{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:52:43Z","timestamp":1768452763334,"version":"3.49.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T00:00:00Z","timestamp":1363651200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1007\/s00394-013-0515-9","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T10:30:48Z","timestamp":1363602648000},"page":"177-185","source":"Crossref","is-referenced-by-count":14,"title":["Effect of ascorbic acid deficiency on catecholamine synthesis in adrenal glands of SMP30\/GNL knockout mice"],"prefix":"10.1007","volume":"53","author":[{"given":"Akiko","family":"Amano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Tsunoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Aigaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Ishigami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,3,19]]},"reference":[{"key":"515_CR1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1021\/jp909314t","volume":"114","author":"T Kawashima","year":"2010","unstructured":"Kawashima T, Ohkubo K, Fukuzumi S (2010) Radical scavenging reactivity of catecholamine neurotransmitters and the inhibition effect for DNA cleavage. J Phys Chem B 114:675\u2013680. doi: 10.1021\/jp909314t","journal-title":"J Phys Chem B"},{"key":"515_CR2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/scientificamerican0674-58","volume":"230","author":"J Axelrod","year":"1974","unstructured":"Axelrod J (1974) Neurotransmitters. Sci Am 230:59\u201371","journal-title":"Sci Am"},{"key":"515_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11906-011-0243-6","volume":"14","author":"MG Ziegler","year":"2012","unstructured":"Ziegler MG, Elayan H, Milic M, Sun P, Gharaibeh M (2012) Epinephrine and the metabolic syndrome. Curr Hypertens Rep 14:1\u20137. doi: 10.1007\/s11906-011-0243-6","journal-title":"Curr Hypertens Rep"},{"key":"515_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1054-3589(08)60682-1","volume":"42","author":"T Nagatsu","year":"1998","unstructured":"Nagatsu T, Stjarne L (1998) Catecholamine synthesis and release. Overview. Adv Pharmacol 42:1\u201314","journal-title":"Adv Pharmacol"},{"key":"515_CR5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0006-291X(89)91582-9","volume":"161","author":"PF Fitzpatrick","year":"1989","unstructured":"Fitzpatrick PF (1989) The metal requirement of rat tyrosine hydroxylase. Biochem Biophys Res Commun 161:211\u2013215","journal-title":"Biochem Biophys Res Commun"},{"key":"515_CR6","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1021\/bi052283j","volume":"45","author":"PA Frantom","year":"2006","unstructured":"Frantom PA, Seravalli J, Ragsdale SW, Fitzpatrick PF (2006) Reduction and oxidation of the active site iron in tyrosine hydroxylase: kinetics and specificity. Biochemistry 45:2372\u20132379. doi: 10.1021\/bi052283j","journal-title":"Biochemistry"},{"key":"515_CR7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1432-1033.1992.tb17386.x","volume":"210","author":"J Haavik","year":"1992","unstructured":"Haavik J, Martinez A, Olafsdottir S, Mallet J, Flatmark T (1992) The incorporation of divalent metal ions into recombinant human tyrosine hydroxylase apoenzymes studied by intrinsic fluorescence and 1H-NMR spectroscopy. Eur J Biochem 210:23\u201331","journal-title":"Eur J Biochem"},{"key":"515_CR8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3940(98)00129-3","volume":"244","author":"G Seitz","year":"1998","unstructured":"Seitz G, Gebhardt S, Beck JF, Bohm W, Lode HN, Niethammer D, Bruchelt G (1998) Ascorbic acid stimulates DOPA synthesis and tyrosine hydroxylase gene expression in the human neuroblastoma cell line SK-N-SH. Neurosci Lett 244:33\u201336","journal-title":"Neurosci Lett"},{"key":"515_CR9","doi-asserted-by":"crossref","first-page":"24395","DOI":"10.1074\/jbc.271.40.24395","volume":"271","author":"AJ Ramsey","year":"1996","unstructured":"Ramsey AJ, Hillas PJ, Fitzpatrick PF (1996) Characterization of the active site iron in tyrosine