{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:07:33Z","timestamp":1767139653647,"version":"build-2238731810"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T00:00:00Z","timestamp":1417651200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s00394-014-0809-6","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T07:23:07Z","timestamp":1417591387000},"page":"667-676","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Maternal vitamin C deficiency during pregnancy results in transient fetal and placental growth retardation in guinea pigs"],"prefix":"10.1007","volume":"54","author":[{"given":"Janne Gram","family":"Schjoldager","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya Devi","family":"Paidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiken Marie","family":"Lindblad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malene Muusfeldt","family":"Birck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid Birch","family":"Kj\u00e6rgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibeke","family":"Dantzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Lykkesfeldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernille","family":"Tveden-Nyborg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,12,4]]},"reference":[{"key":"809_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3177\/jnsv.55.1","volume":"55","author":"YZ Wang","year":"2009","unstructured":"Wang YZ, Ren WH, Liao WQ, Zhang GY (2009) Concentrations of antioxidant vitamins in maternal and cord serum and their effect on birth outcomes. J Nutr Sci Vitaminol (Tokyo) 55:1\u20138","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"809_CR2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1024\/0300-9831.72.3.183","volume":"72","author":"J Dejmek","year":"2002","unstructured":"Dejmek J, Ginter E, Solansky I, Podrazilova K, Stavkova Z, Benes I, Sram RJ (2002) Vitamin C, E and A levels in maternal and fetal blood for Czech and gypsy ethnic groups in the Czech Republic. Int J Vitam Nutr Res 72:183\u2013190","journal-title":"Int J Vitam Nutr Res"},{"key":"809_CR3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1024\/0300-9831.74.3.193","volume":"74","author":"AM Oliveira de","year":"2004","unstructured":"de Oliveira AM, Rondo PHD, Barros SBD (2004) Concentrations of ascorbic acid in the plasma of pregnant smokers and nonsmokers and their newborns. Int J Vitam Nutr Res 74:193\u2013198","journal-title":"Int J Vitam Nutr Res"},{"key":"809_CR4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0188-4409(02)00356-9","volume":"33","author":"G Baydas","year":"2002","unstructured":"Baydas G, Karatas F, Gursu MF, Bozkurt HA, Ilhan N, Yasar A, Canatan H (2002) Antioxidant vitamin levels in term and preterm infants and their relation to maternal vitamin status. Arch Med Res 33:276\u2013280","journal-title":"Arch Med Res"},{"key":"809_CR5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11010-007-9638-8","volume":"309","author":"S Jain","year":"2008","unstructured":"Jain S, Wise R, Yanamandra K, Dhanireddy R, Bocchini J (2008) The effect of maternal and cord-blood vitamin C, vitamin E and lipid peroxide levels on newborn birth weight. Mol Cell Biochem 309:217\u2013221","journal-title":"Mol Cell Biochem"},{"key":"809_CR6","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1017\/S0007114513000913","volume":"110","author":"JG Schjoldager","year":"2013","unstructured":"Schjoldager JG, Tveden-Nyborg P, Lykkesfeldt J (2013) Prolonged maternal vitamin C deficiency overrides preferential fetal ascorbate transport but does not influence perinatal survival in guinea pigs. Br J Nutr 110:1573\u20131579","journal-title":"Br J Nutr"},{"key":"809_CR7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.brainres.2010.06.037","volume":"1349","author":"FE Harrison","year":"2010","unstructured":"Harrison FE, Meredith ME, Dawes SM, Saskowski JL, May JM (2010) Low ascorbic acid and increased oxidative stress in gulo(-\/-) mice during development. Brain Res 1349:143\u2013152","journal-title":"Brain Res"},{"key":"809_CR8","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/01.HYP.0000201444.80784.59","volume":"47","author":"RJ Ramirez","year":"2006","unstructured":"Ramirez RJ, Hubel CA, Novak J, DiCianno JR, Kagan VE, Gandley RE (2006) Moderate ascorbate deficiency increases myogenic tone of arteries from pregnant but not virgin ascorbate-dependent rats. Hypertension 47:454\u2013460","journal-title":"Hypertension"},{"key":"809_CR9","doi-asserted-by":"crossref","first-page":"e48488","DOI":"10.1371\/journal.pone.0048488","volume":"7","author":"P Tveden-Nyborg","year":"2012","unstructured":"Tveden-Nyborg P, Vogt L, Schjoldager JG, Jeannet N, Hasselholt S, Paidi MD, Christen S, Lykkesfeldt J (2012) Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs. PLoS ONE 7:e48488","journal-title":"PLoS ONE"},{"key":"809_CR10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.redox.2014.01.009","volume":"2","author":"MD Paidi","year":"2014","unstructured":"Paidi MD, Schjoldager JG, Lykkesfeldt J, Tveden-Nyborg P (2014) Prenatal vitamin C deficiency results in differential levels of oxidative stress during late gestation in foetal guinea pig brains. Redox Biol 2:361\u2013367","journal-title":"Redox Biol"},{"key":"809_CR11","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.3390\/nu6051809","volume":"6","author":"MD Paidi","year":"2014","unstructured":"Paidi MD, Schjoldager JG, Lykkesfeldt J, Tveden-Nyborg P (2014) Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression. Nutrients 6:1809\u20131822","journal-title":"Nutrients"},{"key":"809_CR12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0300-9629(84)90111-7","volume":"78","author":"R Jenness","year":"1984","unstructured":"Jenness R, Birney EC, Ayaz KL, Buzzell DM (1984) Ontogenetic development of L-gulonolactone oxidase activity in several vertebrates. Comp Biochem Physiol B 78:167\u2013173","journal-title":"Comp Biochem Physiol B"},{"key":"809_CR13","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1126\/science.182.4118.1271","volume":"182","author":"IB Chatterj","year":"1973","unstructured":"Chatterj IB (1973) Evolution and biosynthesis of ascorbic-acid. Science 182:1271\u20131272","journal-title":"Science"},{"key":"809_CR14","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1080\/10408398.2011.649149","volume":"52","author":"B Frei","year":"2012","unstructured":"Frei B, Birlouez-Aragon I, Lykkesfeldt J (2012) Authors\u2019 perspective: What is the optimum intake of vitamin C in humans? Crit Rev Food Sci Nutr 52:815\u2013829","journal-title":"Crit Rev Food Sci Nutr"},{"key":"809_CR15","doi-asserted-by":"crossref","first-page":"9842","DOI":"10.1073\/pnas.171318198","volume":"98","author":"M Levine","year":"2001","unstructured":"Levine M, Wang YH, Padayatty SJ, Morrow J (2001) A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci USA 98:9842\u20139846","journal-title":"Proc Natl Acad Sci USA"},{"key":"809_CR16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/B978-0-12-394294-4.00007-9","volume":"68","author":"MC Vissers","year":"2013","unstructured":"Vissers MC, Carr AC, Pullar JM, Bozonet SM (2013) The bioavailability of vitamin C from kiwifruit. Adv Food Nutr Res 68:125\u2013147","journal-title":"Adv Food Nutr Res"},{"key":"809_CR17","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1017\/S0007114512001808","volume":"108","author":"B Troesch","year":"2012","unstructured":"Troesch B, Hoeft B, McBurney M, Eggersdorfer M, Weber P (2012) Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries. Br J Nutr 108:692\u2013698","journal-title":"Br J Nutr"},{"key":"809_CR18","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1542\/peds.100.3.323","volume":"100","author":"KA Munoz","year":"1997","unstructured":"Munoz KA, Krebs-Smith SM, Ballard-Barbash R, Cleveland LE (1997) Food intakes of US children and adolescents compared with recommendations. Pediatrics 100:323\u2013329","journal-title":"Pediatrics"},{"key":"809_CR19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1079\/BJN19980073","volume":"79","author":"RM Ortega","year":"1998","unstructured":"Ortega RM, Quintas ME, Andres P, Martinez RM, Lopez-Sobaler AM (1998) Ascorbic acid levels in maternal