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Aufgrund dessen sind SSc-Patienten \u00fcberm\u00e4\u00dfig h\u00e4ufig von Osteoporose betroffen, die im Kontext der SSc bislang unzureichend charakterisiert ist und im Praxisalltag oftmals untergeht.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ziel<\/jats:title>\n                    <jats:p>Darstellung der aktuellen Evidenzlage zur Epidemiologie, pathophysiologischen Mechanismen, diagnostischen Besonderheiten sowie therapeutischen Herausforderungen der Osteoporose im Kontext der SSc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodik<\/jats:title>\n                    <jats:p>Narrative \u00dcbersicht relevanter Prim\u00e4r- und Sekund\u00e4rliteratur (2003\u20132025) aus PubMed, Embase und aktuellen Leitlinienquellen mit Fokus auf osteologische Aspekte bei SSc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>Patienten mit SSc zeigen eine signifikant erh\u00f6hte Pr\u00e4valenz von Osteoporose und Frakturen. Die SSc aggraviert \u00fcber Vaskulopathie, Fibrose wie auch Autoimmunit\u00e4t\/Entz\u00fcndungsaktivit\u00e4t Risikofaktoren der Osteoporose wie postmenopausaler Status, Malnutrition und Untergewicht. Diagnostisch erweist sich der Trabecular Bone Score (TBS) als erg\u00e4nzendes Verfahren zur Frakturrisikobeurteilung. Die SSc erschwert v.\u202fa. \u00fcber die gastrointestinale Manifestation zudem die osteospezifische Therapie, insbesondere orale Bisphosphonate scheinen weniger gut zu wirken. Erste Hinweise auf die Wirksamkeit parenteraler Antiresorptiva liegen vor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diskussion<\/jats:title>\n                    <jats:p>Die Osteoporose bei SSc erfordert ein krankheitsspezifisches Risikomanagement und ein individualisiertes diagnostisches sowie therapeutisches Vorgehen. Weitere prospektive Studien sind notwendig, um evidenzbasierte Therapieempfehlungen zu etablieren.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00393-025-01739-4","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:38:26Z","timestamp":1760092706000},"page":"233-239","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapie der Osteoporose bei systemischer Sklerose","Osteoporosis treatment in systemic sclerosis"],"prefix":"10.1007","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0378-3766","authenticated-orcid":false,"given":"Nils","family":"Schulz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"M\u00fcller-Ladner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Klemm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"1739_CR1","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s10067-022-06460-0","volume":"42","author":"X Tu","year":"2023","unstructured":"Tu\u00a0X, Li\u00a0C, Zhuang\u00a0M, Liu\u00a0L, Xu\u00a0C, Wang\u00a0J (2023) High prevalence and risk factors for osteoporosis in 1839 patients with systemic sclerosis: a\u00a0systematic review and meta-analysis. 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