{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:44:39Z","timestamp":1759063479922,"version":"3.37.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018935","name":"Universit\u00e4tsklinikum Erlangen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018935","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Z Rheumatol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Es wurde ein Patient mit rheumatoider Arthritis (RA) vorgestellt, der unter der Therapie mit dem Januskinase-1\/2-Inhibitor Baricitinib eine Infektion mit dem Hepatitis-E-Virus (HEV) entwickelte. Unser Patient hatte bei seiner viertelj\u00e4hrlichen Routineuntersuchung deutlich erh\u00f6hte Transaminasen bei einer unauff\u00e4lligen k\u00f6rperlichen Untersuchung. Es fanden sich Antik\u00f6rper der IgM- und IgG-Klasse gegen HEV und ein erh\u00f6htes C\u2011reaktives Protein (CRP) sowie HEV-RNA mittels Real-Time-PCR, was auf eine frische HEV-Infektion hinwies. Baricitinib wurde sofort abgesetzt. Die ausf\u00fchrliche Anamnese ergab, dass der Patient Tage vor der Konsultation Rindertartar verzehrt hatte, ohne dass gastrointestinale Symptome oder Fieber aufgetreten waren. Im weiteren Verlauf erholte sich der Patient vollst\u00e4ndig, und die Leberfunktionstests und das CRP normalisierten sich innerhalb von 3\u00a0Monaten. Baricitinib wurde daraufhin wieder eingenommen. Bisher wurden nur wenige Daten zu HEV-Infektionen bei RA-Patienten, die mit JAK-Inhibitoren behandelt wurden, publiziert.<\/jats:p>","DOI":"10.1007\/s00393-021-01020-4","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T10:04:49Z","timestamp":1623060289000},"page":"980-983","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hepatitis-E-Virus-Infektion bei einem Patienten mit rheumatoider Arthritis unter Baricitinib-Therapie","Severe Hepatitis\u00a0E virus infection in a patient with rheumatoid arthritis treated with baricitinib"],"prefix":"10.1007","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4872-3502","authenticated-orcid":false,"given":"Larissa","family":"Valor-M\u00e9ndez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Manger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Schett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnd","family":"Kleyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"issue":"1","key":"1020_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.rdc.2017.09.005","volume":"44","author":"E Craig","year":"2018","unstructured":"Craig\u00a0E, Cappelli\u00a0LC (2018) Gastrointestinal and hepatic disease in rheumatoid arthritis. Rheum Dis Clin North Am 44(1):89\u2013111","journal-title":"Rheum Dis Clin North Am"},{"issue":"5","key":"1020_CR2","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1007\/s00296-018-4021-5","volume":"38","author":"B Radovanovi\u0107-Dini\u0107","year":"2018","unstructured":"Radovanovi\u0107-Dini\u0107\u00a0B, Te\u0161i\u0107-Rajkovi\u0107\u00a0S, Zivkovic\u00a0V, Grgov\u00a0S (2018) Clinical connection between rheumatoid arthritis and liver damage. Rheumatol Int 38(5):715\u2013724","journal-title":"Rheumatol Int"},{"issue":"4","key":"1020_CR3","first-page":"694","volume":"37","author":"EHS Choy","year":"2019","unstructured":"Choy\u00a0EHS, Miceli-Richard\u00a0C, Gonz\u00e1lez-Gay\u00a0MA, Sinigaglia\u00a0L, Schlichting\u00a0DE, Meszaros\u00a0G et al (2019) The effect of JAK1\/JAK2 inhibition in rheumatoid arthritis: efficacy and safety of baricitinib. Clin Exp Rheumatol 37(4):694\u2013704","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"1020_CR4","first-page":"376","volume":"5","author":"J Guerra","year":"2017","unstructured":"Guerra\u00a0J, Kampa\u00a0KC, Morsoletto\u00a0DGB, Junior\u00a0AP, Ivantes\u00a0CAP (2017) Hepatitis E: a literature review. J\u00a0Clin Transl Hepatol 5(4):376\u2013383","journal-title":"J Clin Transl