{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:51:18Z","timestamp":1791366678982,"version":"4.3.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Central retinal artery occlusion (CRAO) causes irreversible blindness. Atrial fibrillation (AF) is a recognized cause that may not be present at the time of the event.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to assess the relation of CRAO with new-onset AF and ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched the literature, utilizing the search terms \u201catrial fibrillation\u201d and \u201cretinal artery occlusion\u201d. We used a random effects model to calculate the pooled odds ratio (OR) and 95% confidence intervals (CI) of new-onset AF risk and new-onset ischemic stroke risk in CRAO patients compared to matched controls, as well as the new-onset AF risk compared to ischemic stroke patients. Analysis was performed with Rev-Man 5.4.1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 1479 patients with CRAO, 9843 matched controls without CRAO and stroke at baseline, and 7058 patients with ischemic stroke for meta-analysis. There were 115 cases of new-onset AF (14%) during a follow-up of 34\u00a0months. CRAO was associated with a higher risk for new-onset AF (OR:1.47, 95% CI:1.18\u20131.83;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0006) and new ischemic stroke (OR:2.10, 95% CI:1.57\u20132.82;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001) when compared to control patients. The risk of new-onset AF after CRAO was similar to that observed after ischemic stroke (OR:0.80, 95% CI:0.40\u20131.61;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.54). Follow-up duration and timing of outcome detection varied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CRAO is associated with a higher risk of new-onset AF and ischemic stroke. The risk of AF after CRAO is similar to that after an ischemic stroke. Thus, CRAO may be seen as a stroke-equivalent prompting closer follow-up with screening and eventually anticoagulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-026-03012-3","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:04:29Z","timestamp":1791363869000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Central retinal artery occlusion: meta-analysis of the risk of new-onset atrial fibrillation and ischemic stroke"],"prefix":"10.1007","author":[{"given":"Prakash","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Anjos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateeti","family":"Bekoju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram Chandra","family":"Panthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Salangsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios Arsenios","family":"Lioutas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Hilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm","family":"Seew\u00f6ster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Bode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Bollmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4222-6633","authenticated-orcid":false,"given":"Sotirios","family":"Nedios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"issue":"2","key":"3012_CR1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1161\/STROKEAHA.115.010828","volume":"47","author":"TH Rim","year":"2016","unstructured":"Rim TH, Han J, Choi YS, Hwang SS, Lee CS, Lee SC, Kim SS (2016) Retinal artery occlusion and the risk of stroke development: twelve-year nationwide cohort study. 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