{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:11:25Z","timestamp":1765825885828,"version":"3.37.3"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Z Rheumatol"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s00393-021-01145-6","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T10:02:59Z","timestamp":1641808979000},"page":"189-197","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Medikamenteninduzierte Osteopathien in der Rheumatologie","Drug-induced osteopathy in rheumatology"],"prefix":"10.1007","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9665-1526","authenticated-orcid":false,"given":"Christoph","family":"Fiehn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"Bauhammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"1145_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S1297-319X(03)00024-1","volume":"70","author":"M Soubrier","year":"2003","unstructured":"Soubrier\u00a0M, Dubost\u00a0JJ, Boisgard\u00a0S et\u00a0al (2003) Insufficiency fracture. A survey of 60\u00a0cases and review of the literature. Joint Bone Spine 70:209\u2013218","journal-title":"Joint Bone Spine"},{"key":"1145_CR2","first-page":"77","volume":"20","author":"HM M\u00e4enp\u00e4\u00e4","year":"2002","unstructured":"M\u00e4enp\u00e4\u00e4\u00a0HM, Soini\u00a0I, Lehto\u00a0MUK, Belt\u00a0EA et\u00a0al (2002) Insufficiency fractures in patients with chronic inflammatory joint diseases. Clin Exp Rheumatol 20:77\u201379","journal-title":"Clin Exp Rheumatol"},{"key":"1145_CR3","first-page":"369","volume":"18","author":"O Elkayam","year":"2000","unstructured":"Elkayam\u00a0O, Paran\u00a0D, Flusser\u00a0G et\u00a0al (2000) Insufficiency fractures in rheumatic patients: misdiagnosis and underlying characteristics. Clin Exp Rheumatol 18:369\u2013374","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"1145_CR4","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3390\/geriatrics5040094","volume":"5","author":"P Simonsen Lentz","year":"2020","unstructured":"Simonsen Lentz\u00a0P, Havelund Rasmussen\u00a0A, Yurtsever\u00a0A et\u00a0al (2020) Missing diagnosis, pain, and loss of function in older adults with rheumatoid arthritis and insufficience fractures: a\u00a0qualitative study of the patients perspective. Geriatrics (Basel) 5(4):94. https:\/\/doi.org\/10.3390\/geriatrics5040094","journal-title":"Geriatrics (Basel)"},{"issue":"1","key":"1145_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11914-019-00498-x","volume":"17","author":"NE Lane","year":"2019","unstructured":"Lane\u00a0NE (2019) Glucocorticoid induced osteoporosis: new insights into the pathophysiology and treatment. Curr Osteoporos Rep 17(1):1\u20137","journal-title":"Curr Osteoporos Rep"},{"key":"1145_CR6","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.bone.2006.02.005","volume":"39","author":"A Angeli","year":"2006","unstructured":"Angeli\u00a0A, Gugliemi\u00a0G, Dovio\u00a0A et al (2006) High prevalence of asymptomatic vertebral fractures in post-menopausal women receiving chronic glucocorticoid therapy: a\u00a0cross-sectional outpatient study. Bone 39:253\u2013259","journal-title":"Bone"},{"key":"1145_CR7","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1007\/s00198-017-3976-5","volume":"28","author":"C Roux","year":"2017","unstructured":"Roux\u00a0C, Briot\u00a0K (2017) Imminent fracture risk. Osteoporos Int 28:1765\u20131769","journal-title":"Osteoporos Int"},{"key":"1145_CR8","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1359\/jbmr.2000.15.6.993","volume":"15","author":"TP Van Staa","year":"2000","unstructured":"Van Staa\u00a0TP, Leufkens\u00a0HGM, Abenhaim\u00a0L et\u00a0al (2000) Use of oral corticosteroids and risk of fractures. J\u00a0Bone Miner Res 15:993\u20131000","journal-title":"J Bone Miner Res"},{"key":"1145_CR9","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1007\/s00198-015-3455-9","volume":"27","author":"MA Amiche","year":"2016","unstructured":"Amiche\u00a0MA, Albaum\u00a0JM, Tadrous\u00a0M et al (2016) Fracture risk in oral glucocorticoid users: a\u00a0Bayesian meta-regressionleveraging control arms of