{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:06:43Z","timestamp":1789376803709,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medizinische Fakult\u00e4t Mannheim der Universit\u00e4t Heidelberg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) impairs quality of life (QoL), and catheter ablation (CA) has been shown to improve QoL in symptomatic individuals. The structural and functional cardiovascular determinants of impaired QoL remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants with symptomatic AF scheduled for CA were prospectively enrolled and underwent pulse wave analysis (PWA, VascAssist2.0), echocardiography, and 12-lead electrocardiogram. QoL was assessed using the Atrial Fibrillation Effect on QualiTy-of-life (AFEQT) questionnaire. Univariate Spearman rank-order correlation analyses were performed to assess associations between AFEQT scores and clinical, vascular, echocardiographic, and laboratory parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty-three patients (52 male, 31 female) with a median age of 72 (IQR 63\u201380) years were included. Most participants had paroxysmal AF (82%), moderate to severe symptom severity (median EHRA score 3 (IQR 2\u20133)), and reduced QoL (mean AFEQT score 60\u2009\u00b1\u200919). Lower AFEQT scores correlated with higher vascular resistance (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.64,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), increased arterial stiffness (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.62,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and elevated central systolic blood pressure (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Cardiac variables significantly and inversely correlated with AFEQT scores included left ventricular (LV) ejection fraction\u2009&lt;\u200950% (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), diastolic LV dysfunction (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), heart failure (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.39,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and log-NT-proBNP levels (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Reduced QoL correlates with vascular and myocardial functional impairment in patients with AF scheduled for catheter ablation. The potential incremental value of multimodal cardiovascular assessment warrants further evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-026-03005-2","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:45:58Z","timestamp":1789375558000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of vascular and cardiac parameters on quality of life in patients undergoing catheter ablation for atrial fibrillation"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5339-0386","authenticated-orcid":false,"given":"Mathieu","family":"Kruska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Liebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Fastner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Kranert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Jehle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anselm","family":"Derda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Duerschmied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hohneck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"issue":"11","key":"3005_CR1","doi-asserted-by":"publisher","first-page":"639-54","DOI":"10.1038\/nrcardio.2014.118","volume":"11","author":"F Rahman","year":"2014","unstructured":"Rahman F, Kwan GF, Benjamin EJ (2016) Global epidemiology of atrial fibrillation. 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Data protection was in accordance with the EU Data Protection Directive. The study is registered with DRKS, the German registry for clinical studies (DRKS00019007).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The following authors received honoraria for speaking engagements and\/or reimbursement of travel expenses. MKru: Medtronic GmbH (Meerbusch, Germany), Boston Scientific (Marlborough, USA). CF: Daiichi Sankyo Deutschland GmbH (Munich, Germany), Medtronic GmbH (Meerbusch, Germany), Pfizer Pharma GmbH (Berlin, Germany). AD: AstraZeneca (Cambridge, UK), BMS (New York, USA), Lilly (Indianapolis, USA), Boehringer Ingelheim (Ingelheim am Rhein, Germany), Bayer (Leverkusen, Germany). GS is co-owner of inmediQ and developer of the VascAssist software.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}