{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:30:06Z","timestamp":1791145806749,"version":"4.1.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2010,12,24]],"date-time":"2010-12-24T00:00:00Z","timestamp":1293148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1007\/s00394-010-0157-0","type":"journal-article","created":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T14:54:31Z","timestamp":1293116071000},"page":"507-522","source":"Crossref","is-referenced-by-count":122,"title":["Intestinal transit and systemic metabolism of apple polyphenols"],"prefix":"10.1007","volume":"50","author":[{"given":"Kathrin","family":"Kahle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kempf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schreier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Scheppach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Schrenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Kautenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Hecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Huemmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Ackermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Richling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,12,24]]},"reference":[{"key":"157_CR1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/1040869059096","volume":"45","author":"A Scalbert","year":"2005","unstructured":"Scalbert A, Manach C, Morand C, R\u00e9m\u00e9sy C, Jim\u00e9nez L (2005) Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 45:287\u2013306","journal-title":"Crit Rev Food Sci Nutr"},{"key":"157_CR2","unstructured":"Verband der deutschen Fruchtsaftindustrie e.V (VdF) (2008) Daten und Fakten zur deutschen Fruchtsaft-Industrie 2007. Bonn"},{"key":"157_CR3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1021\/jf020782a","volume":"51","author":"K Wolfe","year":"2003","unstructured":"Wolfe K, Wu X, Liu RH (2003) Antioxidant activity of apple peels. J Agric Food Chem 51:609\u2013614","journal-title":"J Agric Food Chem"},{"key":"157_CR4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1475-2891-3-5","volume":"3","author":"J Boyer","year":"2004","unstructured":"Boyer J, Liu RH (2004) Apple phytochemicals and their health benefits. Nutr J 3:5\u201320","journal-title":"Nutr J"},{"key":"157_CR5","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1093\/carcin\/bgi074","volume":"26","author":"F Goss\u00e9","year":"2005","unstructured":"Goss\u00e9 F, Guyot S, Roussi S, Lobstein A, Fischer B, Seiler NRF (2005) Chemo-preventive properties of apple procyanidins on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Carcinogenesis 26:1291\u20131295","journal-title":"Carcinogenesis"},{"key":"157_CR6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/mnfr.200500136","volume":"50","author":"S Schaefer","year":"2006","unstructured":"Schaefer S, Baum M, Eisenbrand G, Dietrich H, Will F, Janzowski C (2006) Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines. Mol Nutr Food Res 50:24\u201333","journal-title":"Mol Nutr Food Res"},{"key":"157_CR7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/mc.20158","volume":"45","author":"S Veeriah","year":"2006","unstructured":"Veeriah S, Kautenburger T, Habermann N, Sauer J, Dietrich H, Will F, Pool-Zobel BL (2006) Apple flavonoids inhibit growth of HT29 human colon cancer cells and modulate expression of genes involved in the biotransformation of xenobiotics. Mol Carcinog 45:164\u2013174","journal-title":"Mol Carcinog"},{"key":"157_CR8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/jsfa.2707","volume":"87","author":"J Oszmianski","year":"2007","unstructured":"Oszmianski J, Wolniak M, Wojdylo A, Wawer I (2007) Comparative study of polyphenolic content and antiradical activity of cloudy and clear apple juices. J Sci Food Agric 87:573\u2013579","journal-title":"J Sci Food Agric"},{"key":"157_CR9","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/mnfr.200700141","volume":"52","author":"K Decorde","year":"2008","unstructured":"Decorde K, Teissedre PL, Auger C, Cristol JP, Rouanet JM (2008) Phenolics from purple grape, apple, purple grape juice and apple juice prevent early atherosclerosis induced by an atherogenic diet in hamsters. Mol Nutr Food Res 52:400\u2013407","journal-title":"Mol Nutr Food Res"},{"key":"157_CR10","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.1021\/jf049317z","volume":"52","author":"U Vrhovsek","year":"2004","unstructured":"Vrhovsek U, Rigo A, Tonon D, Mattivi F (2004) Quantitation of polyphenols in different apple varieties. J Agric Food Chem 52:6532\u20136538","journal-title":"J Agric Food Chem"},{"key":"157_CR11","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/mnfr.200500064","volume":"49","author":"K Kahle","year":"2005","unstructured":"Kahle K, Kraus M, Richling E (2005) Polyphenol profiles of apple juices. Mol Nutr Food Res 49:797\u2013806","journal-title":"Mol Nutr Food Res"},{"key":"157_CR12","doi-asserted-by":"crossref","first-page":"8723","DOI":"10.1021\/jf071155u","volume":"55","author":"SC Marks","year":"2007","unstructured":"Marks SC, Mullen W, Crozier A (2007) Flavonoid and hydroxycinnamate profile of English apple ciders. J Agric Food Chem 55:8723\u20138730","journal-title":"J Agric Food Chem"},{"key":"157_CR13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2174\/157340110790909554","volume":"6","author":"H Bergmann","year":"2010","unstructured":"Bergmann H, Kahle K, Triebel S, Richling E (2010) The metabolic fate of apple polyphenols in humans. Curr Nutr Food Sci 6:19\u201335","journal-title":"Curr Nutr Food Sci"},{"key":"157_CR14","doi-asserted-by":"crossref","first-page":"10605","DOI":"10.1021\/jf071942r","volume":"55","author":"K Kahle","year":"2007","unstructured":"Kahle K, Huemmer W, Kempf M, Scheppach W, Erk T, Richling E (2007) Polyphenols are intensively metabolized in the human gastrointestinal tract after apple juice consumption. J Agric Food Chem 55:10605\u201310614","journal-title":"J Agric Food Chem"},{"key":"157_CR15","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0278-6915(85)90286-8","volume":"23","author":"PN Gillatt","year":"1985","unstructured":"Gillatt PN, Palmer RC, Smith PLR, Walters CL, Reed PI (1985) Susceptibilities of drugs to nitrosation under simulated gastric conditions. Food Chem Toxic 23:849\u2013855","journal-title":"Food Chem Toxic"},{"key":"157_CR16","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/jn\/128.9.1555","volume":"128","author":"RP Glahn","year":"1998","unstructured":"Glahn RP, Lee OA, Yeung A, Goldman MI, Miller DD (1998) Caco-2 cell ferritin formation predicts nonradiolabeled food iron availability in an in vitro digestion\/Caco-2 cell culture model. J Nutr 128:1555\u20131561","journal-title":"J Nutr"},{"key":"157_CR17","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1006\/fstl.1998.0401","volume":"31","author":"V Lebet","year":"1998","unstructured":"Lebet V, Arrigoni E, Amad\u00f2 R (1998) Measurement of fermentation products and substrate disappearance during incubation of dietary fibre sources with human faecal flora. Lebensm Wiss Technol 31:473\u2013479","journal-title":"Lebensm Wiss Technol"},{"key":"157_CR18","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S0891-5849(00)00416-0","volume":"29","author":"AJ Day","year":"2000","unstructured":"Day AJ, Bao YP, Morgan MRA, Williamson G (2000) Conjugation position of quercetin glucuronides and effect on biological activity. Free Radic Biol Med 29:1234\u20131243","journal-title":"Free Radic Biol Med"},{"key":"157_CR19","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.1021\/jf030470n","volume":"51","author":"SM Kern","year":"2003","unstructured":"Kern SM, Bennett RN, Needs PW, Mellon FA, Kroon PA, Garcia-Conesa MT (2003) Characterization of metabolites of hydroxycinnamates in the in vitro model of human small intestinal epithelium Caco-2 cells. J Agric Food Chem 51:7884\u20137891","journal-title":"J Agric Food Chem"},{"key":"157_CR20","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/mnfr.200500132","volume":"49","author":"K Kahle","year":"2005","unstructured":"Kahle K, Kraus M, Scheppach W, Richling E (2005) Colonic availability of apple polyphenols\u2013a study in ileostomy subjects. Mol Nutr Food Res 49:1143\u20131150","journal-title":"Mol Nutr Food Res"},{"key":"157_CR21","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1021\/tx049826v","volume":"17","author":"H Woude van der","year":"2004","unstructured":"van der Woude H, Boersma MG, Vervoort J, Rietjens IM (2004) Identification of 14 quercetin phase II