{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:00:32Z","timestamp":1781172032897,"version":"3.54.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter aortic valve implantation (TAVI) is increasingly performed in patients at low and intermediate risk, emphasizing the need for accurate long-term risk stratification. Although iliofemoral calcification influences procedural planning, its prognostic relevance beyond peri-procedural complications remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the prognostic value of quantitatively assessed iliofemoral access-site calcification (IASC) for outcomes after TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 1067 patients undergoing TAVI. Pre-procedural computed tomography (CT) was used to quantify IASC-volume along the transfemoral access route. Patients were stratified according to the median IASC-volume, and outcomes were compared using propensity score matching (PSM). The primary endpoint was all-cause mortality at 1, 3, and 5\u00a0years. Secondary endpoints included peri-procedural complications at 30\u00a0days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median IASC-volume was 907 (356\u20131839) mm\n                      <jats:sup>3<\/jats:sup>\n                      . Patients with high IASC-volume had higher prevalence of vascular comorbidities and increased risk scores. IASC-volume was not associated with vascular or bleeding complications. The overall 1-year mortality was 11.7% and did not differ between patients with low and high IASC-volume (10.5% vs. 12.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.20). In contrast, patients with high IASC-volume experienced significantly higher mortality at 3\u00a0years (34.3% vs. 22.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and 5\u00a0years (42.2% vs. 28.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). These findings remained consistent after PSM. In multivariable analysis, IASC-volume was independently associated with long-term mortality (HR 1.24, 95% CI 1.11\u20131.38;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CT-derived IASC-volume is associated with mid- and long-term mortality after TAVI, without affecting short-term or procedural outcomes. These findings suggest that IASC-volume reflects systemic disease burden and may provide incremental prognostic information beyond established risk scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-026-02956-w","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T09:29:06Z","timestamp":1781170146000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of iliofemoral access-site calcification volume on outcomes after transcatheter aortic valve implantation"],"prefix":"10.1007","author":[{"given":"Vivian","family":"Vij","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Schauwienold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Shamekhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Muli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Basha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Markidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zietzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"D\u00fcsing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muntadher","family":"Al Zaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Al-Kassou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Zeus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Mauri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Kelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Marx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Bakhtiary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"L\u00fcsebrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Sedaghat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2967-6613","authenticated-orcid":false,"given":"Baravan","family":"Al-Kassou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"2956_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/eurheartj\/ehaf194","volume":"00","author":"F Praz","year":"2025","unstructured":"Praz F, Borger MA, Lanz J et al (2025) 2025 ESC\/EACTS guidelines for the management of valvular heart disease: developed by the task force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 00:1\u2013102. https:\/\/doi.org\/10.1093\/eurheartj\/ehaf194","journal-title":"Eur Heart J"},{"key":"2956_CR2","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1056\/nejmoa2400685","volume":"390","author":"S Blankenberg","year":"2024","unstructured":"Blankenberg S, Seiffert M, Vonthein R et al (2024) Transcatheter or surgical treatment of aortic-valve stenosis. N Engl J Med 390:1572\u20131583. https:\/\/doi.org\/10.1056\/nejmoa2400685","journal-title":"N Engl J Med"},{"key":"2956_CR3","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1007\/s00392-025-02698-1","volume":"114","author":"J Shamekhi","year":"2025","unstructured":"Shamekhi J, Ebert M, Lorek A et al (2025) Fighting time: the critical importance of pre - TAVR mortality risk prediction. Clin