{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:14:20Z","timestamp":1790720060979,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum D\u00fcsseldorf. Anstalt \u00f6ffentlichen Rechts"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Z Rheumatol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To analyze the composition of the oral microbiome in children and adolescents with chronic nonbacterial osteomyelitis (CNO) with respect to age distribution, gender differences, effects of medication, disease activity and the influence of body site.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The oral microbiome of 20\u00a0patients (12\u00a0male and 8\u00a0female; median age 10.3\u00a0years) and 36\u00a0controls were examined. Two different sites of the oral cavity were swabbed at two time points. Current medication and disease activity were evaluated and registered at these time points. Samples were subjected to amplicon sequencing of the V4 region of the 16S rRNA gene and Qiime2 was used to calculate alpha and beta diversity for multiple alternative metrics.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>On the basis of relative abundances of 975 different suboperational taxonomic units in high throughput next generation sequencing, a\u00a0significant shift in the composition of the oral microbiome (<jats:italic>p<\/jats:italic>\u202f&lt;\u20090.02) was observed among patients being treated with different medications. There was a\u00a0significant difference in bacterial communities between the group aged 3\u20138 years old and the group aged 9\u201314\u00a0years old. Significant differences were also seen in bacterial colonization on different sites in the oral cavity, but not with respect to gender or disease activity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We present first data of a\u00a0pilot study of the oral microbiome in children and adolescents with CNO, a\u00a0rare autoinflammatory bone disease. Differences of the oral microbiome of diseased children to normal adult controls revealed a\u00a0possible role of the oral microbiome as modulatory target or biomarker in CNO.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00393-021-01035-x","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T14:13:18Z","timestamp":1625148798000},"page":"123-133","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Results from a\u00a0pilot study on the oral microbiome in children and adolescents with chronic nonbacterial osteomyelitis","Ergebnisse einer Pilotstudie zum oralen Mikrobiom bei Kindern und Jugendlichen mit chronischer nichtbakterieller Osteomyelitis"],"prefix":"10.1007","volume":"82","author":[{"given":"Mona","family":"Zeus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0955-0589","authenticated-orcid":false,"given":"Stefan","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-J\u00fcrgen","family":"Laws","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6121-4737","authenticated-orcid":false,"given":"Arndt","family":"Borkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-7252","authenticated-orcid":false,"given":"Prasad Thomas","family":"Oommen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"1035_CR1","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1111\/j.1651-2227.2011.02205.x","volume":"100","author":"AF Jansson","year":"2011","unstructured":"Jansson\u00a0AF, Grote\u00a0V (2011) Nonbacterial osteitis in children: data of a\u00a0German Incidence Surveillance Study. 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