mono- and mixed conjugates and their formation by rat and human phase II in vitro model systems. Chem Res Toxicol 17:1520\u20131530","journal-title":"Chem Res Toxicol"},{"key":"157_CR22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0165-7992(83)90044-1","volume":"122","author":"IA Macdonald","year":"1983","unstructured":"Macdonald IA, Mader JA, Bussard RG (1983) The role of rutin and quercitrin in stimulating flavonol glycosidase activity by cultured cell-free microbial preparations of human feces and saliva. Mutat Res 122:95\u2013102","journal-title":"Mutat Res"},{"key":"157_CR23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3136\/fstr.7.239","volume":"7","author":"S Hirota","year":"2001","unstructured":"Hirota S, Nishioka T, Shimoda T, Miura K, Ansai T, Takahama U (2001) Quercetin glucosides are hydrolyzed to quercetin in human oral cavity to participate in peroxidase-dependent scavenging of hydrogen peroxide. Food Sci Technol Res 7:239\u2013245","journal-title":"Food Sci Technol Res"},{"key":"157_CR24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/jn\/135.1.48","volume":"135","author":"T Walle","year":"2005","unstructured":"Walle T, Brownig AM, Steed LL, Reed SG, Walle UK (2005) Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans. J Nutr 135:48\u201352","journal-title":"J Nutr"},{"key":"157_CR25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0378-4347(97)00412-X","volume":"703","author":"H Tsuchiya","year":"1997","unstructured":"Tsuchiya H, Sato M, Kato H, Okubo T, Juneja LR, Kim M (1997) Simultaneous determination of catechins in human saliva by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 703:253\u2013258","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"157_CR26","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1021\/jf011228o","volume":"50","author":"QY Zhu","year":"2002","unstructured":"Zhu QY, Holt RR, Lazarus SA, Ensunsa JL, Hammerstone JF, Schmitz HH, Keen CL (2002) Stability of the flavan-3-ols epicatechin and catechin and related dimeric procyanidins derived from cocoa. J Agric Food Chem 50:1700\u20131705","journal-title":"J Agric Food Chem"},{"key":"157_CR27","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.1021\/jf071645m","volume":"55","author":"AP Neilson","year":"2007","unstructured":"Neilson AP, Hopf AS, Cooper BR, Pereira MA, Bomser JA, Ferruzzi MG (2007) Catechin degradation with concurrent formation of homo- and heterocatechin dimers during in vitro digestion. J Agric Food Chem 55:8941\u20138949","journal-title":"J Agric Food Chem"},{"key":"157_CR28","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.foodchem.2006.06.025","volume":"102","author":"MJ Bermud\u00e9z-Soto","year":"2007","unstructured":"Bermud\u00e9z-Soto MJ, Tom\u00e1s-Barber\u00e1n FA, Garc\u00eda-Conesa MT (2007) Stability of polyphenols in chokeberry (Aronia melanocarpa) subjected to in vitro gastric and pancreatic digestion. Food Chem 102:865\u2013874","journal-title":"Food Chem"},{"key":"157_CR29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/jn\/131.1.66","volume":"131","author":"MR Olthof","year":"2001","unstructured":"Olthof MR, Hollman PC, Katan MB (2001) Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 131:66\u201371","journal-title":"J Nutr"},{"key":"157_CR30","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1093\/jn\/136.5.1192","volume":"136","author":"S Lafay","year":"2006","unstructured":"Lafay S, Gil-Izquierdo A, Manach C, Morand C, Besson C, Scalbert A (2006) Chlorogenic acid is absorbed in its intact form in the stomach of rats. J Nutr 136:1192\u20131197","journal-title":"J Nutr"},{"key":"157_CR31","first-page":"389","volume-title":"Plant biochemistry. Vol I plant phenolics","author":"LJ Porter","year":"2002","unstructured":"Porter LJ (2002) Tannins. In: Harborne JB (ed) Plant biochemistry. Vol I plant phenolics. Academic Press, London, pp 389\u2013418"},{"key":"157_CR32","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/ajcn\/76.5.1106","volume":"76","author":"LY Rios","year":"2002","unstructured":"Rios LY, Bennett RN, Lazarus SA, R\u00e9m\u00e9sy C, Scalbert A, Williamson G (2002) Cocoa procyanidins are stable during gastric transit in humans. Am J Clin Nutr 76:1106\u20131110","journal-title":"Am J Clin Nutr"},{"key":"157_CR33","unstructured":"Farah