hydroxylase. Redox states of the iron. J Biol Chem 271:24395\u201324400","journal-title":"J Biol Chem"},{"key":"515_CR10","doi-asserted-by":"crossref","first-page":"22546","DOI":"10.1074\/jbc.M302227200","volume":"278","author":"N Kuzkaya","year":"2003","unstructured":"Kuzkaya N, Weissmann N, Harrison DG, Dikalov S (2003) Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J Biol Chem 278:22546\u201322554. doi: 10.1074\/jbc.M302227200","journal-title":"J Biol Chem"},{"key":"515_CR11","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/humu.20700","volume":"29","author":"J Haavik","year":"2008","unstructured":"Haavik J, Blau N, Thony B (2008) Mutations in human monoamine-related neurotransmitter pathway genes. Hum Mutat 29:891\u2013902. doi: 10.1002\/humu.20700","journal-title":"Hum Mutat"},{"key":"515_CR12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0305-0491(93)90283-B","volume":"104","author":"D Fortin","year":"1993","unstructured":"Fortin D, Coulon JF, Roberge AG (1993) Comparative study of biochemical parameters and kinetic properties of dopamine-\u03b2-hydroxylase activity from cat and rat adrenals. Comp Biochem Physiol B 104:567\u2013575","journal-title":"Comp Biochem Physiol B"},{"key":"515_CR13","doi-asserted-by":"crossref","first-page":"49691","DOI":"10.1074\/jbc.M300797200","volume":"278","author":"JP Evans","year":"2003","unstructured":"Evans JP, Ahn K, Klinman JP (2003) Evidence that dioxygen and substrate activation are tightly coupled in dopamine \u03b2-monooxygenase. Implications for the reactive oxygen species. J Biol Chem 278:49691\u201349698. doi: 10.1074\/jbc.M300797200","journal-title":"J Biol Chem"},{"key":"515_CR14","doi-asserted-by":"crossref","first-page":"11544","DOI":"10.1016\/S0021-9258(18)98991-X","volume":"266","author":"BG Huyghe","year":"1991","unstructured":"Huyghe BG, Klinman JP (1991) Activity of membranous dopamine \u03b2-monooxygenase within chromaffin granule ghosts. Interaction with ascorbate. J Biol Chem 266:11544\u201311550","journal-title":"J Biol Chem"},{"key":"515_CR15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/157340809787314265","volume":"5","author":"B Alexandre","year":"2009","unstructured":"Alexandre B, Humberto F, Learmonth DA, Patr\u00edcio S (2009) Dopamine \u03b2-monooxygenase: mechanism, substrates and inhibitors. Curr Enzyme Inhib 5:27\u201343","journal-title":"Curr Enzyme Inhib"},{"key":"515_CR16","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1073\/pnas.94.4.1506","volume":"94","author":"DS Koh","year":"1997","unstructured":"Koh DS, Hille B (1997) Modulation by neurotransmitters of catecholamine secretion from sympathetic ganglion neurons detected by amperometry. Proc Natl Acad Sci USA 94:1506\u20131511","journal-title":"Proc Natl Acad Sci USA"},{"key":"515_CR17","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1093\/jn\/115.12.1630","volume":"115","author":"F Horio","year":"1985","unstructured":"Horio F, Ozaki K, Yoshida A, Makino S, Hayashi Y (1985) Requirement for ascorbic acid in a rat mutant unable to synthesize ascorbic acid. J Nutr 115:1630\u20131640","journal-title":"J Nutr"},{"key":"515_CR18","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.freeradbiomed.2009.06.003","volume":"47","author":"DJ Lane","year":"2009","unstructured":"Lane DJ, Lawen A (2009) Ascorbate and plasma membrane electron transport-enzymes vs efflux. Free Radic Biol Med 47:485\u2013495","journal-title":"Free Radic Biol Med"},{"key":"515_CR19","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1096\/fasebj.7.12.8375611","volume":"7","author":"RC Rose","year":"1993","unstructured":"Rose RC, Bode AM (1993) Biology of free radical scavengers: an evaluation of ascorbate. FASEB J 7:1135\u20131142","journal-title":"FASEB J"},{"key":"515_CR20","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0003-9861(72)90246-9","volume":"152","author":"Y Nakashima","year":"1972","unstructured":"Nakashima Y, Suzue R, Sanada H, Kawada S (1972) Effect of ascorbic acid on tyrosine hydroxylase