{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T05:15:49Z","timestamp":1740287749802,"version":"3.37.3"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T00:00:00Z","timestamp":1279238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z. Rheumatol."],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1007\/s00393-010-0633-1","type":"journal-article","created":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T10:15:13Z","timestamp":1279102513000},"page":"496-504","source":"Crossref","is-referenced-by-count":13,"title":["Methotrexat bei der Therapie der juvenilen idiopathischen Arthritis","Methotrexate in the therapy of juvenile idiopathic arthritis"],"prefix":"10.1007","volume":"69","author":[{"given":"D.","family":"Holzinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Frosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"F\u00f6ll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,7,16]]},"reference":[{"key":"633_CR1","first-page":"369P","volume":"63","author":"Aherne","year":"1978","unstructured":"Aherne GW, Marks V, Mould GP et al (1978) The interaction between methotrexate and probenecid in man. Br J Pharmacol 63:369P","journal-title":"Br J Pharmacol"},{"key":"633_CR2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/art.24087","volume":"61","author":"Albers","year":"2009","unstructured":"Albers HM, Wessels JA, Van Der Straaten RJ et al (2009) Time to treatment as an important factor for the response to methotrexate in juvenile idiopathic arthritis. Arthritis Rheum 61:46\u201351","journal-title":"Arthritis Rheum"},{"key":"633_CR3","unstructured":"Pickering LK (ed) (2009) Immunocompromised children. In: Red Book: 2009 Report of the Committee on Infectious Diseases, 28th edn. American Academy of Pediatrics, pp\u00a072\u201386"},{"key":"633_CR4","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1200\/JCO.1988.6.12.1882","volume":"6","author":"Balis","year":"1988","unstructured":"Balis FM, Mirro J Jr, Reaman GH et al (1988) Pharmacokinetics of subcutaneous methotrexate. J Clin Oncol 6:1882\u20131886","journal-title":"J Clin Oncol"},{"key":"633_CR5","first-page":"2342","volume":"43","author":"Balis","year":"1983","unstructured":"Balis FM, Savitch JL, Bleyer WA (1983) Pharmacokinetics of oral methotrexate in children. Cancer Res 43:2342\u20132345","journal-title":"Cancer Res"},{"key":"633_CR6","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1136\/ard.2007.073445","volume":"67","author":"Bartoli","year":"2008","unstructured":"Bartoli M, Taro M, Magni-Manzoni S et al (2008) The magnitude of early response to methotrexate therapy predicts long-term outcome of patients with juvenile idiopathic arthritis. Ann Rheum Dis 67:370\u2013374","journal-title":"Ann Rheum Dis"},{"key":"633_CR7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/(SICI)1096-9926(199802)57:2<51::AID-TERA2>3.0.CO;2-9","volume":"57","author":"Bawle","year":"1998","unstructured":"Bawle EV, Conard JV, Weiss L (1998) Adult and two children with fetal methotrexate syndrome. Teratology 57:51\u201355","journal-title":"Teratology"},{"key":"633_CR8","doi-asserted-by":"crossref","unstructured":"Borte S, Liebert UG, Borte M et al (2009) Efficacy of measles, mumps and rubella revaccination in children with juvenile idiopathic arthritis treated with methotrexate and etanercept. Rheumatology (Oxford) 48:144\u2013148","DOI":"10.1093\/rheumatology\/ken436"},{"key":"633_CR9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/art.23144","volume":"58","author":"Braun","year":"2008","unstructured":"Braun J, Kastner P, Flaxenberg P et al (2008) Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial. Arthritis Rheum 58:73\u201381","journal-title":"Arthritis Rheum"},{"key":"633_CR10","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/ard.57.3.174","volume":"57","author":"Brik","year":"1998","unstructured":"Brik R, Berkowitz D, Berant M (1998) Duration of methotrexate treatment until partial and total remission of refractory juvenile rheumatoid arthritis. Ann Rheum Dis 57:174\u2013175","journal-title":"Ann Rheum Dis"},{"key":"633_CR11","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/art.1780400527","volume":"40","author":"Buckley","year":"1997","unstructured":"Buckley LM, Bullaboy CA, Leichtman L et al (1997) Multiple congenital anomalies associated with weekly low-dose methotrexate