{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:21:18Z","timestamp":1786980078259,"version":"build-2736575974"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Z Rheumatol"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00393-020-00957-2","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T06:58:04Z","timestamp":1610607484000},"page":"214-225","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Schmerz bei rheumatischen Erkrankungen","Pain in rheumatic diseases"],"prefix":"10.1007","volume":"80","author":[{"given":"G.","family":"Pongratz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"issue":"7","key":"957_CR1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.7326\/0003-4819-116-7-598","volume":"116","author":"NM Hadler","year":"1992","unstructured":"Hadler\u00a0NM (1992) Knee pain is the malady\u2014not osteoarthritis. Ann Intern Med 116(7):598\u2013599","journal-title":"Ann Intern Med"},{"key":"957_CR2","doi-asserted-by":"crossref","unstructured":"Pongratz G (2020) Spezielle Schmerztherapie bei rheumatischen Erkrankungen. Aktuelle Rheumatologie 45(05):430\u2013442","DOI":"10.1055\/a-1203-5172"},{"issue":"3","key":"957_CR3","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.joca.2017.11.001","volume":"26","author":"IN Ackerman","year":"2018","unstructured":"Ackerman\u00a0IN, Zomer\u00a0E, Gilmartin-Thomas\u00a0JF, Liew\u00a0D (2018) Forecasting the future burden of opioids for osteoarthritis. Osteoarthr Cartil 26(3):350\u2013355","journal-title":"Osteoarthr Cartil"},{"issue":"9","key":"957_CR4","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1002\/art.40152","volume":"69","author":"JR Curtis","year":"2017","unstructured":"Curtis\u00a0JR, Xie\u00a0F, Smith\u00a0C, Saag\u00a0KG, Chen\u00a0L, Beukelman\u00a0T, Mannion\u00a0M, Yun\u00a0H, Kertesz\u00a0S (2017) Changing trends in opioid use among patients with rheumatoid arthritis in the United States. Arthritis Rheumatol 69(9):1733\u20131740","journal-title":"Arthritis Rheumatol"},{"issue":"6","key":"957_CR5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11926-016-0581-0","volume":"18","author":"SD Boyden","year":"2016","unstructured":"Boyden\u00a0SD, Hossain\u00a0IN, Wohlfahrt\u00a0A, Lee\u00a0YC (2016) Non-inflammatory causes of pain in patients with rheumatoid arthritis. Curr Rheumatol Rep 18(6):30","journal-title":"Curr Rheumatol Rep"},{"issue":"7","key":"957_CR6","doi-asserted-by":"crossref","first-page":"e0180014","DOI":"10.1371\/journal.pone.0180014","volume":"12","author":"S Rifbjerg-Madsen","year":"2017","unstructured":"Rifbjerg-Madsen\u00a0S, Christensen\u00a0AW, Christensen\u00a0R, Hetland\u00a0ML, Bliddal\u00a0H, Kristensen\u00a0LE, Danneskiold-Sams\u00f8e\u00a0B, Amris\u00a0K (2017) Pain and pain mechanisms in patients with inflammatory arthritis: a Danish nationwide cross-sectional DANBIO registry survey. PLoS ONE 12(7):e180014","journal-title":"PLoS ONE"},{"issue":"1","key":"957_CR7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.it.2016.10.001","volume":"38","author":"FA Pinho-Ribeiro","year":"2017","unstructured":"Pinho-Ribeiro\u00a0FA, Verri\u00a0WA Jr., Chiu\u00a0IM (2017) Nociceptor sensory neuron-immune interactions in pain and inflammation. Trends Immunol 38(1):5\u201319","journal-title":"Trends Immunol"},{"issue":"5","key":"957_CR8","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/s13075-014-0470-8","volume":"16","author":"HG Schaible","year":"2014","unstructured":"Schaible\u00a0HG (2014) Nociceptive neurons detect cytokines in arthritis. Arthritis Res Ther 16(5):470","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"957_CR9","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nm.3852","volume":"21","author":"L Vicu\u00f1a","year":"2015","unstructured":"Vicu\u00f1a\u00a0L, Strochlic\u00a0DE, Latremoliere\u00a0A, Bali\u00a0KK, Simonetti\u00a0M, Husainie\u00a0D, Prokosch\u00a0S, Riva\u00a0P, Griffin\u00a0RS, Njoo\u00a0C et al (2015) The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med 21(5):518\u2013523","journal-title":"Nat Med"},{"issue":"11","key":"957_CR10","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1038\/cr.2014.106","volume":"24","author":"XJ Liu","year":"2014","unstructured":"Liu\u00a0XJ, Zhang\u00a0Y, Liu\u00a0T, Xu\u00a0ZZ, Park\u00a0CK, Berta\u00a0T, Jiang\u00a0D, Ji\u00a0RR (2014) Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter. Cell Res 24(11):1374\u20131377","journal-title":"Cell Res"},{"issue":"11","key":"957_CR11","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1182\/blood-2013-04-498105","volume":"122","author":"L