{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T04:31:00Z","timestamp":1794544260345,"version":"4.9.1"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,3,27]],"date-time":"2011-03-27T00:00:00Z","timestamp":1301184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s00394-011-0188-1","type":"journal-article","created":{"date-parts":[[2011,3,26]],"date-time":"2011-03-26T08:38:45Z","timestamp":1301128725000},"page":"151-161","source":"Crossref","is-referenced-by-count":238,"title":["New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases"],"prefix":"10.1007","volume":"50","author":[{"given":"Adeeb","family":"Shehzad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taewook","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazli","family":"Subhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Sup","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,3,27]]},"reference":[{"key":"188_CR1","first-page":"985","volume":"55","author":"C DC","year":"2005","unstructured":"DC C (2005) State-specific prevalence of obesity among adults\u2014United States. MMWR 55:985\u2013988","journal-title":"MMWR"},{"key":"188_CR2","unstructured":"Health Survey for England (2007) http:\/\/www.ic.nhs.uk\/statistics-and-datacollections\/health-and-lifestyles-related-surveys\/health-survey-forengland\/health-survey for england-2007-latest-trends-%5Bns%5D"},{"issue":"2","key":"188_CR3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0092-8674(03)01081-X","volume":"116","author":"JS Flier","year":"2004","unstructured":"Flier JS (2004) Obesity wars: molecular progress confronts an expanding epidemic. Cell 116(2):337\u2013350","journal-title":"Cell"},{"key":"188_CR4","unstructured":"Spiegelman BM, Flier JS (2001)Obesity and the regulation of energy balance. Cell 104(4):531\u2013543"},{"issue":"6778","key":"188_CR5","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/35007504","volume":"404","author":"JM Friedman","year":"2000","unstructured":"Friedman JM (2000) Obesity in the new millennium. Nature 404(6778):632\u2013634","journal-title":"Nature"},{"issue":"6778","key":"188_CR6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/35007519","volume":"404","author":"GS Barsh","year":"2000","unstructured":"Barsh GS, Farooqi IS, O\u2019Rahilly S (2000) Genetics of body-weight regulation. Nature 404(6778):644\u2013651","journal-title":"Nature"},{"key":"188_CR7","doi-asserted-by":"crossref","unstructured":"Luchsinger JA (2006) A work in progress: the metabolic syndrome. Sci Aging Knowl Environ (10):pe19","DOI":"10.1126\/sageke.2006.10.pe19"},{"issue":"9","key":"188_CR8","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s11095-008-9661-9","volume":"25","author":"P Anand","year":"2008","unstructured":"Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB (2008) Cancer is a preventable disease that requires major lifestyle changes. Pharm Res 25(9):2097\u20132116","journal-title":"Pharm Res"},{"key":"188_CR9","first-page":"1","volume":"6","author":"IARC handbooks of cancer prevention","year":"2002","unstructured":"IARC handbooks of cancer prevention (2002) Weight control and physical activity, international agency for research on cancer, Lyon. France 6:1\u2013315","journal-title":"France"},{"issue":"2","key":"188_CR10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1358\/dof.2010.035.02.1426640","volume":"35","author":"A Shehzad","year":"2010","unstructured":"Shehzad A, Lee YS (2010) Curcumin: multiple molecular targets mediate multiple pharmacological actions. Drugs Future 35(2):113\u2013119","journal-title":"Drugs Future"},{"issue":"9","key":"188_CR11","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/ardp.200900319","volume":"343","author":"A Shehzad","year":"2010","unstructured":"Shehzad A, Wahid F, Lee YS (2010) Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm Chem Life Sci 343(9):489\u2013499","journal-title":"Arch Pharm Chem Life Sci"},{"issue":"9","key":"188_CR12","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1172\/JCI34260","volume":"118","author":"S Schenk","year":"2008","unstructured":"Schenk S, Saberi M, Olefsky JM (2008) Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 