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However, vascular complications remain a major source of morbidity and mortality. The protection wire technique was introduced to prevent major access-related complications, but its role in contemporary TAVI practice is uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate whether routine protection wire use reduces vascular complications in contemporary transfemoral TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective, single-centre analysis of 1476 consecutive patients undergoing transfemoral TAVI between January 2020 and August 2023. Until November 2021, protection wire placement was standard-of-care (Group 1,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009801); thereafter procedures were performed without routine protection wire use (Group 2,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009675). Vascular complications were defined according to VARC-3 criteria. Multivariable logistic regression was used to identify independent predictors of minor and major vascular complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The composite of minor and major vascular complications occurred more frequently in Group 1 than in Group 2 (18.6% vs. 10.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In Group 1, 34.8% of access-related complications were associated with the protection wire access. Major vascular complications were numerically less frequent in Group 2 (2.5% vs. 4.2%). Omission of routine protection wire placement was independently associated with a lower risk (OR 0.52, 95% CI 0.38\u20130.72,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In contemporary transfemoral TAVI, routine protection wire use was not associated with reduced major vascular complications and was linked to a higher rate of minor access site injuries. These findings support a restrictive rather than routine use of protection wires in current practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-026-03015-0","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:25:50Z","timestamp":1788413150000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Routine versus selective use of a femoral protection wire in transfemoral TAVI: a single-centre analysis of vascular complications"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2472-4161","authenticated-orcid":false,"given":"Marc Adrian","family":"Rogmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Klingemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7746-8723","authenticated-orcid":false,"given":"Max","family":"Meertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Ahoopai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-8138","authenticated-orcid":false,"given":"Karl-Philipp","family":"Rommel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5993-4487","authenticated-orcid":false,"given":"Philipp","family":"Lurz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1356-0037","authenticated-orcid":false,"given":"Ralph S.","family":"von Bardeleben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9935-8293","authenticated-orcid":false,"given":"Martin","family":"Geyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"3015_CR1","doi-asserted-by":"publisher","first-page":"4635","DOI":"10.1093\/eurheartj\/ehaf194","volume":"46","author":"F Praz","year":"2025","unstructured":"Praz F, Borger MA, Lanz J et al (2025) 2025 ESC\/EACTS guidelines for the management of valvular heart disease. 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Geyer has received honoraria from Edwards Lifesciences, Medtronic, and Abbott and has received proctoring fees from JenaValve Technology. K.P. Rommel has received consulting fees from Edwards Lifesciences, Adona Medical, Gradient Denervation, and ReCor Medical and has received payment or honoraria from ReCor Medical, Edwards Lifesciences, and Boehringer Ingelheim. P. Lurz has been a consultant to Abbott, Edwards Lifesciences, and Recor Medical and holds stock options in Innoventric. R.S. von Bardeleben has received speaker honoraria from Siemens, Philips, Abbott, and Edwards Lifesciences; he conducted trials (unpaid) for Abbott, Edwards Lifesciences, Medtronic, and Jenscare; and he received a fiduciary role on the board of directors of the Heart Valve Society USA (unpaid).M. Rogmann, V. Klingemann, M. Meertens, and M. Ahoopai have no relevant conflicts of interest to declare.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}