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Aktuell wird der Nutzen verschiedener bildgebender Verfahren evaluiert, hierunter die Sonographie, MRT und PET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ziel der Arbeit\/Fragestellung<\/jats:title><jats:p>Ziel war die Evaluation der diagnostischen Wertigkeit der 18-Fluordesoxyglukose-Positronenemissionstomographie\/Computertomographie (18F-FDG-PET\/CT) bei PMR, um die Sensitivit\u00e4t und Spezifit\u00e4t in der diagnostischen Aufarbeitung zu verbessern, sowie die rheumatoide Arthritis (RA) differentialdiagnostisch verbessert abzugrenzen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material und Methoden<\/jats:title><jats:p>Es wurden 18F-FDG-PET\/CT-Untersuchungen von 284 rheumatologischen Patienten \u2013\u00a0hierunter 97\u00a0Patienten mit PMR\u00a0\u2013 aus einem 44-monatigen Zeitraum retrospektiv evaluiert. Weiter wurden 13\u00a0entz\u00fcndlich ver\u00e4nderte Regionen via dreidimensionaler Region-of-interest(ROI)-Messung mit Bestimmung des maximalen Standardized-Uptake-Value (SUVmax) analysiert, gefolgt von statistischen Analysen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse und Diskussion<\/jats:title><jats:p>Patienten mit PMR zeigten im Vergleich mit einer rheumatologisch behandelten Kontrollgruppe signifikant erh\u00f6hte Anreicherungen in allen gemessenen Regionen (<jats:italic>p<\/jats:italic>\u202f&lt;\u20090,001). Die Methode mit der st\u00e4rksten diagnostischen Aussagekraft stellte die Kombination aus vier SUVmax-Messwerten \u2013\u00a0beider anterolateraler H\u00fcftkapseln und beider Tubera ischiadica\u00a0\u2013 dar, mit einer Sensitivit\u00e4t von 91,3\u202f% und einer Spezifit\u00e4t von 97,6\u202f% bei einem Cut-off von 11,0 SUV f\u00fcr die Erstdiagnose von PMR-Patienten, die noch keine immunsuppressive Therapie erhalten hatten. Patienten mit RA konnten bei Erstdiagnose an ebenjenen anatomischen Regionen signifikant von Patienten mit PMR unterschieden werden (<jats:italic>p<\/jats:italic>\u202f&lt;\u20090,001).<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00393-021-01133-w","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T11:03:11Z","timestamp":1638356591000},"page":"91-101","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Polymyalgia rheumatica in der 18-Fluordesoxyglukose-Positronenemissionstomographie\/Computertomographie","Polymyalgia rheumatica in 18-fluorodeoxyglucose-positron-emission-tomography\/computed tomography"],"prefix":"10.1007","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4305-0713","authenticated-orcid":false,"given":"F.","family":"Witte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-J.","family":"Lakomek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Holzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.-D.","family":"Reinbold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"key":"1133_CR1","first-page":"373","volume":"43","author":"F Ameer","year":"2014","unstructured":"Ameer\u00a0F, Mcneil\u00a0J (2014) Polymyalgia rheumatica: clinical update. 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