treatment of the mother. Arthritis Rheum 40:971\u2013973","journal-title":"Arthritis Rheum"},{"key":"633_CR12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s002960050047","volume":"18","author":"Camiciottoli","year":"1998","unstructured":"Camiciottoli G, Trapani S, Castellani W et al (1998) Effect on lung function of methotrexate and non-steroid anti-inflammatory drugs in children with juvenile rheumatoid arthritis. Rheumatol Int 18:11\u201316","journal-title":"Rheumatol Int"},{"key":"633_CR13","doi-asserted-by":"crossref","first-page":"831","DOI":"10.2165\/00003495-199958050-00006","volume":"58","author":"Cassidy","year":"1999","unstructured":"Cassidy JT (1999) Medical management of children with juvenile rheumatoid arthritis. Drugs 58:831\u2013850","journal-title":"Drugs"},{"key":"633_CR14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/ard.2007.075895","volume":"67","author":"Cespedes-Cruz","year":"2008","unstructured":"Cespedes-Cruz A, Gutierrez-Suarez R, Pistorio A et al (2008) Methotrexate improves the health-related quality of life of children with juvenile idiopathic arthritis. Ann Rheum Dis 67:309\u2013314","journal-title":"Ann Rheum Dis"},{"key":"633_CR15","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jbspin.2005.03.006","volume":"72","author":"Chedeville","year":"2005","unstructured":"Chedeville G, Quartier P, Miranda M et al (2005) Improvements in growth parameters in children with juvenile idiopathic arthritis associated with the effect of methotrexate on disease activity. Joint Bone Spine 72:392\u2013396","journal-title":"Joint Bone Spine"},{"key":"633_CR16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/adc.86.1.47","volume":"86","author":"Cleary","year":"2002","unstructured":"Cleary AG, Mcdowell H, Sills JA (2002) Polyarticular juvenile idiopathic arthritis treated with methotrexate complicated by the development of non-Hodgkin\u2019s lymphoma. Arch Dis Child 86:47\u201349","journal-title":"Arch Dis Child"},{"key":"633_CR17","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/ard.60.8.729","volume":"60","author":"Cutolo","year":"2001","unstructured":"Cutolo M, Sulli A, Pizzorni C et al (2001) Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis. Ann Rheum Dis 60:729\u2013735","journal-title":"Ann Rheum Dis"},{"key":"633_CR18","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1373\/49.10.1632","volume":"49","author":"Dervieux","year":"2003","unstructured":"Dervieux T, Orentas LD, Marcelletti J et al (2003) HPLC determination of erythrocyte methotrexate polyglutamates after low-dose methotrexate therapy in patients with rheumatoid arthritis. Clin Chem 49:1632\u20131641","journal-title":"Clin Chem"},{"key":"633_CR19","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/art.20125","volume":"50","author":"Foell","year":"2004","unstructured":"Foell D, Wittkowski H, Hammerschmidt I et al (2004) Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrations. Arthritis Rheum 50:1286\u20131295","journal-title":"Arthritis Rheum"},{"key":"633_CR20","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1001\/jama.2010.375","volume":"303","author":"Foell","year":"2010","unstructured":"Foell D, Wulffraat N, Wedderburn LR et al (2010) Methotrexate withdrawal at 6 vs 12 months in juvenile idiopathic arthritis in remission: a randomized clinical trial. JAMA 303:1266\u20131273","journal-title":"JAMA"},{"key":"633_CR21","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/art.1780310301","volume":"31","author":"Furst","year":"1988","unstructured":"Furst DE, Kremer JM (1988) Methotrexate in rheumatoid arthritis. Arthritis Rheum 31:305\u2013314","journal-title":"Arthritis Rheum"},{"key":"633_CR22","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1056\/NEJM199204163261602","volume":"326","author":"Giannini","year":"1992","unstructured":"Giannini EH, Brewer EJ, Kuzmina N et al (1992) Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The pediatric rheumatology collaborative study group and the cooperative children\u2019s study group. N Engl J Med 326:1043\u20131049","journal-title":"N Engl J Med"},{"key":"633_CR23","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1002\/art.24777","volume":"60","author":"Giannini","year":"2009","unstructured":"Giannini EH, Ilowite NT, Lovell DJ et al (2009) Long-term safety and effectiveness of etanercept in