118(9):2992\u20133002","journal-title":"J Clin Invest"},{"key":"188_CR13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev.med.080708.082713","volume":"61","author":"DL Roberts","year":"2010","unstructured":"Roberts DL, Dive C, Renehan AG (2010) Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med 61:301\u2013316","journal-title":"Annu Rev Med"},{"issue":"1","key":"188_CR14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jcp.21386","volume":"216","author":"P Wang","year":"2008","unstructured":"Wang P, Mariman E, Renes J, Keijer J (2008) The secretory function of adipocytes in the physiology of white adipose tissue. J Cell Physiol 216(1):3\u201313","journal-title":"J Cell Physiol"},{"issue":"6","key":"188_CR15","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.2337\/db06-0263","volume":"55","author":"PE Scherer","year":"2006","unstructured":"Scherer PE (2006) Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 55(6):1537\u20131545","journal-title":"Diabetes"},{"issue":"3","key":"188_CR16","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ecl.2008.07.002","volume":"37","author":"N Halberg","year":"2008","unstructured":"Halberg N, Wernstedt-Asterholm I, Scherer PE (2008) The adipocyte as an endocrine cell. Endocrinol Metab Clin N Am 37(3):753\u2013768","journal-title":"Endocrinol Metab Clin N Am"},{"key":"188_CR17","unstructured":"Hajri T, Tao H, Wattacheril J, Marks-Shulman P, Abumrad NN (2010) Regulation of adiponectin production by insulin: Interactions with tumor necrosis factor-alpha and interleukin-6. Am J Physiol Endocrinol Metab, doi: 10.1152\/ajpendo.00307"},{"issue":"9","key":"188_CR18","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/gut.2010.214577","volume":"59","author":"AR Moschen","year":"2010","unstructured":"Moschen AR, Molnar C, Geiger S, Graziadei I, Ebenbichler CF, Weiss H, Kaser S, Kaser A, Tilg H (2010) Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression. Gut 59(9):1259\u20131264","journal-title":"Gut"},{"issue":"5","key":"188_CR19","doi-asserted-by":"crossref","first-page":"688","DOI":"10.2337\/diabetes.49.5.688","volume":"49","author":"P Lofgren","year":"2000","unstructured":"Lofgren P, Van H, Reynisdottir VS, Naslund E, Ryden M, Rossner S, Arner P (2000) Secretion of tumor necrosis factor-a shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue. Diabetes 49(5):688\u2013692","journal-title":"Diabetes"},{"issue":"51","key":"188_CR20","doi-asserted-by":"crossref","first-page":"35375","DOI":"10.1074\/jbc.M806480200","volume":"283","author":"J Zhang","year":"2008","unstructured":"Zhang J, Gao Z, Yin J, Quon MJ, Ye J (2008) S6\u00a0K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. J Biol Chem 283(51):35375\u201335382","journal-title":"J Biol Chem"},{"issue":"9","key":"188_CR21","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1073\/pnas.0712275105","volume":"105","author":"B Emanuelli","year":"2008","unstructured":"Emanuelli B, Eberle D, Suzuki R, Kahn CR (2008) Overexpression of the dual-specificity phosphatase MKP-4\/DUSP-9 protects against stress-induced insulin resistance. Proc Natl Acad Sci USA 105(9):3545\u20133550","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"188_CR22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/13813450802181047","volume":"114","author":"I Nieto-Vazquez","year":"2008","unstructured":"Nieto-Vazquez I, Fernandez-Veledo S, Kramer DK, Vila-Bedmar R, Garcia-Guerra L, Lorenzo M (2008) Insulin resistance associated to obesity: the link TNF-alpha. Arch Physiol Biochem 114(3):183\u2013194","journal-title":"Arch Physiol Biochem"},{"issue":"6","key":"188_CR23","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1210\/en.2007-0978","volume":"149","author":"H Liang","year":"2008","unstructured":"Liang H, Yin B, Zhang H, Zhang S, Zeng Q, Wang J, Jiang X, Yuan L, Wang CY, Li Z (2008) Blockade of tumor necrosis factor (TNF) receptor type 1-mediated TNF-alpha signaling protected Wistar rats from diet-induced obesity and insulin resistance. Endocrinology 149(6):2943\u20132951","journal-title":"Endocrinology"},{"issue":"38","key":"188_CR24","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.3748\/wjg.v16.i38.4773","volume":"16","author":"G