osteoporosis clinical trials. Osteoporos Int 27:1709\u20131718","journal-title":"Osteoporos Int"},{"key":"1145_CR10","volume-title":"Ten-year analysis of the risk of severe outcomes related to very low-dose glucocorticoids in early rheumatoid arthritis","author":"C Roubille","year":"2020","unstructured":"Roubille\u00a0C, Coffy\u00a0A, Rincheval\u00a0N et al (2020) Ten-year analysis of the risk of severe outcomes related to very low-dose glucocorticoids in early rheumatoid arthritis (Abstract ACR-Kongress; Abstract number 1998)"},{"issue":"11","key":"1145_CR11","doi-asserted-by":"publisher","first-page":"4231","DOI":"10.1210\/jc.2014-2177","volume":"99","author":"S Sutter","year":"2014","unstructured":"Sutter\u00a0S, Nishiyama\u00a0KK, Kepley\u00a0A et\u00a0al (2014) Abnormalities in cortical bone, trabecular plates, and stiffness in postmenopausal women treated with glucocorticoids. J\u00a0Clin Endocrinol Metab 99(11):4231\u20134240","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1145_CR12","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1056\/NEJMoa071408","volume":"357","author":"KG Saag","year":"2007","unstructured":"Saag\u00a0KG, Shane\u00a0E, Boonen\u00a0S et al (2007) Teriparatide or alendronate in glucocorticoid-induced osteoporosis. N\u00a0Eng J Med 357:2028\u20132039","journal-title":"N Eng J Med"},{"key":"1145_CR13","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1007\/s00393-021-01028-w","volume":"80","author":"J Leipe","year":"2021","unstructured":"Leipe\u00a0J, Holle\u00a0JU, Weseloh\u00a0C et al (2021) Empfehlungen der Deutschen Gesellschaft f\u00fcr Rheumatologie zum Management der Glukokortikoid-induzierten Osteoporose. Z\u00a0Rheumatol 80:670\u2013687","journal-title":"Z Rheumatol"},{"key":"1145_CR14","doi-asserted-by":"publisher","first-page":"102460","DOI":"10.1016\/j.jaut.2020.102460","volume":"101","author":"C Chang","year":"2020","unstructured":"Chang\u00a0C, Greenspan\u00a0A, Gershwin\u00a0GE (2020) The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis. J\u00a0Autoimmun 101:102460","journal-title":"J Autoimmun"},{"key":"1145_CR15","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s00198-018-04826-2","volume":"30","author":"J Bergman","year":"2019","unstructured":"Bergman\u00a0J, Nordstr\u00f6m\u00a0A, Nordstr\u00f6m\u00a0P (2019) Epidemiology of osteonecrosis among older adults in Sweden. Osteoporos Int 30:965\u2013973","journal-title":"Osteoporos Int"},{"key":"1145_CR16","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s00198-009-1003-1","volume":"21","author":"C Cooper","year":"2010","unstructured":"Cooper\u00a0C, Steinbuch\u00a0M, Stevenson\u00a0R et\u00a0al (2010) The epidemiology of osteonecrosis: findings from the GPRD and THIN databases in the UK. Osteoporos Int 21:569\u2013577","journal-title":"Osteoporos Int"},{"key":"1145_CR17","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1016\/S0140-6736(96)07088-2","volume":"348","author":"DM Black","year":"1996","unstructured":"Black\u00a0DM, Cummings\u00a0SR, Karpf\u00a0DB et\u00a0al (1996) Randomised trial of effect alendronate on risk of fracture in women with existing vertebral fractures. Lancet 348:1535\u20131541","journal-title":"Lancet"},{"key":"1145_CR18","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1002\/jbmr.1479","volume":"27","author":"HG Bone","year":"2012","unstructured":"Bone\u00a0HG, Charpurlat\u00a0R, Brandi\u00a0ML et\u00a0al (2012) The effect of three or five years of denosumab exposure in women with postmenopausal osteoporosis: results of the FREEDOM extension. J\u00a0Bone\u00a0Miner Res 27:694\u2013701","journal-title":"J Bone Miner Res"},{"issue":"1","key":"1145_CR19","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1177\/8755122520967632","volume":"37","author":"SA Miller","year":"2021","unstructured":"Miller\u00a0SA, Onge\u00a0ELS, Whalen\u00a0KL (2021) Romosozumab: a novel agent in the treatment for postmenopausal osteoporosis. J\u00a0Pharm Technol 37(1):45\u201352","journal-title":"J Pharm Technol"},{"key":"1145_CR20","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1056\/NEJMoa1916525","volume":"383","author":"DM