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To clarify the role of RV dysfunction in arrhythmic risk assessment, we conducted a systematic review and meta-analysis to evaluate its prognostic value for SCD and VA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed, Embase, and Web of Science was conducted from inception to February 2025. The primary endpoint was a composite of SCD or severe VA, including ventricular tachycardia, ventricular fibrillation, or appropriate implantable cardioverter-defibrillator therapy. RV dysfunction was defined as impaired RV fractional area change, RV ejection fraction, or RV strain. A random-effects model was used to calculate pooled odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1296 identified articles, seven studies comprising 1475 patients met the inclusion criteria. RV dysfunction was present in 541 patients. The mean follow-up duration was 2.9\u00a0years. RV dysfunction was significantly associated with an increased risk of SCD and VA (OR 3.69; 95% CI 2.40\u20135.66;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Secondary analysis showed that patients who experienced SCD or VA had significantly lower RVFAC compared to those without events (MD\u2009\u2212\u20095.67; 95% CI\u2009\u2212\u20098.73 to\u2009\u2212\u20092.60;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), whereas LVEF did not differ significantly between groups (MD\u2009\u2212\u20090.59; 95% CI\u2009\u2212\u20094.10 to 2.92;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.74).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RV dysfunction is associated with an increased risk of SCD and VA, indicating that RV parameters may hold prognostic value in arrhythmic risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-026-02976-6","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:04:50Z","timestamp":1782990290000},"page":"2216-2226","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Right ventricular dysfunction: an overlooked predictor of sudden cardiac death and arrhythmic events\u2014a meta-analysis"],"prefix":"10.1007","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8386-7592","authenticated-orcid":false,"given":"Toshinori","family":"Chiba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelie","family":"Beblo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Wainstejn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Lueg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"H\u00e4ttasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Hohendanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Tscholl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Dagres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Haverkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"2976_CR1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.pcad.2008.06.003","volume":"51","author":"SS Chugh","year":"2008","unstructured":"Chugh SS, Reinier K, Teodorescu C, Evanado A, Kehr E, Al Samara M et al (2008) Epidemiology of sudden cardiac death: clinical and research implications. 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