milk: differences with respect to ascorbic acid status during the third trimester of pregnancy. Br J Nutr 79:431\u2013437","journal-title":"Br J Nutr"},{"key":"809_CR20","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/07315724.1998.10718777","volume":"17","author":"CS Johnston","year":"1998","unstructured":"Johnston CS, Thompson LL (1998) Vitamin C status of an outpatient population. J Am Coll Nutr 17:366\u2013370","journal-title":"J Am Coll Nutr"},{"key":"809_CR21","first-page":"323","volume-title":"Vitamins for prevention of human diseases","author":"H Frikke-Schmidt","year":"2011","unstructured":"Frikke-Schmidt H, Tveden-Nyborg P, Lykkesfeldt J (2011) Vitamin C in human nutrition. In: Hermann W, Obeid R (eds) Vitamins for prevention of human diseases, 1st edn. Walter de Gruyter GmbH & Co, KG, Berlin, pp 323\u2013347","edition":"1"},{"key":"809_CR22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/19986","volume":"399","author":"H Tsukaguchi","year":"1999","unstructured":"Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (1999) A family of mammalian Na+-dependent l-ascorbic acid transporters. Nature 399:70\u201375","journal-title":"Nature"},{"key":"809_CR23","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.3390\/nu5082860","volume":"5","author":"M Lindblad","year":"2013","unstructured":"Lindblad M, Tveden-Nyborg P, Lykkesfeldt J (2013) Regulation of vitamin C homeostasis during deficiency. Nutrients 5:2860\u20132879","journal-title":"Nutrients"},{"key":"809_CR24","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1111\/j.1476-5381.2011.01350.x","volume":"164","author":"JM May","year":"2011","unstructured":"May JM (2011) The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C. Br J Pharmacol 164:1793\u20131801","journal-title":"Br J Pharmacol"},{"key":"809_CR25","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/0502-514","volume":"8","author":"S Sotiriou","year":"2002","unstructured":"Sotiriou S, Gispert S, Cheng J, Wang YH, Chen A, Hoogstraten-Miller S, Miller GF, Kwon O, Levine M, Guttentag SH, Nussbaum RL (2002) Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med 8:514\u2013517","journal-title":"Nat Med"},{"key":"809_CR26","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1172\/JCI39191","volume":"120","author":"CP Corpe","year":"2010","unstructured":"Corpe CP, Tu H, Eck P, Wang J, Faulhaber-Walter R, Schnermann J, Margolis S, Padayatty S, Sun H, Wang Y, Nussbaum RL, Espey MG, Levine M (2010) Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. J Clin Invest 120:1069\u20131083","journal-title":"J Clin Invest"},{"key":"809_CR27","doi-asserted-by":"crossref","first-page":"E1667","DOI":"10.1210\/jc.2012-1753","volume":"97","author":"L Chen","year":"2012","unstructured":"Chen L, Zhu H, Pan Y, Tang C, Watanabe M, Ruan H, Wang Y, Wang J, Yao HY, Iguchi T, Wu X (2012) Ascorbic acid uptaken by sodium-dependent vitamin C transporter 2 induces betahCG expression through Sp1 and TFAP2A transcription factors in human choriocarcinoma cells. J Clin Endocrinol Metab 97:E1667\u2013E1676","journal-title":"J Clin Endocrinol Metab"},{"key":"809_CR28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/bmj.319.7206.339","volume":"319","author":"F Mathews","year":"1999","unstructured":"Mathews F, Yudkin P, Neil A (1999) Influence of maternal nutrition on outcome of pregnancy: prospective cohort study. BMJ 319:339\u2013343","journal-title":"BMJ"},{"key":"809_CR29","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/sj.ejcn.1601976","volume":"58","author":"BE Lee","year":"2004","unstructured":"Lee BE, Hong YC, Lee KH, Kim YJ, Kim WK, Chang NS, Park EA, Park HS, Hann HJ (2004) Influence of maternal serum levels of vitamins C and E during the second trimester on birth weight and length. Eur J Clin Nutr 58:1365\u20131371","journal-title":"Eur J Clin Nutr"},{"key":"809_CR30","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1067\/S0002-9378(03)00363-6","volume":"189","author":"AM Siega-Riz","year":"2003","unstructured":"Siega-Riz AM, Promislow JHE, Savitz DA, Thorp JM, McDonald T (2003) Vitamin C intake and the risk of preterm