Black","year":"2020","unstructured":"Black\u00a0DM, Geiger\u00a0EJ, Eastell\u00a0R et\u00a0al (2020) Atypical femur fracture risk versus fragility fracture prevention with bisphosphonates. N\u00a0Engl J Med 383:743\u2013753","journal-title":"N Engl J Med"},{"issue":"06","key":"1145_CR21","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1055\/a-1037-0874","volume":"39","author":"S Hoefert","year":"2019","unstructured":"Hoefert\u00a0S (2019) Medikamenten-assoziierte Kiefernekrosen \u2013 Relevanz aus rheumatologischer Sicht? Arthritis Rheuma 39(06):385\u2013390","journal-title":"Arthritis Rheuma"},{"key":"1145_CR22","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","volume":"72","author":"SL Ruggiero","year":"2014","unstructured":"Ruggiero\u00a0SL, Dodson\u00a0TB, Fantasia\u00a0J et al (2014) American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw-2014 update. J\u00a0Oral Maxillofac Surg 72:1938\u20131956","journal-title":"J Oral Maxillofac Surg"},{"key":"1145_CR23","unstructured":"Schiegnitz E, Al-Nawas B, Hoefert S, Otto S et al (2018) S3-Leitlinie Antiresorptiva-assoziierte Kiefernekrosen (AR-ONJ). https:\/\/www.awmforg\/uploads\/tx_szleitlinien\/007-091l_S3_Antiresorptiva-assoziierte-Kiefernekrosen-AR-ONJ_2018-12pdf. Zugegriffen: 15.\u00a0Okt. 2021"},{"issue":"1","key":"1145_CR24","doi-asserted-by":"publisher","first-page":"e000365","DOI":"10.1136\/rmdopen-2016-000365","volume":"3","author":"IP Perp\u00e9tuo","year":"2017","unstructured":"Perp\u00e9tuo\u00a0IP, Caetano-Lopez\u00a0J, Rodriges\u00a0AM et al (2017) Methotrexate and low-dose prednisolone downregulate osteoclast function by decreasing receptor activator of nuclear factor-\u03ba\u03b2 expression in monocytes from patients with early rheumatoid arthritis. RMD Open 3(1):e365","journal-title":"RMD Open"},{"key":"1145_CR25","first-page":"251","volume":"28","author":"R Uehara","year":"2001","unstructured":"Uehara\u00a0R, Suzuki\u00a0Y, Ichikawa\u00a0Y (2001) Methotrexate (MTX) inhibits osteoblastic differentiation in vitro: possible mechanism of MTX osteopathy. J\u00a0Rheumatol 28:251\u2013256","journal-title":"J Rheumatol"},{"issue":"4","key":"1145_CR26","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1749-799X-4-17","volume":"26","author":"A Malviya","year":"2009","unstructured":"Malviya\u00a0A, Kuioer\u00a0JH, Makwana\u00a0N et al (2009) The effect of newer anti-rheumatic drugs on osteogenic cell proliferation: an in-vitro study. J\u00a0Orthop Surg Res 26(4):17","journal-title":"J Orthop Surg Res"},{"key":"1145_CR27","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s00774-003-0489-4","volume":"22","author":"Y Kobayashi","year":"2004","unstructured":"Kobayashi\u00a0Y, Ueyama\u00a0S, Arai\u00a0Y et al (2004) The active metabolite of leflunomide, A771726, inhibits both the generation of and the bone-resorbing activity of osteoclasts by acting directly on cells of the osteoclast lineage. J\u00a0Bone Miner Metab 22:318\u2013328","journal-title":"J Bone Miner Metab"},{"issue":"3","key":"1145_CR28","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1002\/art.20206","volume":"50","author":"M Urushibara","year":"2004","unstructured":"Urushibara\u00a0M, Takayanagi\u00a0H, Koga\u00a0T et al (2004) The antirheumatic drug leflunomide inhibits osteoclastogenesis by interfering with receptor activator of NF-kappa B ligand-stimulated induction of nuclear factor of activated T cells c1. Arthritis Rheumatol 50(3):794\u2013804","journal-title":"Arthritis Rheumatol"},{"key":"1145_CR29","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s00223-020-00765-5","volume":"108","author":"T Rolvien","year":"2021","unstructured":"Rolvien\u00a0T, Jandl\u00a0NM, St\u00fcrznickel\u00a0J et\u00a0al (2021) Clinical and radiological characterization of patients with immobilizing and progressive stress fractures in methotrexate osteopathy. Calcif Tissue Int 108:219\u2013230","journal-title":"Calcif Tissue Int"},{"key":"1145_CR30","volume-title":"Methotrexat-Osteopathie: Analyse von 7\u00a0F\u00e4llen einer \u00fcbersehenen Komplikation