{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:34:30Z","timestamp":1791174870809,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1007\/s00394-014-0690-3","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T12:09:22Z","timestamp":1396267762000},"page":"101-107","source":"Crossref","is-referenced-by-count":85,"title":["Effects of a caloric restriction weight loss diet on tryptophan metabolism and inflammatory biomarkers in overweight adults"],"prefix":"10.1007","volume":"54","author":[{"given":"Barbara","family":"Strasser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"key":"690_CR1","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1161\/01.ATV.0000134293.31512.be","volume":"24","author":"G Engstr\u00f6m","year":"2004","unstructured":"Engstr\u00f6m G, Hedblad B, Stavenow L, Jonsson S, Lind P, Janzon L, Lindg\u00e4rde F (2004) Incidence of obesity-associated cardiovascular disease is related to inflammation-sensitive plasma proteins: a population-based cohort study. Arterioscler Thromb Vasc Biol 24:1498\u20131502","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"690_CR2","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1139\/H09-037","volume":"34","author":"DJ Dyck","year":"2009","unstructured":"Dyck DJ (2009) Adipokines as regulators of muscle metabolism and insulin sensitivity. Appl Physiol Nutr Metab 34:396\u2013402","journal-title":"Appl Physiol Nutr Metab"},{"key":"690_CR3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jcp.21386","volume":"216","author":"P Wang","year":"2008","unstructured":"Wang P, Mariman E, Renes J, Keijer J (2008) The secretory function of adipocytes in the physiology of white adipose tissue. J Cell Physiol 216:3\u201313","journal-title":"J Cell Physiol"},{"key":"690_CR4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2174\/138920007780362590","volume":"8","author":"G Brandacher","year":"2007","unstructured":"Brandacher G, Hoeller E, Fuchs D, Weiss HG (2007) Chronic immune activation underlies morbid obesity: is IDO a key player? Curr Drug Metab 8:289\u2013295","journal-title":"Curr Drug Metab"},{"key":"690_CR5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1748-1716.2012.02410.x","volume":"205","author":"F Nduhirabandi","year":"2012","unstructured":"Nduhirabandi F, du Toit EF, Lochner A (2012) Melatonin and the metabolic syndrome: a tool for effective therapy in obesity-associated abnormalities? Acta Physiol 205:209\u2013223","journal-title":"Acta Physiol"},{"key":"690_CR6","doi-asserted-by":"crossref","unstructured":"Mangge H, Summers KL, Meinitzer A, Zelzer S, Almer G, Prassl R, Schnedl WJ, Reininghaus E, Paulmichl K, Weghuber D, Fuchs D (2013) Obesity-related dysregulation of the Tryptophan-Kynurenine metabolism: Role of age and parameters of the metabolic syndrome. Obesity. doi: 10.1002\/oby.20491","DOI":"10.1002\/oby.20491"},{"key":"690_CR7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biopsych.2010.12.006","volume":"70","author":"L Capuron","year":"2011","unstructured":"Capuron L, Schroecksnadel S, F\u00e9art C, Aubert A, Higueret D, Barberger-Gateau P, Lay\u00e9 S, Fuchs D (2011) Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms. Biol Psychiatry 70:175\u2013182","journal-title":"Biol Psychiatry"},{"key":"690_CR8","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/sj.mp.4000995","volume":"7","author":"L Capuron","year":"2007","unstructured":"Capuron L, Ravaud A, Neveu PJ, Miller AH, Maes M, Dantzer R (2007) Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy. Mol Psychiatry 7:468\u2013473","journal-title":"Mol Psychiatry"},{"key":"690_CR9","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1001\/jama.297.9.986","volume":"297","author":"L Fontana","year":"2007","unstructured":"Fontana L, Klein S (2007) Aging, adiposity, and calorie restriction. JAMA 