{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T09:10:24Z","timestamp":1778490624019,"version":"3.51.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left atrial appendage (LAA) thrombus formation is associated with elevated stroke risk and mortality. This study was designed to compare different therapeutic strategies in patients presenting with LAA thrombi despite adequate oral anticoagulation (OAC) therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective single-center study, patients with atrial fibrillation (AF) and LAA thrombus despite adequate OAC for more than three weeks were identified. A follow-up transesophageal echo (TEE) was performed at least four weeks after the initial TEE. Thrombus resolution was assessed for each treatment cycle, defined as the interval of OAC therapy between two consecutive TEE examinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 216 patients who underwent a total of 294 treatment cycles. At baseline, 47% (\n                      <jats:italic>n<\/jats:italic>\n                      = 101) of patients were receiving novel oral anticoagulants (NOACs), while 53% (\n                      <jats:italic>n<\/jats:italic>\n                      = 115) were treated with vitamin-K antagonists (VKAs). Treatment options included switching OAC from VKA to NOAC (\n                      <jats:italic>n<\/jats:italic>\n                      = 18), from NOAC to a different NOAC (\n                      <jats:italic>n<\/jats:italic>\n                      = 14) and from NOAC to VKA (\n                      <jats:italic>n<\/jats:italic>\n                      = 77); or maintaining the same NOAC (\n                      <jats:italic>n<\/jats:italic>\n                      = 28) or VKA (\n                      <jats:italic>n<\/jats:italic>\n                      = 157). Overall, LAA thrombi resolved in 70% (152\/216) after a mean follow up time of 130 (SD 195) days). No significant differences regarding resolution rate between the five different anticoagulation strategies were observed (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.866). Multivariate regression analysis identified tricuspid annular plane systolic excursion as independently predictive of LAA thrombus persistence (OR 0.87; 95% CI 0.78\u20130.98;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.026).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the largest cohort of patients presenting with LAA thrombi despite adequate OAC. Overall resolution was 70%. Modification of the anticoagulation regimen did not result in higher thrombus resolution rates compared with continuation of the same therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-026-02917-3","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:23:55Z","timestamp":1776669835000},"page":"1042-1053","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of therapeutic strategies in patients presenting with left atrial thrombus despite oral anticoagulation"],"prefix":"10.1007","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7511-3809","authenticated-orcid":false,"given":"Tobias","family":"Schreiber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Nagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Cretnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Isabel","family":"Adler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Tscholl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Landmesser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sannino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andi","family":"Rroku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Huemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Attanasio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"issue":"23","key":"2917_CR1","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1016\/j.jacc.2021.04.036","volume":"77","author":"A Lurie","year":"2021","unstructured":"Lurie A, Wang J, Hinnegan Kyra J, McIntyre William F, Belley-C\u00f4t\u00e9 Emilie P, Amit G et al (2021) Prevalence of left atrial thrombus in anticoagulated patients with atrial fibrillation. JACC. 77(23):2875\u201386","journal-title":"JACC."