delivery. Am J Obstet Gynecol 189:519\u2013525","journal-title":"Am J Obstet Gynecol"},{"key":"809_CR31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejogrb.2012.06.020","volume":"164","author":"N Hovdenak","year":"2012","unstructured":"Hovdenak N, Haram K (2012) Influence of mineral and vitamin supplements on pregnancy outcome. Eur J Obstet Gynecol Reprod Biol 164:127\u2013132","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"809_CR32","first-page":"503","volume":"204","author":"Conde-Agudelo An","year":"2011","unstructured":"An Conde-Agudelo, Romero R, Kusanovic JP, Hassan SS (2011) Supplementation with vitamins C and E during pregnancy for the prevention of preeclampsia and other adverse maternal and perinatal outcomes: a systematic review and metaanalysis. Am J Obstet Gynecol 204:503\u2013561","journal-title":"Am J Obstet Gynecol"},{"key":"809_CR33","first-page":"1","volume":"2012","author":"AMR Salles","year":"2012","unstructured":"Salles AMR, Galvao TF, Silva MT, Motta LCD, Pereira MG (2012) Antioxidants for preventing preeclampsia: a systematic review. SciWorldJ 2012:1\u201310","journal-title":"SciWorldJ"},{"key":"809_CR34","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1017\/S0007114507787457","volume":"98","author":"J Lykkesfeldt","year":"2007","unstructured":"Lykkesfeldt J, Trueba GP, Poulsen HE, Christen S (2007) Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain. Br J Nutr 98:1116\u20131119","journal-title":"Br J Nutr"},{"key":"809_CR35","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1742-7843.2011.00852.x","volume":"110","author":"P Tveden-Nyborg","year":"2012","unstructured":"Tveden-Nyborg P, Hasselholt S, Miyashita N, Moos T, Poulsen HE, Lykkesfeldt J (2012) Chronic vitamin C deficiency does not accelerate oxidative stress in ageing brains of guinea pigs. Basic Clin Pharmacol Toxicol 110:524\u2013529","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"809_CR36","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3945\/ajcn.2009.27954","volume":"90","author":"P Tveden-Nyborg","year":"2009","unstructured":"Tveden-Nyborg P, Johansen LK, Raida Z, Villumsen CK, Larsen JO, Lykkesfeldt J (2009) Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs. Am J Clin Nutr 90:540\u2013546","journal-title":"Am J Clin Nutr"},{"issue":"17","key":"809_CR37","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1089\/ars.2013.5382","volume":"19","author":"P Tveden-Nyborg","year":"2013","unstructured":"Tveden-Nyborg P, Lykkesfeldt J (2013) Does vitamin C deficiency increase lifestyle-associated vascular disease progression? Evidence based on experimental and clinical studies. Antioxid Redox Signal 19(17):2084\u20132104","journal-title":"Antioxid Redox Signal"},{"key":"809_CR38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","volume":"3","author":"J Dobbing","year":"1979","unstructured":"Dobbing J, Sands J (1979) Comparative aspects of the brain growth spurt. Early Hum Dev 3:79\u201383","journal-title":"Early Hum Dev"},{"key":"809_CR39","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuroscience.2004.07.047","volume":"129","author":"AE Rehn","year":"2004","unstructured":"Rehn AE, Van den Buuse M, Copolov D, Briscoe T, Lambert G, Rees S (2004) An animal model of chronic placental insufficiency: relevance to neurodevelopmental disorders including schizophrenia. Neuroscience 129:381\u2013391","journal-title":"Neuroscience"},{"key":"809_CR40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/aja.1001160103","volume":"116","author":"AC Enders","year":"1965","unstructured":"Enders AC (1965) A comparative study of fine structure of trophoblast in several hemochorial placentas. Am J Anat 116:29","journal-title":"Am J Anat"},{"key":"809_CR41","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.placenta.2006.11.002","volume":"28","author":"AM Carter","year":"2007","unstructured":"Carter AM (2007) Animal models of human placentation\u2014a review. Placenta 28:S41\u2013S47","journal-title":"Placenta"},{"key":"809_CR42","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/ar.1090180408","volume":"18","author":"RL