{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:35:48Z","timestamp":1778733348886,"version":"3.51.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Z Rheumatol"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s00393-019-0625-8","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T14:03:28Z","timestamp":1554127408000},"page":"511-517","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Sj\u00f6gren-Syndrom","Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1007","volume":"78","author":[{"given":"Torsten","family":"Witte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"625_CR1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4049\/jimmunol.130.1.203","volume":"130","author":"TC Adamson 3rd","year":"1983","unstructured":"Adamson TC 3rd, Fox RI et\u00a0al (1983) Immunohistologic analysis of lymphoid infiltrates in primary Sjogren\u2019s syndrome using monoclonal antibodies. J\u00a0Immunol 130:203\u2013208","journal-title":"J Immunol"},{"key":"625_CR2","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/art.10219","volume":"47","author":"MT Brennan","year":"2002","unstructured":"Brennan MT, Sankar V, Leakan RA et\u00a0al (2002) Risk factors for positive minor salivary gland biopsy findings in Sj\u00f6gren\u2019s syndrome and dry mouth patients. Arthritis Rheum 47:189\u2013195","journal-title":"Arthritis Rheum"},{"key":"625_CR3","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/acr.22968","volume":"69","author":"SE Carsons","year":"2017","unstructured":"Carsons SE, Vivino FB, Parke A et\u00a0al (2017) Treatment guidelines for rheumatologic manifestations of Sj\u00f6gren\u2019s syndrome: use of biologic agents, management of fatigue, and inflammatory musculoskeletal pain. Arthritis Care Res (hoboken) 69:517\u2013527","journal-title":"Arthritis Care Res (hoboken)"},{"key":"625_CR4","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1136\/jcp.21.5.656","volume":"21","author":"DM Chisholm","year":"1968","unstructured":"Chisholm DM, Mason DK (1968) Labial salivary gland biopsy in Sjogren\u2019s disease. J\u00a0Clin Pathol 21:656\u2013660","journal-title":"J. Clin. Pathol."},{"key":"625_CR5","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/art.37698","volume":"65","author":"D Cornec","year":"2013","unstructured":"Cornec D, Jousse-Joulin S, Pers JO et al (2013) Contribution of salivary gland ultrasonography to the diagnosis of Sj\u00f6gren\u2019s syndrome: toward new diagnostic criteria? Arthritis Rheum 65:216\u2013225","journal-title":"Arthritis Rheum"},{"key":"625_CR6","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1001\/jama.2014.7682","volume":"312","author":"JE Gottenberg","year":"2014","unstructured":"Gottenberg JE, Ravaud P, Pu\u00e9chal X et\u00a0al (2014) Effects of hydroxychloroquine on symptomatic improvement in primary Sj\u00f6gren syndrome: the JOQUER randomized clinical trial. JAMA 312:249\u2013258","journal-title":"JAMA"},{"key":"625_CR7","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1002\/art.1780281008","volume":"28","author":"PF Kohler","year":"1985","unstructured":"Kohler PF, Winter ME (1985) A quantitative test for xerostomia. The Saxon test, an oral equivalent of the Schirmer test. Arthritis Rheum 28:1128\u20131132","journal-title":"Arthritis Rheum"},{"key":"625_CR8","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1002\/art.27314","volume":"62","author":"JM Meijer","year":"2010","unstructured":"Meijer JM, Meiners PM, Vissink A et al (2010) Effectiveness of rituximab treatment in primary Sj\u00f6gren\u2019s syndrome: a\u00a0randomized, double-blind, placebo-controlled trial. Arthritis Rheum 62:960\u2013968","journal-title":"Arthritis Rheum"},{"key":"625_CR9","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1136\/annrheumdis-2014-205375","volume":"74","author":"B Qin","year":"2015","unstructured":"Qin B, Wang J, Yang Z et al (2015) Epidemiology of primary Sj\u00f6gren\u2019s syndrome: a\u00a0systematic review and meta-analysis. Ann Rheum Dis 74:1983\u20131989","journal-title":"Ann Rheum Dis"},{"key":"625_CR10","unstructured":"Radstake TRDJ, van der Heijden EHM, Moret FM et al (2018) Clinical efficacy of leflunomide\/Hydroxychloroquine combination therapy in patients with primary Sjogren\u2019s syndrome: results of a\u00a0placebo-controlled double-blind randomized clinical trial. Arthritis Rheumatol 70(suppl 10). https:\/\/acrabstracts.org\/abstract\/clinical-efficacy-of-leflunomide-hydroxychloroquine-combination-therapy-in-patients-with-primary-sjogrens-syndrome-results-of-a-placebo-controlled-double-blind-randomized-clinical-trial"},{"key":"625_CR11","doi-asserted-by":"publisher","first-page":"7538","DOI":"10.1073\/pnas.95.13.7538","volume":"95","author":"CP Robinson","year":"1998","unstructured":"Robinson CP, Brayer J, Yamachika S et\u00a0al (1998) Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a\u00a0role for autoantibodies in the loss of secretory function of exocrine tissues in Sj\u00f6gren\u2019s syndrome. Proc Natl Acad Sci U S\u00a0A 95:7538\u20137543","journal-title":"Proc Natl Acad Sci U S A"},{"key":"625_CR12","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1002\/art.20299","volume":"50","author":"V Sankar","year":"2004","unstructured":"Sankar V, Brennan MT, Kok MR (2004) Etanercept in Sj\u00f6gren\u2019s syndrome: a\u00a0twelve-week randomized, double-blind, placebo-controlled pilot clinical trial. Arthritis Rheum 50:2240\u20132245","journal-title":"Arthritis Rheum"},{"key":"625_CR13","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1001\/archinte.159.12.1359","volume":"159","author":"OD Schein","year":"1999","unstructured":"Schein OD, Hochberg MC, Mu\u00f1oz B et al (1999) Dry eye and dry mouth in the elderly: a\u00a0population-based assessment. Arch Intern Med 159:1359\u20131363","journal-title":"Arch Intern Med"},{"key":"625_CR14","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1136\/ard.2009.110619","volume":"69","author":"R Seror","year":"2010","unstructured":"Seror R, Ravaud P, Bowman SJ (2010) EULAR Sjogren\u2019s syndrome disease activity index: development of a\u00a0consensus systemic disease activity index for primary Sjogren\u2019s syndrome. Ann Rheum Dis 69:1103\u20131109","journal-title":"Ann Rheum Dis"},{"key":"625_CR15","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1136\/ard.2010.143743","volume":"70","author":"R Seror","year":"2011","unstructured":"Seror R, Ravaud P, Mariette X et\u00a0al (2011) EULAR Sjogren\u2019s Syndrome Patient Reported Index (ESSPRI): development of a\u00a0consensus patient index for primary Sjogren\u2019s syndrome. Ann Rheum Dis 70:968\u2013972","journal-title":"Ann Rheum Dis"},{"key":"625_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1136\/annrheumdis-2016-210571","volume":"76","author":"CH Shiboski","year":"2017","unstructured":"Shiboski CH, Shiboski SC, Seror R et al (2017) International Sj\u00f6gren\u2019s Syndrome Criteria Working Group.\u00a02016 American College of Rheumatology\/European League Against Rheumatism classification criteria for primary Sj\u00f6gren\u2019s syndrome: a\u00a0consensus and data-driven methodology involving three international patient cohorts. Ann Rheum Dis 76:9\u201316","journal-title":"Ann Rheum Dis"},{"key":"625_CR17","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1002\/acr.21591","volume":"64","author":"SC Shiboski","year":"2012","unstructured":"Shiboski SC, Shiboski CH, Criswell L (2012) American College of Rheumatology classification criteria for Sj\u00f6gren\u2019s syndrome: a\u00a0data-driven, expert consensus approach in the Sj\u00f6gren\u2019s International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken) 64:475\u2013487","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"625_CR18","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/art.1780360309","volume":"36","author":"C Vitali","year":"1993","unstructured":"Vitali C, Bombardieri S, Moutsopoulos HM et\u00a0al (1993) Preliminary criteria for the classification of Sj\u00f6gren\u2019s syndrome. Results of a\u00a0prospective concerted action supported by the European Community. Arthritis Rheum 36:340\u2013347","journal-title":"Arthritis Rheum"},{"key":"625_CR19","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1136\/ard.53.10.637","volume":"53","author":"C Vitali","year":"1994","unstructured":"Vitali C, Moutsopoulos HM, Bombardieri S (1994) The European Community Study Group on diagnostic criteria for Sj\u00f6gren\u2019s syndrome. Sensitivity and specificity of tests for ocular and oral involvement in Sj\u00f6gren\u2019s syndrome. Ann Rheum Dis 53:637\u2013647","journal-title":"Ann Rheum Dis"},{"key":"625_CR20","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1001\/archinte.159.2.174","volume":"159","author":"FB Vivino","year":"1999","unstructured":"Vivino FB, Al-Hashimi I, Khan Z et al (1999) Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sj\u00f6gren syndrome: a\u00a0randomized, placebo-controlled, fixed-dose, multicenter trial. P92-01 Study Group. Arch Intern Med 159:174\u2013181","journal-title":"Arch Intern Med"},{"key":"625_CR21","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.rdc.2016.03.010","volume":"42","author":"FB Vivino","year":"2016","unstructured":"Vivino FB, Carsons SE, Foulks G et\u00a0al (2016) New Treatment Guidelines for Sj\u00f6gren\u2019s Disease. Rheum Dis Clin North Am 42:531\u2013551","journal-title":"Rheum. Dis. Clin. North. Am."},{"key":"625_CR22","first-page":"285","volume":"35","author":"D Wernicke","year":"2008","unstructured":"Wernicke D, Hess H, Gromnica-Ihle E et al (2008) Ultrasonography of salivary glands\u2014a\u00a0highly specific imaging procedure for diagnosis of Sj\u00f6gren\u2019s syndrome. J\u00a0Rheumatol 35:285\u2013293","journal-title":"J Rheumatol"},{"key":"625_CR23","first-page":"2157","volume":"30","author":"T Witte","year":"2003","unstructured":"Witte T, Matthias T, Oppermann M et al (2003) Prevalence of antibodies against alpha-fodrin in Sj\u00f6gren\u2019s syndrome: comparison of 2 sets of classification criteria. J\u00a0Rheumatol 30:2157\u20132159","journal-title":"J Rheumatol"},{"key":"625_CR24","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1001\/archinte.165.20.2337","volume":"165","author":"E Zintzaras","year":"2005","unstructured":"Zintzaras E, Voulgarelis M, Moutsopoulos HM (2005) The risk of lymphoma development in autoimmune diseases: a\u00a0meta-analysis. Arch Intern Med 165:2337\u20132344","journal-title":"Arch Intern Med"}],"container-title":["Zeitschrift f\u00fcr Rheumatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-019-0625-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00393-019-0625-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-019-0625-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T07:18:52Z","timestamp":1694762332000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00393-019-0625-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,1]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["625"],"URL":"https:\/\/doi.org\/10.1007\/s00393-019-0625-8","relation":{},"ISSN":["0340-1855","1435-1250"],"issn-type":[{"value":"0340-1855","type":"print"},{"value":"1435-1250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,1]]},"assertion":[{"value":"1 April 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"T.\u00a0Witte gibt an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden vom Autor keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}