A, Guigon F, Trugo LC (2006) 5-Caffeoylquinic acid digestibility in human digestive fluids. Colloque Scientifique International sur le Caf\u00e9, 21st, Montpellier, Frankreich, 11\u201315, September 2006, pp 97\u2013100"},{"key":"157_CR34","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1021\/jo00136a021","volume":"47","author":"P Kiatgrajai","year":"1982","unstructured":"Kiatgrajai P, Wellons JD, Gollob L, White JD (1982) Kinetics of epimerization of (+)-catechin and its rearrangement to catechinic acid. J Org Chem 47:2910\u20132912","journal-title":"J Org Chem"},{"key":"157_CR35","first-page":"227","volume":"23","author":"K Hashida","year":"2003","unstructured":"Hashida K, Ohara S, Makino R (2003) Base-catalyzed reactions of (\u2212)-epicatechin: formation of enantiomers of base-catalyzed reaction products from (+)-catechin. J Food Chem Technol 23:227\u2013232","journal-title":"J Food Chem Technol"},{"key":"157_CR36","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/mnfr.200800498","volume":"53","author":"H Bergmann","year":"2009","unstructured":"Bergmann H, Rogoll D, Scheppach W, Melcher R, Richling E (2009) The USSING type chamber model to study the intestinal transport and modulation of specific tight-junction genes using a colonic cell line. Mol Nutr Food Res 53:1211\u20131225","journal-title":"Mol Nutr Food Res"},{"key":"157_CR37","doi-asserted-by":"crossref","first-page":"2073S","DOI":"10.1093\/jn\/130.8.2073S","volume":"130","author":"A Scalbert","year":"2000","unstructured":"Scalbert A, Williamson G (2000) Dietary intake and bioavailability of polyphenols. J Nutr 130:2073S\u20132085S","journal-title":"J Nutr"},{"key":"157_CR38","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0014-5793(00)01211-4","volume":"468","author":"AJ Day","year":"2000","unstructured":"Day AJ, Canada FJ, Diaz JC, Kroon PA, Mclauchlan R, Faulds CB, Plumb GW, Morgan MR, Williamson G (2000) Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase. FEBS Lett 468:166\u2013170","journal-title":"FEBS Lett"},{"key":"157_CR39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00394-003-0397-3","volume":"42","author":"K N\u00e9meth","year":"2003","unstructured":"N\u00e9meth K, Plumb GW, Berrin JG, Juge N, Naim HY, Williamson G, Swallow DM, Kroon PA (2003) Deglycosylation by small intestinal epithelial cell \u03b2-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur J Nutr 42:29\u201342","journal-title":"Eur J Nutr"},{"key":"157_CR40","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/mnfr.200700036","volume":"51","author":"B Knaup","year":"2007","unstructured":"Knaup B, Kahle K, Erk T, Schreier P, Richling E (2007) Human intestinal hydrolysis of phenol glycosides\u2013a study with quercetin and p-nitrophenol glycosides using ileostomy fluid. Mol Nutr Food Res 51:1423\u20131429","journal-title":"Mol Nutr Food Res"},{"key":"157_CR41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/mnfr.200400082","volume":"49","author":"SE Rasmussen","year":"2005","unstructured":"Rasmussen SE, Frederiksen H, Krogholm KS, Poulsen L (2005) Dietary proanthocyanidins: occurence, dietary intake, bioavailability, and protection against cardiovascular disease. Mol Nutr Food Res 49:159\u2013174","journal-title":"Mol Nutr Food Res"},{"key":"157_CR42","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1124\/dmd.30.8.897","volume":"30","author":"JB Vaidyanathan","year":"2002","unstructured":"Vaidyanathan JB, Walle T (2002) Glucuronidation and sulfation of the tea flavonoid (\u2212)-epicatechin by the human and rat enzymes. Drug Metab Dispos 30:897\u2013903","journal-title":"Drug Metab Dispos"},{"key":"157_CR43","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0378-4274(02)00105-4","volume":"133","author":"MY Moridani","year":"2002","unstructured":"Moridani MY, Scobie H, O\u2019Brien PJ (2002) Metabolism of caffeic acid by isolated rat hepatocytes and subcellular fractions. Toxicol Lett 133:141\u2013151","journal-title":"Toxicol Lett"},{"key":"157_CR44","first-page":"R212","volume":"275","author":"C Morand","year":"1998","unstructured":"Morand C, Crespy V, Manach C, Besson C, D\u00e9mign\u00e9 C, R\u00e9m\u00e9sy C (1998) Plasma metabolites of quercetin and their antioxidant properties. Am J Physiol 275:R212\u2013R219","journal-title":"Am