{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:31:29Z","timestamp":1759332689211},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z. Rheumatol."],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1007\/s00393-005-0748-y","type":"journal-article","created":{"date-parts":[[2005,6,19]],"date-time":"2005-06-19T15:39:04Z","timestamp":1119195544000},"page":"317-326","source":"Crossref","is-referenced-by-count":11,"title":["Stellenwert der neuen Biologicals und Zytokinantagonisten in der Therapie der juvenilen idiopathischen Arthritis (JIA)"],"prefix":"10.1007","volume":"64","author":[{"given":"G.","family":"Horneff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"748_CR1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/rheumatology\/keh074","volume":"43","author":"Armbrust","year":"2004","unstructured":"Armbrust W, Kamphuis SS, Wolfs TW, Fiselier TJ, Nikkels PG, Kuis W, Wulffraat NAM (2004) Tuberculosis in a nine-year-old girl treated with infliximab for systemic juvenile idiopathic arthritis. Rheumatology (Oxford) 43:527\u2013529","journal-title":"Rheumatology"},{"key":"748_CR2","first-page":"90S","volume":"44","author":"Banares","year":"2001","unstructured":"Banares A, Abasolo L, Maccaron P, HernandezC, Jover JA, Fernandez B, Pato E (2001) Treatment of refractory posterior uveitis with anti-TNF-alpha (infliximab). Arthritis Rheum 44:90S","journal-title":"Arthritis Rheum"},{"key":"748_CR3","first-page":"1111","volume":"29","author":"Billiau","year":"2002","unstructured":"Billiau AD, Cornillie F, Wouters C (2002) Infliximab for systemic onset juvenile idiopathic arthritis: experience in 3 children. J Rheumatol 29:1111\u20131114","journal-title":"J Rheumatol"},{"key":"748_CR4","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1002\/1529-0131(200011)43:11<2606::AID-ANR31>3.0.CO;2-X","volume":"43","author":"Bloom","year":"2000","unstructured":"Bloom BJ (2000) Development of diabetes mellitus during etanercept therapy in a child with systemic onset juvenile rheumatoid arthritis. Arthritis Rheum 43:2606\u20132608","journal-title":"Arthritis Rheum"},{"key":"748_CR5","first-page":"531","volume":"31","author":"Brandt","year":"2004","unstructured":"Brandt J, Khariouzov A, Listing J, Haibel H, Sorensen H, Rudwaleit M, Sieper J, Braun J (2004) Successful short term treatment of patients with severe undifferentiated spondyloarthritis with the anti-tumor necrosis factor-alpha fusion receptor protein etanercept. J Rheumatol 31:531\u2013538","journal-title":"J Rheumatol"},{"key":"748_CR6","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/1529-0131(199812)41:12<2196::AID-ART15>3.0.CO;2-2","volume":"41","author":"Bresnihan","year":"1998","unstructured":"Bresnihan B, Alvaro-Gracia JM, Cobby M, Doherty M, Domljan Z, Emery P, Nuki G, Pavelka K, Rau R, Rozman B, Watt I, Williams B, Aitchison R, McCabe D, Musikic P (1998) Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum 41:2196\u20132204","journal-title":"Arthritis Rheum"},{"key":"748_CR7","first-page":"292S","volume":"44","author":"Brunner","year":"2001","unstructured":"Brunner HI, AL Tomasi, TM Sherrard et al (2001) Effectiveness and safety of etanercept for the treatment of juvenile rheumatoid arthritis (JRA) in clinical practice. Arthritis Rheum 44:292S","journal-title":"Arthritis Rheum"},{"key":"748_CR8","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1002\/art.10623","volume":"46","author":"Choy","year":"2002","unstructured":"Choy EH, Isenberg DA, Garrood T, Farrow S, Ioannou Y, Bird H, Cheung N, Williams B, Hazleman B, Price R, Yoshizaki K, Nishimoto N, Kishimoto T, Panayi GS (2002) Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum 46:3143\u20133150","journal-title":"Arthritis Rheum"},{"key":"748_CR9","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1056\/NEJMoa032534","volume":"350","author":"Edwards","year":"2004","unstructured":"Edwards JC, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close DR, Stevens RM, Shaw T (2004) Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med. 350:2572\u20132581","journal-title":"N Engl J Med."