Tarantino","year":"2010","unstructured":"Tarantino G, Savastano S, Colao A (2010) Hepatic steatosis, low-grade chronic inflammation and hormone\/growth factor\/adipokine imbalance. World J Gastroenterol 16(38):4773\u20134783","journal-title":"World J Gastroenterol"},{"issue":"2","key":"188_CR25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nm1166","volume":"11","author":"D Cai","year":"2005","unstructured":"Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-\u03b2 and NF-\u03baB. Nat Med 11(2):183\u2013190","journal-title":"Nat Med"},{"key":"188_CR26","unstructured":"Shoelson SE, Lee J, Yuan M (2003) Inflammation and the IKK\u03b2\/I\u03ba\u03b2\/NF-\u03baB axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord (Suppl 3):S49\u2013S52"},{"issue":"4","key":"188_CR27","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.bcp.2007.10.010","volume":"75","author":"KS Ahn","year":"2008","unstructured":"Ahn KS, Sethi G, Aggarwal BB (2008) Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway. Biochem Pharmacol 75(4):907\u2013913","journal-title":"Biochem Pharmacol"},{"issue":"11","key":"188_CR28","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","volume":"116","author":"H Shi","year":"2006","unstructured":"Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116(11):3015\u20133025","journal-title":"J Clin Invest"},{"issue":"10","key":"188_CR29","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.2337\/db08-0038","volume":"57","author":"SM Reyna","year":"2008","unstructured":"Reyna SM, Ghosh S, Tantiwong P, Meka CS, Eagan P, Jenkinson CP, Cersosimo E, Defronzo RA, Coletta DK, Sriwijitkamol A, Musi N (2008) Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. Diabetes 57(10):2595\u20132602","journal-title":"Diabetes"},{"issue":"4","key":"188_CR30","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S1471-4892(03)00068-7","volume":"3","author":"BL Bennett","year":"2003","unstructured":"Bennett BL, Satoh Y, Lewis AJ (2003) JNK: a new therapeutic target for diabetes. Curr Opin Pharmacol 3(4):420\u2013425","journal-title":"Curr Opin Pharmacol"},{"issue":"40","key":"188_CR31","doi-asserted-by":"crossref","first-page":"14461","DOI":"10.1073\/pnas.0405786101","volume":"101","author":"S Ogawa","year":"2004","unstructured":"Ogawa S, Lozach J, Jepsen K, Sawka-Verhelle D, Perissi V, Sasik R, Rose DW, Johnson RS, Rosenfeld MG, Glass CK (2004) A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc Natl Acad Sci USA 101(40):14461\u201314466","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"188_CR32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.molcel.2009.05.023","volume":"35","author":"W Huang","year":"2009","unstructured":"Huang W, Ghisletti S, Perissi V, Rosenfeld MG, Glass CK (2009) Transcriptional integration of TLR2 and TLR4 signaling at the NCoR depression checkpoint. Mol Cell 35(1):48\u201357","journal-title":"Mol Cell"},{"issue":"6865","key":"188_CR33","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/414821a","volume":"414","author":"DE Moller","year":"2001","unstructured":"Moller DE (2001) New drug targets for type 2 diabetes and the metabolic syndrome. Nature 414(6865):821\u2013827","journal-title":"Nature"},{"issue":"3","key":"188_CR34","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/ncb942","volume":"5","author":"M Suzawa","year":"2003","unstructured":"Suzawa M, Takada I, Yanagisawa J, Ohtake F, Ogawa S, Yamauchi T, Kadowaki T, Takeuchi Y, Shibuya H, Gotoh Y, Matsumoto K, Kato S (2003) Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1\/TAB 1\/NIK cascade. Nat Cell Biol 5(3):224\u2013230","journal-title":"Nat Cell Biol"},{"issue":"12","key":"188_CR35","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","volume":"112","author":"H Xu","year":"2003","unstructured":"Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112(12):1821\u20131830","journal-title":"J Clin Invest"},{"issue":"8","key":"188_CR36","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/j.1476-5381.2009.00335.x","volume":"157","author":"A Graham","year":"2009","unstructured":"Graham