activity in vivo. Arch Biochem Biophys 152:515\u2013520","journal-title":"Arch Biochem Biophys"},{"key":"515_CR21","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/S0024-3205(02)02481-5","volume":"72","author":"K Kawai","year":"2003","unstructured":"Kawai K, Ito H, Kubota H, Takemori K, Makino S, Horio F (2003) Changes in catecholamine metabolism by ascorbic acid deficiency in spontaneously hypertensive rats unable to synthesize ascorbic acid. Life Sci 72:1717\u20131732","journal-title":"Life Sci"},{"key":"515_CR22","doi-asserted-by":"crossref","first-page":"276","DOI":"10.5925\/jnsv1954.16.276","volume":"16","author":"Y Nakashima","year":"1970","unstructured":"Nakashima Y, Suzue R, Sanada H, Kawada S (1970) Effect of ascorbic acid on hydroxylase activity. I. Stimulation of tyrosine hydroxylase and tryptophan-5-hydroxylase activities by ascorbic acid. J Vitaminol 16:276\u2013280","journal-title":"J Vitaminol"},{"key":"515_CR23","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1096\/fj.02-1167fje","volume":"17","author":"SR Bornstein","year":"2003","unstructured":"Bornstein SR, Yoshida-Hiroi M, Sotiriou S, Levine M, Hartwig HG, Nussbaum RL, Eisenhofer G (2003) Impaired adrenal catecholamine system function in mice with deficiency of the ascorbic acid transporter (SVCT2). FASEB J 17:1928\u20131930. doi: 10.1096\/fj.02-1167fje","journal-title":"FASEB J"},{"key":"515_CR24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00726-007-0555-7","volume":"34","author":"I Savini","year":"2008","unstructured":"Savini I, Rossi A, Pierro C, Avigliano L, Catani MV (2008) SVCT1 and SVCT2: key proteins for vitamin C uptake. Amino Acids 34:347\u2013355. doi: 10.1007\/s00726-007-0555-7","journal-title":"Amino Acids"},{"key":"515_CR25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0304-4165(92)90108-7","volume":"1116","author":"T Fujita","year":"1992","unstructured":"Fujita T, Uchida K, Maruyama N (1992) Purification of senescence marker protein-30 (SMP30) and its androgen-independent decrease with age in the rat liver. Biochim Biophys Acta 1116:122\u2013128","journal-title":"Biochim Biophys Acta"},{"key":"515_CR26","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1248\/cpb.26.1915","volume":"26","author":"M Yamaguchi","year":"1978","unstructured":"Yamaguchi M, Yamamoto T (1978) Purification of calcium binding substance from soluble fraction of normal rat liver. Chem Pharm Bull 26:1915\u20131918","journal-title":"Chem Pharm Bull"},{"key":"515_CR27","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1073\/pnas.0511225103","volume":"103","author":"Y Kondo","year":"2006","unstructured":"Kondo Y, Inai Y, Sato Y, Handa S, Kubo S, Shimokado K, Goto S, Nishikimi M, Maruyama N, Ishigami A (2006) Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Proc Natl Acad Sci USA 103:5723\u20135728","journal-title":"Proc Natl Acad Sci USA"},{"key":"515_CR28","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S0002-9440(10)64404-5","volume":"161","author":"A Ishigami","year":"2002","unstructured":"Ishigami A, Fujita T, Handa S, Shirasawa T, Koseki H, Kitamura T, Enomoto N, Sato N, Shimosawa T, Maruyama N (2002) Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-\u03b1- and Fas-mediated apoptosis. Am J Pathol 161:1273\u20131281","journal-title":"Am J Pathol"},{"key":"515_CR29","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bbrc.2008.08.020","volume":"375","author":"Y Sato","year":"2008","unstructured":"Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, Handa S, Takahashi R, Fukui M, Hasegawa G, Nakamura N, Fujinawa H, Mori T, Ohta M, Obayashi H, Maruyama N, Ishigami A (2008) Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30\/GNL knockout mice. Biochem Biophys Res Commun 375:346\u2013350","journal-title":"Biochem Biophys Res Commun"},{"key":"515_CR30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.bbrc.2008.09.132","volume":"377","author":"Y Kondo","year":"2008","unstructured":"Kondo Y, Sasaki T, Sato Y, Amano A, Aizawa