children with selected categories of juvenile idiopathic arthritis. Arthritis Rheum 60:2794\u20132804","journal-title":"Arthritis Rheum"},{"key":"633_CR24","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1542\/peds.100.6.994","volume":"100","author":"Gottlieb","year":"1997","unstructured":"Gottlieb BS, Keenan GF, Lu T et al (1997) Discontinuation of methotrexate treatment in juvenile rheumatoid arthritis. Pediatrics 100:994\u2013997","journal-title":"Pediatrics"},{"key":"633_CR25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00000441-195102000-00009","volume":"221","author":"Gubner","year":"1951","unstructured":"Gubner R, August S, Ginsberg V (1951) Therapeutic suppression of tissue reactivity. II. Effect of aminopterin in rheumatoid arthritis and psoriasis. Am J Med Sci 221:176\u2013182","journal-title":"Am J Med Sci"},{"key":"633_CR26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1055\/s-0028-1086037","volume":"220","author":"Guellac","year":"2008","unstructured":"Guellac N, Niehues T (2008) Interdisciplinary and evidence-based treatment guideline for juvenile idiopathic arthritis. Klin Padiatr 220:392\u2013402","journal-title":"Klin Padiatr"},{"key":"633_CR27","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1002\/art.1780401218","volume":"40","author":"Hashkes","year":"1997","unstructured":"Hashkes PJ, Balistreri WF, Bove KE et al (1997) The long-term effect of methotrexate therapy on the liver in patients with juvenile rheumatoid arthritis. Arthritis Rheum 40:2226\u20132234","journal-title":"Arthritis Rheum"},{"key":"633_CR28","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1136\/ard.2006.063586","volume":"66","author":"Heijstek","year":"2007","unstructured":"Heijstek MW, Pileggi GC, Zonneveld-Huijssoon E et al (2007) Safety of measles, mumps and rubella vaccination in juvenile idiopathic arthritis. Ann Rheum Dis 66:1384\u20131387","journal-title":"Ann Rheum Dis"},{"key":"633_CR29","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1136\/ard.2007.087593","volume":"68","author":"Horneff","year":"2009","unstructured":"Horneff G, De Bock F, Foeldvari I et al (2009) Safety and efficacy of combination of etanercept and methotrexate compared to treatment with etanercept only in patients with juvenile idiopathic arthritis (JIA): preliminary data from the German JIA registry. Ann Rheum Dis 68:519\u2013525","journal-title":"Ann Rheum Dis"},{"key":"633_CR30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1742-1241.1996.tb09561.x","volume":"50","author":"Huang","year":"1996","unstructured":"Huang Jl (1996) Methotrexate in the treatment of children with chronic arthritis \u2013 long-term observations of efficacy and safety. Br J Clin Pract 50:311\u2013314","journal-title":"Br J Clin Pract"},{"key":"633_CR31","first-page":"2230","volume":"24","author":"Hunt","year":"1997","unstructured":"Hunt PG, Rose CD, Mcilvain-Simpson G et al (1997) The effects of daily intake of folic acid on the efficacy of methotrexate therapy in children with juvenile rheumatoid arthritis. A controlled study. J Rheumatol 24:2230\u20132232","journal-title":"J Rheumatol"},{"key":"633_CR32","first-page":"1845","volume":"20","author":"Jundt","year":"1993","unstructured":"Jundt JW, Browne BA, Fiocco GP et al (1993) A comparison of low dose methotrexate bioavailability: oral solution, oral tablet, subcutaneous and intramuscular dosing. J Rheumatol 20:1845\u20131849","journal-title":"J Rheumatol"},{"key":"633_CR33","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1136\/ard.2008.099861","volume":"68","author":"Katchamart","year":"2009","unstructured":"Katchamart W, Trudeau J, Phumethum V et al (2009) Efficacy and toxicity of methotrexate (MTX) monotherapy versus MTX combination therapy with non-biological disease-modifying antirheumatic drugs in rheumatoid arthritis: a systematic review and meta-analysis. Ann Rheum Dis 68:1105\u20131112","journal-title":"Ann Rheum Dis"},{"key":"633_CR34","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1002\/art.1780401016","volume":"40","author":"Kremer","year":"1997","unstructured":"Kremer JM, Alarcon GS, Weinblatt ME et al (1997) Clinical, laboratory, radiographic, and histopathologic features of methotrexate-associated lung injury in patients with rheumatoid arthritis: a multicenter study with literature review. Arthritis Rheum 