Res Cardiol 114:1565\u20131573. https:\/\/doi.org\/10.1007\/s00392-025-02698-1","journal-title":"Clin Res Cardiol"},{"key":"2956_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jcmg.2018.12.003","volume":"12","author":"P Blanke","year":"2019","unstructured":"Blanke P, Weir-McCall JR, Achenbach S et al (2019) Computed tomography imaging in the context of transcatheter aortic valve implantation (TAVI)\/transcatheter aortic valve replacement (TAVR): an expert consensus document of the Society of Cardiovascular Computed Tomography. JACC Cardiovasc Imaging 12:1\u201324. https:\/\/doi.org\/10.1016\/j.jcmg.2018.12.003","journal-title":"JACC Cardiovasc Imaging"},{"key":"2956_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/CIRCIMAGING.114.001995","volume":"8","author":"K Okuyama","year":"2014","unstructured":"Okuyama K, Jilaihawi H, Kashif M et al (2014) Transfemoral access assessment for transcatheter aortic valve replacement: evidence-based application of computed tomography over invasive angiography. Circ Cardiovasc Imaging 8:1\u20139. https:\/\/doi.org\/10.1161\/CIRCIMAGING.114.001995","journal-title":"Circ Cardiovasc Imaging"},{"key":"2956_CR6","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/s12055-024-01841-3","volume":"41","author":"Y Hohri","year":"2025","unstructured":"Hohri Y, Zen K, Kawajiri H et al (2025) A comparative study on iliofemoral artery calcification distribution in alternative TAVR approaches. Indian J Thorac Cardiovasc Surg 41:272\u2013280. https:\/\/doi.org\/10.1007\/s12055-024-01841-3","journal-title":"Indian J Thorac Cardiovasc Surg"},{"key":"2956_CR7","first-page":"285","volume":"7","author":"TR Foley","year":"2018","unstructured":"Foley TR, Stinis CT (2018) Imaging evaluation and interpretation for vascular access for transcatheter aortic valve replacement. Interv Cardiol Clin 7:285\u2013291","journal-title":"Interv Cardiol Clin"},{"key":"2956_CR8","doi-asserted-by":"publisher","first-page":"E947","DOI":"10.1002\/ccd.29885","volume":"98","author":"DL Staudacher","year":"2021","unstructured":"Staudacher DL, Braxmeier K, Stachon P et al (2021) Ventral calcification in the common femoral artery: a risk factor for major transcatheter aortic valve intervention access site complications. Catheter Cardiovasc Interv 98:E947\u2013E953. https:\/\/doi.org\/10.1002\/ccd.29885","journal-title":"Catheter Cardiovasc Interv"},{"key":"2956_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/CIRCIMAGING.115.003843","volume":"8","author":"D Bos","year":"2015","unstructured":"Bos D, Leening MJG, Kavousi M et al (2015) Comparison of atherosclerotic calcification in major vessel beds on the risk of all-cause and cause-specific mortality: the Rotterdam study. Circ Cardiovasc Imaging 8:1\u20139. https:\/\/doi.org\/10.1161\/CIRCIMAGING.115.003843","journal-title":"Circ Cardiovasc Imaging"},{"key":"2956_CR10","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1016\/j.jcin.2024.07.009","volume":"17","author":"M Nakase","year":"2024","unstructured":"Nakase M, Tomii D, Samim D et al (2024) Impact of severity and extent of iliofemoral atherosclerosis on clinical outcomes in patients undergoing TAVR. JACC Cardiovasc Interv 17:2353\u20132363. https:\/\/doi.org\/10.1016\/j.jcin.2024.07.009","journal-title":"JACC Cardiovasc Interv"},{"key":"2956_CR11","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/ccd.30918","volume":"103","author":"V Androshchuk","year":"2024","unstructured":"Androshchuk V, Chehab O, Prendergast B et al (2024) Computed tomography derived anatomical predictors of vascular access complications following transfemoral transcatheter aortic valve implantation: a systematic review. Catheter Cardiovasc Interv 103:169\u2013185. https:\/\/doi.org\/10.1002\/ccd.30918","journal-title":"Catheter Cardiovasc Interv"},{"key":"2956_CR12","doi-asserted-by":"publisher","first-page":"297","DOI":"10.5152\/akd.2014.5311","volume":"15","author":"M Reinthaler","year":"2015","unstructured":"Reinthaler M, Aggarwal SK, De Palma R et al (2015) Predictors of clinical outcome in transfemoral TAVI: circumferential iliofemoral calcifications and manufacturer-derived recommendations. Anatol J Cardiol 15:297\u2013305. https:\/\/doi.org\/10.5152\/akd.2014.5311","journal-title":"Anatol J Cardiol"},{"key":"2956_CR13","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.jcin.2011.03.019","volume":"4","author":"K Hayashida","year":"2011","unstructured":"Hayashida K, Lefvre T, Chevalier B et al (2011) Transfemoral aortic valve implantation: new criteria to predict vascular complications. JACC Cardiovasc Interv 4:851\u2013858. https:\/\/doi.org\/10.1016\/j.jcin.2011.03.019","journal-title":"JACC Cardiovasc Interv"},{"key":"2956_CR14","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.atherosclerosis.2014.12.041","volume":"239","author":"S Mori","year":"2015","unstructured":"Mori S, Takaya T, Kinugasa M et al (2015) Three-dimensional quantification and visualization of aortic calcification by multidetector-row computed tomography: a simple approach using a volume-rendering method. Atherosclerosis 239:622\u2013628. