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The primary clinical manifestations involve acute-onset and self-limiting asymmetric large joint inflammation in the lower limbs. Although bacterial or chlamydia infections have long been recognized as playing a\u00a0pivotal role in its pathogenesis, recent studies suggest that antibiotic treatment may perpetuate rather than eradicate chlamydia within the host, indicating an involvement of other mechanisms in Reactive arthritis. Reactive arthritis is currently believed to be associated with infection, genetic marker (HLA-B27), and immunologic derangement. As an autoimmune disease, increasing attention has been given to understanding the role of the immune system in Reactive arthritis. This review focuses on elucidating how the immune system mediates reactive arthritis and explores the roles of intestinal dysbiosis-induced immune disorders and stress-related factors in autoimmune diseases, providing novel insights into understanding reactive arthritis.<\/jats:p>","DOI":"10.1007\/s00393-024-01480-4","type":"journal-article","created":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T21:26:48Z","timestamp":1708896408000},"page":"305-313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immunologic derangement caused by intestinal dysbiosis and stress is the intrinsic basis of reactive arthritis","Immunologische St\u00f6rung durch intestinale Dysbiose und Stress als wesentliche Grundlage der reaktiven Arthritis"],"prefix":"10.1007","volume":"83","author":[{"given":"Tao","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqing","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,25]]},"reference":[{"issue":"3","key":"1480_CR1","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/jdv.12741","volume":"29","author":"PG Stavropoulos","year":"2015","unstructured":"Stavropoulos\u00a0PG, Soura\u00a0E, Kanelleas\u00a0A, Katsambas\u00a0A, Antoniou\u00a0C (2015) Reactive arthritis. 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