbH. BPS is co-founder and stakeholder of northh Medical GmbH. All other authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}