},{"key":"748_CR10","first-page":"741","volume":"59","author":"Fantini","year":"2000","unstructured":"Fantini et al (2000) Infliximab in the treatment of refractory JIA Pres Meeting Abstract: Ann Rheum Dis 59:741","journal-title":"Ann Rheum Dis"},{"key":"748_CR11","first-page":"S 90","volume":"50","author":"Giannini","year":"2004","unstructured":"Giannini EH, Lovell DJ, Ilowite NT et al: Safety Outcomes from a Phase IV Pediatric Registry (2004) Etanercept (Enbrel\u00ae) Therapy in Children and Adolescents with Juvenile Rheumatoid Arthritis (JRA). Arthritis Rheum 50:S 90\u2013S 91","journal-title":"Arthritis Rheum"},{"key":"748_CR12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa020732","volume":"348","author":"Ghosh","year":"2003","unstructured":"Ghosh S, Goldin E, Gordon FH, Malchow HA, Rask-Madsen J, Rutgeerts P, Vyhnalek P, Zadorova Z, Palmer T, Donoghue S (2003) Natalizumab Pan-European Study Group. Natalizumab for active Crohn\u2019s disease. N Engl J Med 348:24\u201332","journal-title":"N Engl J Med"},{"key":"748_CR13","first-page":"438S","volume":"50","author":"Henrickson","year":"2004","unstructured":"Henrickson M (2004) Efficacy of Anakinra in Refractory Systemic Arthritis. Arthritis Rheum 50:438S","journal-title":"Arthritis Rheum"},{"key":"748_CR14","first-page":"540","volume":"21","author":"Horneff","year":"2003","unstructured":"Horneff G, Biedermann T, Foeldvari I, Kuester RM, Moebius D, Michels H, Rogalski B, Schmeling H (2003) Combination therapy with methotrexate and etanercept compared to etanercept monotherapy. Clin Exp Rheumatol 21:540","journal-title":"Clin Exp Rheumatol"},{"key":"748_CR15","first-page":"S 93","volume":"50","author":"Horneff","year":"2004","unstructured":"Horneff G, Girschick H, Hartmut Michels H et al (2004) Factors Associated with Failure of Etanercept Therapy in Systemic Onset Juvenile Idiopathic Arthritis. Arthritis Rheum 50:S 93\u2013S 94","journal-title":"Arthritis Rheum"},{"key":"748_CR16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s003930070043","volume":"59","author":"Horneff","year":"2001","unstructured":"Horneff G, Forster J, Seyberth W, Michels H, f\u00fcr die Arbeitsgemeinschaft Kinder- und Jugendrheumatologie (2001) Empfehlungen der Arbeitsgemeinschaft Kinder- und Jugendrheumatologie zur Therapie mit Etanercept (P75 TNF-Rezeptor-Immunglobulinfusionsprotein). Z Rheumatol 59:365\u2013369","journal-title":"Z Rheumatol"},{"key":"748_CR17","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1136\/ard.2003.014886","volume":"63","author":"Horneff","year":"2004","unstructured":"Horneff G, Schmeling H, Biedermann T, Foeldvari I, Ganser G, Girschick HJ, Hosbach T, Huppertz HI, Keitzer R, Kuester RM, Michels H, Moebius D, Rogalski B, Thon A (2004) The German Etanercept Registry for Treatment of Juvenile Idiopathic Arthritis (JIA). Ann Rheum 63:1638\u20131644","journal-title":"Ann Rheum"},{"key":"748_CR18","doi-asserted-by":"crossref","first-page":"S 86","DOI":"10.1136\/ard.62.1.86","volume":"62","author":"Ilowite","year":"2003","unstructured":"Ilowite