{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:23:13Z","timestamp":1786112593207,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Z Rheumatol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00393-026-01849-7","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:10:50Z","timestamp":1783426250000},"page":"450-457","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunzellpopulationen in der rheumatoiden Arthritis und Riesenzellarteriitis","Immune cell populations in rheumatoid arthritis and giant cell arteritis"],"prefix":"10.1007","volume":"85","author":[{"given":"Laurin","family":"Braune","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"1849_CR1","volume":"44","author":"M Anandan","year":"2025","unstructured":"Anandan\u00a0M, Narayanan\u00a0J (2025) Role of T cells and cytokines in the pathogenesis of rheumatoid arthritis. Biochem Biophys Rep 44:102278","journal-title":"Biochem Biophys Rep"},{"issue":"1","key":"1849_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-025-01180-1","volume":"27","author":"A Chin","year":"2025","unstructured":"Chin\u00a0A et\u00a0al (2025) T Cell Dysregulation in Rheumatoid Arthritis: from Genetic Susceptibility to Established Disease. Curr Rheumatol Rep 27(1):14","journal-title":"Curr Rheumatol Rep"},{"issue":"5","key":"1849_CR3","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1136\/annrheumdis-2021-221865","volume":"81","author":"MC Cid","year":"2022","unstructured":"Cid\u00a0MC et\u00a0al (2022) Efficacy and safety of mavrilimumab in giant cell arteritis: a phase 2, randomised, double-blind, placebo-controlled trial. Ann Rheum Dis 81(5):653\u2013661","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"1849_CR4","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1002\/art.22025","volume":"54","author":"SB Cohen","year":"2006","unstructured":"Cohen\u00a0SB et\u00a0al (2006) Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum 54(9):2793\u20132806","journal-title":"Arthritis Rheum"},{"key":"1849_CR5","doi-asserted-by":"publisher","first-page":"4741","DOI":"10.2147\/JIR.S503144","volume":"18","author":"Y Deng","year":"2025","unstructured":"Deng\u00a0Y, Li\u00a0J, Wu\u00a0R (2025) Neutrophils in Rheumatoid Arthritis Synovium: Implications on Disease Activity and Inflammation State. J\u00a0Inflamm Res 18:4741\u20134753","journal-title":"J Inflamm Res"},{"issue":"10416","key":"1849_CR6","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","volume":"402","author":"A Di Matteo","year":"2023","unstructured":"Di Matteo\u00a0A, Bathon\u00a0JM, Emery\u00a0P (2023) Rheumatoid arthritis. Lancet 402(10416):2019\u20132033","journal-title":"Lancet"},{"issue":"6","key":"1849_CR7","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.immuni.2015.05.015","volume":"42","author":"D Hu","year":"2015","unstructured":"Hu\u00a0D et\u00a0al (2015) Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin \u03b2 Receptors. Immunity 42(6):1100\u20131115","journal-title":"Immunity"},{"issue":"1","key":"1849_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17749-6","volume":"11","author":"E J\u00e4ger","year":"2020","unstructured":"J\u00e4ger\u00a0E et\u00a0al (2020) Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis. Nat Commun 11(1):4243","journal-title":"Nat Commun"},{"issue":"1","key":"1849_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-025-00534-8","volume":"19","author":"A Jain","year":"2025","unstructured":"Jain\u00a0A et\u00a0al (2025) Targeting rheumatoid arthritis: a molecular perspective on biologic therapies and clinical progress. J\u00a0Biol Eng 19(1):67","journal-title":"J Biol Eng"},{"issue":"1","key":"1849_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2024.111185","volume":"86","author":"HR Kim","year":"2025","unstructured":"Kim\u00a0HR et\u00a0al (2025) Natural killer cell activity and its relationship with disease activity in rheumatoid arthritis patients. Hum Immunol 86(1):111185","journal-title":"Hum Immunol"},{"issue":"4","key":"1849_CR11","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1002\/art.40044","volume":"69","author":"CA Langford","year":"2017","unstructured":"Langford\u00a0CA et\u00a0al (2017) A Randomized, Double-Blind Trial of Abatacept (CTLA-4Ig) for the Treatment of Giant Cell Arteritis. Arthritis & Rheumatology 69(4):837\u2013845","journal-title":"Arthritis & Rheumatology"},{"issue":"1","key":"1849_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44304-w","volume":"15","author":"Y Lei","year":"2024","unstructured":"Lei\u00a0Y et\u00a0al (2024) Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis. Nat Commun 15(1):113","journal-title":"Nat Commun"},{"issue":"2","key":"1849_CR13","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1084\/jem.20030850","volume":"199","author":"W Ma-Krupa","year":"2004","unstructured":"Ma-Krupa\u00a0W et\u00a0al (2004) Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. J\u00a0Exp Med 199(2):173\u2013183","journal-title":"J Exp Med"},{"issue":"4","key":"1849_CR14","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1093\/rheumatology\/keab505","volume":"61","author":"DA Palamidas","year":"2022","unstructured":"Palamidas\u00a0DA et\u00a0al (2022) Neutrophil extracellular traps in giant cell arteritis biopsies: presentation, localization and co-expression with inflammatory cytokines. Rheumatology (Oxford) 61(4):1639\u20131644","journal-title":"Rheumatology (Oxford)"},{"key":"1849_CR15","doi-asserted-by":"crossref","unstructured":"Paroli M, Caccavale R, Accapezzato D (2024) Giant Cell Arteritis: Advances in Understanding Pathogenesis and Implications for Clinical Practice. Cells 13(3)","DOI":"10.3390\/cells13030267"},{"issue":"7639","key":"1849_CR16","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature20810","volume":"542","author":"DA