},{"key":"2917_CR2","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2022.28","volume":"9","author":"J Katic","year":"2023","unstructured":"Katic J, Borovac JA (2023) Treatment of persistent left atrial appendage thrombus in patients with atrial fibrillation on adequate oral anticoagulation: pathways of care for all-comers and heart failure patients. Card Fail Rev 9:e05","journal-title":"Card Fail Rev"},{"issue":"1","key":"2917_CR3","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/s41598-023-27622-3","volume":"13","author":"M Hautmann","year":"2023","unstructured":"Hautmann M, Zacher M, Fuchs S, P\u00e9rez CM, Ahmidou A, Kerber S et al (2023) Left atrial appendage thrombus formation, potential of resolution and association with prognosis in a large real-world cohort. Sci Rep. 13(1):889","journal-title":"Sci Rep."},{"key":"2917_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11041128","author":"K Kosmalska","year":"2022","unstructured":"Kosmalska K, Gilis-Malinowska N, Rzyman M, Danilowicz-Szymanowicz L, Fijalkowski M (2022) Risk of death and ischemic stroke in patients with atrial arrhythmia and thrombus or sludge in left atrial appendage at one-year follow-up. J Clin Med. https:\/\/doi.org\/10.3390\/jcm11041128","journal-title":"J Clin Med"},{"issue":"1","key":"2917_CR5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1093\/europace\/euz257","volume":"22","author":"MM Farkowski","year":"2020","unstructured":"Farkowski MM, Jubele K, Mar\u00edn F, Gandjbakhch E, Ptaszynski P, Merino JL et al (2020) Diagnosis and management of left atrial appendage thrombus in patients with atrial fibrillation undergoing cardioversion or percutaneous left atrial procedures: results of the European Heart Rhythm Association survey. Europace. 22(1):162\u20139","journal-title":"Europace."},{"key":"2917_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2022.100670","volume":"96","author":"SJ Dong","year":"2022","unstructured":"Dong SJ, Luo CY, Xiao CL, Zhang FZ, Li L, Han ZL et al (2022) Efficacy and safety profile of novel oral anticoagulants in the treatment of left atrial thrombosis: a systematic review and meta-analysis. Curr Ther Res Clin Exp. 96:100670","journal-title":"Curr Ther Res Clin Exp."},{"issue":"1","key":"2917_CR7","doi-asserted-by":"publisher","first-page":"26055","DOI":"10.31083\/RCM26055","volume":"26","author":"GL Mo","year":"2025","unstructured":"Mo GL, Wen J, Ye YY, Lu YQ, Gan TM, Yang YJ et al (2025) Efficacy and safety of new oral anticoagulants versus warfarin in the resolution of atrial fibrillation with left atrial\/left atrial appendage thrombus: a systematic review and meta-analysis. Rev Cardiovasc Med. 26(1):26055","journal-title":"Rev Cardiovasc Med."},{"key":"2917_CR8","doi-asserted-by":"crossref","unstructured":"Koml\u00f3si F, Arn\u00f3th B, Szak\u00e1l I, T\u00f3th P, M\u00e9sz\u00e1ros H, S\u00e1nta H, et al. (2025) Comparative analysis of therapeutic strategies in atrial fibrillation patients with left atrial appendage thrombus despite optimal NOAC therapy. Clin Res Cardiol","DOI":"10.1007\/s00392-025-02665-w"},{"issue":"1","key":"2917_CR9","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s10557-021-07278-9","volume":"37","author":"K Ko\u0142akowski","year":"2023","unstructured":"Ko\u0142akowski K, Farkowski MM, Pytkowski M, Gardziejczyk P, Kowalik I, D\u0105browski R et al (2023) The comparative effectiveness and safety of different anticoagulation strategies for treatment of left atrial appendage thrombus in the setting of chronic anticoagulation for atrial fibrillation or flutter. Cardiovasc Drugs Ther. 37(1):159\u201368","journal-title":"Cardiovasc Drugs Ther."},{"issue":"1","key":"2917_CR10","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s00392-020-01651-8","volume":"110","author":"D Nelles","year":"2021","unstructured":"Nelles D, Lambers M, Schafigh M, Morais P, Schueler R, Vij V et al (2021) Clinical outcomes and thrombus resolution in patients with solid left atrial appendage thrombi: results of a single-center real-world registry. Clin Res Cardiol. 110(1):72\u201383","journal-title":"Clin Res Cardiol."},{"issue":"36","key":"2917_CR11","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","volume":"45","author":"IC Van Gelder","year":"2024","unstructured":"Van Gelder IC, Rienstra M, Bunting KV, Casado-Arroyo R, Caso V, Crijns H et al (2024) 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 45(36):3314\u2013414","journal-title":"Eur Heart J."