Hepatol"},{"issue":"2","key":"1020_CR5","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3390\/jcm9020331","volume":"9","author":"S Lhomme","year":"2020","unstructured":"Lhomme\u00a0S, Marion\u00a0O, Abravanel\u00a0F, Izopet\u00a0J, Kamar\u00a0N (2020) Clinical manifestations, pathogenesis and treatment of Hepatitis E virus infections. J\u00a0Clin Med 9(2):331. https:\/\/doi.org\/10.3390\/jcm9020331","journal-title":"J\u00a0Clin Med"},{"issue":"14","key":"1020_CR6","doi-asserted-by":"publisher","first-page":"e675","DOI":"10.1097\/MD.0000000000000675","volume":"94","author":"H Bauer","year":"2015","unstructured":"Bauer\u00a0H, Luxembourger\u00a0C, Gottenberg\u00a0JE, Fournier\u00a0S, Abravanel\u00a0F, Cantagrel\u00a0A et\u00a0al (2015) Outcome of hepatitis E virus infection in patients with inflammatory arthritides treated with immunosuppressants: a\u00a0French retrospective multicenter study. Medicine (Baltimore) 94(14):e675","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"1020_CR7","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nrgastro.2017.150","volume":"15","author":"I Nimgaonkar","year":"2018","unstructured":"Nimgaonkar\u00a0I, Ding\u00a0Q, Schwartz\u00a0RE, Ploss\u00a0A (2018) Hepatitis E virus: advances and challenges. Nat Rev Gastroenterol Hepatol 15(2):96\u2013110","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1020_CR8","first-page":"6873276","volume":"2018","author":"H Ikeuchi","year":"2018","unstructured":"Ikeuchi\u00a0H, Koinuma\u00a0K, Nakasatomi\u00a0M, Sakairi\u00a0T, Kaneko\u00a0Y, Maeshima\u00a0A et\u00a0al (2018) Hepatitis E during Tocilizumab therapy in a\u00a0patient with rheumatoid arthritis: case report and literature review. Case Rep Rheumatol 2018:6873276","journal-title":"Case Rep Rheumatol"},{"issue":"1","key":"1020_CR9","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12985-020-01343-9","volume":"17","author":"C Wu","year":"2020","unstructured":"Wu\u00a0C, Wu\u00a0X, Xia\u00a0J (2020) Hepatitis E virus infection during pregnancy. Virol\u00a0J 17(1):73","journal-title":"Virol J"},{"issue":"suppl_2","key":"1020_CR10","first-page":"ii50","volume":"57","author":"G Schett","year":"2018","unstructured":"Schett\u00a0G (2018) Physiological effects of modulating the interleukin\u20116 axis. Rheumatolgy (Oxford) 57(suppl_2):ii50\u2013ii43","journal-title":"Rheumatolgy (Oxford)"},{"issue":"6","key":"1020_CR11","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1002\/hep.29105","volume":"65","author":"L Xu","year":"2017","unstructured":"Xu\u00a0L, Wang\u00a0W, Li\u00a0Y, Zhou\u00a0X, Yin\u00a0Y, Wang\u00a0Y et al (2017) RIG\u2011I is a\u00a0key antiviral interferon-stimulated gene against hepatitis E virus regardless of interferon production. Hepatology 65(6):1823\u20131839","journal-title":"Hepatology"}],"container-title":["Zeitschrift f\u00fcr Rheumatologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-021-01020-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00393-021-01020-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-021-01020-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T15:05:04Z","timestamp":1638889504000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00393-021-01020-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,7]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1020"],"URL":"https:\/\/doi.org\/10.1007\/s00393-021-01020-4","relation":{},"ISSN":["0340-1855","1435-1250"],"issn-type":[{"type":"print","value":"0340-1855"},{"type":"electronic","value":"1435-1250"}],"subject":[],"published":{"date-parts":[[2021,6,7]]},"assertion":[{"value":"30 April 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"L.\u00a0Valor-M\u00e9ndez, B.\u00a0Manger, G.\u00a0Schett und A.\u00a0Kleyer geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patienten zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}