S, Iwama M, Handa S, Shimada N, Fukuda M, Akita M, Lee J, Jeong KS, Maruyama N, Ishigami A (2008) Vitamin C depletion increases superoxide generation in brains of SMP30\/GNL knockout mice. Biochem Biophys Res Commun 377:291\u2013296","journal-title":"Biochem Biophys Res Commun"},{"key":"515_CR31","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.exer.2011.11.010","volume":"94","author":"Y Ishikawa","year":"2012","unstructured":"Ishikawa Y, Hashizume K, Kishimoto S, Tezuka Y, Nishigori H, Yamamoto N, Kondo Y, Maruyama N, Ishigami A, Kurosaka D (2012) Effect of vitamin C depletion on UVR-B induced cataract in SMP30\/GNL knockout mice. Exp Eye Res 94:85\u201389. doi: 10.1016\/j.exer.2011.11.010","journal-title":"Exp Eye Res"},{"key":"515_CR32","doi-asserted-by":"crossref","first-page":"L784","DOI":"10.1152\/ajplung.00256.2009","volume":"298","author":"K Koike","year":"2010","unstructured":"Koike K, Kondo Y, Sekiya M, Sato Y, Tobino K, Iwakami SI, Goto S, Takahashi K, Maruyama N, Seyama K, Ishigami A (2010) Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice. Am J Physiol Lung Cell Mol Physiol 298:L784\u2013L792. doi: 00256.2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"515_CR33","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.bbrc.2009.05.104","volume":"385","author":"KY Arai","year":"2009","unstructured":"Arai KY, Sato Y, Kondo Y, Kudo C, Tsuchiya H, Nomura Y, Ishigami A, Nishiyama T (2009) Effects of vitamin C deficiency on the skin of the senescence marker protein-30 (SMP30) knockout mouse. Biochem Biophys Res Commun 385:478\u2013483","journal-title":"Biochem Biophys Res Commun"},{"key":"515_CR34","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1038\/jid.2012.105","volume":"132","author":"Y Sato","year":"2012","unstructured":"Sato Y, Arai KY, Nishiyama T, Nomura Y, Kishimoto Y, Aizawa S, Maruyama N, Ishigami A (2012) Ascorbic acid deficiency leads to epidermal atrophy and UVB-induced skin pigmentation in SMP30\/GNL knockout hairless mice. J Invest Dermatol 132:2112\u20132115. doi: 10.1038\/jid.2012.105","journal-title":"J Invest Dermatol"},{"key":"515_CR35","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.abb.2010.01.012","volume":"496","author":"A Amano","year":"2010","unstructured":"Amano A, Aigaki T, Maruyama N, Ishigami A (2010) Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30\/GNL knockout mice. Arch Biochem Biophys 496:38\u201344","journal-title":"Arch Biochem Biophys"},{"key":"515_CR36","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1248\/bpb.31.1673","volume":"31","author":"H Furusawa","year":"2008","unstructured":"Furusawa H, Sato Y, Tanaka Y, Inai Y, Amano A, Iwama M, Kondo Y, Handa S, Murata A, Nishikimi M, Goto S, Maruyama N, Takahashi R, Ishigami A (2008) Vitamin C is not essential for carnitine biosynthesis in vivo: verification in vitamin C-depleted senescence marker protein-30\/gluconolactonase knockout mice. Biol Pharm Bull 31:1673\u20131679","journal-title":"Biol Pharm Bull"},{"key":"515_CR37","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.nut.2010.04.010","volume":"27","author":"M Iwama","year":"2011","unstructured":"Iwama M, Shimokado K, Maruyama N, Ishigami A (2011) Time course of vitamin C distribution and absorption after oral administration in SMP30\/GNL knockout mice. Nutrition 27:471\u2013478. doi: 10.1016\/j.nut.2010.04.010","journal-title":"Nutrition"},{"key":"515_CR38","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1248\/bpb.33.364","volume":"33","author":"Y Sato","year":"2010","unstructured":"Sato Y, Uchiki T, Iwama M, Kishimoto Y, Takahashi R, Ishigami A (2010) Determination of dehydroascorbic acid in mouse tissues and plasma by using tris(2-carboxyethyl)phosphine hydrochloride as reductant in metaphosphoric acid\/ethylenediaminetetraacetic acid solution. Biol Pharm Bull 33:364\u2013369","journal-title":"Biol Pharm Bull"},{"key":"515_CR39","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s00216-006-0675-z","volume":"386","author":"M