Draper","year":"1920","unstructured":"Draper RL (1920) The prenatal growth of the guinea-pig. Anat Rec 18:369\u2013392","journal-title":"Anat Rec"},{"key":"809_CR43","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/ar.1091280408","volume":"128","author":"RW Goy","year":"1957","unstructured":"Goy RW, Hoar RM, Young WC (1957) Length of gestation in the guinea pig with data on the frequency and time of abortion and stillbirth. Anat Rec 128:747\u2013757","journal-title":"Anat Rec"},{"key":"809_CR44","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nutres.2011.11.005","volume":"32","author":"J Lykkesfeldt","year":"2012","unstructured":"Lykkesfeldt J (2012) Ascorbate and dehydroascorbic acid as biomarkers of oxidative stress: validity of clinical data depends on vacutainer system used. Nutr Res 32:66\u201369","journal-title":"Nutr Res"},{"key":"809_CR45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/abio.2000.4592","volume":"282","author":"J Lykkesfeldt","year":"2000","unstructured":"Lykkesfeldt J (2000) Determination of ascorbic acid and dehydroascorbic acid in biological samples by high-performance liquid chromatography using subtraction methods: reliable reduction with tris[2-carboxyethyl] phosphine hydrochloride. Anal Biochem 282:89\u201393","journal-title":"Anal Biochem"},{"key":"809_CR46","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1158\/1055-9965.EPI-07-0639","volume":"16","author":"J Lykkesfeldt","year":"2007","unstructured":"Lykkesfeldt J (2007) Ascorbate and dehydroascorbic acid as reliable biomarkers of oxidative stress: analytical reproducibility and long-term stability of plasma samples subjected to acidic deproteinization. Cancer Epidemiol Biomark Prev 16:2513\u20132516","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"809_CR47","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/ajcn\/65.4.959","volume":"65","author":"J Lykkesfeldt","year":"1997","unstructured":"Lykkesfeldt J, Loft S, Nielsen JB, Poulsen HE (1997) Ascorbic acid and dehydroascorbic acid as biomarkers of oxidative stress caused by smoking. Am J Clin Nutr 65:959\u2013963","journal-title":"Am J Clin Nutr"},{"key":"809_CR48","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","volume":"74","author":"PJ Hissin","year":"1976","unstructured":"Hissin PJ, Hilf R (1976) A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74:214\u2013226","journal-title":"Anal Biochem"},{"key":"809_CR49","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0945-053X(01)00193-7","volume":"21","author":"AG Clark","year":"2002","unstructured":"Clark AG, Rohrbaugh AL, Otterness I, Kraus VB (2002) The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. Matrix Biol 21:175\u2013184","journal-title":"Matrix Biol"},{"key":"809_CR50","doi-asserted-by":"crossref","first-page":"130.e1","DOI":"10.1016\/j.ajog.2012.11.014","volume":"208","author":"AK von Beckerath","year":"2013","unstructured":"von Beckerath AK, Kollmann M, Rotky-Fast C, Karpf E, Lang U, Klaritsch P (2013) Perinatal complications and long-term neurodevelopmental outcome of infants with intrauterine growth restriction. Am J Obstet Gynecol 208:130.e1\u20136","journal-title":"Am J Obstet Gynecol"},{"key":"809_CR51","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/uog.6109","volume":"32","author":"NG Pedersen","year":"2008","unstructured":"Pedersen NG, Wojdemann KR, Scheike T, Tabor A (2008) Fetal growth between the first and second trimesters and the risk of adverse pregnancy outcome. Ultrasound Obstet Gynecol 32:147\u2013154","journal-title":"Ultrasound Obstet Gynecol"},{"key":"809_CR52","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bpobgyn.2004.02.009","volume":"18","author":"SM Kady","year":"2004","unstructured":"Kady SM, Gardosi J (2004) Perinatal mortality and fetal growth restriction. Best Pract Res Clin Obstet Gynaecol 18:397\u2013410","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"809_CR53","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1479-828X.2011.01299.x","volume":"51","author":"M Damodaram","year":"2011","unstructured":"Damodaram M, Story L, Kulinskaya E, Rutherford M, Kumar S (2011) Early adverse perinatal complications in preterm growth-restricted fetuses. Aust N Z J Obstet Gynaecol 51:204\u2013209","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"809_CR54","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/uog.4042","volume":"29","author":"E Tideman","year":"2007","unstructured":"Tideman E, Marsal K, Ley D (2007) Cognitive function in young adults following intrauterine growth restriction with abnormal fetal aortic blood flow. Ultrasound Obstet Gynecol 29:614\u2013618","journal-title":"Ultrasound Obstet Gynecol"},{"key":"809_CR55","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/BF00400248","volume":"35","author":"CN Hales","year":"1992","unstructured":"Hales CN, Barker DJ (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35:595\u2013601","journal-title":"Diabetologia"},{"key":"809_CR56","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1471-0528.1997.tb11975.x","volume":"104","author":"KM Godfrey","year":"1997","unstructured":"Godfrey KM, Barker DJP, Robinson S, Osmond C (1997) Maternal birthweight and diet in pregnancy in relation to the infant\u2019s thinness at birth. Br J Obstet Gynaecol 104:663\u2013667","journal-title":"Br J Obstet Gynaecol"},{"key":"809_CR57","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ajog.2004.03.040","volume":"191","author":"TJ Garite","year":"2004","unstructured":"Garite TJ, Clark RH, Elliott JP, Thorp JA (2004) Twins and triplets: the effect of plurality and growth on neonatal outcome compared with singleton infants. Am J Obstet Gynecol 191:700\u2013707","journal-title":"Am J Obstet Gynecol"},{"key":"809_CR58","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/ajcn\/79.1.103","volume":"79","author":"F Mathews","year":"2004","unstructured":"Mathews F, Youngman L, Neil A (2004) Maternal circulating nutrient concentrations in pregnancy: implications for birth and placental weights of term infants. Am J Clin Nutr 79:103\u2013110","journal-title":"Am J Clin Nutr"},{"key":"809_CR59","doi-asserted-by":"crossref","first-page":"F117","DOI":"10.1136\/adc.2004.056440","volume":"90","author":"BA Darlow","year":"2005","unstructured":"Darlow BA, Buss H, McGill F, Fletcher L, Graham P, Winterbourn CC (2005) Vitamin C supplementation in very preterm infants: a randomised controlled trial. Arch Dis Child 90:F117\u2013F122","journal-title":"Arch Dis Child"},{"key":"809_CR60","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/jn\/100.2.217","volume":"100","author":"JM Rivers","year":"1970","unstructured":"Rivers JM, Krook L, Cormier A (1970) Biochemical and histological study of guinea pig fetal and uterine tissue in ascorbic acid deficiency. J Nutr 100:217\u2013227","journal-title":"J Nutr"},{"key":"809_CR61","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.placenta.2008.04.009","volume":"29","author":"DS Tannetta","year":"2008","unstructured":"Tannetta DS, Sargent IL, Linton EA, Redman CW (2008) Vitamins C and E inhibit apoptosis of cultured human term placenta trophoblast. Placenta 29:680\u2013690","journal-title":"Placenta"},{"key":"809_CR62","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1753-4887.1992.tb01271.x","volume":"50","author":"RT Franceschi","year":"1992","unstructured":"Franceschi RT (1992) The role of ascorbic-acid in mesenchymal differentiation. Nutr Rev 50:65\u201370","journal-title":"Nutr Rev"},{"key":"809_CR63","first-page":"251","volume":"75","author":"SA Barnett","year":"1941","unstructured":"Barnett SA, Bourne G (1941) The distribution of ascorbic acid (vitamin C) in the early stages of the developing chick embryo. J Anat 75:251\u2013264","journal-title":"J Anat"},{"key":"809_CR64","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/0955-2863(96)00109-X","volume":"7","author":"SK Pate","year":"1996","unstructured":"Pate SK, Lukert BP, Kipp DE (1996) Tissue vitamin C levels of guinea pig offspring are influenced by maternal vitamin C intake during pregnancy. J Nutr Biochem 7:524\u2013528","journal-title":"J Nutr Biochem"},{"key":"809_CR65","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1006\/bbrc.1999.1272","volume":"262","author":"DP