NT, Porras O, Reiff A, Rudge SR, Punaro MG, Martin AL, Allen R, Harville TO, Kazazi F, Zhou L, Newmark R (2003) A twelve-week open label safety and efficacy study of anakinra (Kineret) in juvenile rheumatoid arthritis. Ann Rheum Dis 62:S 86","journal-title":"Ann Rheum Dis"},{"key":"748_CR19","first-page":"S 437","volume":"50","author":"Irigoyen","year":"2004","unstructured":"Irigoyen PI, Olson J, Hom C et al (2004) Treatment of Systemic Onset Juvenile Rheumatoid Arthritis with Anakinra. Arthritis Rheum 50:S 437\u2013S 438","journal-title":"Arthritis Rheum"},{"key":"748_CR20","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/1529-0131(200005)43:5<1001::AID-ANR7>3.0.CO;2-P","volume":"43","author":"Jiang","year":"2000","unstructured":"Jiang Y, Genant HK, Watt I, Cobby M, Bresnihan B, Aitchison R, McCabe D (2000) A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores. Arthritis Rheum 43:1001\u20131009","journal-title":"Arthritis Rheum"},{"key":"748_CR21","first-page":"S 92","volume":"50","author":"Kahn","year":"2004","unstructured":"Kahn PJ, Weiss M, Imundo LF et al (2004) Favorable Response to Higher Dose Infliximab in Refractory Uveitis: Eleven Cases. Arthritis Rheum 50:S 92","journal-title":"Arthritis Rheum"},{"key":"748_CR22","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/art.20217","volume":"50","author":"Keystone","year":"2004","unstructured":"Keystone EC, Kavanaugh AF, Sharp JT, Tannenbaum H, Hua Y, Teoh LS, Fischkoff SA, Chartash EK (2004) Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial. Arthritis Rheum 50:1400\u20131411","journal-title":"Arthritis Rheum"},{"key":"748_CR23","first-page":"360","volume":"28","author":"Kietz","year":"2001","unstructured":"Kietz DA, Permuelller PH, Moore TL (2001) Clinical response to Etanercept in polyarticular course juvenile rheumatoid arthritis. J Rheumatol 28:360\u2013362","journal-title":"J Rheumatol"},{"key":"748_CR24","first-page":"S 272","volume":"44","author":"Kimura","year":"2001","unstructured":"Kimura Y, LF Imundo, SC Li (2001) High dose infliximab in the treatment of resistant systemic JRA. Arthritis Rheum 44:S 272","journal-title":"Arthritis Rheum"},{"key":"748_CR25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1136\/ard.62.3.245","volume":"62","author":"Lahdenne","year":"2003","unstructured":"Lahdenne P, Vahasalo P, Honkanen V (2003) Infliximab or etanercept in the treatment of children with refractory juvenile idiopathic arthritis: an open label study. Ann Rheum Dis 62:245\u2013247","journal-title":"Ann Rheum Dis"},{"key":"748_CR26","first-page":"S 436","volume":"50","author":"Lovell","year":"2004","unstructured":"Lovell D, Reiff A, Jones OY et al (2004) Long-Term Safety and Efficacy Experience with Etanercept (Enbrel\u00ae) in Children with Polyarticular Juvenile Rheumatoid Arthritis. Arthritis Rheum 50:S 436","journal-title":"Arthritis Rheum"},{"key":"748_CR27","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1056\/NEJM200003163421103","volume":"342","author":"Lovell","year":"2000","unstructured":"Lovell DJ, Giannini EH, Reiff A et al (2000) Etanercept in children with polyarticular juvenile rheumatoid arthritis. N Engl J Med 342:763\u2013769","journal-title":"N Engl J Med"},{"key":"748_CR28","first-page":"S 436","volume":"50","author":"Lovell","year":"2004","unstructured":"Lovell DJ, Ruperto N, Goodman S, Reiff A, Martini A, Giannini EH, Radin AR, Rao VS, Spencer-Green G (2004) Preliminary Data from the Study of Adalimumab in Children with Juvenile Idiopathic Arthritis (JIA). Arthritis Rheum 50:S 436\u2013S 