{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:49:49Z","timestamp":1765547389059,"version":"3.48.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"S5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Z Rheumatol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00393-025-01717-w","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T15:36:20Z","timestamp":1756740980000},"page":"210-217","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cancer risk across sex, region, and disease subtype in ANCA-associated vasculitis patients","Krebsrisiko nach Geschlecht, Region und Krankheitssubtyp bei Patienten mit ANCA-assoziierter Vaskulitis"],"prefix":"10.1007","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4213-1909","authenticated-orcid":false,"given":"Young Ho","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwan Gyu","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"issue":"2","key":"1717_CR1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41584-018-0145-y","volume":"15","author":"D Nakazawa","year":"2019","unstructured":"Nakazawa\u00a0D, Masuda\u00a0S, Tomaru\u00a0U, Ishizu\u00a0A (2019) Pathogenesis and therapeutic interventions for ANCA-associated vasculitis. Nat Rev Rheumatol 15(2):91\u2013101","journal-title":"Nat Rev Rheumatol"},{"issue":"8","key":"1717_CR2","first-page":"1345","volume":"54","author":"M Faurschou","year":"2015","unstructured":"Faurschou\u00a0M, Mellemkjaer\u00a0L, Voss\u00a0A, Keller\u00a0KK, Hansen\u00a0IT, Baslund\u00a0B (2015) Prolonged risk of specific malignancies following cyclophosphamide therapy among patients with granulomatosis with polyangiitis. Baillieres Clin Rheumatol 54(8):1345\u20131350","journal-title":"Baillieres Clin Rheumatol"},{"issue":"2","key":"1717_CR3","doi-asserted-by":"publisher","first-page":"72","DOI":"10.4078\/jrd.2022.0002","volume":"30","author":"SS Ahn","year":"2023","unstructured":"Ahn\u00a0SS, Lee\u00a0S\u2011W (2023) Management of antineutrophil cytoplasmic antibody-associated vasculitis: a\u00a0review of recent guidelines. J\u00a0Rheum Dis 30(2):72\u201387","journal-title":"J Rheum Dis"},{"issue":"3","key":"1717_CR4","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4078\/jrd.2024.0045","volume":"31","author":"JG Ahn","year":"2024","unstructured":"Ahn\u00a0JG (2024) Overview of childhood vasculitis. J\u00a0Rheum Dis 31(3):135\u2013142","journal-title":"J Rheum Dis"},{"issue":"1","key":"1717_CR5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13075-024-03345-2","volume":"26","author":"X-Y Han","year":"2024","unstructured":"Han\u00a0X\u2011Y, Li\u00a0Z\u2011Y, Zhao\u00a0M\u2011H, Little\u00a0MA, Chen\u00a0M (2024) Malignancy is increased in patients with antineutrophil cytoplasmic antibody-associated vasculitis in China. Arthritis Res Ther 26(1):113","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"1717_CR6","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s11739-024-03577-9","volume":"19","author":"E Bilgin","year":"2024","unstructured":"Bilgin\u00a0E, Demirci\u00a0YT, Ulusoy \u00d6B et\u00a0al (2024) Unveiling cancer risk in ANCA-associated vasculitis: result from the Turkish Vasculitis Study Group (TRVaS). Intern Emerg Med 19(4):1025\u20131034","journal-title":"Intern Emerg Med"},{"issue":"3","key":"1717_CR7","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/acr2.11378","volume":"4","author":"J Tieu","year":"2022","unstructured":"Tieu\u00a0J, Lester\u00a0S, Raymond\u00a0W, Keen\u00a0H, Hill\u00a0CL, Nossent\u00a0J (2022) Cancer in Anti-Neutrophil Cytoplasm Antibody-Associated Vasculitis and Polyarteritis Nodosa in Australia: A\u00a0Population-Based Study. Acr Open Rheumatol 4(3):223\u2013230","journal-title":"Acr Open Rheumatol"},{"issue":"8","key":"1717_CR8","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.3899\/jrheum.181438","volume":"47","author":"C Heijl","year":"2020","unstructured":"Heijl\u00a0C, Westman\u00a0K, H\u00f6glund\u00a0P, Mohammad\u00a0AJ (2020) Malignancies in patients with antineutrophil cytoplasmic antibody-associated vasculitis: a\u00a0population-based cohort study. J\u00a0Rheumatol 47(8):1229\u20131237","journal-title":"J Rheumatol"},{"issue":"Suppl 111","key":"1717_CR9","first-page":"73","volume":"36","author":"J Yoo","year":"2018","unstructured":"Yoo\u00a0J, Ahn\u00a0SS, Jung\u00a0SM, Song\u00a0JJ, Park\u00a0YB, Lee\u00a0SW (2018) Cancer development in Korean patients with ANCA-associated vasculitis: a\u00a0single centre study. Clin Exp Rheumatol 36(Suppl 111):73\u201377","journal-title":"Clin Exp Rheumatol"},{"issue":"3","key":"1717_CR10","doi-asserted-by":"publisher","first-page":"314","DOI":"10.3899\/jrheum.160885","volume":"44","author":"EE