{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T21:39:50Z","timestamp":1768513190980,"version":"3.49.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Z Rheumatol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Therapierefrakt\u00e4re Arthritiden sind ein h\u00e4ufiges Problem im rheumatologischen Alltag und k\u00f6nnen eine differentialdiagnostische Herausforderung darstellen. Chronische Infektionen durch <jats:italic>Tropheryma whipplei <\/jats:italic>(<jats:italic>T.\u00a0whipplei<\/jats:italic>) sollten in diesen F\u00e4llen bedacht werden.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel der Arbeit<\/jats:title>\n                <jats:p>Anhand von 5\u00a0klinischen F\u00e4llen werden in dieser fallbasierten \u00dcbersichtsarbeit die diagnostischen und therapeutischen Prinzipien im Management der chronischen <jats:italic>T.-whipplei<\/jats:italic>-Infektion erl\u00e4utert.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnis<\/jats:title>\n                <jats:p>Der Morbus Whipple ist eine infekti\u00f6se Multisystemerkrankung, die durch das Bakterium <jats:italic>T.\u00a0whipplei<\/jats:italic> ausgel\u00f6st wird. Typischerweise manifestiert sich die Erkrankung mit Arthralgien, Gewichtsverlust und Diarrhoen. Die Gelenkmanifestationen gehen den gastrointestinalen Krankheitserscheinungen h\u00e4ufig mehrere Jahre voraus. Neben systemischen Manifestationen (Morbus Whipple) kann <jats:italic>T.\u00a0whipplei<\/jats:italic> auch zu lokalisierten Infektionen der Gelenke ohne gastrointestinale Beteiligung f\u00fchren. Die Gelenkmanifestationen systemischer und lokalisierter <jats:italic>T.-whipplei<\/jats:italic>-Infektionen werden f\u00e4lschlicherweise h\u00e4ufig als Zeichen verschiedener autoimmunologischer Arthritiden gedeutet.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Diskussion<\/jats:title>\n                <jats:p>Bei der Abkl\u00e4rung therapierefrakt\u00e4rer Arthritiden sollte an einen Morbus Whipple und lokalisierte Gelenkinfektionen durch <jats:italic>T.\u00a0whipplei<\/jats:italic> gedacht werden. Diagnostisch wegweisend ist die Untersuchung des Gelenkpunktates auf <jats:italic>T.\u00a0whipplei<\/jats:italic> mittels Polymerasekettenreaktion.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00393-022-01194-5","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T11:03:01Z","timestamp":1649242981000},"page":"885-891","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chronische Tropheryma-whipplei-Infektion: Eine wichtige Differentialdiagnose der therapierefrakt\u00e4ren Polyarthritis","Chronic Tropheryma whipplei infection: an important differential diagnosis of refractory polyarthritis"],"prefix":"10.1007","volume":"82","author":[{"given":"Nikolas","family":"Ruffer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2064-6728","authenticated-orcid":false,"given":"Marie-Therese","family":"Holzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannik","family":"Gkanatsas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Schinglerov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damir","family":"Boro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Krusche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"K\u00f6tter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"issue":"1","key":"1194_CR1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/00002281-200101000-00012","volume":"13","author":"X Puechal","year":"2001","unstructured":"Puechal\u00a0X (2001) Whipple disease and arthritis. 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