Rao","year":"2017","unstructured":"Rao\u00a0DA et\u00a0al (2017) Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature 542(7639):110\u2013114","journal-title":"Nature"},{"issue":"1","key":"1849_CR17","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1093\/rheumatology\/keac250","volume":"62","author":"RD Reitsema","year":"2022","unstructured":"Reitsema\u00a0RD et\u00a0al (2022) Phenotypic, transcriptomic and functional profiling reveal reduced activation thresholds of CD8+ T cells in giant cell arteritis. Rheumatology (Oxford) 62(1):417\u2013427","journal-title":"Rheumatology (Oxford)"},{"issue":"9","key":"1849_CR18","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1332","volume":"10","author":"M Samson","year":"2021","unstructured":"Samson\u00a0M et\u00a0al (2021) Improvement of Treg immune response after treatment with tocilizumab in giant cell arteritis. Clin Transl Immunology 10(9):e1332","journal-title":"Clin Transl Immunology"},{"key":"1849_CR19","doi-asserted-by":"crossref","unstructured":"Shiomi M et\u00a0al (2025) Uncovering the New Biology of Giant Cell Arteritis to Guide Therapeutic Strategies. J\u00a0Clin Med 14(18)","DOI":"10.3390\/jcm14186350"},{"key":"1849_CR20","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.bcp.2019.03.029","volume":"165","author":"E Siouti","year":"2019","unstructured":"Siouti\u00a0E, Andreakos\u00a0E (2019) The many facets of macrophages in rheumatoid arthritis. Biochem Pharmacol 165:152\u2013169","journal-title":"Biochem Pharmacol"},{"key":"1849_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1058600","volume":"9","author":"P Stamatis","year":"2022","unstructured":"Stamatis\u00a0P et\u00a0al (2022) Pathogenesis of giant cell arteritis with focus on cellular populations. Front Med (Lausanne) 9:1058600","journal-title":"Front Med (Lausanne)"},{"issue":"4","key":"1849_CR22","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1056\/NEJMoa1613849","volume":"377","author":"JH Stone","year":"2017","unstructured":"Stone\u00a0JH et\u00a0al (2017) Trial of Tocilizumab in Giant-Cell Arteritis. N Engl J Med 377(4):317\u2013328","journal-title":"N Engl J Med"},{"issue":"1","key":"1849_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-023-03259-5","volume":"26","author":"J Straube","year":"2024","unstructured":"Straube\u00a0J et\u00a0al (2024) PD\u20111 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis. Arthritis Res Ther 26(1):32","journal-title":"Arthritis Res Ther"},{"key":"1849_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1161148","volume":"14","author":"Y Suwa","year":"2023","unstructured":"Suwa\u00a0Y et\u00a0al (2023) The role of dendritic cells and their immunometabolism in rheumatoid arthritis. Front Immunol 14:1161148","journal-title":"Front Immunol"},{"issue":"2","key":"1849_CR25","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s40744-017-0086-y","volume":"4","author":"H Tahir","year":"2017","unstructured":"Tahir\u00a0H et\u00a0al (2017) Secukinumab in Active Rheumatoid Arthritis after Anti-TNF\u03b1 Therapy: A Randomized, Double-Blind Placebo-Controlled Phase 3 Study. Rheumatol Ther 4(2):475\u2013488","journal-title":"Rheumatol Ther"},{"issue":"1","key":"1849_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06826-4","volume":"7","author":"Y van Sleen","year":"2017","unstructured":"van Sleen\u00a0Y et\u00a0al (2017) Involvement of Monocyte Subsets in the Immunopathology of Giant Cell Arteritis. Sci Rep 7(1):6553","journal-title":"Sci Rep"},{"issue":"4","key":"1849_CR27","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.jbspin.2016.07.005","volume":"84","author":"R Watanabe","year":"2017","unstructured":"Watanabe\u00a0R et\u00a0al (2017) Pro-inflammatory and anti-inflammatory T cells in giant cell arteritis. Joint Bone Spine 84(4):421\u2013426","journal-title":"Joint Bone Spine"},{"issue":"6","key":"1849_CR28","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1161\/CIRCRESAHA.118.313206","volume":"123","author":"R Watanabe","year":"2018","unstructured":"Watanabe\u00a0R et\u00a0al (2018) MMP (Matrix Metalloprotease)-9-Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis. Circ Res 123(6):700\u2013715","journal-title":"Circ Res"},{"key":"1849_CR29","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1196\/annals.1358.023","volume":"1062","author":"CM Weyand","year":"2005","unstructured":"Weyand\u00a0CM et\u00a0al (2005) Vascular dendritic cells in giant cell arteritis. Ann N Y Acad Sci 1062:195\u2013208","journal-title":"Ann N Y Acad Sci"},{"issue":"7987","key":"1849_CR30","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/s41586-023-06708-y","volume":"623","author":"F Zhang","year":"2023","unstructured":"Zhang\u00a0F et\u00a0al (2023) Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes. Nature 623(7987):616\u2013624","journal-title":"Nature"}],"container-title":["Zeitschrift f\u00fcr Rheumatologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-026-01849-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00393-026-01849-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00393-026-01849-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:21:03Z","timestamp":1785943263000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00393-026-01849-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["1849"],"URL":"https:\/\/doi.org\/10.1007\/s00393-026-01849-7","relation":{},"ISSN":["0340-1855","1435-1250"],"issn-type":[{"value":"0340-1855","type":"print"},{"value":"1435-1250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"21 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"L.\u00a0Braune und C.\u00a0Schmidt geben an, dass kein Interessenkonflikt besteht.","order":1,"name":"Ethics","label":"Interessenkonflikt","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}}]}}