},{"issue":"23","key":"2917_CR12","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","volume":"123","author":"R Mehran","year":"2011","unstructured":"Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J et al (2011) Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium. Circulation 123(23):2736\u201347","journal-title":"Circulation"},{"issue":"4","key":"2917_CR13","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/ehjci\/jev354","volume":"17","author":"E Donal","year":"2016","unstructured":"Donal E, Lip GY, Galderisi M, Goette A, Shah D, Marwan M et al (2016) EACVI\/EHRA Expert Consensus Document on the role of multi-modality imaging for the evaluation of patients with atrial fibrillation. Eur Heart J Cardiovasc Imaging. 17(4):355\u201383","journal-title":"Eur Heart J Cardiovasc Imaging."},{"issue":"9","key":"2917_CR14","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.echo.2013.07.009","volume":"26","author":"RT Hahn","year":"2013","unstructured":"Hahn RT, Abraham T, Adams MS, Bruce CJ, Glas KE, Lang RM et al (2013) Guidelines for performing a comprehensive transesophageal echocardiographic examination: recommendations from the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists. J Am Soc Echocardiogr 26(9):921\u201364","journal-title":"J Am Soc Echocardiogr"},{"issue":"1","key":"2917_CR15","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0735-1097(86)80275-3","volume":"7","author":"W Aschenberg","year":"1986","unstructured":"Aschenberg W, Schl\u00fcter M, Kremer P, Schr\u00f6der E, Siglow V, Bleifeld W (1986) Transesophageal two-dimensional echocardiography for the detection of left atrial appendage thrombus. J Am Coll Cardiol 7(1):163\u20136","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"2917_CR16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00392-024-02492-5","volume":"114","author":"A Hagendorff","year":"2025","unstructured":"Hagendorff A, St\u00f6be S, Helfen A, Knebel F, Altiok E, Beckmann S et al (2025) Echocardiographic assessment of left atrial appendage morphology and function-an expert proposal by the German working group of cardiovascular ultrasound. Clin Res Cardiol. 114(1):25\u201340","journal-title":"Clin Res Cardiol."},{"issue":"10","key":"2917_CR17","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.echo.2023.05.013","volume":"36","author":"G Fiore","year":"2023","unstructured":"Fiore G, Gaspardone C, Ingallina G, Rizza V, Melillo F, Stella S et al (2023) Accuracy and reliability of left atrial appendage morphology assessment by three-dimensional transesophageal echocardiographic glass rendering modality: a comparative study with computed tomography. J Am Soc Echocardiogr. 36(10):1083\u201391","journal-title":"J Am Soc Echocardiogr."},{"issue":"12","key":"2917_CR18","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.jcmg.2014.08.009","volume":"7","author":"R Beigel","year":"2014","unstructured":"Beigel R, Wunderlich NC, Ho SY, Arsanjani R, Siegel RJ (2014) The left atrial appendage: anatomy, function, and noninvasive evaluation. JACC Cardiovasc Imaging 7(12):1251\u201365","journal-title":"JACC Cardiovasc Imaging"},{"issue":"1","key":"2917_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2018.06.004","volume":"32","author":"C Mitchell","year":"2019","unstructured":"Mitchell C, Rahko PS, Blauwet LA, Canaday B, Finstuen JA, Foster MC et al (2019) Guidelines for performing a comprehensive transthoracic echocardiographic examination in adults: recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr. 32(1):1\u201364","journal-title":"J Am Soc Echocardiogr."},{"issue":"6","key":"2917_CR20","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1093\/ehjci\/jey042","volume":"19","author":"LP Badano","year":"2018","unstructured":"Badano LP, Kolias TJ, Muraru D, Abraham TP, Aurigemma G, Edvardsen T et al (2018) Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging. Eur Heart J Cardiovasc Imaging 19(6):591\u2013600","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"1","key":"2917_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","volume":"28","author":"RM Lang","year":"2015","unstructured":"Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L et al (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the