Vincent","year":"2013","unstructured":"Vincent\u00a0L, Vang\u00a0D, Nguyen\u00a0J, Gupta\u00a0M, Luk\u00a0K, Ericson\u00a0ME, Simone\u00a0DA, Gupta\u00a0K (2013) Mast cell activation contributes to sickle cell pathobiology and pain in mice. Blood 122(11):1853\u20131862","journal-title":"Blood"},{"issue":"3","key":"957_CR12","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jpain.2010.08.003","volume":"12","author":"CF Kim","year":"2011","unstructured":"Kim\u00a0CF, Moalem-Taylor\u00a0G (2011) Interleukin-17 contributes to neuroinflammation and neuropathic pain following peripheral nerve injury in mice. J\u00a0Pain 12(3):370\u2013383","journal-title":"J Pain"},{"issue":"3","key":"957_CR13","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1476-5381.1992.tb14503.x","volume":"107","author":"FQ Cunha","year":"1992","unstructured":"Cunha\u00a0FQ, Poole\u00a0S, Lorenzetti\u00a0BB, Ferreira\u00a0SH (1992) The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol 107(3):660\u2013664","journal-title":"Br J Pharmacol"},{"issue":"4","key":"957_CR14","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0306-4522(00)00523-6","volume":"102","author":"CA Parada","year":"2001","unstructured":"Parada\u00a0CA, Tambeli\u00a0CH, Cunha\u00a0FQ, Ferreira\u00a0SH (2001) The major role of peripheral release of histamine and 5\u2011hydroxytryptamine in formalin-induced nociception. Neuroscience 102(4):937\u2013944","journal-title":"Neuroscience"},{"issue":"10","key":"957_CR15","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/cns.12305","volume":"20","author":"JX Yue","year":"2014","unstructured":"Yue\u00a0JX, Wang\u00a0RR, Yu\u00a0J, Tang\u00a0YY, Hou\u00a0WW, Lou\u00a0GD, Zhang\u00a0SH, Chen\u00a0Z (2014) Histamine upregulates Nav1.8 expression in primary afferent neurons via H2 receptors: involvement in neuropathic pain. Cns Neurosci Ther 20(10):883\u2013892","journal-title":"Cns Neurosci Ther"},{"issue":"1","key":"957_CR16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0896-6273(02)00908-X","volume":"36","author":"RR Ji","year":"2002","unstructured":"Ji\u00a0RR, Samad\u00a0TA, Jin\u00a0SX, Schmoll\u00a0R, Woolf\u00a0CJ (2002) p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 36(1):57\u201368","journal-title":"Neuron"},{"issue":"4","key":"957_CR17","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1523\/JNEUROSCI.1263-03.2004","volume":"24","author":"XQ Tang","year":"2004","unstructured":"Tang\u00a0XQ, Tanelian\u00a0DL, Smith\u00a0GM (2004) Semaphorin3A inhibits nerve growth factor-induced sprouting of nociceptive afferents in adult rat spinal cord. J\u00a0Neurosci 24(4):819\u2013827","journal-title":"J Neurosci"},{"issue":"12","key":"957_CR18","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1002\/art.34675","volume":"64","author":"M Ebbinghaus","year":"2012","unstructured":"Ebbinghaus\u00a0M, Uhlig\u00a0B, Richter\u00a0F, von Banchet\u00a0GS, Gajda\u00a0M, Br\u00e4uer\u00a0R, Schaible\u00a0HG (2012) The role of interleukin-1\u03b2 in arthritic pain: main involvement in thermal, but not mechanical, hyperalgesia in rat antigen-induced arthritis. Arthritis Rheum 64(12):3897\u20133907","journal-title":"Arthritis Rheum"},{"issue":"52","key":"957_CR19","doi-asserted-by":"crossref","first-page":"14062","DOI":"10.1523\/JNEUROSCI.3795-08.2008","volume":"28","author":"AM Binshtok","year":"2008","unstructured":"Binshtok\u00a0AM, Wang\u00a0H, Zimmermann\u00a0K, Amaya\u00a0F, Vardeh\u00a0D, Shi\u00a0L, Brenner\u00a0GJ, Ji\u00a0RR, Bean\u00a0BP, Woolf\u00a0CJ et al (2008) Nociceptors are interleukin-1beta sensors. J\u00a0Neurosci 28(52):14062\u201314073","journal-title":"J Neurosci"},{"issue":"2","key":"957_CR20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2015.06.007","volume":"87","author":"S Talbot","year":"2015","unstructured":"Talbot\u00a0S, Abdulnour\u00a0RE, Burkett\u00a0PR, Lee\u00a0S, Cronin\u00a0SJ, Pascal\u00a0MA, Laedermann\u00a0C, Foster\u00a0SL, Tran\u00a0JV, Lai\u00a0N et\u00a0al (2015) Silencing nociceptor neurons reduces allergic airway inflammation. Neuron 87(2):341\u2013354","journal-title":"Neuron"},{"issue":"6","key":"957_CR21","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1097\/j.pain.0000000000000158","volume":"156","author":"D Fang","year":"2015","unstructured":"Fang\u00a0D, Kong\u00a0LY, Cai\u00a0J, Li\u00a0S, Liu\u00a0XD, Han\u00a0JS, Xing\u00a0GG (2015) Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK\/PI3K signaling pathway: roles in the development of bone cancer pain in a\u00a0rat model. Pain 156(6):1124\u20131144","journal-title":"Pain"},{"issue":"30","key":"957_CR22","doi-asserted-by":"crossref","first-page":"9845","DOI":"10.1523\/JNEUROSCI.5161-13.2014","volume":"34","author":"P