40:1829\u20131837","journal-title":"Arthritis Rheum"},{"key":"633_CR35","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/art.1780290703","volume":"29","author":"Kremer","year":"1986","unstructured":"Kremer JM, Galivan J, Streckfuss A et al (1986) Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates. Arthritis Rheum 29:832\u2013835","journal-title":"Arthritis Rheum"},{"key":"633_CR36","first-page":"400","volume":"60","author":"Kremer","year":"2009","unstructured":"Kremer JM, Zablocki R, Dervieux T (2009) Switching from oral to parenteral methotrexate administration produces clinical improvements through selective accumulation of long-chains methotrexate polyglutamates. Arthritis Rheum 60:400","journal-title":"Arthritis Rheum"},{"key":"633_CR37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0046-8177(00)80230-0","volume":"31","author":"Krugmann","year":"2000","unstructured":"Krugmann J, Sailer-Hock M, Muller T et al (2000) Epstein-Barr virus-associated Hodgkin\u2019s lymphoma and legionella pneumophila infection complicating treatment of juvenile rheumatoid arthritis with methotrexate and cyclosporine A. Hum Pathol 31:253\u2013255","journal-title":"Hum Pathol"},{"key":"633_CR38","first-page":"1245","volume":"25","author":"Londino","year":"1998","unstructured":"Londino AV Jr, Blatt J, Knisely AS (1998) Hodgkin\u2019s disease in a patient with juvenile rheumatoid arthritis taking weekly low dose methotrexate. J Rheumatol 25:1245\u20131246","journal-title":"J Rheumatol"},{"key":"633_CR39","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1056\/NEJMoa0706290","volume":"359","author":"Lovell","year":"2008","unstructured":"Lovell DJ, Ruperto N, Goodman S et al (2008) Adalimumab with or without methotrexate in juvenile rheumatoid arthritis. N Engl J Med 359:810\u2013820","journal-title":"N Engl J Med"},{"key":"633_CR40","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V99.11.3909","volume":"99","author":"Mariette","year":"2002","unstructured":"Mariette X, Cazals-Hatem D, Warszawki J et al (2002) Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France. Blood 99:3909\u20133915","journal-title":"Blood"},{"key":"633_CR41","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.3899\/jrheum.081156","volume":"36","author":"Masi","year":"2009","unstructured":"Masi L, Ricci L, Zulian F et al (2009) Serum osteopontin as a predictive marker of responsiveness to methotrexate in juvenile idiopathic arthritis. J Rheumatol 36:2308\u20132313","journal-title":"J Rheumatol"},{"key":"633_CR42","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0889-857X(05)70367-7","volume":"23","author":"Mckendry","year":"1997","unstructured":"Mckendry RJ (1997) The remarkable spectrum of methotrexate toxicities. Rheum Dis Clin North Am 23:939\u2013954","journal-title":"Rheum Dis Clin North Am"},{"key":"633_CR43","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1002\/art.22643","volume":"56","author":"Montesinos","year":"2007","unstructured":"Montesinos MC, Takedachi M, Thompson LF et al (2007) The antiinflammatory mechanisms of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5\u2019-nucleotidase: findings in a study of ecto-5\u2019-nucleotidase gene-deficient mice. Arthritis Rheum 56:1440\u20131445","journal-title":"Arthritis Rheum"},{"key":"633_CR44","doi-asserted-by":"crossref","first-page":"833","DOI":"10.7326\/0003-4819-121-11-199412010-00002","volume":"121","author":"Morgan","year":"1994","unstructured":"Morgan SL, Baggott JE, Vaughn WH et al (1994) Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Ann Intern Med 121:833\u2013841","journal-title":"Ann Intern Med"},{"key":"633_CR45","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/ard.57.9.513","volume":"57","author":"Munro","year":"1998","unstructured":"Munro R, Porter DR, Sturrock RD (1998) Lymphadenopathy in a patient with systemic onset juvenile chronic arthritis. Ann Rheum Dis 57:513\u2013517","journal-title":"Ann Rheum Dis"},{"key":"633_CR46","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00393-004-0534-2","volume":"63","author":"Niehues","year":"2004","unstructured":"Niehues T, Horneff G, Michels H et al (2004) Evidence-based use of methotrexate in children with rheumatic disorders. Consensus statement of the Working Group for Children and Adolescents with Rheumatic Diseases in Germany (AGKJR) and the Working Group