A (2009) Curcumin adds spice to the debate: lipid metabolism in liver disease. Br J Pharmacol 157(8):1352\u20131353","journal-title":"Br J Pharmacol"},{"issue":"7","key":"188_CR37","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1358\/dot.2010.46.7.1509560","volume":"46","author":"A Shehzad","year":"2010","unstructured":"Shehzad A, Khan S, Shehzad O, Lee YS (2010) Curcumin therapeutic promises and bioavailability in colorectal cancer. Drugs Today 46(7):523\u2013532","journal-title":"Drugs Today"},{"issue":"1\u20132","key":"188_CR38","first-page":"109","volume":"34","author":"P Yoysungnoen","year":"2006","unstructured":"Yoysungnoen P, Wirachwong P, Bhattarakosol P, Niimi H, Patumraj S (2006) Effects of curcumin on tumor angiogenesis and biomarkers, COX-2 and VEGF, in hepatocellular carcinoma cell-implanted nude mice. Clin Hemorheol Microcirc 34(1\u20132):109\u2013115","journal-title":"Clin Hemorheol Microcirc"},{"issue":"10","key":"188_CR39","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.lfs.2006.11.030","volume":"80","author":"HM Woo","year":"2007","unstructured":"Woo HM, Kang JH, Kawada T, Yoo H, Sung MK, Yu R (2007) Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes. Life Sci 80(10):926\u2013931","journal-title":"Life Sci"},{"issue":"55","key":"188_CR40","doi-asserted-by":"crossref","first-page":"8414","DOI":"10.1038\/sj.onc.1205947","volume":"21","author":"AS Jaiswal","year":"2002","unstructured":"Jaiswal AS, Marlow BP, Gupta N, Narayan S (2002) Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 21(55):8414\u20138427","journal-title":"Oncogene"},{"issue":"6","key":"188_CR41","doi-asserted-by":"crossref","first-page":"C1510","DOI":"10.1152\/ajpcell.00369.2009","volume":"298","author":"J Ahn","year":"2010","unstructured":"Ahn J, Lee H, Kim S, Ha T (2010) Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt\/beta-catenin signaling. Am J Physiol Cell Physiol 298(6):C1510\u2013C1516","journal-title":"Am J Physiol Cell Physiol"},{"issue":"8","key":"188_CR42","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1093\/jn\/131.8.2090","volume":"131","author":"K Okada","year":"2001","unstructured":"Okada K, Wangpoengtrakul C, Tanaka T, Toyokuni S, Uchida K, Osawa T (2001) Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice. J Nutr 131(8):2090\u20132095","journal-title":"J Nutr"},{"issue":"1","key":"188_CR43","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.freeradbiomed.2006.03.008","volume":"41","author":"SK Jain","year":"2006","unstructured":"Jain SK, Rains J, Jones K (2006) Effect of curcumin on protein glycosylation, lipid peroxidation, and oxygen radical generation in human red blood cells exposed to high glucose levels. Free Radic Biol Med 41(1):92\u201396","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"188_CR44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jnutbio.2006.03.007","volume":"18","author":"D Peschel","year":"2007","unstructured":"Peschel D, Koerting R, Nass N (2007) Curcumin induces changes in expression of genes involved in cholesterol homeostasis. J Nutr Biochem 18(2):113\u2013119","journal-title":"J Nutr Biochem"},{"issue":"Pt 3","key":"188_CR45","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1042\/bj20021619","volume":"371","author":"E Balogun","year":"2003","unstructured":"Balogun E, Hoque M, Gong P, Killeen E, Green CJ, Foresti R, Alam J, Motterlini R (2003) Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem J 371(Pt 3):887\u2013895","journal-title":"Biochem J"},{"issue":"4","key":"188_CR46","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0049-3848(99)00148-6","volume":"97","author":"UR Pendurthi","year":"2000","unstructured":"Pendurthi UR, Rao LV (2000) Suppression of transcription factor Egr-1 by curcumin. Thromb Res 97(4):179\u2013189","journal-title":"Thromb Res"},{"issue":"7","key":"188_CR47","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1210\/en.2008-1601","volume":"150","author":"Y Tang","year":"2009","unstructured":"Tang Y, Zheng S, Chen A (2009) Curcumin eliminates leptin\u2019s effects on hepatic stellate cell activation via interrupting leptin signaling. Endocrinology 