Malsch","year":"2014","unstructured":"Malsch\u00a0P, Andratsch\u00a0M, Vogl\u00a0C, Link\u00a0AS, Alzheimer\u00a0C, Brierley\u00a0SM, Hughes\u00a0PA, Kress\u00a0M (2014) Deletion of interleukin\u20116 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression. J\u00a0Neurosci 34(30):9845\u20139856","journal-title":"J Neurosci"},{"issue":"12","key":"957_CR23","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1002\/art.37695","volume":"64","author":"F Richter","year":"2012","unstructured":"Richter\u00a0F, Natura\u00a0G, Ebbinghaus\u00a0M, von Banchet\u00a0GS, Hensellek\u00a0S, K\u00f6nig\u00a0C, Br\u00e4uer\u00a0R, Schaible\u00a0HG (2012) Interleukin-17 sensitizes joint nociceptors to mechanical stimuli and contributes to arthritic pain through neuronal interleukin-17 receptors in rodents. Arthritis Rheum 64(12):4125\u20134134","journal-title":"Arthritis Rheum"},{"issue":"2","key":"957_CR24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pain.2009.11.006","volume":"148","author":"LG Pinto","year":"2010","unstructured":"Pinto\u00a0LG, Cunha\u00a0TM, Vieira\u00a0SM, Lemos\u00a0HP, Verri\u00a0WA Jr., Cunha\u00a0FQ, Ferreira\u00a0SH (2010) IL-17 mediates articular hypernociception in antigen-induced arthritis in mice. Pain 148(2):247\u2013256","journal-title":"Pain"},{"issue":"2","key":"957_CR25","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1152\/jn.00652.2014","volume":"113","author":"S Gudes","year":"2015","unstructured":"Gudes\u00a0S, Barkai\u00a0O, Caspi\u00a0Y, Katz\u00a0B, Lev\u00a0S, Binshtok\u00a0AM (2015) The role of slow and persistent TTX-resistant sodium currents in acute tumor necrosis factor-\u03b1-mediated increase in nociceptors excitability. J\u00a0Neurophysiol 113(2):601\u2013619","journal-title":"J Neurophysiol"},{"issue":"3","key":"957_CR26","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/art.30150","volume":"63","author":"ES Fernandes","year":"2011","unstructured":"Fernandes\u00a0ES, Russell\u00a0FA, Spina\u00a0D, McDougall\u00a0JJ, Graepel\u00a0R, Gentry\u00a0C, Staniland\u00a0AA, Mountford\u00a0DM, Keeble\u00a0JE, Malcangio\u00a0M et al (2011) A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor \u03b1\u2011induced inflammatory hyperalgesia and Freund\u2019s complete adjuvant-induced monarthritis. Arthritis Rheum 63(3):819\u2013829","journal-title":"Arthritis Rheum"},{"issue":"19","key":"957_CR27","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1523\/JNEUROSCI.4476-07.2008","volume":"28","author":"CE Constantin","year":"2008","unstructured":"Constantin\u00a0CE, Mair\u00a0N, Sailer\u00a0CA, Andratsch\u00a0M, Xu\u00a0ZZ, Blumer\u00a0MJ, Scherbakov\u00a0N, Davis\u00a0JB, Bluethmann\u00a0H, Ji\u00a0RR et\u00a0al (2008) Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a\u00a0mouse cancer model. J\u00a0Neurosci 28(19):5072\u20135081","journal-title":"J Neurosci"},{"issue":"1","key":"957_CR28","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1523\/JNEUROSCI.3858-05.2006","volume":"26","author":"X Jin","year":"2006","unstructured":"Jin\u00a0X, Gereau\u00a0RW (2006) Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha. J\u00a0Neurosci 26(1):246\u2013255","journal-title":"J Neurosci"},{"issue":"2","key":"957_CR29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1046\/j.1529-8027.2000.00012.x","volume":"5","author":"LS Sorkin","year":"2000","unstructured":"Sorkin\u00a0LS, Doom\u00a0CM (2000) Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat. J\u00a0Peripher Nerv Syst 5(2):96\u2013100","journal-title":"J Peripher Nerv Syst"},{"issue":"3","key":"957_CR30","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1523\/JNEUROSCI.17-03-00975.1997","volume":"17","author":"GD Nicol","year":"1997","unstructured":"Nicol\u00a0GD, Lopshire\u00a0JC, Pafford\u00a0CM (1997) Tumor necrosis factor enhances the capsaicin sensitivity of rat sensory neurons. J\u00a0Neurosci 17(3):975\u2013982","journal-title":"J Neurosci"},{"key":"957_CR31","doi-asserted-by":"publisher","unstructured":"Daou I, Beaudry H, Ase AR, Wieskopf JS, Ribeiro-da-Silva A, Mogil JS, Seguela P (2016) Optogenetic silencing of Nav1.8-positive afferents alleviates inflammatory and neuropathic pain. eNeuro3(1). https:\/\/doi.org\/10.1523\/ENEURO.0140-15.2016","DOI":"10.1523\/ENEURO.0140-15.2016"},{"issue":"2","key":"957_CR32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0167-8760(00)00087-8","volume":"37","author":"T Hummel","year":"2000","unstructured":"Hummel\u00a0T, Schiessl\u00a0C, Wendler\u00a0J, Kobal\u00a0G (2000) Peripheral and central nervous changes in patients