Tsunoda","year":"2006","unstructured":"Tsunoda M (2006) Recent advances in methods for the analysis of catecholamines and their metabolites. Anal Bioanal Chem 386:506\u2013514. doi: 10.1007\/s00216-006-0675-z","journal-title":"Anal Bioanal Chem"},{"key":"515_CR40","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156\u2013159. doi: 10.1006\/abio.1987.99990003-2697(87)90021-2","journal-title":"Anal Biochem"},{"key":"515_CR41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/ecam\/nem184","volume":"7","author":"R Aalinkeel","year":"2010","unstructured":"Aalinkeel R, Hu Z, Nair BB, Sykes DE, Reynolds JL, Mahajan SD, Schwartz SA (2010) Genomic analysis highlights the role of the JAK-STAT Signaling in the anti-proliferative effects of dietary flavonoid-\u2018Ashwagandha\u2019 in prostate cancer cells. Evid Based Complement Alternat Med 7:177\u2013187","journal-title":"Evid Based Complement Alternat Med"},{"key":"515_CR42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1756-0500-2-89","volume":"2","author":"W Zhu","year":"2009","unstructured":"Zhu W, Qin W, Atasoy U, Sauter ER (2009) Circulating microRNAs in breast cancer and healthy subjects. BMC Res Notes 2:89","journal-title":"BMC Res Notes"},{"key":"515_CR43","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680\u2013685","journal-title":"Nature"},{"key":"515_CR44","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","volume":"76","author":"H Towbin","year":"1979","unstructured":"Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350\u20134354","journal-title":"Proc Natl Acad Sci USA"},{"key":"515_CR45","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1113\/expphysiol.2009.048553","volume":"95","author":"H Tsuchimochi","year":"2010","unstructured":"Tsuchimochi H, Nakamoto T, Matsukawa K (2010) Centrally evoked increase in adrenal sympathetic outflow elicits immediate secretion of adrenaline in anaesthetized rats. Exp Physiol 95:93\u2013106","journal-title":"Exp Physiol"},{"key":"515_CR46","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0165-022X(00)00142-1","volume":"48","author":"N Markoglou","year":"2001","unstructured":"Markoglou N, Wainer IW (2001) Synthesis and characterization of immobilized dopamine \u03b2-hydroxylase in membrane-bound and solubilized formats. J Biochem Biophys Methods 48:61\u201375","journal-title":"J Biochem Biophys Methods"},{"key":"515_CR47","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1016\/S0021-9258(18)93832-9","volume":"239","author":"T Nagatsu","year":"1964","unstructured":"Nagatsu T, Levitt M, Udenfriend S (1964) Tyrosine hydroxylase. The initial step in norepinephrine biosynthesis. J Biol Chem 239:2910\u20132917","journal-title":"J Biol Chem"},{"key":"515_CR48","doi-asserted-by":"crossref","first-page":"15598","DOI":"10.1016\/S0021-9258(17)36300-7","volume":"260","author":"M Levine","year":"1985","unstructured":"Levine M, Morita K, Heldman E, Pollard HB (1985) Ascorbic acid regulation of norepinephrine biosynthesis in isolated chromaffin granules from bovine adrenal medulla. J Biol Chem 260:15598\u201315603","journal-title":"J Biol Chem"},{"key":"515_CR49","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0006-2952(69)90034-3","volume":"18","author":"ML Sears","year":"1969","unstructured":"Sears ML (1969) Vitamin C as a requirement for the storage of norepinephrine by the iris. Biochem Pharmacol 18:253\u2013256","journal-title":"Biochem Pharmacol"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-013-0515-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-013-0515-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-013-0515-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T18:56:50Z","timestamp":1644605810000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-013-0515-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,19]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["515"],"URL":"https:\/\/doi.org\/10.1007\/s00394-013-0515-9","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,19]]}}}