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Das gleichzeitige Auftreten einer Sarkoidose mit Multisystembeteiligung einer Myositis ist in der Literatur bisher nur extrem selten beschrieben worden.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Fallbericht<\/jats:title>\n            <jats:p>Wir berichten \u00fcber den Fall eines 39-j\u00e4hriger Mannes mit einer seit 3\u00a0Jahren bekannten Anti-MDA-5-positiven Dermatomyositis, der unter sukzessiver Reduktion der immunsuppressiven Therapie eine subjektive Verschlechterung der Dyspnoe sowie eine Hyperkalz\u00e4mie mit akuter Nierensch\u00e4digung und deutlicher Allgemeinzustandsverschlechterung entwickelte. Mittels Bronchoskopie und Lymphknotenbiopsie konnte letztlich die Diagnose einer Sarkoidose gesichert werden.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Schlussfolgerung<\/jats:title>\n            <jats:p>Der vorliegende Fallbericht verdeutlicht die Wichtigkeit, im Krankheitsverlauf einer seltenen Erkrankung die Diagnose bei neu aufgetretenen Symptomen kontinuierlich zu reevaluieren. Beim Vorliegen einer ausgepr\u00e4gten Lymphadenopathie, einer neu aufgetretenen Hyperkalz\u00e4mie und f\u00fcr eine Dermatomyositis atypischen Lungenparenchymver\u00e4nderungen sollte somit auch an die Differenzialdiagnose einer Sarkoidose gedacht werden.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00393-025-01627-x","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T15:14:32Z","timestamp":1740755672000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sequenzielle Autoimmunit\u00e4t? Der seltene Fall einer MDA5-Dermatomyositis und Sarkoidose","Sequential autoimmunity? 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