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Eine muskul\u00e4re Mitbeteiligung ist selten. Es existieren einige Fallberichte und Studien zur mit dem SjS assoziierten Einschlussk\u00f6rpermyositis (IBM). Eine weitere assoziierte Myositisform mit mitochondrialen Ver\u00e4nderungen, die oft auch als Spektrum der IBM angesehen wird, ist die Polymyositis mit mitochondrialer Pathologie (PM-Mito).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Fallbericht<\/jats:title>\n                    <jats:p>Wir berichten den Fall einer 90-j\u00e4hrigen Patientin, welche sich mit progredienter Dysphagie, Gewichtsverlust und letztlich einer voranschreitenden Einschr\u00e4nkung beim Gehen vorstellte. In der diagnostischen Aufarbeitung konnte ein prim\u00e4res SjS diagnostiziert werden, und eine Muskelbiopsie erm\u00f6glichte die Diagnosestellung einer PM-Mito.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Schlussfolgerung<\/jats:title>\n                    <jats:p>Der vorliegende Fallbericht verdeutlicht die Wichtigkeit, differenzialdiagnostisch an eine neuromuskul\u00e4re Mitbeteiligung im Rahmen des SjSs zu denken. Das komorbide Auftreten einer Myositis mit mitochondrialer Pathologie (PM-Mito oder IBM) mit dem SjS f\u00fchrt zu aktuellen Diskussionen \u00fcber \u00e4hnliche pathomechanistische Aspekte. Weiterhin unterstreicht dieser Fallbericht die Wichtigkeit einer histopathologischen Beurteilung bei einer zun\u00e4chst unklaren Myopathie als Schl\u00fcsselelement zur korrekten Diagnose.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00393-025-01702-3","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T10:32:44Z","timestamp":1755858764000},"page":"739-745","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u201eNot just frailty\u201c\u00a0\u2013 Sj\u00f6gren-Syndrom und Polymyositis mit mitochondrialer Pathologie","Not just frailty\u2014Sj\u00f6gren\u2019s syndrome and polymyositis with mitochondrial pathology"],"prefix":"10.1007","volume":"84","author":[{"given":"Phillip","family":"Kremer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Melderis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Matschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Stenzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"K\u00f6tter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Krusche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2064-6728","authenticated-orcid":false,"given":"Marie-Therese","family":"Holzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"1702_CR1","doi-asserted-by":"publisher","first-page":"101498","DOI":"10.1016\/j.arr.2021.101498","volume":"72","author":"N Veronese","year":"2021","unstructured":"Veronese\u00a0N, Custodero\u00a0C, Cella\u00a0A, Demurtas\u00a0J, Zora\u00a0S, Maggi\u00a0S, Barbagallo\u00a0M, Sabb\u00e0\u00a0C, Ferrucci\u00a0L, Pilotto\u00a0A (2021) Prevalence of Multidimensional Frailty and Pre-Frailty in Older People in Different Settings: A\u00a0Systematic Review and Meta-Analysis. 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