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Data on the incidence of CTEPH\/D signs and outcome after LBT are lacking. These angiographic signs are not equivalent to a confirmed diagnosis of CTEPH\/D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the efficacy and safety of LBT in patients with acute PE and angiographic signs of CTEPH\/D compared to patients without (N-CTEPH\/D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 250 patients from five centers (CTEPH\/D\u2009=\u200998, N-CTEPH\/D\u2009=\u2009152) were retrospectively analyzed. Efficacy of LBT was assessed by comparing clinical, echocardiographic, and invasive data between the groups. Safety endpoints included periprocedural death, procedural complications, or bleeding defined as the need for blood transfusion or hemoglobin drop of at least 5\u00a0g\/dl.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, the CTEPH\/D group had higher systolic pulmonary artery pressure (sPAP) (CTEPH\/D: 54\u2009\u00b1\u200914\u00a0mmHg, N-CTEPH\/D: 49\u2009\u00b1\u200913\u00a0mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). After LBT, right ventricular\/left ventricular-ratio (CTEPH\/D:\u2009\u2212\u20090.30\u2009\u00b1\u20090.26, N-CTEPH\/D:\u2009\u2212\u20090.27\u2009\u00b1\u20090.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for both), sPAP (CTEPH\/D:\u2009\u2212\u200913\u2009\u00b1\u20098, N-CTEPH\/D:\u2009\u2212\u200911\u2009\u00b1\u20098\u00a0mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for both), heart rate (CTEPH\/D:\u2009\u2212\u200919\u2009\u00b1\u200920 beats\/min, N-CTEPH\/D:\u2009\u2212\u200921\u2009\u00b1\u200915 beats\/min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for both) and respiratory rate (CTEPH\/D:\u2009\u2212\u20096\u2009\u00b1\u20096 respirations\/min, N-CTEPH\/D: by\u2009\u2212\u20098\u2009\u00b1\u20097 respirations \/min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for both) were significantly reduced in both groups without significant differences. Peri-interventional safety was comparable between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LBT appears to be safe and effective in patients with acute PE and angiographic signs of CTEPH\/D. Long-term effects should be further investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-026-02893-8","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:45:34Z","timestamp":1777358734000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Catheter-directed thrombectomy in acute pulmonary embolism and angiographic signs of chronic thromboembolic pulmonary disease"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2854-5501","authenticated-orcid":false,"given":"Parham","family":"Shahidi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luise","family":"Mentzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Lauder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Stojanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maike","family":"Knorr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl Friedrich","family":"Drummer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Sulimov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"M\u00f6bius-Winkler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Piorkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Hobohm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"P\u00f6ss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Fengler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"2893_CR1","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1161\/ATVBAHA.114.304488","volume":"34","author":"GE Raskob","year":"2014","unstructured":"Raskob GE, Angchaisuksiri P, Blanco AN, Buller H, Gallus A, Hunt BJ, Hylek EM, Kakkar A, Konstantinides SV, McCumber M, Ozaki Y, Wendelboe A, Weitz JI (2014) Thrombosis: a major contributor to global disease burden. 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FM has been supported by Deutsche Forschungsgemeinschaft (SFB TRR219, Project-ID 322900939), and Deutsche Herzstiftung. Saarland University has received scientific support from Ablative Solutions, Medtronic, and ReCor Medical. Until May 2024, FM has received speaker honoraria\/consulting fees from Ablative Solutions, Astra-Zeneca, Inari, Medtronic, Merck, Novartis, Philips, and ReCor Medical. LH personal lecture\/consultant fees from MSD, Janssen, Boston Scientific, Inari Medical, and Penumbra. LL has received speaker honoraria from AstraZeneca, Medtronic, Pfizer, Servier, and Recor Medical and consulting fees from Medtronic and Recor Medical. MP has received speaker honoraria\/consulting fees from Inari Medical, Boston Scientific, Becton Dickinson, and Veryan Medical. All the other authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}