J Physiol"},{"key":"157_CR45","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1021\/jf802757x","volume":"57","author":"SC Marks","year":"2009","unstructured":"Marks SC, Mullen W, Borges G, Crozier A (2009) Absorption, metabolism, and excretion of cider dihydrochalcones in healthy humans and subjects with an ileostomy. J Agric Food Chem 57:2009\u20132015","journal-title":"J Agric Food Chem"},{"key":"157_CR46","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/jn\/132.2.172","volume":"132","author":"MS DuPont","year":"2002","unstructured":"DuPont MS, Bennett RN, Mellon FA, Williamso G (2002) Polyphenols from alcoholic apple cider are absorbed, metabolized and excreted by humans. J Nutr 132:172\u2013175","journal-title":"J Nutr"},{"key":"157_CR47","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1021\/jf000764y","volume":"49","author":"P Cremin","year":"2001","unstructured":"Cremin P, Kasim-Karakas S, Waterhouse AL (2001) LC\/ES-MS detection of hydroxyl-cinnamates in human plasma and urine. J Agric Food Chem 49:1747\u20131750","journal-title":"J Agric Food Chem"},{"key":"157_CR48","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.3945\/jn.108.095554","volume":"138","author":"A Farah","year":"2008","unstructured":"Farah A, Monteiro M, Donangelo CM, Lafay S (2008) Chlorogenic acids from green coffee extract are highly bioavailable in humans. J Nutr 138:2309\u20132315","journal-title":"J Nutr"},{"key":"157_CR49","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1124\/dmd.109.028019","volume":"37","author":"A Stalmach","year":"2009","unstructured":"Stalmach A, Mullen W, Barron D, Uchida K, Yokota T, Cavin C, Steiling H, Williamson G, Crozier A (2009) Metabolite profiling of hydroxycinnamate derivates in plasma and urine following the ingestion of coffee by humans: identification of biomarkers of coffee consumption. Drug Metab Dispos 37:1749\u20131758","journal-title":"Drug Metab Dispos"},{"key":"157_CR50","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3945\/jn.109.113027","volume":"140","author":"M Renouf","year":"2010","unstructured":"Renouf M, Marmet C, Guy P, Fraering AL, Longet K, Moulin J, Enslen M, Barron D, Cavin C, Dionisi F, Rezzi S, Kochhar S, Steiling H, Williamson G (2010) Nondairy creamer, but not milk, delays the appearance of coffee phenolic acid equivalents in human plasma. J Nutr 140:259\u2013263","journal-title":"J Nutr"},{"key":"157_CR51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF03189921","volume":"13","author":"T Adzet","year":"1988","unstructured":"Adzet T, Camarasa J, Escubedu E, Merlos M (1988) In vitro study of caffeic acid-bovine serum albumin interaction. Eur J Drug Metab Pharmacokinet 13:11\u201314","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"157_CR52","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.phymed.2003.11.002","volume":"12","author":"SM Wittemer","year":"2005","unstructured":"Wittemer SM, Ploch M, Windeck T, M\u00fcller SC, Drewelow B, Derendorf H, Veit M (2005) Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of artichoke leaf extracts in humans. Phytomedicine 12:28\u201338","journal-title":"Phytomedicine"},{"key":"157_CR53","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.1021\/jf0257547","volume":"50","author":"M Nardini","year":"2002","unstructured":"Nardini M, Cirillo E, Natella F, Scaccini C (2002) Absorption of phenolic acids in humans after coffee consumption. J Agric Food Chem 50:5735\u20135741","journal-title":"J Agric Food Chem"},{"key":"157_CR54","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1021\/jf000483q","volume":"48","author":"K Azuma","year":"2000","unstructured":"Azuma K, Ippoushi K, Nakayama M, Ito H, Higashio H, Terao J (2000) Absorption of chlorogenic acid and caffeic acid in rats after oral administration. J Agric Food Chem 48:5496\u20135500","journal-title":"J Agric Food Chem"},{"key":"157_CR55","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1079\/BJN20051480","volume":"94","author":"C Tsang","year":"2005","unstructured":"Tsang C, Auger C, Mullen W, Bornet A, Rouanet JM, Crozier A, Teissedre PL (2005) The absorption, metabolism and excretion of flavan-3-ols and procyanidins following the ingestion of grape seed extract by rats. Brit J Nutr 94:170\u2013181","journal-title":"Brit