297:986\u2013994","journal-title":"JAMA"},{"key":"690_CR10","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412\u2013419","journal-title":"Diabetologia"},{"key":"690_CR11","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.clinbiochem.2013.10.015","volume":"46","author":"G Neurauter","year":"2013","unstructured":"Neurauter G, Scholl-B\u00fcrgi S, Haara A, Geisler S, Mayersbach P, Schennach H, Fuchs D (2013) Simultaneous measurement of phenylalanine and tyrosine by high performance liquid chromatography (HPLC) with fluorescence detection. Clin Biochem 46:1848\u20131851","journal-title":"Clin Biochem"},{"key":"690_CR12","doi-asserted-by":"crossref","first-page":"342","DOI":"10.2337\/dc11-1267","volume":"35","author":"M Bl\u00fcher","year":"2012","unstructured":"Bl\u00fcher M, Rudich A, Kl\u00f6ting N, Golan R, Henkin Y, Rubin E, Schwarzfuchs D, Gepner Y, Stampfer MJ, Fiedler M, Thiery J, Stumvoll M, Shai I (2012) Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention. Diabetes Care 35:342\u2013349","journal-title":"Diabetes Care"},{"key":"690_CR13","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1291\/hypres.25.881","volume":"25","author":"K Itoh","year":"2002","unstructured":"Itoh K, Imai K, Masuda T, Abe S, Tanaka M, Koga R, Itoh H, Matsuyama T, Nakamura M (2002) Relationship between changes in serum leptin levels and blood pressure after weight loss. Hypertens Res 25:881\u2013886","journal-title":"Hypertens Res"},{"key":"690_CR14","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1055\/s-0032-1306341","volume":"44","author":"F Oberhauser","year":"2012","unstructured":"Oberhauser F, Schulte DM, Faust M, G\u00fcdelh\u00f6fer H, Hahn M, M\u00fcller N, Neumann K, Krone W, Laudes M (2012) Weight loss due to a very low calorie diet nondiabetic obese human subjects. Horm Metab Res 44:465\u2013470","journal-title":"Horm Metab Res"},{"key":"690_CR15","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.metabol.2009.02.010","volume":"58","author":"T Ruge","year":"2009","unstructured":"Ruge T, Lockton JA, Renstrom F, Lystig T, Sukonina V, Svensson MK, Eriksson JW (2009) Acute hyperinsulinemia raises plasma interleukin-6 in both nondiabetic and type 2 diabetes mellitus subjects, and this effect is inversely associated with body mass index. Metabolism 58:860\u2013866","journal-title":"Metabolism"},{"key":"690_CR16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.psyneuen.2010.07.009","volume":"36","author":"S H\u00e4fner","year":"2011","unstructured":"H\u00e4fner S, Zierer A, Emeny RT, Thorand B, Herder C, Koenig W, Rupprecht R, Ladwig KH, KORA Study Investigators (2011) Social isolation and depressed mood are associated with elevated serum leptin levels in men but not in women. Psychoneuroendocrinology 36:200\u2013209","journal-title":"Psychoneuroendocrinology"},{"key":"690_CR17","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0889-1591(02)00006-5","volume":"16","author":"B Widner","year":"2002","unstructured":"Widner B, Laich A, Sperner-Unterweger B, Ledochowski M, Fuchs D (2002) Neopterin production tryptophan degradation and mental depression: what is the link? Brain Behav Immun 16:590\u2013595","journal-title":"Brain Behav Immun"},{"key":"690_CR18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1515\/pteridines.1997.8.3.211","volume":"8","author":"G Reibnegger","year":"1997","unstructured":"Reibnegger G, Vrecko K, Mlekusch W, Lamprecht M (1997) Influence of three different diet modes combined with exercise loads on urinary and plasma neopterin concentrations: a longitudinal study. Pteridines 8:211\u2013215","journal-title":"Pteridines"},{"key":"690_CR19","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1017\/S0033291700036473","volume":"20","author":"IM Anderson","year":"1990","unstructured":"Anderson IM, Parry-Billings M, Newsholme EA, Fairburn CH, Cowen PJ (1990) Dieting reduces plasma tryptophan and alters brain 5-HT function in women. Psychol Med 