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Daneben kann auch die Skelettmuskulatur betroffen sein. Myalgien, Paresen und Sensibilit\u00e4tsst\u00f6rungen sind in diesem Zusammenhang typische Krankheitszeichen, die zu schwerwiegenden Funktionseinschr\u00e4nkungen und einer Beeintr\u00e4chtigung der Lebensqualit\u00e4t f\u00fchren k\u00f6nnen. Eine vaskulitische Affektion der Skelettmuskulatur (vaskulitische Myopathie, VM) und peripherer Nerven (vaskulitische Neuropathie, VN) tritt vorwiegend bei der Polyarteriitis nodosa und Kleingef\u00e4\u00dfvaskulitiden auf. Die VM pr\u00e4sentiert sich mit erh\u00f6hten Entz\u00fcndungsparametern und ist typischerweise durch immobilisierende Myalgien mit normwertiger Kreatinkinaseaktivit\u00e4t und diffuse oder fleckige Hyperintensit\u00e4ten in der T2-Wichtung in der MRT-Bildgebung gekennzeichnet (\u201eMRT-Myositis ohne Myositis\u201c). Bei der VN entwickeln sich vorwiegend im Bereich der unteren Extremit\u00e4t sensomotorische Defizite im Versorgungsgebiet mehrerer peripherer Nerven (z.\u202fB. Mononeuritis multiplex) mit akuter bis subakuter Anamnese. Die histopathologische Untersuchung von Nerven- und Muskelbiopsien ist der Goldstandard f\u00fcr die Diagnose vaskulitischer Manifestationen und hat einen bedeutsamen Einfluss auf das therapeutische Vorgehen.<\/jats:p>","DOI":"10.1007\/s00393-024-01567-y","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:27:41Z","timestamp":1727184461000},"page":"210-218","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vaskulitische Beteiligung der Skelettmuskulatur und des peripheren Nervensystems: Klinische und neuropathologische Perspektive","Vasculitic involvement of the skeletal muscle and the peripheral nervous system: clinical and neuropathologic perspective"],"prefix":"10.1007","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8394-969X","authenticated-orcid":false,"given":"Nikolas","family":"Ruffer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Kleefeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Therese","family":"Holzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Krusche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"K\u00f6tter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Stenzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"issue":"1","key":"1567_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00292-009-1156-x","volume":"31","author":"K Holl-Ulrich","year":"2010","unstructured":"Holl-Ulrich\u00a0K (2010) Histopathologie systemischer Vaskulitiden. 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