{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T08:05:39Z","timestamp":1751357139072},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,2,28]],"date-time":"2008-02-28T00:00:00Z","timestamp":1204156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z. Rheumatol."],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1007\/s00393-007-0245-6","type":"journal-article","created":{"date-parts":[[2008,2,26]],"date-time":"2008-02-26T08:28:45Z","timestamp":1204014525000},"page":"121-127","source":"Crossref","is-referenced-by-count":8,"title":["Lyme-Arthritis bei Kindern und Jugendlichen","Lyme arthritis in children and adolescents"],"prefix":"10.1007","volume":"67","author":[{"given":"F.","family":"Dressler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-I.","family":"Huppertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,2,28]]},"reference":[{"key":"245_CR1","unstructured":"Huppertz HI, Dressler F (2005) Lyme disease. In: Cassidy JT, Petty RE, Laxer RM, Lindsley CB (eds) Textbook of Pediatric Rheumatology. 5th edn. Elsevier Saunders, Philadelphia, pp\u00a0591\u2013603"},{"key":"245_CR2","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1007\/BF02072065","volume":"149","author":"Huppertz","year":"1990","unstructured":"Huppertz HI (1990) Childhood Lyme borreliosis in Europe. Eur J Pediatr 149: 814\u2013821","journal-title":"Eur J Pediatr"},{"key":"245_CR3","first-page":"S49","volume":"Rheumatol","author":"Dressler","year":"1994","unstructured":"Dressler F (1994) Lyme borreliosis in European children and adolescents. Clin Exp Rheumatol (Suppl 10) 12: S49","journal-title":"Clin Exp"},{"key":"245_CR4","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1056\/NEJM199511163332004","volume":"333","author":"Berglund","year":"1995","unstructured":"Berglund J, Eitrem R, Ornstein K et al. (1995) An epidemiologic study of Lyme disease in Southern Sweden. N Engl J Med 333: 1319\u20131327","journal-title":"N Engl J Med"},{"key":"245_CR5","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s100960050381","volume":"18","author":"Huppertz","year":"1999","unstructured":"Huppertz HI, B\u00f6hme M, Standaert SM et al. (1999) Incidence of Lyme borreliosis in the W\u00fcrzburg region of Germany. Eur J Clin Microbiol Infect Dis 18: 697\u2013703","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"245_CR6","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1056\/NEJM199610243351703","volume":"335","author":"Gerber","year":"1996","unstructured":"Gerber MA, Shapiro ED, Burke GS et al. (1996) Lyme disease in children in southeastern Connecticut. N Engl J Med 335: 1270\u20131274","journal-title":"N Engl J Med"},{"key":"245_CR7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780380310","volume":"38","author":"Huppertz","year":"1995","unstructured":"Huppertz HI, Karch H, Suschke HJ et al. (1995) Lyme arthritis in European children and adolescents. Arthritis Rheum 38: 361\u2013368","journal-title":"Arthritis Rheum"},{"key":"245_CR8","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1099\/ijs.0.64050-0","volume":"56","author":"Richter","year":"2006","unstructured":"Richter D, Postic D, Sertour N et al. (2006) Delineation of Borrelia burgdorferi sensu lato species by multilocus sequence analysis and confirmation of the delineation of Borrelia spielmanii sp. Nov. Int J Syst Evol Microbiol 56: 873\u2013881","journal-title":"Int J Syst Evol Microbiol"},{"key":"245_CR9","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/37551","volume":"390","author":"Fraser","year":"1997","unstructured":"Fraser CM, Casjens S, Huang WM et al. (1997) Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390: 580\u2013586","journal-title":"Nature"},{"key":"245_CR10","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1128\/IAI.66.5.1946-1952.1998","volume":"66","author":"Coburn","year":"1998","unstructured":"Coburn J, Magoun L, Bodary SC et al. (1998) Integrins alpha(v)beta3 and alpha5beta1 mediate attachment of Lyme disease spirochetes to human cells. Infect Immun 66: 1946\u20131952","journal-title":"Infect Immun"},{"key":"245_CR11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF01409985","volume":"16","author":"Girschick","year":"1996","unstructured":"Girschick