{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:00:24Z","timestamp":1760644824809},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2004,8,17]],"date-time":"2004-08-17T00:00:00Z","timestamp":1092700800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1007\/s00394-004-0516-9","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:22:39Z","timestamp":1092439359000},"page":"242-249","source":"Crossref","is-referenced-by-count":22,"title":["Effect of folate\u2013binding protein on intestinal transport of folic acid and 5\u2013methyltetrahydrofolate across Caco\u20132 cells"],"prefix":"10.1007","volume":"44","author":[{"given":"M.","family":"Verwei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Havenaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Groten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,8,17]]},"reference":[{"key":"516_CR1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S1368980000000173","volume":"3","author":"Fishman","year":"2000","unstructured":"Fishman SM, Christian P, West KP (2000) The role of vitamins in the prevention and control of anaemia. Public Health Nutr 3:125\u2013150","journal-title":"Public Health Nutr"},{"key":"516_CR2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0140-6736(91)92605-2","volume":"338","author":"Wald","year":"1991","unstructured":"Wald N, Sneddon J, Frost C, Stone R (1991) MRC Vitamin Study Group Prevention of neural tube defects. Results of the Medical Research Council Vitamin Study. Lancet 338:131\u2013137","journal-title":"Lancet"},{"key":"516_CR3","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1001\/jama.1995.03530210052030","volume":"247","author":"Daly","year":"1995","unstructured":"Daly LE, Kirke PN, Molloy A, Weir DG, Scott JM (1995) Folate levels and neural tube defects. J Am Med Assoc 247:1698\u20131702","journal-title":"J Am Med Assoc"},{"key":"516_CR4","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S0002-8223(02)90281-6","volume":"102","author":"Rampersaud","year":"2002","unstructured":"Rampersaud GC, Bailey LB, Kauwell GPA (2002) Relationship of folate to colorectal and cervical cancer: review and recommendations for practitioners. J Am Diet Assoc 102:1273\u20131282","journal-title":"J Am Diet Assoc"},{"key":"516_CR5","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.1995.03530130055028","volume":"274","author":"Boushey","year":"1996","unstructured":"Boushey CJ, Beresford AA, Omen GS, Motulsky AG (1996) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. J Am Med Assoc 274:1049\u20131057","journal-title":"J Am Med Assoc"},{"key":"516_CR6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/00041433-200012000-00003","volume":"11","author":"Graham","year":"2000","unstructured":"Graham IA, O\u2019Allaghan P (2000) The role of folic acid in the prevention of cardiovascular disease. Curr Opin Lipidol 11:577\u2013587","journal-title":"Curr Opin Lipidol"},{"key":"516_CR7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/sj.ejcn.1600467","volume":"51","author":"De Bree","year":"1997","unstructured":"De Bree A, Van Dusseldorp M, Brouwer IA, Van het Hof KH, Steegers-Theunissen RP (1997) Folate intake in Europe: recommended, actual and desired intake. Eur J Clin Nutr 51:643\u2013660","journal-title":"Eur J Clin Nutr"},{"key":"516_CR8","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/ajcn\/73.4.765","volume":"73","author":"Konings","year":"2001","unstructured":"Konings EJM, Roomans H, Dorant E, Goldbohm R, Saris W, van den Brandt P (2001) Folate intake of the Dutch population based newly established liquid chromatography data for foods. Am J Clin Nutr 73:765\u2013776","journal-title":"Am J Clin Nutr"},{"key":"516_CR9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/jn\/120.2.172","volume":"120","author":"Swiatlo","year":"1990","unstructured":"Swiatlo N, O\u2019Conner DL, Andrews J, Picciano MF (1990) Relative folate bioavailability from diets containing human, bovine and goat milk. J Nutr 120:172\u2013177","journal-title":"J Nutr"},{"key":"516_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ajcn\/20.1.1","volume":"20","author":"Ghitis","year":"1967","unstructured":"Ghitis J (1967) The folate binding in milk. Am J Clin Nutr 20:1\u20134","journal-title":"Am J Clin Nutr"},{"key":"516_CR11","first-page":"293","volume":"43","author":"Wagner","year":"1985","unstructured":"Wagner C (1985) Folate Binding Proteins. Nutr Rev 43:293\u2013299","journal-title":"Nutr Rev"},{"key":"516_CR12","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1042\/bj1930469","volume":"193","author":"Salter","year":"1981","unstructured":"Salter DN, Scott KJ, Slade H, Andrews P (1981) The preparation and properties of folate-binding protein from cow\u2019s milk. Biochem J 