american society of echocardiography and the European association of cardiovascular imaging. J Am Soc Echocardiograph 28(1):1-39.e14","journal-title":"J Am Soc Echocardiograph"},{"issue":"4","key":"2917_CR22","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","volume":"30","author":"WA Zoghbi","year":"2017","unstructured":"Zoghbi WA, Adams D, Bonow RO, Enriquez-Sarano M, Foster E, Grayburn PA et al (2017) Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American society of echocardiography developed in collaboration with the society for cardiovascular magnetic resonance. J Am Soc Echocardiograph 30(4):303\u201371","journal-title":"J Am Soc Echocardiograph"},{"issue":"3","key":"2917_CR23","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1159\/000361028","volume":"23","author":"O Uz","year":"2014","unstructured":"Uz O, Atalay M, Do\u011fan M, Isilak Z, Yalcin M, Uzun M et al (2014) The CHA2DS2-VASc score as a predictor of left atrial thrombus in patients with non-valvular atrial fibrillation. Med Princ Pract 23(3):234\u20138","journal-title":"Med Princ Pract"},{"key":"2917_CR24","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.amjcard.2025.10.015","volume":"258","author":"M Gawa\u0142ko","year":"2026","unstructured":"Gawa\u0142ko M, Budnik M, Scis\u0142o P, Pi\u0105tkowski R, Uzi\u0119b\u0142o-\u017byczkowska B, Krzesi\u0144ski P et al (2026) Changes in anticoagulation treatment and associated resolution or persistence of left atrial thrombus: insights from LATTEE registry. Am J Cardiol. 258:340\u20135","journal-title":"Am J Cardiol."},{"issue":"3","key":"2917_CR25","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.joa.2016.01.009","volume":"32","author":"Y Miwa","year":"2016","unstructured":"Miwa Y, Minamishima T, Sato T, Sakata K, Yoshino H, Soejima K (2016) Resolution of a warfarin and dabigatran-resistant left atrial appendage thrombus with apixaban. J Arrhythm 32(3):233\u20135","journal-title":"J Arrhythm"},{"issue":"11","key":"2917_CR26","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.1253\/circj.CJ-18-0398","volume":"82","author":"M Harada","year":"2018","unstructured":"Harada M, Koshikawa M, Motoike Y, Ichikawa T, Sugimoto K, Watanabe E et al (2018) Left atrial appendage thrombus prior to atrial fibrillation ablation in the era of direct oral anticoagulants. Circ J 82(11):2715\u201321","journal-title":"Circ J"},{"issue":"2","key":"2917_CR27","doi-asserted-by":"publisher","first-page":"289","DOI":"10.5114\/aoms.2019.86616","volume":"16","author":"R Piotrowski","year":"2020","unstructured":"Piotrowski R, Zaborska B, Pilichowska-Paszkiet E, Sikora-Fr\u0105c M, Baran J, Ku\u0142akowski P (2020) RIVAroxaban twice daily for lysis of thrombus in the left atrial appendage in patients with non-valvular atrial fibrillation: the RIVA-TWICE study. Arch Med Sci 16(2):289\u201396","journal-title":"Arch Med Sci"},{"issue":"4","key":"2917_CR28","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.joa.2014.12.010","volume":"31","author":"H Mitamura","year":"2015","unstructured":"Mitamura H, Nagai T, Watanabe A, Takatsuki S, Okumura K (2015) Left atrial thrombus formation and resolution during dabigatran therapy: a Japanese Heart Rhythm Society report. J Arrhythm 31(4):226\u201331","journal-title":"J Arrhythm"},{"issue":"7","key":"2917_CR29","first-page":"1908","volume":"27","author":"Anticoagulants in left atrial thrombus resolution","year":"2021","unstructured":"Anticoagulants in left atrial thrombus resolution (2021) Annals of medical. Research. 27(7):1908\u201312","journal-title":"Research."},{"issue":"7","key":"2917_CR30","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1111\/jce.16718","volume":"36","author":"A Kushnir","year":"2025","unstructured":"Kushnir A, Bernstein S, Barbhaiya CR, Jankelson L, Holmes D, Aizer A et al (2025) Persistent left atrial appendage thrombus in atrial fibrillation despite anticoagulation. J Cardiovasc Electrophysiol. 36(7):1613\u20138","journal-title":"J Cardiovasc Electrophysiol."},{"issue":"11","key":"2917_CR31","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.jacc.2024.12.030","volume":"85","author":"S Rashedi","year":"2025","unstructured":"Rashedi S, Keykhaei M, Sato A, Steg PG, Piazza G, Eikelboom JW et al (2025) Anticoagulation and antiplatelet therapy for atrial fibrillation and stable coronary disease: meta-analysis of randomized trials. J Am Coll Cardiol. 