with rheumatoid arthritis in response to repetitive painful stimulation. Int J Psychophysiol 37(2):177\u2013183","journal-title":"Int J Psychophysiol"},{"issue":"2","key":"957_CR33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1053\/eujp.2001.0313","volume":"6","author":"AS Leffler","year":"2002","unstructured":"Leffler\u00a0AS, Kosek\u00a0E, Lerndal\u00a0T, Nordmark\u00a0B, Hansson\u00a0P (2002) Somatosensory perception and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from rheumatoid arthritis. Eur J Pain 6(2):161\u2013176","journal-title":"Eur J Pain"},{"issue":"Suppl 1","key":"957_CR34","first-page":"S10","volume":"154","author":"RR Ji","year":"2013","unstructured":"Ji\u00a0RR, Berta\u00a0T, Nedergaard\u00a0M (2013) Glia and pain: is chronic pain a\u00a0gliopathy? Pain 154(Suppl 1):S10\u2013S28","journal-title":"Pain"},{"issue":"1\u20132","key":"957_CR35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0165-5728(00)00453-7","volume":"114","author":"VI Shubayev","year":"2001","unstructured":"Shubayev\u00a0VI, Myers\u00a0RR (2001) Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors. J\u00a0Neuroimmunol 114(1\u20132):48\u201356","journal-title":"J Neuroimmunol"},{"issue":"8","key":"957_CR36","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nn.4053","volume":"18","author":"RE Sorge","year":"2015","unstructured":"Sorge\u00a0RE, Mapplebeck\u00a0JC, Rosen\u00a0S, Beggs\u00a0S, Taves\u00a0S, Alexander\u00a0JK, Martin\u00a0LJ, Austin\u00a0JS, Sotocinal\u00a0SG, Chen\u00a0D et\u00a0al (2015) Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci 18(8):1081\u20131083","journal-title":"Nat Neurosci"},{"key":"957_CR37","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbi.2015.10.006","volume":"55","author":"S Taves","year":"2016","unstructured":"Taves\u00a0S, Berta\u00a0T, Liu\u00a0DL, Gan\u00a0S, Chen\u00a0G, Kim\u00a0YH, Van de Ven\u00a0T, Laufer\u00a0S, Ji\u00a0RR (2016) Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord. Brain Behav Immun 55:70\u201381","journal-title":"Brain Behav Immun"},{"issue":"2","key":"957_CR38","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.neuroimage.2007.12.016","volume":"40","author":"P Schweinhardt","year":"2008","unstructured":"Schweinhardt\u00a0P, Kalk\u00a0N, Wartolowska\u00a0K, Chessell\u00a0I, Wordsworth\u00a0P, Tracey\u00a0I (2008) Investigation into the neural correlates of emotional augmentation of clinical pain. Neuroimage 40(2):759\u2013766","journal-title":"Neuroimage"},{"issue":"3","key":"957_CR39","doi-asserted-by":"crossref","first-page":"101439","DOI":"10.1016\/j.berh.2019.101439","volume":"33","author":"J Lampa","year":"2019","unstructured":"Lampa\u00a0J (2019) Pain without inflammation in rheumatic diseases. Best Pract Res Clin Rheumatol 33(3):101439","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"957_CR40","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbi.2014.12.012","volume":"45","author":"\u00c9 Borb\u00e9ly","year":"2015","unstructured":"Borb\u00e9ly \u00c9, Botz\u00a0B, B\u00f6lcskei\u00a0K, Keny\u00e9r\u00a0T, Kereskai\u00a0L, Kiss\u00a0T, Szolcs\u00e1nyi\u00a0J, Pint\u00e9r\u00a0E, Csepregi\u00a0JZ, M\u00f3csai\u00a0A et al (2015) Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis. Brain Behav Immun 45:50\u201359","journal-title":"Brain Behav Immun"},{"issue":"5","key":"957_CR41","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.4049\/jimmunol.1500303","volume":"196","author":"W Ding","year":"2016","unstructured":"Ding\u00a0W, Stohl\u00a0LL, Xu\u00a0L, Zhou\u00a0XK, Manni\u00a0M, Wagner\u00a0JA, Granstein\u00a0RD (2016) Calcitonin gene-related peptide-exposed endothelial cells bias antigen presentation to CD4+ T cells toward a\u00a0th17 response. J\u00a0Immunol 196(5):2181\u20132194","journal-title":"J Immunol"},{"key":"957_CR42","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s13075-015-0858-0","volume":"17","author":"M Ebbinghaus","year":"2015","unstructured":"Ebbinghaus\u00a0M, Segond von Banchet\u00a0G, Massier\u00a0J, Gajda\u00a0M, Br\u00e4uer\u00a0R, Kress\u00a0M, Schaible\u00a0HG (2015) Interleukin-6-dependent influence of nociceptive sensory neurons on antigen-induced arthritis. Arthritis Res Ther 17:334","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"957_CR43","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.pain.2010.09.027","volume":"152","author":"F Wolfe","year":"2011","unstructured":"Wolfe\u00a0F, Hauser\u00a0W, Hassett\u00a0AL, Katz\u00a0RS, Walitt\u00a0BT (2011) The development of fibromyalgia\u2014I: examination of rates and predictors in patients with rheumatoid arthritis (RA). Pain 