{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:23:07Z","timestamp":1786112587428,"version":"build-2736575974"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Z Rheumatol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Bewegungstherapie ist ein zentraler Bestandteil der Behandlung der axialen Spondyloarthritis (axSpA) und wird in der deutschen S3-Leitlinie unabh\u00e4ngig von der medikament\u00f6sen Therapie als Basisma\u00dfnahme empfohlen. In der Versorgungspraxis wird eine kontinuierliche physiotherapeutische Betreuung jedoch h\u00e4ufig nicht ausreichend umgesetzt. Digitale Gesundheitsanwendungen (DiGA) k\u00f6nnten dazu beitragen, leitliniengerechte Bewegungstherapie im Alltag besser zu unterst\u00fctzen.<\/jats:p>\n                  <jats:p>Mit der App Axia\u00a0\u2013 f\u00fcr axiale Spondyloarthritis steht erstmals eine dauerhaft im DiGA-Verzeichnis des Bundesinstituts f\u00fcr Arzneimittel und Medizinprodukte (BfArM) gelistete digitale Therapie f\u00fcr eine entz\u00fcndlich-rheumatische Erkrankung zur Verf\u00fcgung. Die Anwendung kombiniert evidenzbasierte Bewegungstherapie mit edukativen Inhalten und strukturierten Selbstmanagement-Elementen und richtet sich an Patientinnen und Patienten mit axSpA.<\/jats:p>\n                  <jats:p>Die klinische Wirksamkeit wurde im prospektiven, randomisiert-kontrollierten Bechterew-App-Trial untersucht. Insgesamt wurden 200 Patientinnen und Patienten mit gesicherter axSpA unter stabiler medikament\u00f6ser Therapie randomisiert; 186 schlossen die 12-w\u00f6chige Studie vollst\u00e4ndig ab. Die Interventionsgruppe nutzte Axia zus\u00e4tzlich zur Standardversorgung, w\u00e4hrend die Kontrollgruppe ausschlie\u00dflich Standardversorgung erhielt.<\/jats:p>\n                  <jats:p>\n                    Nach 12\u00a0Wochen zeigte sich ein signifikanter Vorteil zugunsten der Interventionsgruppe in allen koprim\u00e4ren Endpunkten: Krankheitsaktivit\u00e4t (BASDAI \u22121,51), Funktionsf\u00e4higkeit (BASFI \u22121,14) und krankheitsspezifische Lebensqualit\u00e4t (ASQoL \u22122,30; jeweils\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&lt;\u20090,001). Auch in den Responderanalysen zeigte sich ein h\u00f6heres Ansprechen (ASAS20: 51\u202f% vs.\u00a09\u202f%; ASAS40: 23\u202f% vs.\u00a03\u202f%).\n                  <\/jats:p>\n                  <jats:p>Sicherheitsrelevante Ereignisse wurden nicht berichtet.<\/jats:p>\n                  <jats:p>Die Ergebnisse zeigen, dass eine digital vermittelte Bewegungstherapie bei axSpA klinisch relevante Verbesserungen erzielen kann. Damit steht erstmals eine evidenzbasierte, verordnungsf\u00e4hige digitale Erg\u00e4nzung zur leitliniengerechten Therapie der axSpA zur Verf\u00fcgung.<\/jats:p>","DOI":"10.1007\/s00393-026-01826-0","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:48:48Z","timestamp":1778161728000},"page":"469-472","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Erste zugelassene rheumatologische DiGA f\u00fcr die axiale Spondyloarthritis","First approved rheumatological digital health application for axial spondyloarthritis"],"prefix":"10.1007","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0582-7790","authenticated-orcid":false,"given":"Martin","family":"Krusche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"issue":"Suppl 1","key":"1826_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00393-019-0670-3","volume":"78","author":"U Kiltz","year":"2019","unstructured":"Kiltz\u00a0U, Braun\u00a0J, DGRh, Becker\u00a0A, DEGAM, Chenot\u00a0JF et\u00a0al (2019) Long version on the S3 guidelines for axial spondyloarthritis including Bechterew\u2019s disease and early forms, Update 2019 : Evidence-based guidelines of the German Society for Rheumatology (DGRh) and participating medical scientific specialist societies and other organizations. Z\u00a0Rheumatol 78(Suppl 1):3\u201364. https:\/\/doi.org\/10.1007\/s00393-019-0670-3","journal-title":"Z Rheumatol"},{"issue":"5","key":"1826_CR2","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1007\/s00393-022-01180-x","volume":"81","author":"K Albrecht","year":"2022","unstructured":"Albrecht\u00a0K, Marschall\u00a0U, Zink\u00a0A, Callhoff\u00a0J (2022) Verordnungsh\u00e4ufigkeit von physikalischer Therapie bei entz\u00fcndlich rheumatischen Erkrankungen. Z\u00a0F\u00fcr Rheumatol 81(5):360\u2013368. https:\/\/doi.org\/10.1007\/s00393-022-01180-x","journal-title":"Z F\u00fcr Rheumatol"},{"issue":"10","key":"1826_CR3","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s00393-025-01731-y","volume":"84","author":"PP Strunz","year":"2025","unstructured":"Strunz\u00a0PP, Kiltz\u00a0U, Kiefer\u00a0D, Schmalzing\u00a0M (2025) Digital health applications and axial spondyloarthritis. Z\u00a0Rheumatol 84(10):805\u2013810. https:\/\/doi.org\/10.1007\/s00393-025-01731-y","journal-title":"Z Rheumatol"},{"issue":"6","key":"1826_CR4","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s00296-024-05600-w","volume":"44","author":"PP Strunz","year":"2024","unstructured":"Strunz\u00a0PP, Le Maire\u00a0M, Heusinger\u00a0T, Klein\u00a0J, Labinsky\u00a0H, Fleischer\u00a0A et\u00a0al (2024) The exercise-app Axia for axial spondyloarthritis enhances the home-based exercise frequency in axial spondyloarthritis patients - A cross-sectional survey. Rheumatol Int 44(6):1143\u20131154. https:\/\/doi.org\/10.1007\/s00296-024-05600-w","journal-title":"Rheumatol Int"},{"key":"1826_CR5","doi-asserted-by":"crossref","unstructured":"Strunz PP, Froehlich M, Heusinger T, Le Maire M, Fleischer A, Luetkens KS, u.\u202fa. An app-based nonpharmacological intervention improves patient-reported disease activity, functionality, and quality of life in patients with axial spondyloarthritis: a\u00a0randomised controlled trial. Ann Rheum Dis. M\u00e4rz 2026;S0003496726000981. https:\/\/doi.org\/10.1016\/j.ard.2026.02.016","DOI":"10.1016\/j.ard.2026.02.016"},{"issue":"10","key":"1826_CR6","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s00393-024-01570-3","volume":"83","author":"J Knitza","year":"2024","unstructured":"Knitza\u00a0J, Krusche\u00a0M, Chehab\u00a0G, Specker\u00a0C, Richter\u00a0JG (2024) Digital health applications-What we should know as rheumatologists. 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