HJ, Huppertz HI, R\u00fcssmann H et al. (1996) Intracellular persistence of Borrelia burgdorferi in human synovial cells. Rheumatol Int 16: 125\u2013132","journal-title":"Rheumatol Int"},{"key":"245_CR12","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4049\/jimmunol.160.2.1022","volume":"160","author":"Gross","year":"1998","unstructured":"Gross DM, Steere AC, Huber BT (1998) T helper 1 response is dominant and localized to the synovial fluid in patients with Lyme arthritis. J Immunol 160: 1022\u20131028","journal-title":"J Immunol"},{"key":"245_CR13","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.4049\/jimmunol.157.8.3534","volume":"157","author":"Busch","year":"1996","unstructured":"Busch DH, Jassoy C, Brinckmann U et al. (1996) Detection of Borrelia burgdorferi\u2013specific CD8 cytotoxic T-cells in patients with Lyme arthritis. J Immunol 157: 3534\u20133541","journal-title":"J Immunol"},{"key":"245_CR14","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.4049\/jimmunol.170.5.2702","volume":"170","author":"Roessner","year":"2003","unstructured":"Roessner K, Wolfe J, Shi C et al. (2003) High expression of Fas ligand by synovial fluid-derived \u03b3\u03b4-T cells in Lyme arthritis. J Immunol 170: 2702\u20132710","journal-title":"J Immunol"},{"key":"245_CR15","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/art.22441","volume":"56","author":"Shin","year":"2007","unstructured":"Shin JJ, Glickstein LJ, Steere AC (2007) High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory Lyme arthritis. Arthritis Rheum 56: 1325\u20131335","journal-title":"Arthritis Rheum"},{"key":"245_CR16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0167-5699(92)90012-V","volume":"13","author":"Weigelt","year":"1992","unstructured":"Weigelt W, Schneider T, Lange R (1992) Sequence homology between spirochaete flagellin and human myelin basic protein. Immunol Today 13: 279\u2013280","journal-title":"Immunol Today"},{"key":"245_CR17","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1093\/infdis\/167.6.1372","volume":"167","author":"Sigal","year":"1993","unstructured":"Sigal LH (1993) Cross-reactivity between Borrelia burgdorferi flagellin and a human axonal 64000 molecular weight protein. J Infect Dis 167: 1372\u20131378","journal-title":"J Infect Dis"},{"key":"245_CR18","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1128\/IAI.61.7.2774-2779.1993","volume":"61","author":"Kalish","year":"1993","unstructured":"Kalish R, Leong JM, Steere AC (1993) Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi. Infect Immun 61: 2774\u20132779","journal-title":"Infect Immun"},{"key":"245_CR19","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1128\/IAI.64.4.1284-1289.1996","volume":"64","author":"Kamradt","year":"1996","unstructured":"Kamradt T, Lengl-Janssen B, Strauss AF et al. (1996) Dominant recognition of a Borrelia burgdorferi outer surface protein A peptide by T helper cells in patients with treatment-resistant Lyme arthritis. Infect Immun 64: 1284\u20131289","journal-title":"Infect Immun"},{"key":"245_CR20","doi-asserted-by":"crossref","unstructured":"Drouin EE, Glickstein L, Kwok WW et al. (in press) Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis. Mol Immunol: Epub ahead of print","DOI":"10.1016\/j.molimm.2007.04.017"},{"key":"245_CR21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1126\/science.281.5377.703","volume":"281","author":"Gross","year":"1998","unstructured":"Gross DM, Forsthuber T, Tary-Lehmann M et al. (1998) Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science 281: 703\u2013706","journal-title":"Science"},{"key":"245_CR22","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/art.10772","volume":"48","author":"Steere","year":"2003","unstructured":"Steere AC, Falk B, Drouin EE et al. (2003) Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritis. Arthritis Rheum 48: 534\u2013540","journal-title":"Arthritis Rheum"},{"key":"245_CR23","first-page":"759","volume":"139","author":"Huppertz","year":"1991","unstructured":"Huppertz HI, Karch H (1991) Die Lyme-Arthritis im Kindesalter: Monarthritis des Kniegelenks, klinisch nicht unterscheidbar von