Pediatric Rheumatology Austria. Z Rheumatol 63:147\u2013158","journal-title":"Z Rheumatol"},{"key":"633_CR47","doi-asserted-by":"crossref","unstructured":"Nixon R, Bansback N, Brennan A (2007) The efficacy of inhibiting tumour necrosis factor alpha and interleukin 1 in patients with rheumatoid arthritis: a meta-analysis and adjusted indirect comparisons. Rheumatology (Oxford, England) 46:1140\u20131147","DOI":"10.1093\/rheumatology\/kem072"},{"key":"633_CR48","first-page":"21","volume":"62","author":"O","year":"2001","unstructured":"O\u2019dell J (2001) Conventional DMARD options for patients with a suboptimal response to methotrexate. J Rheumatol Suppl 62:21\u201326","journal-title":"J Rheumatol Suppl"},{"key":"633_CR49","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0889-857X(05)70360-4","volume":"23","author":"O","year":"1997","unstructured":"O\u2019dell JR (1997) Methotrexate use in rheumatoid arthritis. Rheum Dis Clin North Am 23:779\u2013796","journal-title":"Rheum Dis Clin North Am"},{"key":"633_CR50","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/art.1780350603","volume":"35","author":"Oguey","year":"1992","unstructured":"Oguey D, Kolliker F, Gerber NJ et al (1992) Effect of food on the bioavailability of low-dose methotrexate in patients with rheumatoid arthritis. Arthritis Rheum 35:611\u2013614","journal-title":"Arthritis Rheum"},{"key":"633_CR51","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/anr.1780320404","volume":"32","author":"Olsen","year":"1989","unstructured":"Olsen NJ, Murray LM (1989) Antiproliferative effects of methotrexate on peripheral blood mononuclear cells. Arthritis Rheum 32:378\u2013385","journal-title":"Arthritis Rheum"},{"key":"633_CR52","first-page":"36","volume":"25","author":"Ortiz","year":"1998","unstructured":"Ortiz Z, Shea B, Suarez-Almazor ME et al (1998) The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A metaanalysis of randomized controlled trials. J Rheumatol 25:36\u201343","journal-title":"J Rheumatol"},{"key":"633_CR53","first-page":"2035","volume":"24","author":"Padeh","year":"1997","unstructured":"Padeh S, Sharon N, Schiby G et al (1997) Hodgkin\u2019s lymphoma in systemic onset juvenile rheumatoid arthritis after treatment with low dose methotrexate. J Rheumatol 24:2035\u20132037","journal-title":"J Rheumatol"},{"key":"633_CR54","first-page":"675","volume":"12","author":"Pelucchi","year":"1994","unstructured":"Pelucchi A, Lomater C, Gerloni V et al (1994) Lung function and diffusing capacity for carbon monoxide in patients with juvenile chronic arthritis: effect of disease activity and low dose methotrexate therapy. Clin Exp Rheumatol 12:675\u2013679","journal-title":"Clin Exp Rheumatol"},{"key":"633_CR55","first-page":"199","volume":"53","author":"Rau","year":"1994","unstructured":"Rau R (1994) Treatment of chronic polyarthritis with methotrexate 1994 \u2013 a review. Z Rheumatol 53:199\u2013229","journal-title":"Z Rheumatol"},{"key":"633_CR56","first-page":"1830","volume":"27","author":"Ravelli","year":"2000","unstructured":"Ravelli A, Martini A (2000) Methotrexate in juvenile idiopathic arthritis: answers and questions. J Rheumatol 27:1830\u20131833","journal-title":"J Rheumatol"},{"key":"633_CR57","first-page":"625","volume":"17","author":"Ravelli","year":"1999","unstructured":"Ravelli A, Migliavacca D, Viola S et al (1999) Efficacy of folinic acid in reducing methotrexate toxicity in juvenile idiopathic arthritis. Clin Exp Rheumatol 17:625\u2013627","journal-title":"Clin Exp Rheumatol"},{"key":"633_CR58","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0022-3476(99)70127-7","volume":"135","author":"Ravelli","year":"1999","unstructured":"Ravelli A, Viola S, Migliavacca D et al (1999) The extended oligoarticular subtype is the best predictor of methotrexate efficacy in juvenile idiopathic arthritis. J Pediatr 135:316\u2013320","journal-title":"J Pediatr"},{"key":"633_CR59","first-page":"1574","volume":"22","author":"Ravelli","year":"1995","unstructured":"Ravelli A, Viola S, Ramenghi B et al (1995) Frequency of relapse after discontinuation of methotrexate therapy for clinical remission in juvenile rheumatoid arthritis. J Rheumatol 22:1574\u20131576","journal-title":"J Rheumatol"},{"key":"633_CR60","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0026-895X(25)13579-7","volume":"14","author":"Rosenblatt","year":"1978","unstructured":"Rosenblatt