{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:58:35Z","timestamp":1785445115047,"version":"3.56.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008375","name":"University of Basel","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008375","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Large-bore mechanical thrombectomy (LBMT) is a catheter-directed therapy for acute pulmonary embolism (PE). The relationship between aspirated thrombus weight and volume with outcomes remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim was to evaluate the impact of aspirated thrombus weight and volume on outcomes after LBMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, open-label, single-arm, single-center registry study included 48 patients undergoing LBMT using the FlowTriever system (Inari Medical\/Stryker, Irvine, CA, USA). Thrombus weight and volume were quantified, and clot composition assessed. Associations between thrombus characteristics and clinical, invasive hemodynamics, echocardiographic parameters, and biomarkers were evaluated immediately after the procedure, at hospital discharge, and at 3-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thrombus material was available in 48 patients (31% women), of which 41 presented with intermediate-risk and 7 with high-risk PE. LBMT resulted in significant reductions in systolic pulmonary artery pressures (sPAP) intraprocedurally (\u2212\u200912.8\u2009\u00b1\u20098.3 mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with a further invasively measured decrease through 3 months (\u2212\u20099.6\u2009\u00b1\u200910.6 mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). From baseline to discharge, right ventricular coupling improved (+\u20090.24,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and right ventricle (RV)\/left ventricle (LV) ratio decreased (\u2212\u20090.23,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). NT-proBNP and high-sensitivity cardiac troponin T declined significantly. Neither thrombus weight nor volume correlated with acute changes in sPAP (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      <jats:sub>volume<\/jats:sub>\n                      \u2009=\u20090.06;\n                      <jats:italic>\u03c1<\/jats:italic>\n                      <jats:sub>weight<\/jats:sub>\n                      \u2009=\u20090.10), RV-uncoupling (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      <jats:sub>volume<\/jats:sub>\n                      \u2009=\u20090.47;\n                      <jats:italic>\u03c1<\/jats:italic>\n                      <jats:sub>weight<\/jats:sub>\n                      \u2009=\u20090.46), and RV\/LV ratio (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      <jats:sub>volume<\/jats:sub>\n                      \u2009= \u2212\u20090.02;\n                      <jats:italic>\u03c1<\/jats:italic>\n                      <jats:sub>weight<\/jats:sub>\n                      \u2009= \u2212\u20090.005) (\n                      <jats:italic>p<\/jats:italic>\n                      for all\u2009&gt;\u20090.05), nor with outcomes at 3 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aspirated thrombus weight and volume were not associated with improvements after LBMT, suggesting that, beyond mechanical obstruction, additional mechanisms potentially including paracrine and endocrine effects of thrombus material may contribute to acute and chronic PE-related cardiopulmonary dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                    <jats:p>Abbreviations: PE \u2013 pulmonary embolism, LBMT \u2013 large bore mechanical thrombectomy, PVR - pulmonary vascular resistance,\u00a0RV \u2013 right ventricular, TTE \u2013 transthoracic echocardiography, sPAP \u2013 systolic pulmonary artery pressure, IQR \u2013 interquartile range, BH \u2013 Benjamin Hochberg. Acknowledgment: Images partly created with AI<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-026-02986-4","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T07:26:25Z","timestamp":1785396385000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aspirated thrombus weight and volume are not associated with improvements in hemodynamics after large-bore mechanical thrombectomy in pulmonary embolism"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-3060","authenticated-orcid":false,"given":"Felix","family":"G\u00f6tzinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Lauder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Perez","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kunz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mert","family":"Tokcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Boeddinghaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Leibundgut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Link","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Scheller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"2986_CR1","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/s41569-023-00876-0","volume":"20","author":"F G\u00f6tzinger","year":"2023","unstructured":"G\u00f6tzinger F, Lauder L, Sharp ASP, Lang IM, Rosenkranz S, Konstantinides S, Edelman ER, B\u00f6hm M, Jaber W, Mahfoud F (2023) Interventional therapies for pulmonary embolism. 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He received travel support from Boehringer Ingelheim. He is currently funded by the University of Basel \u201cJunior Excellence Fond.\u201d F.G. is a consultant to Alpalix GmbH. L.L. received consulting honoraria from Medtronic, Recor, and Biosensors as well as speaker honoraria from AstraZeneca, Medtronic, Pfizer, Recor, Sanofi, and Servier; all of which were paid to his institution. M.K. received honoraria from Merck. M.K. is a consultant to Alpalix GmbH. M.T. is supported by the Hans und Ria Messer Stiftung (HMS 20243118). M.B. is supported by the Deutsche Forschungsgemeinschaft (German Research Foundation; TTR 219, project number 322900939) and reports personal fees from Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Cytokinetics, Edwards, Medtronic, Novartis, ReCor, Servier, and Vifor. GL has received consulting\/speaker\/proctoring honoraria from Ashai Intecc, Biotronik, Teleflex, Terumo, and Novartis. JB has been supported by an Edinburgh Doctoral College Scholarship and research grants from the University of Basel, the University Hospital of Basel, the Division of Internal Medicine, the Swiss Academy of Medical Sciences, the Gottfried and Julia Bangerter-Rhyner Foundation, the Swiss National Science Foundation, and the Swiss Heart Foundation, and has received honoraria from Siemens, Roche Diagnostics, Ortho Clinical Diagnostics, Quidel Corporation, and Beckman Coulter, and travel support from Medtronic and Vascularmedical, all outside the submitted work. B. Scheller is a shareholder of InnoRa GmbH and has received lecture fees and travel support from B. Braun, Cordis, and Medtronic. F. M. has been supported by Deutsche Forschungsgemeinschaft (SFB TRR219, Project-ID 322900939) and Deutsche\u00a0Herzstiftung. Saarland University has received scientific support from Ablative Solutions, Medtronic, and ReCor Medical. Until May 2024, F. Mahfoud has received speaker honoraria\/consulting fees from Ablative Solutions, AstraZeneca, Inari, Medtronic, Merck, Novartis, Philips, and ReCor Medical. All other authors do not report any conflicts of interest related to this work.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}