Monarthritiden unbekannter Ursache. Monatsschr Kinderheilkd 139: 759\u2013764","journal-title":"Monatsschr Kinderheilkd"},{"key":"245_CR24","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1651-2227.1992.tb12136.x","volume":"81","author":"Hammers-Berggren","year":"1992","unstructured":"Hammers-Berggren S, Andersson U, Stiernstedt G (1992) Borrelia arthritis in Swedish children: clinical manifestations in 10 children. Acta Paediatr 81: 921\u2013924","journal-title":"Acta Paediatr"},{"key":"245_CR25","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1542\/peds.102.4.905","volume":"102","author":"Gerber","year":"1998","unstructured":"Gerber MA, Zemel LS, Shapiro ED (1998) Lyme arthritis in children: clinical epidemiology and long-term outcomes. Pediatrics 102: 905\u2013908","journal-title":"Pediatrics"},{"key":"245_CR26","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/rheumatology\/35.10.1016","volume":"35","author":"Huppertz","year":"1996","unstructured":"Huppertz HI, Michels H (1996) Pattern of joint involvement in children with Lyme arthritis. Br J Rheumatol 35: 1016\u20131018","journal-title":"Br J Rheumatol"},{"key":"245_CR27","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1136\/bjo.83.10.1149","volume":"83","author":"Huppertz","year":"1999","unstructured":"Huppertz HI, M\u00fcnchmeier D, Lieb W (1999) Ocular manifestations in children and adolescents with Lyme arthritis. Br J Ophthalmol 83: 1149\u20131152","journal-title":"Br J Ophthalmol"},{"key":"245_CR28","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/01241398-198709000-00005","volume":"7","author":"Christoforo","year":"1987","unstructured":"Christoforo RL, Appel MH, Gelb RF, Williams CL (1987) Musculoskeletal manifestations of Lyme disease in children. J Pediatr Orthop 7: 527","journal-title":"J Pediatr Orthop"},{"key":"245_CR29","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1542\/peds.90.4.523","volume":"90","author":"Sigal","year":"1992","unstructured":"Sigal LH, Patella SJ (1992) Lyme arthritis as the incorrect diagnosis in pediatric and adolescent fibromyalgia. Pediatrics 90: 523\u2013528","journal-title":"Pediatrics"},{"key":"245_CR30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1099\/00222615-23-3-261","volume":"23","author":"De","year":"1987","unstructured":"De Koning J, Bosma RB, Hoogkamp-Korstanje JAA (1987) Demonstration of spirochaetes in patients with Lyme disease with a modified silver stain. J Med Microbiol 23: 261\u2013267","journal-title":"J Med Microbiol"},{"key":"245_CR31","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/ajcp\/99.2.168","volume":"99","author":"Golightly","year":"1993","unstructured":"Golightly M (1993) Laboratory considerations in the diagnosis and management of Lyme borreliosis. Am J Clin Pathol 99: 168\u2013174","journal-title":"Am J Clin Pathol"},{"key":"245_CR32","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJM199401273300401","volume":"330","author":"Nocton","year":"1994","unstructured":"Nocton JJ, Dressler F, Rutledge BJ et al. (1994) Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis. N Engl J Med 330: 229\u2013234","journal-title":"N Engl J Med"},{"key":"245_CR33","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1002\/1529-0131(199912)42:12<2705::AID-ANR29>3.0.CO;2-H","volume":"42","author":"Carlson","year":"1999","unstructured":"Carlson D, Hernandez J, Bloom BJ et al. (1999) Lack of Borrelia burgdorferi DNA in synovial fluid samples from patients with antibiotic treatment\u2013resistant Lyme arthritis. Arthritis Rheum 42: 2705\u20132709","journal-title":"Arthritis Rheum"},{"key":"245_CR34","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1128\/JCM.35.3.685-690.1997","volume":"35","author":"Priem","year":"1997","unstructured":"Priem S, Rittig MG, Kamradt T et al. (1997) An optimized PCR leads to rapid and highly sensitive detection of Borrelia burgdorferi in patients with Lyme borreliosis. J Clin Microbiol 35: 685\u2013690","journal-title":"J Clin Microbiol"},{"key":"245_CR35","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/art.1780390505","volume":"39","author":"Jaulhac","year":"1996","unstructured":"Jaulhac B, Chary-Valckenaere I, Sibila J et