van Daalen","year":"2017","unstructured":"van Daalen\u00a0EE, Rahmattulla\u00a0C, Wolterbeek\u00a0R, Bruijn\u00a0JA, Bajema\u00a0IM (2017) Incidence of Malignancy Prior to Antineutrophil Cytoplasmic Antibody\u2013associated Vasculitis Compared to the General Population. J\u00a0Rheumatol 44(3):314\u2013318","journal-title":"J Rheumatol"},{"issue":"1","key":"1717_CR11","first-page":"6013038","volume":"2017","author":"S Sriskandarajah","year":"2017","unstructured":"Sriskandarajah\u00a0S, Bostad\u00a0L, Myklebust\u00a0T\u00c5, M\u00f8ller\u00a0B, Skrede\u00a0S, Bj\u00f8rneklett\u00a0R (2017) Cancer in ANCA-Associated Glomerulonephritis: A\u00a0Registry-Based Cohort Study. Int J Nephrol 2017(1):6013038","journal-title":"Int J Nephrol"},{"issue":"12","key":"1717_CR12","doi-asserted-by":"publisher","first-page":"3270","DOI":"10.1002\/art.39317","volume":"67","author":"C Rahmattulla","year":"2015","unstructured":"Rahmattulla\u00a0C, Berden\u00a0AE, Wakker\u00a0SC et\u00a0al (2015) Incidence of malignancies in patients with antineutrophil cytoplasmic antibody\u2013associated vasculitis diagnosed between 1991 and 2013. Arthritis Rheumatol 67(12):3270\u20133278","journal-title":"Arthritis Rheumatol"},{"key":"1717_CR13","doi-asserted-by":"crossref","unstructured":"Zycinska K, Kostrzewa-Janicka J, Nitsch-Osuch A, Wardyn K (2013) Cancer incidence in pulmonary vasculitis. Neurobiol Respir: 349\u2013353","DOI":"10.1007\/978-94-007-6627-3_47"},{"issue":"1","key":"1717_CR14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/art.27763","volume":"63","author":"JU Holle","year":"2011","unstructured":"Holle\u00a0JU, Gross\u00a0WL, Latza\u00a0U et\u00a0al (2011) Improved outcome in 445 patients with Wegener\u2019s granulomatosis in a\u00a0German vasculitis center over four decades. Arthritis Rheum 63(1):257\u2013266","journal-title":"Arthritis Rheum"},{"issue":"8","key":"1717_CR15","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1136\/ard.2010.145250","volume":"70","author":"C Heijl","year":"2011","unstructured":"Heijl\u00a0C, Harper\u00a0L, Flossmann\u00a0O et\u00a0al (2011) Incidence of malignancy in patients treated for antineutrophil cytoplasm antibody-associated vasculitis: follow-up data from European Vasculitis Study Group clinical trials. Ann Rheum Dis 70(8):1415\u20131421","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"1717_CR16","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/ijc.10444","volume":"100","author":"A Knight","year":"2002","unstructured":"Knight\u00a0A, Askling\u00a0J, Ekbom\u00a0A (2002) Cancer incidence in a\u00a0population-based cohort of patients with Wegener\u2019s granulomatosis. Intl Journal of Cancer 100(1):82\u201385","journal-title":"Intl Journal of Cancer"},{"issue":"5","key":"1717_CR17","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1681\/ASN.V95842","volume":"9","author":"K Westman","year":"1998","unstructured":"Westman\u00a0K, Bygren\u00a0PG, Olsson\u00a0H, Ranstam\u00a0J, Wieslander\u00a0J (1998) Relapse rate, renal survival, and cancer morbidity in patients with Wegener\u2019s granulomatosis or microscopic polyangiitis with renal involvement. J\u00a0Am Soc Nephrol 9(5):842\u2013852","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"1717_CR18","doi-asserted-by":"publisher","first-page":"108","DOI":"10.4078\/jrd.2023.0059","volume":"31","author":"P Waitayangkoon","year":"2024","unstructured":"Waitayangkoon\u00a0P, Leesutipornchai\u00a0T, Techasatian\u00a0W et\u00a0al (2024) Urate-lowering therapy is associated with a\u00a0reduced risk of arrhythmias: a\u00a0systematic review and meta-analysis. J\u00a0Rheum Dis 31(2):108\u2013115","journal-title":"J Rheum Dis"},{"issue":"1","key":"1717_CR19","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4078\/jrd.2024.0095","volume":"32","author":"YH Lee","year":"2025","unstructured":"Lee\u00a0YH, Song\u00a0GG (2025) Associations between circulating interleukin-18\u00a0levels and adult-onset Still\u2019s disease: a\u00a0meta-analysis. J\u00a0Rheum Dis 32(1):48\u201356","journal-title":"J Rheum Dis"},{"issue":"9085","key":"1717_CR20","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/S0140-6736(05)63833-0","volume":"350","author":"DG Smith","year":"1997","unstructured":"Smith\u00a0DG, Egger\u00a0M (1997) Meta-analyses of randomised controlled trials. Lancet 350(9085):1182","journal-title":"Lancet"},{"issue":"11","key":"1717_CR21","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/sim.1186","volume":"21","author":"JP Higgins","year":"2002","unstructured":"Higgins\u00a0JP, Thompson\u00a0SG (2002) Quantifying heterogeneity in a\u00a0meta-analysis. Stat Med 21(11):1539\u20131558","journal-title":"Stat