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2014.12.041","journal-title":"Atherosclerosis"},{"key":"2956_CR15","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","volume":"15","author":"AS Agatston","year":"1990","unstructured":"Agatston AS, Janowitz WR, Hildner FJ et al (1990) Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 15:827\u2013832. https:\/\/doi.org\/10.1016\/0735-1097(90)90282-T","journal-title":"J Am Coll Cardiol"},{"key":"2956_CR16","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1016\/j.jacc.2021.02.038","volume":"77","author":"P G\u00e9n\u00e9reux","year":"2021","unstructured":"G\u00e9n\u00e9reux P, Piazza N, Alu MC et al (2021) Valve academic research consortium 3: updated endpoint definitions for aortic valve clinical research. J Am Coll Cardiol 77:2717\u20132746. https:\/\/doi.org\/10.1016\/j.jacc.2021.02.038","journal-title":"J Am Coll Cardiol"},{"key":"2956_CR17","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.jcin.2014.03.007","volume":"7","author":"OK Khalique","year":"2014","unstructured":"Khalique OK, Hahn RT, Gada H et al (2014) Quantity and location of aortic valve complex calcification predicts severity and location of paravalvular regurgitation and frequency of post-dilation after balloon-expandable transcatheter aortic valve replacement. JACC Cardiovasc Interv 7:885\u2013894. https:\/\/doi.org\/10.1016\/j.jcin.2014.03.007","journal-title":"JACC Cardiovasc Interv"},{"key":"2956_CR18","doi-asserted-by":"publisher","unstructured":"Nishida K, Saji M, Higuchi R et al (2023) Predictors for all-cause mortality in men after transcatheter aortic valve replacement: a report from the LAPLACE-TAVI registry. IJC Hear Vasc 48. https:\/\/doi.org\/10.1016\/j.ijcha.2023.101257","DOI":"10.1016\/j.ijcha.2023.101257"},{"key":"2956_CR19","doi-asserted-by":"publisher","unstructured":"Shibata R, Seki T, Takeda Y et al (2025) External validation of mortality prediction models in Japanese transcatheter aortic valve replacement registry. Eur J Cardio-Thoracic Surg 67(7). https:\/\/doi.org\/10.1093\/ejcts\/ezaf227","DOI":"10.1093\/ejcts\/ezaf227"},{"key":"2956_CR20","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s00392-013-0596-8","volume":"102","author":"A Sedaghat","year":"2013","unstructured":"Sedaghat A, Sinning J-M, Vasa-Nicotera M et al (2013) The revised EuroSCORE II for the prediction of mortality in patients undergoing transcatheter aortic valve implantation. Clin Res Cardiol 102:821\u2013829. https:\/\/doi.org\/10.1007\/s00392-013-0596-8","journal-title":"Clin Res Cardiol"},{"key":"2956_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijcha.2024.101423","volume":"52","author":"L Marqvard S\u00f8rensen","year":"2024","unstructured":"Marqvard S\u00f8rensen L, Kofoed Petersen J, Emanuel Strange J et al (2024) N-terminal pro-B-type natriuretic peptide levels pre-transcatheter aortic valve implantation and relationship with long-term outcomes. IJC Hear Vasc 52:1\u20137. https:\/\/doi.org\/10.1016\/j.ijcha.2024.101423","journal-title":"IJC Hear Vasc"},{"key":"2956_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/JAHA.120.017574","volume":"9","author":"CJ Allen","year":"2020","unstructured":"Allen CJ, Joseph J, Patterson T et al (2020) Baseline NT-proBNP accurately predicts symptom response to transcatheter aortic valve implantation. J Am Heart Assoc 9:1\u201311. https:\/\/doi.org\/10.1161\/JAHA.120.017574","journal-title":"J Am Heart Assoc"},{"key":"2956_CR23","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1007\/s00392-025-02715-3","volume":"114","author":"M Basha","year":"2025","unstructured":"Basha M, Baravan B, Kassou A et al (2025) EASIX as a predictor of 3-year mortality in aortic stenosis patients undergoing TAVR. Clin Res Cardiol 114:1585\u20131594. https:\/\/doi.org\/10.1007\/s00392-025-02715-3","journal-title":"Clin Res Cardiol"},{"key":"2956_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijchv.2014.02.001","volume":"3","author":"R Nicoll","year":"2014","unstructured":"Nicoll R, Henein MY (2014) The predictive value of arterial and valvular calcification for mortality and cardiovascular events. IJC Heart Vessels 3:1\u20135","journal-title":"IJC Heart Vessels"},{"key":"2956_CR25","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1161\/ATVBAHA.111.235234","volume":"32","author":"MA Allison","year":"2012","unstructured":"Allison MA, Hsi S, Wassel CL et al (2012) Clinical and population studies calcified atherosclerosis in different vascular beds and the risk of mortality. Arterioscler Thromb Vasc Biol 32:140\u2013146. https:\/\/doi.org\/10.1161\/ATVBAHA.111.235234","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2956_CR26","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.acvd.2008.10.011","volume":"102","author":"J Tarti\u00e8re","year":"2009","unstructured":"Tarti\u00e8re J, Kesri-tarti\u00e8re L, Rusinaru D et al (2009) Vascular disease as a predictor of long-term mortality in patients hospitalized for new-onset heart failure. Arch Cardiovasc Dis 102:11\u201318. https:\/\/doi.org\/10.1016\/j.acvd.2008.10.011","journal-title":"Arch Cardiovasc Dis"},{"key":"2956_CR27","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1161\/CIRCULATIONAHA.107.743161","volume":"117","author":"LL Demer","year":"2008","unstructured":"Demer LL, Tintut Y (2008) Vascular calcification: pathobiology of a multifaceted disease. Circulation 117:2938\u20132948. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.743161","journal-title":"Circulation"},{"key":"2956_CR28","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s00223-013-9712-z","volume":"93","author":"M Wu","year":"2013","unstructured":"Wu M, Rementer C, Giachelli CM (2013) Vascular calcification: an update on mechanisms and challenges in treatment. Calcif Tissue Int 93:365\u2013373. https:\/\/doi.org\/10.1007\/s00223-013-9712-z","journal-title":"Calcif Tissue Int"},{"key":"2956_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms252313096","volume":"25","author":"C Siracusa","year":"2024","unstructured":"Siracusa C, Carabetta N, Morano MB et al (2024) Understanding vascular calcification in chronic kidney disease: pathogenesis and therapeutic implications. Int J Mol Sci 25:1\u201321. https:\/\/doi.org\/10.3390\/ijms252313096","journal-title":"Int J Mol Sci"},{"key":"2956_CR30","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s11547-023-01603-y","volume":"128","author":"SM Milo","year":"2023","unstructured":"Milo SM, Toia P, Midiri F et al (2023) Aortic valve and vascular calcium score in pre-TAVI CT: correlation with early post-procedural complications. Radiol Med 128:299\u2013306","journal-title":"Radiol Med"},{"key":"2956_CR31","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1056\/nejmoa1103510","volume":"364","author":"CR Smith","year":"2011","unstructured":"Smith CR, Leon MB, Mack MJ et al (2011) Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med 364:2187\u20132198. https:\/\/doi.org\/10.1056\/nejmoa1103510","journal-title":"N Engl J Med"},{"key":"2956_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/CIRCINTERVENTIONS.119.008227","volume":"13","author":"MW Sherwood","year":"2020","unstructured":"Sherwood MW, Xiang K, Matsouaka R et al (2020) Incidence, temporal trends, and associated outcomes of vascular and bleeding complications in patients undergoing transfemoral transcatheter aortic valve replacement. Circ Cardiovasc Interv 13:1\u20138. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.119.008227","journal-title":"Circ Cardiovasc Interv"},{"key":"2956_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biomedicines9040404","volume":"9","author":"P Dube","year":"2021","unstructured":"Dube P, DeRiso A, Patel M et al (2021) Vascular calcification in chronic kidney disease: diversity in the vesselwall. Biomedicines 9:1\u201321. https:\/\/doi.org\/10.3390\/biomedicines9040404","journal-title":"Biomedicines"},{"key":"2956_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/JAHA.120.019300","volume":"10","author":"S Park","year":"2021","unstructured":"Park S, Cho N-J, Heo NH et al (2021) Vascular calcification as a novel risk factor for kidney function deterioration in the nonelderly. J Am Heart Assoc 10:1\u201312. https:\/\/doi.org\/10.1161\/JAHA.120.019300","journal-title":"J Am Heart Assoc"},{"key":"2956_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fneph.2025.1582775","volume":"5","author":"M Fakhfakh","year":"2026","unstructured":"Fakhfakh M, Lassoued T, Nouri F et al (2026) New insights into contrast- associated acute kidney injury: the key role of endothelial dysfunction. Front Nephrol 5:1\u20139. https:\/\/doi.org\/10.3389\/fneph.2025.1582775","journal-title":"Front Nephrol"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-026-02956-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00392-026-02956-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-026-02956-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T09:29:07Z","timestamp":1781170147000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00392-026-02956-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":35,"alternative-id":["2956"],"URL":"https:\/\/doi.org\/10.1007\/s00392-026-02956-w","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]},"assertion":[{"value":"18 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"G. Nickenig and S. Zimmer have received speaker honoraria and research grants from Abbott, Abiomed, Medtronic, Boston Scientific, and Edwards Lifesciences. M. Kelm has received institutional grant support and\/or personal fees from Philips, Abbott, Medtronic, Boston Scientific, Mars, Boehringer Ingelheim, Daiichi-Sanyko GmbH, Amgen, Ancora Heart, and B. Braun. S. Baldus has received speaker honoraria from JenaValve and Edwards Lifesciences. M. Adam has received personal fees from Abbott, JenaValve, Edwards Lifesciences, Medtronic and Meril. The other authors report no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}