al. (1996) Detection of Borrelia burgdorferi by DNA amplification in synovial tissue samples from patients with Lyme arthritis. Arthritis Rheum 39: 736\u2013745","journal-title":"Arthritis Rheum"},{"key":"245_CR36","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1136\/ard.57.2.118","volume":"57","author":"Priem","year":"1998","unstructured":"Priem S, Burmester GR, Kamradt T et al. (1998) Detection of Borrelia burgdorferi by polymerase chain reaction in synovial membrane, but not in synovial fluid from patients with persisting Lyme arthritis after antibiotic therapy. Ann Rheum Dis 57: 118\u2013121","journal-title":"Ann Rheum Dis"},{"key":"245_CR37","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1128\/JCM.32.9.2312-2314.1994","volume":"32","author":"Karch","year":"1994","unstructured":"Karch H, Huppertz HI, B\u00f6hme M et al. (1994) Demonstration of Borrelia burgdorferi DNA in urine samples from healthy humans whose sera contain B. burgdorferi\u2013specific antibodies. J Clin Microbiol 32: 2312\u20132314","journal-title":"J Clin Microbiol"},{"key":"245_CR38","unstructured":"(1995) Recommendations for test performance and interpretation from the second national conference on serologic diagnosis of Lyme disease. MMWR Morb Mortal Wkly Rep 44: 590\u2013591"},{"key":"245_CR39","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/infdis\/167.2.392","volume":"167","author":"Dressler","year":"1993","unstructured":"Dressler F, Whalen JA, Reinhardt BN et al. (1993) Western blotting in the serodiagnosis of Lyme disease. J Infect Dis 167: 392\u2013400","journal-title":"J Infect Dis"},{"key":"245_CR40","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1128\/JCM.35.6.1433-1444.1997","volume":"35","author":"Hauser","year":"1997","unstructured":"Hauser U, Lehnert G, Lobentanzer R et al. (1997) Interpretation criteria for standardized Western blots for three European species of Borrelia burgdorferi sensu lato. J Clin Microbiol 35: 1433\u20131444","journal-title":"J Clin Microbiol"},{"key":"245_CR41","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1128\/JCM.37.7.2241-2247.1999","volume":"37","author":"Hauser","year":"1999","unstructured":"Hauser U, Lehnert G, Wilkske B (1999) Validity of interpretation criteria for standardized Western blots (immunoblots) for serodiagnosis of Lyme borreliosis based on sera collected throughout Europe. J Clin Microbiol 37: 2241\u20132247","journal-title":"J Clin Microbiol"},{"key":"245_CR42","first-page":"367","volume":"23","author":"Rose","year":"1996","unstructured":"Rose CD, Fawcett PT, Gibney KM et al. (1996) Residual serologic reactivity in children with resolved Lyme arthritis. J Rheumatol 23: 367","journal-title":"J Rheumatol"},{"key":"245_CR43","doi-asserted-by":"crossref","first-page":"37","DOI":"10.7326\/0003-4819-128-1-199801010-00007","volume":"128","author":"Nichol","year":"1998","unstructured":"Nichol G, Dennis DT, Steere AC et al. (1998) Test-treatment strategies for patients suspected of having Lyme disease: a cost-effectiveness analysis. Ann Intern Med 128: 37\u201348","journal-title":"Ann Intern Med"},{"key":"245_CR44","doi-asserted-by":"crossref","first-page":"533","DOI":"10.7326\/0003-4819-115-7-533","volume":"115","author":"Dressler","year":"1991","unstructured":"Dressler F, Yoshinari NH, Steere AC (1991) The T-cell proliferative assay in the diagnosis of Lyme disease. Ann Intern Med 115: 533\u2013539","journal-title":"Ann Intern Med"},{"key":"245_CR45","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF02002716","volume":"155","author":"Huppertz","year":"1996","unstructured":"Huppertz HI, M\u00f6sbauer S, Busch DH et al. (1996) Lymphoproliferative responses to Borrelia burgdorferi in the diagnosis of Lyme arthritis in children and adolescents. Eur J Pediatr 155: 297\u2013302","journal-title":"Eur J Pediatr"},{"key":"245_CR46","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s00296-007-0333-6","volume":"27","author":"Holl-Wieden","year":"2007","unstructured":"Holl-Wieden A, Suerbaum S, Girschick HJ (2007) Seronegative Lyme arthritis. Rheumatol Int 27: 1091\u20131093","journal-title":"Rheumatol