DS, Whitehead VM, Vera N et al (1978) Prolonged inhibition of DNA synthesis associated with the accumulation of methotrexate polyglutamates by cultured human cells. Mol Pharmacol 14:1143\u20131147","journal-title":"Mol Pharmacol"},{"key":"633_CR61","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1002\/art.22838","volume":"56","author":"Ruperto","year":"2007","unstructured":"Ruperto N, Lovell DJ, Cuttica R et al (2007) A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis. Arthritis Rheum 56:3096\u20133106","journal-title":"Arthritis Rheum"},{"key":"633_CR62","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1002\/art.27431","volume":"62","author":"Ruperto","year":"2010","unstructured":"Ruperto N, Lovell DJ, Quartier P et al (2010) Long-term safety and efficacy of abatacept in children with juvenile idiopathic arthritis. Arthritis Rheum 62:1792\u20131802","journal-title":"Arthritis Rheum"},{"key":"633_CR63","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0140-6736(08)60998-8","volume":"372","author":"Ruperto","year":"2008","unstructured":"Ruperto N, Lovell DJ, Quartier P et al (2008) Abatacept in children with juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled withdrawal trial. Lancet 372:383\u2013391","journal-title":"Lancet"},{"key":"633_CR64","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1002\/art.20288","volume":"50","author":"Ruperto","year":"2004","unstructured":"Ruperto N, Murray KJ, Gerloni V et al (2004) A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate. Arthritis Rheum 50:2191\u20132201","journal-title":"Arthritis Rheum"},{"key":"633_CR65","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/BF02238967","volume":"16","author":"Salaffi","year":"1997","unstructured":"Salaffi F, Manganelli P, Carotti M et al (1997) Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: report of five cases and review of the literature. Clin Rheumatol 16:296\u2013304","journal-title":"Clin Rheumatol"},{"key":"633_CR66","first-page":"1832","volume":"32","author":"Schmeling","year":"2005","unstructured":"Schmeling H, Biber D, Heins S et al (2005) Influence of methylenetetrahydrofolate reductase polymorphisms on efficacy and toxicity of methotrexate in patients with juvenile idiopathic arthritis. J Rheumatol 32:1832\u20131836","journal-title":"J Rheumatol"},{"key":"633_CR67","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1136\/ard.60.4.410","volume":"60","author":"Schmeling","year":"2001","unstructured":"Schmeling H, Mathony K, John V et al (2001) A combination of etanercept and methotrexate for the treatment of refractory juvenile idiopathic arthritis: a pilot study. Ann Rheum Dis 60:410\u2013412","journal-title":"Ann Rheum Dis"},{"key":"633_CR68","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s003930200025","volume":"61","author":"Schmeling","year":"2002","unstructured":"Schmeling H, Stephan V, Burdach S et al (2002) Pulmonary function in children with juvenile idiopathic arthritis and effects of methotrexate therapy. Z Rheumatol 61:168\u2013172","journal-title":"Z Rheumatol"},{"key":"633_CR69","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1002\/1529-0131(199811)41:11<2032::AID-ART19>3.0.CO;2-J","volume":"41","author":"Seitz","year":"1998","unstructured":"Seitz M, Zwicker M, Loetscher P (1998) Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes. Arthritis Rheum 41:2032\u20132038","journal-title":"Arthritis Rheum"},{"key":"633_CR70","first-page":"612","volume":"19","author":"Shaikov","year":"1992","unstructured":"Shaikov AV, Maximov AA, Speransky AI et al (1992) Repetitive use of pulse therapy with methylprednisolone and cyclophosphamide in addition to oral methotrexate in children with systemic juvenile rheumatoid arthritis \u2013 preliminary results of a longterm study. J Rheumatol 19:612\u2013616","journal-title":"J Rheumatol"},{"key":"633_CR71","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/art.1780360609","volume":"36","author":"Shiroky","year":"1993","unstructured":"Shiroky JB, Neville C, Esdaile JM et al (1993) Low-dose methotrexate with leucovorin (folinic acid) in the management of rheumatoid arthritis. Results of a multicenter randomized, double-blind, placebo-controlled trial. Arthritis Rheum 36:795\u2013803","journal-title":"Arthritis