193:469\u2013476","journal-title":"Biochem J"},{"key":"516_CR13","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1023\/A:1015576522416","volume":"21","author":"Holm","year":"2001","unstructured":"Holm J,Hansen SI (2001) Binding of radiolabeled folate and 5-methyltetrahydrofolate to cow\u2019s milk folate binding protein at pH 7.4 and 5.0. Relationship to concentration and polymerization equilibrium of the purified protein. Biosci Rep 21:733\u2013743","journal-title":"Biosci Rep"},{"key":"516_CR14","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1093\/jn\/133.7.2377","volume":"133","author":"Verwei","year":"2003","unstructured":"Verwei M, Arkb\u00e5ge K, Havenaar R, van den Berg H, Witth\u00f6ft C, Schaafsma G (2003) Folic acid and 5-Methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model. J Nutr 133:2377\u20132383","journal-title":"J Nutr"},{"key":"516_CR15","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1093\/jn\/133.11.3678","volume":"133","author":"Arkb\u00e5ge","year":"2003","unstructured":"Arkb\u00e5ge K, Verwei M, Havenaar R, Witth\u00f6ft C (2003) Addition of folate-binding protein lowers the bioaccessibility of folic acid and 5-methyltetrahydrofolate from fortified yogurt as studied in a dynamic in vitro gastrointestinal model. J Nutr 133:3678\u20133683","journal-title":"J Nutr"},{"key":"516_CR16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/jn\/134.1.31","volume":"134","author":"Verwei","year":"2004","unstructured":"Verwei M, Arkb\u00e5ge K, Mocking H, Havenaar R, Groten J (2004) The FBP binding characteristics during gastric passage are different for folic acid and 5-CH3H4 folate as studied in a dynamic in vitro gastrointestinal model. J Nutr 134:31\u201337","journal-title":"J Nutr"},{"key":"516_CR17","first-page":"567","volume":"249","author":"Said","year":"1985","unstructured":"Said HM, Grishan FK, Murrell JE (1985) Ontogenesis of the intestinal transport of 5-methyltetrahydrofolate in the rat. Am J Physiol 249:567\u2013571","journal-title":"Am J Physiol"},{"key":"516_CR18","first-page":"95","volume":"226","author":"Said","year":"1983","unstructured":"Said HM, Strum WB (1983) A pH-dependent, carrier-mediated system for transport of 5-methyltetrahydrofolate in rat jejunum. J Pharmacol Exp Ther 226:95\u201399","journal-title":"J Pharmacol Exp Ther"},{"key":"516_CR19","first-page":"G515","volume":"246","author":"Selhub","year":"1984","unstructured":"Selhub J, Powell GM, Rosenberg IH (1984) Intestinal transport of 5-methyltetrahydrofolate. Am J Physiol 246:G515\u2013G520","journal-title":"Am J Physiol"},{"key":"516_CR20","first-page":"229","volume":"252","author":"Said","year":"1987","unstructured":"Said HM, Grishan FK, Redha R (1987) Folate transport by human intestinal brush-border membrane vesicles. Am J Physiol 252:229\u2013236","journal-title":"Am J Physiol"},{"key":"516_CR21","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.6781067","volume":"211","author":"Colman","year":"1981","unstructured":"Colman N, Hettiarachchy N, Herbert V (1981) Detection of a milk factor that facilitates folate uptake by intestinal cells. Science 211:1427\u20131429","journal-title":"Science"},{"key":"516_CR22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1079\/BJN19880059","volume":"59","author":"Salter","year":"1988","unstructured":"Salter D, Blakeborough P (1988) Influence of goat\u2019s-milk folate-binding protein on transport of 5-methyltetrahydrofolate in neonatal-goat small intestinal brush-border-membrane vesicles. Br J Nutr 59:497\u2013507","journal-title":"Br J Nutr"},{"key":"516_CR23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0003-9861(86)90057-3","volume":"251","author":"Said","year":"1986","unstructured":"Said HM, Horne DW, Wagner C (1986) Effect of human folate binding protein on folate intestinal transport. Archiv Biochem Biophys 251:114\u2013120","journal-title":"Archiv Biochem Biophys"},{"key":"516_CR24","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0304-4165(83)90051-X","volume":"757","author":"Tani","year":"1983","unstructured":"Tani M, Fushiki T, Iwai K (1983) Influence of folate binding protein from bovine milk on the absorption of folate in gastrointestinal tract of rat. Biochim Biophys Acta 757:274\u2013281","journal-title":"Biochim Biophys Acta"},{"key":"516_CR25","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/0016-5085(89)90897-4","volume":"96","author":"Hidalgo","year":"1989","unstructured":"Hidalgo IJ, Raub TJ, Borchardt RT (1989) Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96:736\u2013749","journal-title":"Gastroenterology"},{"key":"516_CR26","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/med.2610150202","volume":"15","author":"Hillgren","year":"1995","unstructured":"Hillgren