Rajan","year":"1999","unstructured":"Rajan DP, Huang W, Dutta B, Devoe LD, Leibach FH, Ganapathy V, Prasad PD (1999) Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. Biochem Biophys Res Commun 262:762\u2013768","journal-title":"Biochem Biophys Res Commun"},{"key":"809_CR66","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/molehr\/gal092","volume":"13","author":"C Biondi","year":"2007","unstructured":"Biondi C, Pavan B, Dalpiaz A, Medici S, Lunghi L, Vesce F (2007) Expression and characterization of vitamin C transporter in the human trophoblast cell line HTR-8\/SVneo: effect of steroids, flavonoids and NSAIDs. Mol Hum Reprod 13:77\u201383","journal-title":"Mol Hum Reprod"},{"key":"809_CR67","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1017\/S0007114598001561","volume":"80","author":"S Das","year":"1998","unstructured":"Das S, Powers HJ (1998) The effects of maternal intake and gestational age on materno-fetal transport of vitamin C in the guinea-pig. Br J Nutr 80:485\u2013491","journal-title":"Br J Nutr"},{"key":"809_CR68","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1079\/BJN19890147","volume":"61","author":"S Zalani","year":"1989","unstructured":"Zalani S, Rajalakshmi R, Parekh LJ (1989) Ascorbic-acid concentration of human-fetal tissues in relation to fetal size and gestational-age. Br J Nutr 61:601\u2013606","journal-title":"Br J Nutr"},{"key":"809_CR69","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0002-9378(16)40500-4","volume":"46","author":"CJ Lund","year":"1943","unstructured":"Lund CJ, Kimble MS (1943) Some determinants of maternal and plasma vitamin C levels. Am J Obstet Gynecol 46:635\u2013647","journal-title":"Am J Obstet Gynecol"},{"key":"809_CR70","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00404-010-1741-5","volume":"284","author":"JA Osaikhuwuomwan","year":"2011","unstructured":"Osaikhuwuomwan JA, Okpere EE, Okonkwo CA, Ande AB, Idogun ES (2011) Plasma vitamin C levels and risk of preterm prelabour rupture of membranes. Arch Gynecol Obstet 284:593\u2013597","journal-title":"Arch Gynecol Obstet"},{"key":"809_CR71","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.3109\/14767058.2011.633672","volume":"25","author":"R Negi","year":"2012","unstructured":"Negi R, Pande D, Kumar A, Khanna RS, Khanna HD (2012) Evaluation of biomarkers of oxidative stress and antioxidant capacity in the cord blood of preterm low birth weight neonates. J Matern Fetal Neonatal Med 25:1338\u20131341","journal-title":"J Matern Fetal Neonatal Med"},{"key":"809_CR72","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/humupd\/dml016","volume":"12","author":"E Jauniaux","year":"2006","unstructured":"Jauniaux E, Poston L, Burton GJ (2006) Placental-related diseases of pregnancy: involvement of oxidative stress and implications in human evolution. Hum Reprod Update 12:747\u2013755","journal-title":"Hum Reprod Update"},{"key":"809_CR73","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1017\/S0007114509993229","volume":"103","author":"J Lykkesfeldt","year":"2010","unstructured":"Lykkesfeldt J, Poulsen HE (2010) Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials. Br J Nutr 103:1251\u20131259","journal-title":"Br J Nutr"},{"key":"809_CR74","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1210\/en.2007-0262","volume":"149","author":"X Wu","year":"2008","unstructured":"Wu X, Iguchi T, Itoh N, Okamoto K, Takagi T, Tanaka K, Nakanishi T (2008) Ascorbic acid transported by sodium-dependent vitamin C transporter 2 stimulates steroidogenesis in human choriocarcinoma cells. Endocrinology 149:73\u201383","journal-title":"Endocrinology"},{"key":"809_CR75","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-1-60327-009-0_7","volume":"550","author":"JT Sanderson","year":"2009","unstructured":"Sanderson JT (2009) Placental and fetal steroidogenesis. Methods Mol Biol 550:127\u2013136","journal-title":"Methods Mol Biol"},{"key":"809_CR76","first-page":"553","volume":"58","author":"SR Pinnell","year":"1985","unstructured":"Pinnell SR (1985) Regulation of collagen biosynthesis by ascorbic acid: a review. Yale