Rheum"},{"key":"633_CR72","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMoa041810","volume":"352","author":"Silverman","year":"2005","unstructured":"Silverman E, Mouy R, Spiegel L et al (2005) Leflunomide or methotrexate for juvenile rheumatoid arthritis. N Engl J Med 352:1655\u20131666","journal-title":"N Engl J Med"},{"key":"633_CR73","first-page":"188","volume":"18","author":"Singh","year":"1991","unstructured":"Singh G, Fries JF, Williams CA et al (1991) Toxicity profiles of disease modifying antirheumatic drugs in rheumatoid arthritis. J Rheumatol 18:188\u2013194","journal-title":"J Rheumatol"},{"key":"633_CR74","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0889-857X(05)70362-8","volume":"23","author":"Singsen","year":"1997","unstructured":"Singsen BH, Goldbach-Mansky R (1997) Methotrexate in the treatment of juvenile rheumatoid arthritis and other pediatric rheumatoid and nonrheumatic disorders. Rheum Dis Clin North Am 23:811\u2013840","journal-title":"Rheum Dis Clin North Am"},{"key":"633_CR75","first-page":"928","volume":"25","author":"Ting","year":"2007","unstructured":"Ting TV, Hashkes PJ (2007) Methotrexate\/naproxen-associated severe hepatitis in a child with juvenile idiopathic arthritis. Clin Exp Rheumatol 25:928\u2013929","journal-title":"Clin Exp Rheumatol"},{"key":"633_CR76","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/art.1780290616","volume":"29","author":"Truckenbrodt","year":"1986","unstructured":"Truckenbrodt H, Hafner R (1986) Methotrexate therapy in juvenile rheumatoid arthritis: a retrospective study. Arthritis Rheum 29:801\u2013807","journal-title":"Arthritis Rheum"},{"key":"633_CR77","doi-asserted-by":"crossref","first-page":"358","DOI":"10.7326\/0003-4819-107-2-358","volume":"107","author":"Tugwell","year":"1987","unstructured":"Tugwell P, Bennett K, Gent M (1987) Methotrexate in rheumatoid arthritis. Indications, contraindications, efficacy, and safety. Ann Intern Med 107:358\u2013366","journal-title":"Ann Intern Med"},{"key":"633_CR78","first-page":"480","volume":"25","author":"Van","year":"2007","unstructured":"Van Der Meer A, Wulffraat NM, Prakken BJ et al (2007) Psychological side effects of MTX treatment in juvenile idiopathic arthritis: a pilot study. Clin Exp Rheumatol 25:480\u2013485","journal-title":"Clin Exp Rheumatol"},{"key":"633_CR79","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/1529-0131(199803)41:3<381::AID-ART2>3.0.CO;2-3","volume":"41","author":"Wallace","year":"1998","unstructured":"Wallace CA (1998) The use of methotrexate in childhood rheumatic diseases. Arthritis Rheum 41:381\u2013391","journal-title":"Arthritis Rheum"},{"key":"633_CR80","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1002\/art.1780401019","volume":"40","author":"Wallace","year":"1997","unstructured":"Wallace CA, Sherry DD (1997) Trial of intravenous pulse cyclophosphamide and methylprednisolone in the treatment of severe systemic-onset juvenile rheumatoid arthritis. Arthritis Rheum 40:1852\u20131855","journal-title":"Arthritis Rheum"},{"key":"633_CR81","first-page":"4","volume":"42","author":"Weinblatt","year":"1993","unstructured":"Weinblatt ME (1993) Methotrexate in rheumatoid arthritis. Bull Rheum Dis 42:4\u20137","journal-title":"Bull Rheum Dis"},{"key":"633_CR82","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1056\/NEJM199901283400401","volume":"340","author":"Weinblatt","year":"1999","unstructured":"Weinblatt ME, Kremer JM, Bankhurst AD et al (1999) A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 340:253\u2013259","journal-title":"N Engl J Med"}],"container-title":["Zeitschrift f\u00fcr Rheumatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-010-0633-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00393-010-0633-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-010-0633-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T22:16:37Z","timestamp":1740262597000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00393-010-0633-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,16]]},"references-count":82,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["633"],"URL":"https:\/\/doi.org\/10.1007\/s00393-010-0633-1","relation":{},"ISSN":["0340-1855","1435-1250"],"issn-type":[{"type":"print","value":"0340-1855"},{"type":"electronic","value":"1435-1250"}],"subject":[],"published":{"date-parts":[[2010,7,16]]}}}