85(11):1189\u2013203","journal-title":"J Am Coll Cardiol."},{"key":"2917_CR32","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae120","author":"M Okada","year":"2024","unstructured":"Okada M, Inoue K, Tanaka N, Tanaka K, Hirao Y, Iwakura K et al (2024) Impact of left atrial appendage flow velocity on thrombus resolution and clinical outcomes in patients with atrial fibrillation and silent left atrial thrombi: insights from the LAT study. Europace. https:\/\/doi.org\/10.1093\/europace\/euae120","journal-title":"Europace"},{"issue":"12","key":"2917_CR33","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1007\/s00134-007-0881-y","volume":"33","author":"B Lamia","year":"2007","unstructured":"Lamia B, Teboul JL, Monnet X, Richard C, Chemla D (2007) Relationship between the tricuspid annular plane systolic excursion and right and left ventricular function in critically ill patients. Intensive Care Med 33(12):2143\u20139","journal-title":"Intensive Care Med"},{"issue":"6","key":"2917_CR34","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.ejheart.2008.04.003","volume":"10","author":"FL Dini","year":"2008","unstructured":"Dini FL, Fontanive P, Panicucci E, Andreini D, Chella P, De Tommasi SM (2008) Prognostic significance of tricuspid annular motion and plasma NT-proBNP in patients with heart failure and moderate-to-severe functional mitral regurgitation. Eur J Heart Fail 10(6):573\u201380","journal-title":"Eur J Heart Fail"},{"issue":"5","key":"2917_CR35","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/imj.12112","volume":"43","author":"MH Lee","year":"2013","unstructured":"Lee MH, Chang CL, Davies AR, Davis M, Hancox RJ (2013) Cardiac dysfunction and N-terminal pro-B-type natriuretic peptide in exacerbations of chronic obstructive pulmonary disease. Intern Med J 43(5):595\u20138","journal-title":"Intern Med J"},{"issue":"4","key":"2917_CR36","doi-asserted-by":"publisher","first-page":"euae035","DOI":"10.1093\/europace\/euae035","volume":"26","author":"T Potpara","year":"2024","unstructured":"Potpara T, Grygier M, H\u00e4usler KG, Nielsen-Kudsk JE, Berti S, Genovesi S et al (2024) Practical guide on left atrial appendage closure for the non-implanting physician: an international consensus paper. EP Europace. 26(4):euae035","journal-title":"EP Europace."},{"key":"2917_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115020","volume":"165","author":"M Rottura","year":"2023","unstructured":"Rottura M, Drago SFA, Molonia A, Irrera N, Marino S, Scoglio R et al (2023) Prescriptive behavior of non-vitamin K oral anticoagulants in patients affected by atrial fibrillation in general practice. Biomed Pharmacother. 165:115020","journal-title":"Biomed Pharmacother."},{"key":"2917_CR38","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ijcard.2016.10.009","volume":"225","author":"E Aloia","year":"2016","unstructured":"Aloia E, Cameli M, D\u2019Ascenzi F, Sciaccaluga C, Mondillo S (2016) TAPSE: an old but useful tool in different diseases. Int J Cardiol 225:177\u201383","journal-title":"Int J Cardiol"},{"issue":"3","key":"2917_CR39","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.cardfail.2011.12.003","volume":"18","author":"T Damy","year":"2012","unstructured":"Damy T, Kallvikbacka-Bennett A, Goode K, Khaleva O, Lewinter C, Hobkirk J et al (2012) Prevalence of, associations with, and prognostic value of tricuspid annular plane systolic excursion (TAPSE) among out-patients referred for the evaluation of heart failure. J Card Fail 18(3):216\u201325","journal-title":"J Card Fail"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-026-02917-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00392-026-02917-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-026-02917-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T08:39:53Z","timestamp":1778488793000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00392-026-02917-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["2917"],"URL":"https:\/\/doi.org\/10.1007\/s00392-026-02917-3","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"assertion":[{"value":"11 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}