J Biol Med 58:553","journal-title":"Yale J Biol Med"},{"key":"809_CR77","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1242\/dev.01037","volume":"131","author":"E Poschl","year":"2004","unstructured":"Poschl E, Schlotzer-Schrehardt U, Brachvogel B, Saito K, Ninomiya Y, Mayer U (2004) Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development 131:1619\u20131628","journal-title":"Development"},{"key":"809_CR78","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/BJ20091609","volume":"427","author":"E Flashman","year":"2010","unstructured":"Flashman E, Davies SL, Yeoh KK, Schofield CJ (2010) Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents. Biochem J 427:135\u2013142","journal-title":"Biochem J"},{"key":"809_CR79","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm0603-677","volume":"9","author":"CW Pugh","year":"2003","unstructured":"Pugh CW, Ratcliffe PJ (2003) Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9:677\u2013684","journal-title":"Nat Med"},{"key":"809_CR80","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/jn\/124.2.241","volume":"124","author":"I Wegger","year":"1994","unstructured":"Wegger I, Palludan B (1994) Vitamin-c-deficiency causes hematological and skeletal abnormalities during fetal development in swine. J Nutr 124:241\u2013248","journal-title":"J Nutr"},{"key":"809_CR81","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/pr.2013.22","volume":"73","author":"Y Kishimoto","year":"2013","unstructured":"Kishimoto Y, Kanai T, Sato K, Lee J, Jeong KS, Shimokado K, Maruyama N, Ishigami A (2013) Insufficient ascorbic acid intake during gestation induces abnormal cardiac dilation in fetal and neonatal SMP30\/GNL knockout mice. Pediatr Res 73:578\u2013584","journal-title":"Pediatr Res"},{"key":"809_CR82","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.freeradbiomed.2010.06.008","volume":"49","author":"FE Harrison","year":"2010","unstructured":"Harrison FE, Dawes SM, Meredith ME, Babaev VR, Li L, May JM (2010) Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2. Free Radic Biol Med 49:821\u2013829","journal-title":"Free Radic Biol Med"},{"key":"809_CR83","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/adc.48.10.757","volume":"48","author":"J Dobbing","year":"1973","unstructured":"Dobbing J, Sands J (1973) Quantitative Growth and Development of Human Brain. Arch Dis Child 48:757\u2013767","journal-title":"Arch Dis Child"},{"key":"809_CR84","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1089\/ars.2010.3581","volume":"14","author":"C Ikonomidou","year":"2011","unstructured":"Ikonomidou C, Kaindl AM (2011) Neuronal death and oxidative stress in the developing brain. Antioxid Redox Signal 14:1535\u20131550","journal-title":"Antioxid Redox Signal"},{"key":"809_CR85","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1001\/archpedi.1938.01980170050008","volume":"56","author":"HM Teel","year":"1938","unstructured":"Teel HM, Burke BS, Draper R (1938) Vitamin C in human pregnancy and lactation I Studies during pregnancy. Am J Dis Child 56:1004\u20131010","journal-title":"Am J Dis Child"},{"key":"809_CR86","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1093\/jn\/109.12.2205","volume":"109","author":"EP Norkus","year":"1979","unstructured":"Norkus EP, Bassi J, Rosso P (1979) Maternal\u2013fetal transfer of ascorbic-acid in the guinea-pig. J Nutr 109:2205\u20132212","journal-title":"J Nutr"}],"updated-by":[{"DOI":"10.1007\/s00394-015-0909-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000}}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-014-0809-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-014-0809-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-014-0809-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T18:48:21Z","timestamp":1747162101000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-014-0809-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,4]]},"references-count":86,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["809"],"URL":"https:\/\/doi.org\/10.1007\/s00394-014-0809-6","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,4]]}}}