Med"},{"issue":"2","key":"1717_CR22","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3904\/kjim.2016.195","volume":"33","author":"YH Lee","year":"2017","unstructured":"Lee\u00a0YH (2017) An overview of meta-analysis for clinicians. Korean J Intern Med 33(2):277\u2013283","journal-title":"Korean J Intern Med"},{"issue":"2","key":"1717_CR23","doi-asserted-by":"publisher","first-page":"122","DOI":"10.4078\/jrd.2024.0103","volume":"32","author":"YH Lee","year":"2025","unstructured":"Lee\u00a0YH, Song\u00a0GG (2025) Circulating VEGF levels and genetic polymorphisms in Behçet’s disease: a\u00a0meta-analysis. J\u00a0Rheum Dis 32(2):122\u2013129","journal-title":"J Rheum Dis"},{"issue":"3","key":"1717_CR24","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3343\/alm.2015.35.3.283","volume":"35","author":"YH Lee","year":"2015","unstructured":"Lee\u00a0YH (2015) Meta-analysis of genetic association studies. Ann Lab Med 35(3):283","journal-title":"Ann Lab Med"},{"key":"1717_CR25","volume-title":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses","author":"G Wells","year":"2000","unstructured":"Wells\u00a0G, Shea\u00a0B, O\u2019connell\u00a0D et\u00a0al (2000) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses"},{"issue":"7","key":"1717_CR26","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher\u00a0D, Liberati\u00a0A, Tetzlaff\u00a0J, Altman\u00a0DG, Group\u00a0P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):e1000097","journal-title":"PLoS Med"},{"issue":"7109","key":"1717_CR27","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger\u00a0M, Smith\u00a0DG, Schneider\u00a0M, Minder\u00a0C (1997) Bias in meta-analysis detected by a\u00a0simple, graphical test. BMJ 315(7109):629\u2013634","journal-title":"BMJ"},{"issue":"2","key":"1717_CR28","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","volume":"56","author":"S Duval","year":"2000","unstructured":"Duval\u00a0S, Tweedie\u00a0R (2000) Trim and fill: A\u00a0simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56(2):455\u2013463","journal-title":"Biometrics"},{"issue":"5","key":"1717_CR29","doi-asserted-by":"publisher","first-page":"e0126016","DOI":"10.1371\/journal.pone.0126016","volume":"10","author":"W Shang","year":"2015","unstructured":"Shang\u00a0W, Ning\u00a0Y, Xu\u00a0X et\u00a0al (2015) Incidence of cancer in ANCA-associated vasculitis: a\u00a0meta-analysis of observational studies. PLoS ONE 10(5):e126016","journal-title":"PLoS ONE"},{"issue":"1","key":"1717_CR30","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s12350-018-1406-5","volume":"26","author":"S-W Lee","year":"2019","unstructured":"Lee\u00a0S\u2011W, Kim\u00a0S\u2011J, Seo\u00a0Y, Jeong\u00a0SY, Ahn\u00a0B\u2011C, Lee\u00a0J (2019) F\u201118 FDG PET for assessment of disease activity of large vessel vasculitis: A\u00a0systematic review and meta-analysis. J\u00a0Nucl Cardiol 26(1):59\u201367","journal-title":"J Nucl Cardiol"},{"key":"1717_CR31","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s00393-014-1415-y","volume":"74(3","author":"Y Lee","year":"2015","unstructured":"Lee\u00a0Y, Bae\u00a0S, Kim\u00a0J, Song\u00a0G (2015) Meta-analysis of genetic polymorphisms in programmed cell death 1. Associations with rheumatoid arthritis, ankylosing spondylitis, and type\u00a01 diabetes susceptibility. Z\u00a0Rheumatol 74(3:230\u2013239","journal-title":"Z Rheumatol"}],"container-title":["Zeitschrift f\u00fcr Rheumatologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-025-01717-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00393-025-01717-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-025-01717-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:45:55Z","timestamp":1765547155000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00393-025-01717-w"}},"subtitle":["A\u00a0meta-analysis","Eine Metaanalyse"],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":31,"journal-issue":{"issue":"S5","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1717"],"URL":"https:\/\/doi.org\/10.1007\/s00393-025-01717-w","relation":{},"ISSN":["0340-1855","1435-1250"],"issn-type":[{"type":"print","value":"0340-1855"},{"type":"electronic","value":"1435-1250"}],"subject":[],"published":{"date-parts":[[2025,9,1]]},"assertion":[{"value":"14 August 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Y.H.\u00a0Lee and G.G.\u00a0Song declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this article no studies with human participants or animals were performed by any of the authors. All studies mentioned were in accordance with the ethical standards indicated in each case.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}