437","journal-title":"Arthritis Rheum"},{"key":"748_CR29","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/art.10294","volume":"46","author":"Moreland","year":"2002","unstructured":"Moreland LW, Alten R, Van den Bosch F, Appelboom T, Leon M, Emery P, Cohen S, Luggen M, Shergy W, Nuamah I, Becker JC (2002) Costimulatory blockade in patients with rheumatoid arthritis: a pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion. Arthritis Rheum 46:1470\u20131479","journal-title":"Arthritis Rheum"},{"key":"748_CR30","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/rheumatology\/38.8.739","volume":"38","author":"Petty","year":"1999","unstructured":"Petty RE (1999) Prognosis in children with rheumatic diseases: justification for consideration of new therapies. Rheumatology 38:739\u2013742","journal-title":"Rheumatology"},{"key":"748_CR31","first-page":"1991","volume":"25","author":"Petty","year":"1998","unstructured":"Petty RE, Southwood TR, Baum J et al (1998) Revision of the proposed criteria for juvenile idiopathic arthritis: Durban 1997. J Rheumatol 25:1991\u20131994","journal-title":"J Rheumatol"},{"key":"748_CR32","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/art.10885","volume":"48","author":"Quartier","year":"2003","unstructured":"Quartier P, Taupin P, Bourdeaut F, Lemelle I, Pillet P, Bost M, Sibilia J, Kone-Paut I, Gandon-Laloum S, LeBideau M, Bader-Meunier B, Mouy R, Debre M, Landais P, Prieur AM (2003) Efficacy of etanercept for the treatment of juvenile idiopathic arthritis according to the onset type. Arthritis Rheum 48:1093\u20131101","journal-title":"Arthritis Rheum"},{"key":"748_CR33","doi-asserted-by":"crossref","first-page":"S 292","DOI":"10.1002\/1529-0131(200106)44:6<1411::AID-ART235>3.0.CO;2-O","volume":"44","author":"Reiff","year":"2001","unstructured":"Reiff A, M Henrickson (2001) Prolonged efficacy of etanercept in refractory juvenile ankylosing spondylitis. Arthritis Rheum 44:S 292","journal-title":"Arthritis Rheum"},{"key":"748_CR34","unstructured":"Reiff A, Porras O, Rudge S, Punaro M, Allen R, Ilowite N, Martin AL, Lovell D, Kazazi F, Sun G, Newmark R (2002) Preliminary Data from a Study of Kineret (anakinra) in Children with Juvenile Rheumatoid Arthritis. 2002 Annual Scientific meeting of the American College of Rheumatology, October 25\u201329, New Orleans, USA"},{"key":"748_CR35","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1002\/1529-0131(200106)44:6<1411::AID-ART235>3.0.CO;2-O","volume":"44","author":"Reiff","year":"2001","unstructured":"Reiff A, Takei S, Sadeghi S, Stout A, Shaham B, Bernstein B, Gallagher K, Stout T (2001) Etanercept therapy in children with treatment-resistant uveitis. Arthritis Rheum 44:1411\u20131415","journal-title":"Arthritis Rheum"},{"key":"748_CR36","first-page":"S 81","volume":"63","author":"Saadeh","year":"2004","unstructured":"Saadeh et al (2004) Successful treatment of stills disease with anakinra after failure to respond to multiple therapeutic modalities including methotrexate, infliximab, immunoglobulins, etanercept and adalimumab. Ann Rheum Dis 63:S 81","journal-title":"Ann Rheum Dis"},{"key":"748_CR37","first-page":"S 92","volume":"50","author":"Saurenmann","year":"2004","unstructured":"Saurenmann R, Rose J, Tyrell P (2004) The Effect of Anti-TNF Treatment in Children With Uveitis Arthritis Rheum 50:S 92","journal-title":"Arthritis Rheum"},{"key":"748_CR38","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1136\/ard.60.4.410","volume":"60","author":"Schmeling","year":"2001","unstructured":"Schmeling H, Mathony