150(7):3011\u20133020","journal-title":"Endocrinology"},{"issue":"7","key":"188_CR48","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1210\/en.2008-0262","volume":"149","author":"SP Weisberg","year":"2009","unstructured":"Weisberg SP, Leibel R, Tortoriello DV (2009) Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 149(7):3549\u20133558","journal-title":"Endocrinology"},{"issue":"5","key":"188_CR49","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3945\/jn.108.100966","volume":"139","author":"A Ejaz","year":"2009","unstructured":"Ejaz A, Wu D, Kwan P, Meydani M (2009) Curcumin inhibits adipogenesis in 3T3\u2013L1 adipocytes and angiogenesis and obesity in C57\/BL mice. J Nutr 139(5):919\u2013925","journal-title":"J Nutr"},{"issue":"1","key":"188_CR50","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1021\/jf802737z","volume":"57","author":"YK Lee","year":"2009","unstructured":"Lee YK, Lee WS, Hwang JT, Kwon DY, Surh YJ, Park OJ (2009) Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3\u2013L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells. J Agric Food Chem 57(1):305\u2013310","journal-title":"J Agric Food Chem"},{"issue":"1","key":"188_CR51","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0895-3988(09)60019-2","volume":"22","author":"SL Wang","year":"2009","unstructured":"Wang SL, Li Y, Wen Y, Chen YF, Na LX, Li ST, Sun CH (2009) Curcumin, a potential inhibitor of up-regulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kappaB and JNK pathway. Biomed Environ Sci 22(1):32\u201339","journal-title":"Biomed Environ Sci"},{"issue":"1","key":"188_CR52","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.fct.2009.09.013","volume":"48","author":"JH Lim","year":"2010","unstructured":"Lim JH, Kwon TK (2010) Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity. Food Chem Toxicol 48(1):47\u201352","journal-title":"Food Chem Toxicol"},{"issue":"12","key":"188_CR53","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.1210\/en.2009-0517","volume":"150","author":"Q Kang","year":"2009","unstructured":"Kang Q, Chen A (2009) Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1. Endocrinology 150(12):5384\u20135394","journal-title":"Endocrinology"},{"issue":"5","key":"188_CR54","doi-asserted-by":"crossref","first-page":"G883","DOI":"10.1152\/ajpgi.00450.2005","volume":"290","author":"S Zheng","year":"2006","unstructured":"Zheng S, Chen A (2006) Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor. Am J Physiol Gastrointest Liver Physiol 290(5):G883\u2013G893","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"9","key":"188_CR55","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1210\/en.2010-0191","volume":"151","author":"Y Tang","year":"2010","unstructured":"Tang Y, Chen A (2010) Curcumin protects hepatic stellate cells against leptin-induced activation in vitro by accumulating intracellular lipids. Endocrinology 151(9):4168\u20134177","journal-title":"Endocrinology"},{"issue":"5","key":"188_CR56","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/j.1476-5381.2010.00956.x","volume":"161","author":"Y Tang","year":"2010","unstructured":"Tang Y, Chen A (2010) Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase. Br J Pharmacol 161(5):1137\u20131149","journal-title":"Br J Pharmacol"},{"issue":"5","key":"188_CR57","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/jcb.20698","volume":"97","author":"A Masamune","year":"2006","unstructured":"Masamune A, Suzuki N, Kikuta K, Satoh M, Satoh K, Shimosegawa T (2006) Curcumin blocks activation of pancreatic stellate cells. J Cell Biochem 97(5):1080\u20131093","journal-title":"J Cell Biochem"},{"issue":"4","key":"188_CR58","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/MPA.0b013e318196c3e7","volume":"38","author":"AN Balamurugan","year":"2009","unstructured":"Balamurugan AN, Akhov L, Selvaraj G, Pugazhenthi S (2009) Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation. Pancreas 38(4):454\u2013460","journal-title":"Pancreas"},{"issue":"5","key":"188_CR59","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/bjp.2008.311","volume":"155","author":"M Kanitkar","year":"2008","unstructured":"Kanitkar