Int"},{"key":"245_CR47","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s004310050816","volume":"157","author":"Huppertz","year":"1998","unstructured":"Huppertz HI, Bentas W, Haubitz I et al. (1998) Diagnosis of pediatric Lyme arthritis using a clinical score. Eur J Pediatr 157: 304\u2013308","journal-title":"Eur J Pediatr"},{"key":"245_CR48","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.2214\/ajr.184.6.01841904","volume":"184","author":"Ecklund","year":"2005","unstructured":"Ecklund K, Vargas S, Zurakowski D, Sundel RP (2005) MRI features of Lyme arthritis in children. AJR Am J Roentgenol 184: 1904\u20131909","journal-title":"AJR Am J Roentgenol"},{"key":"245_CR49","unstructured":"(1990) Case definitions for public health surveillance. MMWR Morb Mortal Wkly Rep 39: 19"},{"key":"245_CR50","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00006454-200201000-00003","volume":"21","author":"Zahid","year":"2002","unstructured":"Zahid Qureshi M, New D, Zulqarni NJ, Nachman S (2002) Overdiagnosis and overtreatment of Lyme disease in children. Pediatr Infect Dis J 21: 12","journal-title":"Pediatr Infect Dis J"},{"key":"245_CR51","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00301775","volume":"15","author":"Huppertz","year":"1995","unstructured":"Huppertz HI, Karch H, Heesemann J (1995) Diagnostic value of synovial fluid analysis in children with reactive arthritis. Rheumatol Int 15: 167\u2013170","journal-title":"Rheumatol Int"},{"key":"245_CR52","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/0140-6736(90)93103-V","volume":"336","author":"Dattwyler","year":"1990","unstructured":"Dattwyler RJ, Volkman DJ, Conaty SM et al. (1990) Amoxicillin plus probenecid versus doxycycline for treatment of erythema migrans borreliosis. Lancet 336: 1404\u20131406","journal-title":"Lancet"},{"key":"245_CR53","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0140-6736(88)92011-9","volume":"1","author":"Dattwyler","year":"1988","unstructured":"Dattwyler RJ, Halperin JJ, Volkman DJ et al. (1988) Treatment of late Lyme borreliosis \u2013 randomised comparison of ceftriaxone and penicillin. Lancet 1: 1191\u20131194","journal-title":"Lancet"},{"key":"245_CR54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF01641422","volume":"18","author":"Weber","year":"1990","unstructured":"Weber K, Preac-Mursic V, Wilske B et al. (1990) A randomized trial of ceftriaxone versus oral penicillin for the treatment of early European Lyme borreliosis. Infection 18: 91\u201396","journal-title":"Infection"},{"key":"245_CR55","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1001\/archneur.1989.00520470044025","volume":"46","author":"Pfister","year":"1989","unstructured":"Pfister HW, Preac-Mursic V, Wilske B et al. (1989) Cefotaxime versus penicillin G for acute neurologic manifestations in Lyme borreliosis. A prospective randomized study. Arch Neurol 46: 1190\u20131194","journal-title":"Arch Neurol"},{"key":"245_CR56","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/BF01644967","volume":"19","author":"M\u00fcllegger","year":"1991","unstructured":"M\u00fcllegger RR, Millner MM, Stanek G et al. (1991) Penicillin G sodium and ceftriaxone in the treatment of neuroborreliosis in children \u2013 a prospective study. Infection 19: 279\u2013283","journal-title":"Infection"},{"key":"245_CR57","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0002-9343(92)90270-L","volume":"92","author":"Massarotti","year":"1992","unstructured":"Massarotti EM, Luger SW, Rahn DW et al. (1992) Treatment of early Lyme disease. Am J Med 92: 396\u2013403","journal-title":"Am J Med"},{"key":"245_CR58","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1542\/peds.109.6.1173","volume":"109","author":"Eppes","year":"2002","unstructured":"Eppes SC, Childs JA (2002) Comparative study of cefuroxime axetil versus amoxicillin in children with early Lyme disease. Pediatrics 109: 1173\u20131177","journal-title":"Pediatrics"},{"key":"245_CR59","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1056\/NEJM199707313370501","volume":"337","author":"Dattwyler","year":"1997","unstructured":"Dattwyler RJ, Luft BJ, Kunkel MJ et al. (1997) Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease. N Engl J Med 337: 289","journal-title":"N