K, John V, Key\u00dfer G, Burdach St. Horneff G (2001) Combination of etanercept and methotrexate for the treatment of refractory juvenile idiopathic arthritis\u2014a pilot study. Ann Rheum Dis 60:410\u2013412","journal-title":"Ann Rheum Dis"},{"key":"748_CR39","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1212\/WNL.57.10.1885","volume":"57","author":"Sicotte","year":"2001","unstructured":"Sicotte NL, Voskuhl RR (2001) Onset of multiple sclerosis associated with anti-TNF therapy. Neurology 57:1885\u20131888","journal-title":"Neurology"},{"key":"748_CR40","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/art.20904","volume":"53","author":"Smith","year":"2005","unstructured":"Smith JA, Thompson DJS, Whitcup SM et al (2005) A randomised, placebo-controlled, double-masked clinical trial of etanercept for the treatment of uveitis associated with juvenile idiopathic arthritis. Arthritis Rheum 53:18\u201323","journal-title":"Arthritis Rheum"},{"key":"748_CR41","first-page":"S 292","volume":"44","author":"Striegel","year":"2001","unstructured":"Striegel KH, Onel KB, Lehman TJA (2001) Leukopenia in children receiving sulfasalazine and etanercept. Arthritis Rheum 44:S 292","journal-title":"Arthritis Rheum"},{"key":"748_CR42","first-page":"1677","volume":"28","author":"Takei","year":"2001","unstructured":"Takei S, Groh D, Bernsteinn B, Shaham B, Gallagher K, Reiff A (2001) Safety and efficacy of high dose Etanercept in treatment of juvenile rheumatoid arthritis. J Rheumatol 28:1677\u20131680","journal-title":"J Rheumatol"},{"key":"748_CR43","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/rheumatology\/keh142","volume":"43","author":"Tutar","year":"2004","unstructured":"Tutar E, Ekici F, Nacar N, Arici S, Atalay S (2004) Delayed maculopapular, urticarial rash due to infliximab in two children with systemic onset juvenile idiopathic arthritis. Rheumatology (Oxford) 43:674\u2013675","journal-title":"Rheumatology"},{"key":"748_CR44","first-page":"259","volume":"20","author":"Wendling","year":"1993","unstructured":"Wendling D, Racadot E, Wijdenes J (1993) Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody. J Rheumatol 20:259\u2013262","journal-title":"J Rheumatol"},{"key":"748_CR45","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/art.20944","volume":"52","author":"Yokota","year":"2005","unstructured":"Yokota S, Miyamae T, Imagawa T, et al (2005) Therapeutic efficacy of humanized recombinant anti-Interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 52:818\u2013825","journal-title":"Arthritis Rheum"},{"key":"748_CR46","first-page":"S 123","volume":"44","author":"El-Shabrawi","year":"2001","unstructured":"Yosuf El-Shabrawi, Josef Hermann Graz (2001) Anti-TNF therapy with infliximab in the treatment o acute anterior uveitis\u2014a one year follow up. Arthritis Rheum 44:S 123","journal-title":"Arthritis Rheum"}],"container-title":["Zeitschrift f\u00fcr Rheumatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-005-0748-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00393-005-0748-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-005-0748-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T16:29:35Z","timestamp":1559060975000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00393-005-0748-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["748"],"URL":"https:\/\/doi.org\/10.1007\/s00393-005-0748-y","relation":{},"ISSN":["0340-1855","1435-1250"],"issn-type":[{"value":"0340-1855","type":"print"},{"value":"1435-1250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}