152(2):291\u2013299","journal-title":"Pain"},{"issue":"8","key":"957_CR44","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/rheumatology\/kes032","volume":"51","author":"SL Whittle","year":"2012","unstructured":"Whittle\u00a0SL, Colebatch\u00a0AN, Buchbinder\u00a0R, Edwards\u00a0CJ, Adams\u00a0K, Englbrecht\u00a0M, Hazlewood\u00a0G, Marks\u00a0JL, Radner\u00a0H, Ramiro\u00a0S et al (2012) Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis: integrating systematic literature research and expert opinion of a\u00a0broad panel of rheumatologists in the 3e Initiative. Rheumatology 51(8):1416\u20131425","journal-title":"Rheumatology"},{"issue":"6","key":"957_CR45","first-page":"797","volume":"77","author":"R Geenen","year":"2018","unstructured":"Geenen\u00a0R, Overman\u00a0CL, Christensen\u00a0R, \u00c5senl\u00f6f\u00a0P, Capela\u00a0S, Huisinga\u00a0KL, Huseb\u00f8\u00a0MEP, K\u00f6ke\u00a0AJA, Paskins\u00a0Z, Pitsillidou\u00a0IA et\u00a0al (2018) EULAR recommendations for the health professional\u2019s approach to pain management in inflammatory arthritis and osteoarthritis. Ann Rheum Dis 77(6):797\u2013807","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"957_CR46","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1024\/1661-8157\/a003387","volume":"109","author":"UT Egle","year":"2020","unstructured":"Egle\u00a0UT, Seeher\u00a0C, Cattapan\u00a0K (2020) Bio-psycho-social therapy for stress-induced chronic pain. Praxis 109(4):259\u2013263","journal-title":"Praxis"},{"issue":"6","key":"957_CR47","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1185\/03007995.2016.1157460","volume":"32","author":"R Freynhagen","year":"2016","unstructured":"Freynhagen\u00a0R, Tolle\u00a0TR, Gockel\u00a0U, Baron\u00a0R (2016) The painDETECT project\u2014far more than a\u00a0screening tool on neuropathic pain. Curr Med Res Opin 32(6):1033\u20131057","journal-title":"Curr Med Res Opin"},{"issue":"3","key":"957_CR48","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00393-020-00768-5","volume":"79","author":"R Alten","year":"2020","unstructured":"Alten\u00a0R, Mischkewitz\u00a0M, Stefanski\u00a0AL, D\u00f6rner\u00a0T (2020) Janus kinase inhibitors : State of the art in clinical use and future perspectives. Z\u00a0Rheumatol 79(3):241\u2013254","journal-title":"Z Rheumatol"},{"issue":"Suppl 2","key":"957_CR49","first-page":"ii86","volume":"62","author":"D Hammaker","year":"2003","unstructured":"Hammaker\u00a0D, Sweeney\u00a0S, Firestein\u00a0GS (2003) Signal transduction networks in rheumatoid arthritis. Ann Rheum Dis 62(Suppl 2):ii86\u2013ii89","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"957_CR50","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrrheum.2016.194","volume":"13","author":"D Hwang","year":"2017","unstructured":"Hwang\u00a0D, Kim\u00a0WU (2017) Rheumatoid arthritis: modelling cytokine signalling networks. Nat Rev Rheumatol 13(1):5\u20136","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"957_CR51","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/1744666X.2019.1544892","volume":"15","author":"L Serhal","year":"2019","unstructured":"Serhal\u00a0L, Edwards\u00a0CJ (2019) Upadacitinib for the treatment of rheumatoid arthritis. Expert Rev Clin Immunol 15(1):13\u201325","journal-title":"Expert Rev Clin Immunol"},{"issue":"5","key":"957_CR52","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1093\/rheumatology\/kex489","volume":"57","author":"MC Genovese","year":"2018","unstructured":"Genovese\u00a0MC, Kremer\u00a0JM, Kartman\u00a0CE, Schlichting\u00a0DE, Xie\u00a0L, Carmack\u00a0T, Pantojas\u00a0C, Sanchez Burson\u00a0J, Tony\u00a0HP, Macias\u00a0WL et\u00a0al (2018) Response to baricitinib based on prior biologic use in patients with refractory rheumatoid arthritis. Rheumatology 57(5):900\u2013908","journal-title":"Rheumatology"},{"issue":"4","key":"957_CR53","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1136\/annrheumdis-2016-209821","volume":"76","author":"JS Smolen","year":"2017","unstructured":"Smolen\u00a0JS, Kremer\u00a0JM, Gaich\u00a0CL, DeLozier\u00a0AM, Schlichting\u00a0DE, Xie\u00a0L, Stoykov\u00a0I, Rooney\u00a0T, Bird\u00a0P, Sanchez Burson\u00a0JM et al (2017) Patient-reported outcomes from a\u00a0randomised phase III study of baricitinib in patients with rheumatoid arthritis and an inadequate response to biological agents (RA-BEACON). Ann Rheum Dis 76(4):694\u2013700","journal-title":"Ann Rheum Dis"},{"key":"957_CR54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/PROM.S62879","volume":"7","author":"EG Boyce","year":"2016","unstructured":"Boyce\u00a0EG, Vyas\u00a0D, Rogan\u00a0EL, Valle-Oseguera\u00a0CS, O\u2019Dell\u00a0KM (2016) Impact of tofacitinib on patient outcomes in rheumatoid arthritis\u2014review of clinical studies. Patient Relat Outcome Meas 7:1\u201312","journal-title":"Patient Relat Outcome Meas"},{"issue":"1","key":"957_CR55","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s13075-019-2059-8","volume":"21","author":"V Strand","year":"2019","unstructured":"Strand\u00a0V, Schiff\u00a0M, Tundia\u00a0N, Friedman\u00a0A, Meerwein\u00a0S, Pangan\u00a0A, Ganguli\u00a0A, Fuldeore\u00a0M, Song\u00a0Y, Pope\u00a0J (2019) Effects of upadacitinib on patient-reported outcomes: results from SELECT-BEYOND, a\u00a0phase 3 randomized trial in patients with rheumatoid arthritis and inadequate responses to biologic disease-modifying antirheumatic drugs. Arthritis Res Ther 21(1):263","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"957_CR56","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s13075-017-1410-1","volume":"19","author":"M Schiff","year":"2017","unstructured":"Schiff\u00a0M, Takeuchi\u00a0T, Fleischmann\u00a0R, Gaich\u00a0CL, DeLozier\u00a0AM, Schlichting\u00a0D, Kuo\u00a0WL, Won\u00a0JE, Carmack\u00a0T, Rooney\u00a0T et al (2017) Patient-reported outcomes of baricitinib in patients with rheumatoid arthritis and no or limited prior disease-modifying antirheumatic drug treatment. Arthritis Res Ther 19(1):208","journal-title":"Arthritis Res Ther"},{"issue":"13","key":"957_CR57","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1056\/NEJMoa1507247","volume":"374","author":"MC Genovese","year":"2016","unstructured":"Genovese\u00a0MC, Kremer\u00a0J, Zamani\u00a0O, Ludivico\u00a0C, Krogulec\u00a0M, Xie\u00a0L, Beattie\u00a0SD, Koch\u00a0AE, Cardillo\u00a0TE, Rooney\u00a0TP et\u00a0al (2016) Baricitinib in patients with refractory rheumatoid arthritis. N\u00a0Engl J Med 374(13):1243\u20131252","journal-title":"N Engl J Med"},{"issue":"3","key":"957_CR58","first-page":"430","volume":"34","author":"GV Wallenstein","year":"2016","unstructured":"Wallenstein\u00a0GV, Kanik\u00a0KS, Wilkinson\u00a0B, Cohen\u00a0S, Cutolo\u00a0M, Fleischmann\u00a0RM, Genovese\u00a0MC, Gomez Reino\u00a0J, Gruben\u00a0D, Kremer\u00a0J et al (2016) Effects of the oral Janus kinase inhibitor tofacitinib on patient-reported outcomes in patients with active rheumatoid arthritis: results of two Phase 2 randomised controlled trials. Clin Exp Rheumatol 34(3):430\u2013442","journal-title":"Clin Exp Rheumatol"},{"issue":"10139","key":"957_CR59","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1016\/S0140-6736(18)31116-4","volume":"391","author":"MC Genovese","year":"2018","unstructured":"Genovese\u00a0MC, Fleischmann\u00a0R, Combe\u00a0B, Hall\u00a0S, Rubbert-Roth\u00a0A, Zhang\u00a0Y, Zhou\u00a0Y, Mohamed\u00a0MF, Meerwein\u00a0S, Pangan\u00a0AL (2018) Safety and efficacy of upadacitinib in patients with active rheumatoid arthritis refractory to biologic disease-modifying anti-rheumatic drugs (SELECT-BEYOND): a\u00a0double-blind, randomised controlled phase 3 trial. Lancet 391(10139):2513\u20132524","journal-title":"Lancet"},{"issue":"5","key":"957_CR60","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrrheum.2015.8","volume":"11","author":"JS Smolen","year":"2015","unstructured":"Smolen\u00a0JS, Aletaha\u00a0D (2015) Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges. Nat Rev Rheumatol 11(5):276\u2013289","journal-title":"Nat Rev Rheumatol"},{"issue":"16","key":"957_CR61","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1523\/JNEUROSCI.5007-09.2010","volume":"30","author":"E Dominguez","year":"2010","unstructured":"Dominguez\u00a0E, Mauborgne\u00a0A, Mallet\u00a0J, Desclaux\u00a0M, Pohl\u00a0M (2010) SOCS3-mediated blockade of JAK\/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury. J\u00a0Neurosci 30(16):5754\u20135766","journal-title":"J Neurosci"},{"issue":"12","key":"957_CR62","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/glia.22415","volume":"60","author":"CS Sung","year":"2012","unstructured":"Sung\u00a0CS, Cherng\u00a0CH, Wen\u00a0ZH, Chang\u00a0WK, Huang\u00a0SY, Lin\u00a0SL, Chan\u00a0KH, Wong\u00a0CS (2012) Minocycline and fluorocitrate suppress spinal nociceptive signaling in intrathecal IL-1beta-induced thermal hyperalgesic rats. Glia 60(12):2004\u20132017","journal-title":"Glia"},{"issue":"2","key":"957_CR63","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbi.2007.07.009","volume":"22","author":"W Kleibeuker","year":"2008","unstructured":"Kleibeuker\u00a0W, Gabay\u00a0E, Kavelaars\u00a0A, Zijlstra\u00a0J, Wolf\u00a0G, Ziv\u00a0N, Yirmiya\u00a0R, Shavit\u00a0Y, Tal\u00a0M, Heijnen\u00a0CJ (2008) IL\u20111 beta signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2. Brain Behav Immun 22(2):200\u2013208","journal-title":"Brain Behav Immun"},{"issue":"4","key":"957_CR64","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11926-015-0501-8","volume":"17","author":"AM Orbai","year":"2015","unstructured":"Orbai\u00a0AM, Bingham\u00a0CO 3rd (2015) Patient reported outcomes in rheumatoid arthritis clinical trials. Curr Rheumatol Rep 17(4):28","journal-title":"Curr Rheumatol Rep"},{"key":"957_CR65","doi-asserted-by":"crossref","unstructured":"Rodrigues-Manica S, Silva J, Cruz-Machado R, Coelho C, Duarte J, Vieira-Sousa E, Tavares-Costa J, Pimentel-Santos FM (2021) Biologic disease-modifying anti-rheumatic drugs and patient-reported outcomes in axial SpA: a\u00a0systematic review and a\u00a0call for action. Clin Rheumatol 40(1):33\u201341","DOI":"10.1007\/s10067-020-05209-x"},{"issue":"5","key":"957_CR66","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.semarthrit.2017.09.002","volume":"47","author":"P Hojgaard","year":"2018","unstructured":"Hojgaard\u00a0P, Klokker\u00a0L, Orbai\u00a0AM, Holmsted\u00a0K, Bartels\u00a0EM, Leung\u00a0YY, Goel\u00a0N, de Wit\u00a0M, Gladman\u00a0DD, Mease\u00a0P et al (2018) A systematic review of measurement properties of patient reported outcome measures in psoriatic arthritis: a\u00a0GRAPPA-OMERACT initiative. Semin Arthritis Rheum 47(5):654\u2013665","journal-title":"Semin Arthritis Rheum"},{"issue":"1","key":"957_CR67","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s13075-018-1769-7","volume":"20","author":"V Strand","year":"2018","unstructured":"Strand\u00a0V, Alemao\u00a0E, Lehman\u00a0T, Johnsen\u00a0A, Banerjee\u00a0S, Ahmad\u00a0HA, Mease\u00a0PJ (2018) Improved patient-reported outcomes in patients with psoriatic arthritis treated with abatacept: results from a\u00a0phase 3 trial. Arthritis Res Ther 20(1):269","journal-title":"Arthritis Res Ther"},{"issue":"9194","key":"957_CR68","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/S0140-6736(99)05246-0","volume":"354","author":"R Maini","year":"1999","unstructured":"Maini\u00a0R, St Clair\u00a0EW, Breedveld\u00a0F, Furst\u00a0D, Kalden\u00a0J, Weisman\u00a0M, Smolen\u00a0J, Emery\u00a0P, Harriman\u00a0G, Feldmann\u00a0M et al (1999) Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a\u00a0randomised phase III trial. ATTRACT Study Group. Lancet 354(9194):1932\u20131939","journal-title":"Lancet"},{"issue":"9","key":"957_CR69","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1073\/pnas.1011774108","volume":"108","author":"A Hess","year":"2011","unstructured":"Hess\u00a0A, Axmann\u00a0R, Rech\u00a0J, Finzel\u00a0S, Heindl\u00a0C, Kreitz\u00a0S, Sergeeva\u00a0M, Saake\u00a0M, Garcia\u00a0M, Kollias\u00a0G et al (2011) Blockade of TNF\u2011\u03b1 rapidly inhibits pain responses in the central nervous system. Proc Natl Acad Sci USA 108(9):3731\u20133736","journal-title":"Proc Natl Acad Sci USA"},{"key":"957_CR70","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007848.pub2.","author":"JA Singh","year":"2009","unstructured":"Singh\u00a0JA, Christensen\u00a0R, Wells\u00a0GA, Suarez-Almazor\u00a0ME, Buchbinder\u00a0R, Lopez-Olivo\u00a0MA, Tanjong Ghogomu\u00a0E, Tugwell\u00a0P (2009) Biologics for rheumatoid arthritis: an overview of Cochrane reviews. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD007848.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"957_CR71","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00296-018-4180-4","volume":"39","author":"K Kr\u00fcger","year":"2019","unstructured":"Kr\u00fcger\u00a0K, Burmester\u00a0GR, Wassenberg\u00a0S, Bohl-B\u00fchler\u00a0M, Thomas\u00a0MH (2019) Patient-reported outcomes with golimumab in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: non-interventional study GO-NICE in Germany. Rheumatol Int 39(1):131\u2013140","journal-title":"Rheumatol Int"},{"issue":"5","key":"957_CR72","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1136\/annrheumdis-2016-209835","volume":"76","author":"LH van Tuyl","year":"2017","unstructured":"van Tuyl\u00a0LH, Sadlonova\u00a0M, Hewlett\u00a0S, Davis\u00a0B, Flurey\u00a0C, Goel\u00a0N, Gossec\u00a0L, Heegaard Brahe\u00a0C, Hill\u00a0CL, Hoogland\u00a0W et al (2017) The patient perspective on absence of disease activity in rheumatoid arthritis: a\u00a0survey to identify key domains of patient-perceived remission. Ann Rheum Dis 76(5):855\u2013861","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"957_CR73","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrrheum.2013.138","volume":"9","author":"AM