Engl J Med"},{"key":"245_CR60","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2340\/0001555572297300","volume":"Venerol","author":"Hansen","year":"1992","unstructured":"Hansen K, Hovmark A, Lebeque AM et al. (1992) Roxithromycine in Lyme borreliosis: discrepant results of an in vitro and in vivo animal susceptibility study and a clinical trial in patients with erythema migrans. Acta Derm Venerol (Stockh) 72: 297\u2013300","journal-title":"Acta Derm"},{"key":"245_CR61","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF01728915","volume":"21","author":"Weber","year":"1993","unstructured":"Weber K, Wilske B, Preac-Mursic V et al. (1993) Azithromycin versus penicillin V for the treatment of early Lyme borreliosis. Infection 21: 367","journal-title":"Infection"},{"key":"245_CR62","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF01710737","volume":"21","author":"Strle","year":"1993","unstructured":"Strle F, Preac-Mursic V, Cimperman J et al. (1993) Azithromycin versus doxycycline for treatment of erythema migrans: clinical and microbiologic findings. Infection 21: 83\u201388","journal-title":"Infection"},{"key":"245_CR63","doi-asserted-by":"crossref","first-page":"785","DOI":"10.7326\/0003-4819-124-9-199605010-00002","volume":"124","author":"Luft","year":"1996","unstructured":"Luft BJ, Dattwyler RJ, Johnson RC et al. (1996) Azithromycin compared with amoxicillin in the treatment of erythema migrans. A double-blind, randomized, controlled trial. Ann Intern Med 124: 785\u2013791","journal-title":"Ann Intern Med"},{"key":"245_CR64","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/art.1780370616","volume":"37","author":"Steere","year":"1994","unstructured":"Steere AC, Levin RE, Molloy PJ et al. (1994) Treatment of Lyme arthritis. Arthritis Rheum 37: 878\u2013888","journal-title":"Arthritis Rheum"},{"key":"245_CR65","doi-asserted-by":"crossref","first-page":"697","DOI":"10.7326\/0003-4819-138-9-200305060-00005","volume":"138","author":"Wormser","year":"2003","unstructured":"Wormser GP, Ramanathan R, Nowakowski J et al. (2003) Duration of antibiotic therapy for early Lyme disease. Ann Intern Med 138: 697\u2013704","journal-title":"Ann Intern Med"},{"key":"245_CR66","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1097\/00006454-200212000-00011","volume":"21","author":"Thorstrand","year":"2002","unstructured":"Thorstrand C, Belfrage E, Bennet R et al. (2002) Successful treatment of neuroborreliosis with ten day regimens. Pediatr Infect Dis J 21: 1142","journal-title":"Pediatr Infect Dis J"},{"key":"245_CR67","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM199707313370525","volume":"337","author":"Eckman","year":"1997","unstructured":"Eckman MH, Steere AC, Kalish RA et al. (1997) Cost effectiveness of oral as compared with intravenous antibiotic therapy for patients with early Lyme disease or Lyme arthritis. N Engl J Med 337: 357\u2013363","journal-title":"N Engl J Med"},{"key":"245_CR68","doi-asserted-by":"crossref","unstructured":"Gasser R, Wendelin I, Reisinger E et al. (1995) Roxithromycin in the treatment of Lyme disease \u2013 update and perspectives. Infection (Suppl 1) 23: S39","DOI":"10.1007\/BF02464959"},{"key":"245_CR69","first-page":"2025","volume":"27","author":"Bentas","year":"2000","unstructured":"Bentas W, Karch H, Huppertz HI (2000) Lyme arthritis in children and adolescents: outcome 12 months after initiation of antibiotic therapy. J Rheumatol 27: 2025\u20132039","journal-title":"J Rheumatol"},{"key":"245_CR70","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1542\/peds.105.1.142","volume":"105","author":"American","year":"2000","unstructured":"American Academy of Pediatrics, Committee on Infectious Diseases (2000) Prevention of Lyme disease. Pediatrics 105: 142","journal-title":"Pediatrics"},{"key":"245_CR71","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1056\/NEJMra021397","volume":"348","author":"Hayes","year":"2003","unstructured":"Hayes EB, Piesman J (2003) How can we prevent Lyme disease? N Engl J Med 348: 2424\u20132430","journal-title":"N Engl J Med"},{"key":"245_CR72","first-page":"2S","volume":"Med","author":"Fish","year":"1995","unstructured":"Fish D (1995) Environmental risk and prevention of Lyme disease. Am J Med (Suppl 4A) 98: 2S\u20138S","journal-title":"Am J"},{"key":"245_CR73","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/153036602760260724","volume":"2","author":"Crippa","year":"2002","unstructured":"Crippa M, Rais O, Gern L (2002) Investigations on the mode and dynamics of transmission and infectivity of Borrelia burgdorferi sensu stricto and Borrelia afzelii in Ixodes ricinus ticks. Vector Borne Zoonotic Dis 2: 3","journal-title":"Vector Borne Zoonotic Dis"},{"key":"245_CR74","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1056\/NEJM200107123450201","volume":"345","author":"Nadelman","year":"2001","unstructured":"Nadelman RB, Nowakowski J, Fish D et al. (2001) Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N Engl J Med 345: 79\u201384","journal-title":"N Engl J Med"},{"key":"245_CR75","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF02600042","volume":"11","author":"Warshafsky","year":"1996","unstructured":"Warshafsky S, Nowakowski J, Nadelman RB et al. (1996) Efficacy of antibiotic prophylaxis for prevention of Lyme disease. J Gen Intern Med 11: 329\u2013333","journal-title":"J Gen Intern Med"},{"key":"245_CR76","first-page":"1190","volume":"26","author":"Adams","year":"1999","unstructured":"Adams WV, Rose CD, Eppes SC et al. (1999) Cognitive effects of Lyme disease in children: a 4\u00a0year followup study. J Rheumatol 26: 1190","journal-title":"J Rheumatol"},{"key":"245_CR77","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0022-3476(05)83541-3","volume":"122","author":"Salazar","year":"1993","unstructured":"Salazar JC, Gerber MA, Goff CW (1993) Long-term outcome of Lyme disease in children given early treatment. J Pediatr 122: 591","journal-title":"J Pediatr"},{"key":"245_CR78","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/jama.283.5.609","volume":"283","author":"Seltzer","year":"2000","unstructured":"Seltzer EG, Gerber MA, Cartter M et al. (2000) Long-term outcomes of persons with Lyme disease. JAMA 283: 609\u2013616","journal-title":"JAMA"},{"key":"245_CR79","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM199107183250304","volume":"325","author":"Szer","year":"1991","unstructured":"Szer IS, Taylor E, Steere AC (1991) The long-term course of Lyme arthritis in children. N Engl J Med 325: 159\u2013163","journal-title":"N Engl J Med"},{"key":"245_CR80","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s00431-004-1500-3","volume":"163","author":"Hendrickx","year":"2004","unstructured":"Hendrickx G, De Boeck H, Goossens A et al. (2004) Persistent synovitis in children with Lyme arthritis: two unusual cases. An immunogenetic approach. Eur J Pediatr 163: 646\u2013650","journal-title":"Eur J Pediatr"},{"key":"245_CR81","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1542\/peds.94.2.185","volume":"94","author":"Adams","year":"1994","unstructured":"Adams WV, Rose CD, Eppes SC, Klein JD (1994) Cognitive effects of Lyme disease in children. Pediatrics 94: 185","journal-title":"Pediatrics"},{"key":"245_CR82","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00006454-199803000-00004","volume":"17","author":"Bloom","year":"1998","unstructured":"Bloom BJ, Wycoff PM, Meissner HC et al. (1998) Neurocognitive abnormalities in children after classic manifestations of Lyme disease. Pediatr Infect Dis J 17: 189\u2013196","journal-title":"Pediatr Infect Dis J"}],"container-title":["Zeitschrift f\u00fcr Rheumatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-007-0245-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00393-007-0245-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-007-0245-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T19:59:37Z","timestamp":1708631977000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00393-007-0245-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,28]]},"references-count":82,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["245"],"URL":"https:\/\/doi.org\/10.1007\/s00393-007-0245-6","relation":{},"ISSN":["0340-1855","1435-1250"],"issn-type":[{"value":"0340-1855","type":"print"},{"value":"1435-1250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,28]]}}}