{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T09:41:09Z","timestamp":1675330869328},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Bern"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Z Rheumatol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Die axiale Spondyloarthritis (axSpA) ist unter den chronischen R\u00fcckenerkrankungen wohl die Entit\u00e4t mit dem gr\u00f6\u00dften Spektrum spezifischer antientz\u00fcndlicher Behandlungsoptionen. Sie wird aber erst nach R\u00fcckenmark- oder Cauda-equina-Kompression, Knochenmetastasen, epiduralem Abszess oder Osteomyelitis der Wirbelk\u00f6rper, Radikulopathie oder engem Spinalkanal nur als eine ferner zu ber\u00fccksichtigende \u00c4tiologie von R\u00fcckenschmerzen in den allgemeinmedizinisch orientierten Praxishilfen erw\u00e4hnt. Es besteht wegen einer vergleichsweise niedrigen Pr\u00e4valenz und erst sp\u00e4ter zu erwartender Folgen die tendenzielle Gefahr, dass die axSpA als eine Entit\u00e4t f\u00fcr Spezialisten vernachl\u00e4ssigt wird.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Diese Arbeit rekapituliert die Empfehlungen der internationalen Gesellschaft f\u00fcr das Assessment der ankylosierenden Spondylitis (ASAS). Dieser Review weist auf die praktischen Aspekte der detaillierten Evaluation bisheriger Therapieversuche mit nichtsteroidalen Antirheumatika (NSAR) bei R\u00fcckenschmerzen hin. Von besonderem Interesse k\u00f6nnen dabei unerw\u00fcnschte Effekte auf eine Symptomatik des unteren Intestinaltraktes sein. Die geschlechtsspezifischen Unterschiede im Ansprechen auf eine TNF(Tumor-Nekrose-Faktor)-Inhibitor-Therapie bei axSpA finden Erw\u00e4hnung, ebenso wie weitere Aspekte der biologischen Therapieoptionen bei axSpA anhand eines Falles von anhaltender Remission einer HLA-B27 und Magnetresonanztomographie(MRT)-positiven axSpA nach Anti-IL(Interleukin)-17-Behandlung und dem mehrj\u00e4hrigen guten Ansprechen auf eine IL-12\/23-Inhibitor-Therapie bei axialer Psoriasisarthritis besprochen werden. Ferner wird die Literatur im Hinblick auf Uveitis, Karditis und Amyloidose im Kontext der axSpA diskutiert.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Die rechtzeitige Erkennung im allgemeinmedizinischen Kontext und die spezifische Ber\u00fccksichtigung zahlreicher pr\u00e4diktiver Faktoren spielen bei der personalisierten Behandlung der axSpA eine weiter zunehmende Rolle.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00393-022-01256-8","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T10:03:14Z","timestamp":1661940194000},"page":"10-17","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronische R\u00fcckenschmerzen bei axialer Spondyloarthritis"],"prefix":"10.1007","volume":"82","author":[{"given":"Burkhard","family":"M\u00f6ller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"1256_CR1","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1097\/BOR.0000000000000619","volume":"31","author":"S Arepalli","year":"2019","unstructured":"Arepalli\u00a0S, Rosenbaum\u00a0JT (2019) The use of biologics for uveitis associated with spondyloarthritis. 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Er deklariert Zusammenarbeiten mit AbbVie, Amgen, Celgene, Eli Lilly, Janssen, MSD, Novartis, Pfizer und Roche in Form von Vortragshonoraren, Kongressbeitr\u00e4gen, Reiskostenerstattungen oder Forschungskooperationen.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden vom Autor keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patient\/-innen zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern\/Vertreterinnen eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}