Malfait","year":"2013","unstructured":"Malfait\u00a0AM, Schnitzer\u00a0TJ (2013) Towards a\u00a0mechanism-based approach to pain management in osteoarthritis. Nat Rev Rheumatol 9(11):654\u2013664","journal-title":"Nat Rev Rheumatol"},{"key":"957_CR74","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neuroscience.2016.06.006","volume":"338","author":"KA Sluka","year":"2016","unstructured":"Sluka\u00a0KA, Clauw\u00a0DJ (2016) Neurobiology of fibromyalgia and chronic widespread pain. Neuroscience 338:114\u2013129","journal-title":"Neuroscience"},{"key":"957_CR75","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010585.pub2.","author":"J Thorpe","year":"2018","unstructured":"Thorpe\u00a0J, Shum\u00a0B, Moore\u00a0RA, Wiffen\u00a0PJ, Gilron\u00a0I (2018) Combination pharmacotherapy for the treatment of fibromyalgia in adults. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD010585.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"957_CR76","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1093\/pm\/pny214","volume":"20","author":"T Dimitroulas","year":"2019","unstructured":"Dimitroulas\u00a0T, Lambe\u00a0T, Raphael\u00a0JH, Kitas\u00a0GD, Duarte\u00a0RV (2019) Biologic drugs as analgesics for the management of low back pain and sciatica. Pain Med 20(9):1678\u20131686","journal-title":"Pain Med"},{"issue":"2","key":"957_CR77","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cyto.2014.06.019","volume":"70","author":"RE Miller","year":"2014","unstructured":"Miller\u00a0RE, Miller\u00a0RJ, Malfait\u00a0AM (2014) Osteoarthritis joint pain: the cytokine connection. Cytokine 70(2):185\u2013193","journal-title":"Cytokine"},{"issue":"9","key":"957_CR78","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1136\/annrheumdis-2014-205348","volume":"74","author":"X Chevalier","year":"2015","unstructured":"Chevalier\u00a0X, Ravaud\u00a0P, Maheu\u00a0E, Baron\u00a0G, Rialland\u00a0A, Vergnaud\u00a0P, Roux\u00a0C, Maugars\u00a0Y, Mulleman\u00a0D, Lukas\u00a0C et al (2015) Adalimumab in patients with hand osteoarthritis refractory to analgesics and NSAIDs: a\u00a0randomised, multicentre, double-blind, placebo-controlled trial. Ann Rheum Dis 74(9):1697\u20131705","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"957_CR79","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1136\/annrheumdis-2018-213202","volume":"77","author":"M Kloppenburg","year":"2018","unstructured":"Kloppenburg\u00a0M, Ramonda\u00a0R, Bobacz\u00a0K, Kwok\u00a0WY, Elewaut\u00a0D, Huizinga\u00a0TWJ, Kroon\u00a0FPB, Punzi\u00a0L, Smolen\u00a0JS, Vander Cruyssen\u00a0B et al (2018) Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a\u00a0multicentre, randomised, double-blind, placebo-controlled trial. Ann Rheum Dis 77(12):1757\u20131764","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"957_CR80","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/art.24096","volume":"61","author":"X Chevalier","year":"2009","unstructured":"Chevalier\u00a0X, Goupille\u00a0P, Beaulieu\u00a0AD, Burch\u00a0FX, Bensen\u00a0WG, Conrozier\u00a0T, Loeuille\u00a0D, Kivitz\u00a0AJ, Silver\u00a0D, Appleton\u00a0BE (2009) Intraarticular injection of anakinra in osteoarthritis of the knee: a\u00a0multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum 61(3):344\u2013352","journal-title":"Arthritis Rheum"}],"container-title":["Zeitschrift f\u00fcr Rheumatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-020-00957-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00393-020-00957-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-020-00957-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T08:06:27Z","timestamp":1617091587000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00393-020-00957-2"}},"subtitle":["Was haben Biologika und Januskinaseinhibitoren zu bieten?","What can biologics and JAK inhibitors offer?"],"short-title":[],"issued":{"date-parts":[[2021,1,14]]},"references-count":80,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["957"],"URL":"https:\/\/doi.org\/10.1007\/s00393-020-00957-2","relation":{},"ISSN":["0340-1855","1435-1250"],"issn-type":[{"value":"0340-1855","type":"print"},{"value":"1435-1250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,14]]},"assertion":[{"value":"12 December 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"G.\u00a0Pongratz hat in den letzten drei Jahren Berater- und Vortragshonorare von Lilly Deutschland und Boehringer Ingelheim erhalten, sowie Vortragshonorare von Sanofi.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden vom Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}