KM, Kato A, Borchardt RT (1995) In vitro systems for studying intestinal drug absorption. Med Res Rev 15:82\u2013109","journal-title":"Med Res Rev"},{"key":"516_CR27","first-page":"355","volume":"39C","author":"Vincent","year":"1985","unstructured":"Vincent ML,Russell RM, Sasak V (1985) Folic acid uptake characteristics of a human colon carcinoma cell line Caco- 2. A newly described cellular model for small intestinal epithelium.Human Nutrition: Clinical Nutrition 39C:355\u2013360","journal-title":"Clinical Nutrition"},{"key":"516_CR28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/0006-291X(91)91647-U","volume":"175","author":"Artusson","year":"1991","unstructured":"Artusson P, Karlsson J (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Com 175:880\u2013885","journal-title":"Biochem Biophys Res Com"},{"key":"516_CR29","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1023\/A:1011930411574","volume":"15","author":"Yazdanian","year":"1998","unstructured":"Yazdanian M, Glynn SL, Wright JL, Hawi A (1998) Correlating partitioning and Caco-2 cell permeability of structurally diverse small molecular weight compounds. Pharm Res 15:1490\u20131494","journal-title":"Pharm Res"},{"key":"516_CR30","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1023\/A:1012102522787","volume":"14","author":"Yee","year":"1997","unstructured":"Yee S (1997) In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man \u2013 fact or myth. Pharm Res 14:763\u2013766","journal-title":"Pharm Res"},{"key":"516_CR31","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1023\/A:1011919003030","volume":"15","author":"Gr\u00e8s","year":"1998","unstructured":"Gr\u00e8s M-C, Julian B, Bourri\u00e9 M, Meunier V, Roques C, Berger M, Boulenc X, Berger Y, Fabre G (1998) Correlation between oral drug absorption in humans, and apparent drug permeability in TC- 7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line. Pharm Res 15:726\u2013733","journal-title":"Pharm Res"},{"key":"516_CR32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1018937416447","volume":"10","author":"Rubas","year":"1993","unstructured":"Rubas W, Jezyk N, Grass GM (1993) Comparison of the permeability characteristics of human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption. Pharm Res 10:113\u2013118","journal-title":"Pharm Res"},{"key":"516_CR33","first-page":"288","volume":"64","author":"Van den Berg","year":"1994","unstructured":"Van den Berg H, Finglas PM, Bates C (1994) FLAIR intercomparison on serum and red cell folate. Int J Vitam Nutr Res 64:288\u2013293","journal-title":"Int J Vitam Nutr Res"},{"key":"516_CR34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/A:1022210801734","volume":"20","author":"Faassen","year":"2003","unstructured":"Faassen F, Kelder J, Lenders J, Onderwater R, Vromans H (2003) Physicochemical properties and transport of steroids across Caco-2 cells. Pharm Res 20:177\u2013186","journal-title":"Pharm Res"},{"key":"516_CR35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0168-3659(97)00058-8","volume":"49","author":"Duizer","year":"1997","unstructured":"Duizer E, Penninks AH, Stenhuis WH, Groten JP (1997) Comparison of permeability characteristics of the human colonic Caco-2 and rat small intestinal IEC-18 cell lines. J Contr Rel 49:39\u201349","journal-title":"J Contr Rel"},{"key":"516_CR36","doi-asserted-by":"crossref","first-page":"100S","DOI":"10.1080\/07315724.2000.10718071","volume":"19","author":"Forss\u00e9n","year":"2000","unstructured":"Forss\u00e9n KM, J\u00e4gerstad MI, Wigertz K, Witth\u00f6ft CM (2000) Folates and dairy products: a critical update. J Am Coll Nutr 19:100S\u2013110S","journal-title":"J Am Coll Nutr"},{"key":"516_CR37","unstructured":"Shane B (1995) In: Bailey LB (ed) Folate in Health and Disease, Marcel Dekker, Inc., New York, pp 1\u201322"},{"key":"516_CR38","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1021\/bi00376a025","volume":"26","author":"Cichowicz","year":"1987","unstructured":"Cichowicz DJ, Shane B (1987) Mammalian folylpoly-\u03b3-glutamate synthetase. 2. substrate specificity and kinetic properties. Biochem 26:513\u2013521","journal-title":"Biochem"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-004-0516-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-004-0516-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-004-0516-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T12:37:44Z","timestamp":1559047064000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-004-0516-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,17]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["516"],"URL":"https:\/\/doi.org\/10.1007\/s00394-004-0516-9","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,17]]}}}