M, Gokhale K, Galande S, Bhonde RR (2008) Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo. Br J Pharmacol 155(5):702\u2013713","journal-title":"Br J Pharmacol"},{"key":"188_CR60","doi-asserted-by":"crossref","unstructured":"Karthikesan K, Pari L, Menon VP (2010) Combined treatment of tetrahydrocurcumin and chlorogenic acid exerts potential antihyperglycemic effect on streptozotocin-nicotinamide-induced diabetic rats. Gen Physiol Biophys 29(1):23\u201330","DOI":"10.4149\/gpb_2010_01_23"},{"issue":"7\u20138","key":"188_CR61","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.nut.2009.02.001","volume":"25","author":"A Pongchaidecha","year":"2009","unstructured":"Pongchaidecha A, Lailerd N, Boonprasert W, Chattipakorn N (2009) Effects of curcuminoid supplement on cardiac autonomic status in high-fat-induced obese rats. Nutrition 25(7\u20138):870\u2013878","journal-title":"Nutrition"},{"issue":"3","key":"188_CR62","first-page":"868","volume":"118","author":"T Morimoto","year":"2008","unstructured":"Morimoto T, Sunagawa Y, Kawamura T, Takaya T, Wada H, Nagasawa A, Komeda M, Fujita M, Shimatsu A, Kita T, Hasegawa K (2008) The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Invest 118(3):868\u2013878","journal-title":"J Clin Invest"},{"issue":"7","key":"188_CR63","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/01.ATV.0000020676.11586.F2","volume":"22","author":"JL Quiles","year":"2002","unstructured":"Quiles JL, Mesa MD, Ramirez-Tortosa CL, Aguilera CM, Battino M, Gil A, Ram\u00edrez-Tortosa MC (2002) Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler Thromb Vasc Biol 22(7):1225\u20131231","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"188_CR64","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2215\/CJN.05721108","volume":"4","author":"NG Kutner","year":"2009","unstructured":"Kutner NG, Johansen KL, Kaysen GA, Pederson S, Chen SC, Agodoa LY, Eggers PW, Chertow GM (2009) The Comprehensive Dialysis Study (CDS): A USRDS Special Study. Clin J Am Soc Nephrol 4:645\u2013650","journal-title":"Clin J Am Soc Nephrol"},{"issue":"9","key":"188_CR65","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.nut.2008.12.007","volume":"25","author":"J Chiu","year":"2009","unstructured":"Chiu J, Khan ZA, Farhangkhoee H, Chakrabarti S (2009) Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB. Nutrition 25(9):964\u2013972","journal-title":"Nutrition"},{"issue":"1","key":"188_CR66","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1023\/A:1013106527829","volume":"57","author":"N Arun","year":"2002","unstructured":"Arun N, Nalini N (2002) Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum Nutr 57(1):41\u201352","journal-title":"Plant Foods Hum Nutr"},{"issue":"9","key":"188_CR67","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/mnfr.200700184","volume":"52","author":"KI Seo","year":"2008","unstructured":"Seo KI, Choi MS, Jung UJ, Kim HJ, Yeo J, Jeon SM, Lee MK (2008) Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db\/db mice. Mol Nutr Food Res 52(9):995\u20131004","journal-title":"Mol Nutr Food Res"},{"issue":"1\u20133","key":"188_CR68","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejphar.2007.08.001","volume":"576","author":"A Kuhad","year":"2007","unstructured":"Kuhad A, Chopra K (2007) Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences. Eur J Pharmacol 576(1\u20133):34\u201342","journal-title":"Eur J Pharmacol"},{"issue":"1\u20132","key":"188_CR69","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0047-6374(00)00169-X","volume":"119","author":"A Ram\u00edrez-Bosc\u00e1","year":"2000","unstructured":"Ram\u00edrez-Bosc\u00e1 A, Soler A, Carri\u00f3n MA, D\u00edaz-Alperi J, Bernd A, Quintanilla C, Quintanilla Almagro E, Miquel J (2000) An hydroalcoholic extract of Curcuma longa lowers the apo B\/apo A ratio. Implications for atherogenesis prevention. Mech Ageing Dev 119(1\u20132):41\u201347","journal-title":"Mech Ageing Dev"},{"issue":"3","key":"188_CR70","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0047-6374(00)00089-0","volume":"114","author":"A Ramirez Bosc\u00e1","year":"2000","unstructured":"Ramirez Bosc\u00e1 