20:785\u2013791","journal-title":"Psychol Med"},{"key":"690_CR20","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/mp.2009.116","volume":"15","author":"CL Raison","year":"2010","unstructured":"Raison CL, Dantzer R, Kelley KW, Lawson MA, Woolwine BJ, Vogt G, Spivey JR, Saito K, Miller AH (2010) CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Mol Psychiatry 15:393\u2013403","journal-title":"Mol Psychiatry"},{"key":"690_CR21","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.psyneuen.2010.09.012","volume":"36","author":"R Dantzer","year":"2011","unstructured":"Dantzer R, O\u2019Connor JC, Lawson MA, Kelley KW (2011) Inflammation-associated depression: from serotonin to kynurenine. Psychoneuroendocrinology 36:426\u2013436","journal-title":"Psychoneuroendocrinology"},{"key":"690_CR22","doi-asserted-by":"crossref","first-page":"20110375","DOI":"10.1098\/rstb.2011.0375","volume":"368","author":"SN Young","year":"2013","unstructured":"Young SN (2013) The effect of raising and lowering tryptophan levels on human mood and social behaviour. Philos Trans R Soc Lond B Biol Sci 368:20110375","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"690_CR23","first-page":"81","volume":"64","author":"E Gatti","year":"1994","unstructured":"Gatti E, Porrini M, Noe D, Crovetti R, Testolin G (1994) Plasma amino acids changes in obese patients on very low-calorie diets. Int J Vitam Nutr Res 64:81\u201385","journal-title":"Int J Vitam Nutr Res"},{"key":"690_CR24","doi-asserted-by":"crossref","first-page":"477S","DOI":"10.1002\/j.1550-8528.1995.tb00215.x","volume":"3","author":"RJ Wurtman","year":"1995","unstructured":"Wurtman RJ, Wurtman JJ (1995) Brain serotonin, carbohydrate-craving, obesity and depression. Obes Res 3:477S\u2013480S","journal-title":"Obes Res"},{"key":"690_CR25","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/13548500600621545","volume":"12","author":"I Amigo","year":"2007","unstructured":"Amigo I, Fern\u00e1ndez C (2007) Effects of diets and their role in weight control. Psychol Health Med 12:321\u2013327","journal-title":"Psychol Health Med"},{"key":"690_CR26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1053\/meta.2002.29976","volume":"51","author":"T Kajioka","year":"2002","unstructured":"Kajioka T, Tsuzuku S, Shimokata H, Sato Y (2002) Effects of intentional weight cycling on non-obese young women. Metabolism 51:149\u2013154","journal-title":"Metabolism"},{"key":"690_CR27","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1745-7599.2012.00808.x","volume":"25","author":"JL Banasik","year":"2013","unstructured":"Banasik JL, Walker MK, Randall JM, Netjes RB, Foutz MS (2013) Low-calorie diet induced weight loss may alter regulatory hormones and contribute to rebound visceral adiposity in obese persons with a family history of type-2 diabetes. J Am Assoc Nurse Pract 25:440\u2013448","journal-title":"J Am Assoc Nurse Pract"},{"key":"690_CR28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.metabol.2012.06.012","volume":"62","author":"C Mason","year":"2013","unstructured":"Mason C, Foster-Schubert KE, Imayama I, Xiao L, Kong A, Campbell KL, Duggan CR, Wang CY, Alfano CM, Ulrich CM, Blackburn GL, McTiernan A (2013) History of weight cycling does not impede future weight loss or metabolic improvements in postmenopausal women. Metabolism 62:127\u2013136","journal-title":"Metabolism"},{"key":"690_CR29","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1600-0447.2011.01706.x","volume":"124","author":"G Parker","year":"2011","unstructured":"Parker G, Brotchie H (2011) Mood effects of the amino acids tryptophan and tyrosine: \u2018Food for Thought\u2019 III. Acta Psychiatr Scand 124:417\u2013426","journal-title":"Acta Psychiatr Scand"},{"key":"690_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/IJTR.S2097","volume":"2","author":"Y Chen","year":"2009","unstructured":"Chen Y, Guillemin GJ (2009) Kynurenine pathway metabolites in humans: disease and healthy states. Int J Tryptophan Res 2:1\u201319","journal-title":"Int J Tryptophan Res"},{"key":"690_CR31","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.metabol.2006.10.015","volume":"56","author":"MJ Dekker","year":"2007","unstructured":"Dekker MJ, Lee S, Hudson R, Kilpatrick K, Graham TE, Ross R, Robinson LE (2007) An exercise intervention without weight loss decreases circulating interleukin-6 in lean and obese men with and without type 2 diabetes mellitus. Metabolism 56:332\u2013338","journal-title":"Metabolism"},{"key":"690_CR32","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.numecd.2009.04.015","volume":"20","author":"S Balducci","year":"2010","unstructured":"Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P, Fallucca S, Alessi E, Letizia C, Jimenez A, Fallucca F, Pugliese G (2010) Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis 20:608\u2013617","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"690_CR33","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1467-789X.2012.00988.x","volume":"13","author":"B Strasser","year":"2012","unstructured":"Strasser B, Arvandi M, Siebert U (2012) Resistance training, visceral obesity and inflammatory response: a review of the evidence. Obes Rev 13:578\u2013591","journal-title":"Obes Rev"},{"key":"690_CR34","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0031-9384(92)90465-E","volume":"52","author":"S Dey","year":"1992","unstructured":"Dey S, Singh RH, Dey PK (1992) Exercise training: significance of regional alterations in serotonin metabolism of rat brain in relation to antidepressant effect of exercise. Physiol Behav 52:1095\u20131099","journal-title":"Physiol Behav"},{"key":"690_CR35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0006-8993(96)00872-4","volume":"740","author":"R Meeusen","year":"1996","unstructured":"Meeusen R, Thorr\u00e9 K, Chaouloff F, Sarre S, De Meirleir K, Ebinger G, Michotte Y (1996) Effects of tryptophan and\/or acute running on extracellular 5-HT and 5-HIAA levels in the hippocampus of food-deprived rats. Brain Res 740:245\u2013252","journal-title":"Brain Res"},{"key":"690_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.amepre.2004.09.003","volume":"28","author":"AL Dunn","year":"2005","unstructured":"Dunn AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO (2005) Exercise treatment for depression: efficacy and dose response. Am J Prev Med 28:1\u20138","journal-title":"Am J Prev Med"},{"key":"690_CR37","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/00006842-200009000-00006","volume":"62","author":"M Babyak","year":"2000","unstructured":"Babyak M, Blumenthal JA, Herman S, Khatri P, Doraiswamy M, Moore K, Craighead WE, Baldewicz TT, Krishnan KR (2000) Exercise treatment for major depression: maintenance of therapeutic benefit at 10\u00a0months. Psychosom Med 62:633\u2013638","journal-title":"Psychosom Med"},{"key":"690_CR38","doi-asserted-by":"crossref","first-page":"291371","DOI":"10.1155\/2013\/291371","volume":"2013","author":"CE Blake","year":"2013","unstructured":"Blake CE, H\u00e9bert JR, Lee DC, Adams SA, Steck SE, Sui X, Kuk JL, Baruth M, Blair SN (2013) Adults with greater weight satisfaction report more positive health behaviors and have better health status regardless of BMI. J Obes 2013:291371","journal-title":"J Obes"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-014-0690-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-014-0690-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-014-0690-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T14:00:00Z","timestamp":1716645600000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-014-0690-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["690"],"URL":"https:\/\/doi.org\/10.1007\/s00394-014-0690-3","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,1]]}}}