{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:05:37Z","timestamp":1772445937763,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Heart failure with reduced ejection fraction (HFrEF) causes reduced functional capacity, impaired quality of life, and frequent rehospitalisation. Although guidelines recommend cardiac rehabilitation (CardRehab), referral rates remain low. The MEDIAN Heart Failure Registry evaluated short- and midterm outcomes of inpatient CardRehab in routine practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective multicentre registry included 808 patients with clinically stable HFrEF (LVEF\u2009\u2264\u200940%) undergoing inpatient cardiac rehabilitation across 17 German centres (2019\u20132020). Clinical outcomes\u20146-min walk test, bicycle ergometry, echocardiographic LVEF, NYHA class, NT-proBNP (subset), and patient-reported outcomes (KCCQ, HADS)\u2014were assessed at admission, discharge, and 6\u00a0months post-discharge. A structured follow-up survey evaluated adherence to lifestyle changes and the sustainability of effects after the 22.8-day inpatient stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 808 patients (mean age, 65\u00a0years; 16.6% females) showed significant improvements in physical and psychosocial parameters. Mean LVEF increased from 31.1% (SD 9.0) to 35.9% (SD 10.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), mean 6-min walk distance from 306\u00a0m (SD 136) to 388\u00a0m (SD 158;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), and mean bicycle ergometry from 27.8 W (SD 15.4) to 49.5 W (SD 26.4;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Mean NT-proBNP decreased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). KCCQ and HADS scores improved significantly. Inpatient mortality rate during rehabilitation was 0.6% (5\/808), and the rehospitalisation rate due to heart failure was 2.8% (23\/808). There were two documented cancellations of rehabilitation. At 6-month follow-up, benefits remained stable with high adherence to recommended behaviours.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cardiac rehabilitation was associated with improvements in physical capacity, left ventricular function, psychological well-being, and quality of life in patients with chronic heart failure, alongside low observed rehospitalisation rates during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-026-02873-y","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T09:21:20Z","timestamp":1772443280000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac rehabilitation in patients with reduced left ventricular function in Germany: insights from the multicentre MEDIAN Heart Failure Registry"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4699-9210","authenticated-orcid":false,"given":"E.","family":"Kutali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sch\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Altmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Brezger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Eddicks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the MEDIAN Medical Board Cardiology","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"2873_CR1","unstructured":"Gesundheitsberichterstattung des Bundes https:\/\/www.gbebund.de\/gbe\/pkg_olap_tables.prc_sort_indp_uid=gast&p_aid=27862160&p_sprache=D&p_help=2&p_indnr=659&p_ansnr=71833487&p_version=2&p_sortorder=d&p_dim_1=D.100&p_dw_1=10104&p_dim_2=D.000&p_dw_2=3743#SOURCES"},{"issue":"17","key":"2873_CR2","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1016\/j.jacc.2019.01.072","volume":"73","author":"MG Del Buono","year":"2019","unstructured":"Del Buono MG, Arena R, Borlaug BA, Carbone S, Canada JM, Kirkman DL, Garten R, Rodriguez-Miguelez P, Guazzi M, Lavie CJ et al (2019) Exercise intolerance in patients with heart failure: JACC state-of-the-art review. 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Ethical approval was obtained from the Ethics Committee of the S\u00e4chsische Landes\u00e4rztekammer Dresden and all procedures were performed in compliance with institutional and national guidelines. All participants provided written informed consent prior to their inclusion in the study. Data collection and processing were conducted ensuring confidentiality and adherence to data protection regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The views expressed in this article are those of the authors and do not necessarily reflect the position of the MEDIAN Kliniken or associated institutions.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}