A, Soler A, Carri\u00f3n-Guti\u00e9rrez MA, Pamies Mira D, Pardo Zapata J, Diaz-Alperi J, Bernd A, Quintanilla Almagro E, Miquel J (2000) An hydroalcoholic extract of Curcuma longa lowers the abnormally high values of human-plasma fibrinogen. Mech Ageing Dev 114(3):207\u2013210","journal-title":"Mech Ageing Dev"},{"issue":"4","key":"188_CR71","first-page":"201","volume":"40","author":"I Alwi","year":"2008","unstructured":"Alwi I, Santoso T, Suyono S, Sutrisna B, Suyatna FD, Kresno SB, Ernie S (2008) The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med Indones 40(4):201\u2013210","journal-title":"Acta Med Indones"},{"issue":"6","key":"188_CR72","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.phrs.2007.09.013","volume":"56","author":"L Baum","year":"2007","unstructured":"Baum L, Cheung SK, Mok VC, Lam LC, Leung VP et al (2007) Curcumin effects on blood lipid profile in a 6-month human study. Pharmacol Res 56(6):509\u2013514","journal-title":"Pharmacol Res"},{"issue":"4","key":"188_CR73","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2165\/00126839-200809040-00004","volume":"9","author":"P Usharani","year":"2008","unstructured":"Usharani P, Mateen AA, Naidu MU, Raju YS, Chandra N (2008) Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R D 9(4):243\u2013250","journal-title":"Drugs R D"},{"issue":"6","key":"188_CR74","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1345\/aph.1M533","volume":"44","author":"Y Chen","year":"2010","unstructured":"Chen Y, Liu WH, Chen BL, Fan L, Han Y, Wang G, Hu DL, Tan ZR, Zhou G, Cao S, Zhou HH (2010) Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers. Ann Pharmacother 44(6):1038\u20131045","journal-title":"Ann Pharmacother"},{"key":"188_CR75","unstructured":"Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G (2010) Product-evaluation registry of Meriva\u00ae, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med 52(2 Suppl 1):55\u201362"},{"key":"188_CR76","first-page":"1201","volume":"4","author":"P Allegri","year":"2010","unstructured":"Allegri P, Mastromarino A, Neri P (2010) Management of chronic anterior uveitis relapses: efficacy of oral phospholipidic curcumin treatment. Long-term follow-up. Clin Ophthalmol 4:1201\u20131206","journal-title":"Clin Ophthalmol"},{"issue":"8","key":"188_CR77","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1080\/01635581.2010.513802","volume":"62","author":"R Epelbaum","year":"2010","unstructured":"Epelbaum R, Schaffer M, Vizel B, Badmaev V, Bar-Sela G (2010) Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutr Cancer 62(8):1137\u20131141","journal-title":"Nutr Cancer"},{"key":"188_CR78","first-page":"891","volume-title":"WHO technical report series","author":"Evaluation of Certain Food Additives","year":"2000","unstructured":"Evaluation of Certain Food Additives (2000) WHO technical report series. WHO, Geneva, p 891"},{"issue":"4","key":"188_CR79","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2310\/6620.2006.06004","volume":"17","author":"M Liddle","year":"2006","unstructured":"Liddle M, Hull C, Liu C, Powell D (2006) Contact urticaria from curcumin. Dermatitis 17(4):196\u2013197","journal-title":"Dermatitis"},{"issue":"4","key":"188_CR80","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1046\/j.1440-6047.2002.00296.x","volume":"11","author":"A Rasyid","year":"2002","unstructured":"Rasyid A, Rahman AR, Jaalam K, Lelo A (2002) Effect of different curcumin dosages on human gall bladder. Asia Pac J Clin Nutr 11(4):314\u2013318","journal-title":"Asia Pac J Clin Nutr"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-011-0188-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-011-0188-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-011-0188-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T13:07:23Z","timestamp":1560085643000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-011-0188-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,27]]},"references-count":80,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["188"],"URL":"https:\/\/doi.org\/10.1007\/s00394-011-0188-1","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,27]]}}}