J Nutr"},{"key":"157_CR56","doi-asserted-by":"crossref","first-page":"230S","DOI":"10.1093\/ajcn\/81.1.230S","volume":"81","author":"C Manach","year":"2005","unstructured":"Manach C, Williamson G, Morand C, Scalbert A, R\u00e9m\u00e9sy C (2005) Bioavailability and bioefficacy of polyphenols in humans. I review of 97 bioavailability studies. Am J Clin Nutr 81:230S\u2013242S","journal-title":"Am J Clin Nutr"},{"key":"157_CR57","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1079\/BJN20061809","volume":"96","author":"W Mullen","year":"2006","unstructured":"Mullen W, Edwards CA, Crozier A (2006) Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. Brit J Nutr 96:107\u2013116","journal-title":"Brit J Nutr"},{"key":"157_CR58","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1079\/BJN20051522","volume":"94","author":"H Ito","year":"2005","unstructured":"Ito H, Gonthier MP, Manach C, Morand C, Mennen L, R\u00e9m\u00e9sy C, Scalbert A (2005) Polyphenol levels in human urine after intake of six different polyphenol-rich beverages. Brit J Nutr 94:500\u2013509","journal-title":"Brit J Nutr"},{"key":"157_CR59","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1093\/jn\/137.10.2196","volume":"137","author":"M Monteiro","year":"2007","unstructured":"Monteiro M, Farah A, Perrone D (2007) Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans. J Nutr 137:2196\u20132201","journal-title":"J Nutr"},{"key":"157_CR60","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1093\/jn\/133.6.1806","volume":"133","author":"MR Olthof","year":"2003","unstructured":"Olthof MR, Hollman PCH, Buijsman MNCP, van Amelsvoort JMM, Katan MB (2003) Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. J Nutr 133:1806\u20131814","journal-title":"J Nutr"},{"key":"157_CR61","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/004982500237703","volume":"30","author":"MN Clifford","year":"2000","unstructured":"Clifford MN, Copeland EL, Bloxsidge JP, Mitchell LA (2000) Hippuric acid as a major excretion product associated with black tea consumption. Xenobiotica 30:317\u2013326","journal-title":"Xenobiotica"},{"key":"157_CR62","doi-asserted-by":"crossref","first-page":"917","DOI":"10.3109\/00498258409151490","volume":"14","author":"P Monge","year":"1984","unstructured":"Monge P, Solheim E, Scheline RR (1984) Dihydrochalcone metabolism in the rat: phloretin. Xenobiotica 14:917\u2013924","journal-title":"Xenobiotica"},{"key":"157_CR63","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1093\/ajcn\/77.4.912","volume":"77","author":"LY Rios","year":"2003","unstructured":"Rios LY, Gonthier MP, R\u00e9m\u00e9sy C, Mila I, Lapierre C, Lazarus SA, Williamson G, Scalbert A (2003) Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects. Am J Clin Nutr 77:912\u2013918","journal-title":"Am J Clin Nutr"},{"key":"157_CR64","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/jn\/130.11.2733","volume":"130","author":"S D\u00e9pr\u00e9z","year":"2000","unstructured":"D\u00e9pr\u00e9z S, Br\u00e9zillon C, Rabot S, Philippe C, Mila I, Lapierre C, Scalbert A (2000) Polymeric proanthocyanidins are catabolized by human colonic microflora into low molecular weight phenolic acids. J Nutr 130:2733\u20132738","journal-title":"J Nutr"},{"key":"157_CR65","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1021\/jf049404r","volume":"52","author":"NC Ward","year":"2004","unstructured":"Ward NC, Croft KD, Puddey IB, Hodgson JM (2004) Supplementation with grape seed polyphenols results in urinary excretion of 3-hydroxyphenylpropionic acid, an important metabolite of proanthocyanidins in humans. J Agric Food Chem 52:5545\u20135549","journal-title":"J Agric Food Chem"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-010-0157-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-010-0157-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-010-0157-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T08:35:23Z","timestamp":1559896523000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-010-0157-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,24]]},"references-count":65,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["157"],"URL":"https:\/\/doi.org\/10.1007\/s00394-010-0157-0","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,24]]}}}