der rheumatologischen Therapie","author":"C Fiehn","year":"2021","unstructured":"Fiehn\u00a0C, Bauhammer\u00a0J (2021) Methotrexat-Osteopathie: Analyse von 7\u00a0F\u00e4llen einer \u00fcbersehenen Komplikation der rheumatologischen Therapie"},{"key":"1145_CR31","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1136\/ard.2005.043281","volume":"65","author":"P Alonso-Bartolome","year":"2006","unstructured":"Alonso-Bartolome\u00a0P, Martinez-Taboada\u00a0VM, Canga\u00a0A et al (2006) Medial tibial stress syndrome due to methotrexate osteopathy. Ann Rheum Dis 65:832\u2013833","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"1145_CR32","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s00198-020-05664-x","volume":"32","author":"F Robin","year":"2021","unstructured":"Robin\u00a0F, Cadiou\u00a0S, Albert\u00a0JD et\u00a0al (2021) Methotrexate osteopathy: five cases and literature review. Osteoporos Int 32(2):225\u2013232","journal-title":"Osteoporos Int"},{"issue":"2","key":"1145_CR33","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1001\/archderm.1996.03890260086013","volume":"132","author":"IM Zonneveld","year":"1996","unstructured":"Zonneveld\u00a0IM, Bakker\u00a0WK, Dijkstra\u00a0PF et\u00a0al (1996) Methotrexat osteopathy in long term, low dose methotrexate treatment for psoriasis and rheumatoid arthritis. Arch Dermatol 132(2):184\u2013187","journal-title":"Arch Dermatol"},{"issue":"11","key":"1145_CR34","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.3899\/jrheum.100385","volume":"37","author":"L Meier","year":"2010","unstructured":"Meier\u00a0L, van Tuyll van Sersooskerken\u00a0A, Liverton\u00a0E et\u00a0al (2010) Fractures of the proximal tibia associated with longterm use of methotrexate: 3 case reports and a review of literature. J\u00a0Rheumatol 37(11):2434\u20132438. https:\/\/doi.org\/10.3899\/jrheum.100385","journal-title":"J Rheumatol"},{"key":"1145_CR35","doi-asserted-by":"publisher","DOI":"10.3205\/16dgrh244","author":"J Bauhammer","year":"2016","unstructured":"Bauhammer\u00a0J, Fiehn\u00a0C (2016) 3\u00a0F\u00e4lle von anhaltenden Pseudarthrosen unter einer Therapie mit Leflunomid, reversibel nach Absetzen und Auswaschen des aktiven Metaboliten. Z\u00a0Rheumatol. https:\/\/doi.org\/10.3205\/16dgrh244","journal-title":"Z Rheumatol"},{"key":"1145_CR36","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1210\/jc.2011-2645","volume":"97","author":"SR Majumdar","year":"2012","unstructured":"Majumdar\u00a0SR, Lix\u00a0LM, Yogendran\u00a0M et al (2012) Population-based trends in osteoporosis management after new initiations of long-term systemic glucocorticoids (1998\u20132008). J\u00a0Clin Endocrinol Metab 97:1236\u20131242","journal-title":"J Clin Endocrinol Metab"},{"key":"1145_CR37","doi-asserted-by":"publisher","first-page":"e249","DOI":"10.1136\/rmdopen-2016-000249","volume":"2","author":"S Trijau","year":"2016","unstructured":"Trijau\u00a0S, de Lamotte\u00a0G, Pradel\u00a0V et\u00a0al (2016) Osteoporosis prevention among chronic glucocorticoid users: results from a\u00a0public health insurance database. RMD Open 2:e249","journal-title":"RMD Open"}],"container-title":["Zeitschrift f\u00fcr Rheumatologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-021-01145-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00393-021-01145-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-021-01145-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T17:08:31Z","timestamp":1648660111000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00393-021-01145-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["1145"],"URL":"https:\/\/doi.org\/10.1007\/s00393-021-01145-6","relation":{},"ISSN":["0340-1855","1435-1250"],"issn-type":[{"type":"print","value":"0340-1855"},{"type":"electronic","value":"1435-1250"}],"subject":[],"published":{"date-parts":[[2022,1,10]]},"assertion":[{"value":"1 December 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"C.\u00a0Fiehn und J.\u00a0Bauhammer geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patienten zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}