{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:38:02Z","timestamp":1782513482410,"version":"3.54.5"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T00:00:00Z","timestamp":1428710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1007\/s00394-015-0895-0","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T01:23:34Z","timestamp":1428715414000},"page":"749-758","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Acute administration of single oral dose of grape seed polyphenols restores blood pressure in a rat model of metabolic syndrome: role of nitric oxide and prostacyclin"],"prefix":"10.1007","volume":"55","author":[{"given":"Zara","family":"Pons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Margalef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca I.","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Arola-Arnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Muguerza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,11]]},"reference":[{"key":"895_CR1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/hr.2010.223","volume":"34","author":"DE Papadogiannis","year":"2010","unstructured":"Papadogiannis DE, Protogerou AD (2010) Blood pressure variability: a confounder and a cardiovascular risk factor. Hypertens Res 34:162\u2013163. doi: 10.1038\/hr.2010.223","journal-title":"Hypertens Res"},{"key":"895_CR2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0140-6736(90)90944-Z","volume":"335","author":"R Collins","year":"1990","unstructured":"Collins R, Peto R, MacMahon S, Godwin J, Qizilbash N, Hebert P, Eberlein KA, Taylor JO, Hennekens CH, Fiebach NH (1990) Blood pressure, stroke, and coronary heart disease: part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 335:827\u2013838","journal-title":"Lancet"},{"key":"895_CR3","first-page":"328","volume":"95","author":"SA Isezuo","year":"2003","unstructured":"Isezuo SA, Badung SLH, Omotoso ABO (2003) Comparative analysis of lipid profiles among patients with type 2 diabetes mellitus, hypertension and concurrent type 2 diabetes, and hypertension: a view of metabolic syndrome. J Natl Med Assoc 95:328\u2013334","journal-title":"J Natl Med Assoc"},{"key":"895_CR4","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/oby.2011.18","volume":"19","author":"BP Sampey","year":"2011","unstructured":"Sampey BP, Vanhoose AM, Winfield HM, Freemerman AJ, Muehlbauer MJ, Fueger PT, Newgard CB, Makowski L (2011) Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obesity 19:1109\u20131117. doi: 10.1038\/oby.2011.18","journal-title":"Obesity"},{"key":"895_CR5","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1097\/HJH.0b013e328302ca38","volume":"26","author":"J Redon","year":"2008","unstructured":"Redon J, Cifkova R, Laurent S, Nilsson P, Narkiewicz K, Erdine S, Mancia G (2008) The metabolic syndrome in hypertension: European society of hypertension position statement. J Hypertens 26:1891\u20131900. doi: 10.1097\/HJH.0b013e328302ca38","journal-title":"J Hypertens"},{"key":"895_CR6","first-page":"351982","volume":"2011","author":"SK Panchal","year":"2010","unstructured":"Panchal SK, Brown L (2010) Rodent models for metabolic syndrome research. J Biomed Biotechnol 2011:351982. doi: 10.1155\/2011\/351982","journal-title":"J Biomed Biotechnol"},{"key":"895_CR7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1124\/jpet.102.045682","volume":"305","author":"G Coatmellec-Taglioni","year":"2003","unstructured":"Coatmellec-Taglioni G, Dausse JP, Giudicelli Y, Ribi\u00e8re C (2003) Sexual dimorphism in cafeteria diet-induced hypertension is associated with gender-related difference in renal leptin receptor down-regulation. J Pharmacol Exp Ther 305:362\u2013367","journal-title":"J Pharmacol Exp Ther"},{"key":"895_CR8","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s13105-014-0329-0","volume":"70","author":"Z Pons","year":"2014","unstructured":"Pons Z, Guerrero L, Margalef M, Arola L, Arola-Arnal A, Muguerza B (2014) Effect of low molecular grape seed proanthocyanidins on blood pressure and lipid homeostasis in cafeteria diet-fed rats. J Physiol Biochem 70:629\u2013637. doi: 10.1007\/s13105-014-0329-0","journal-title":"J Physiol Biochem"},{"key":"895_CR9","first-page":"1462","volume":"28","author":"G Mancia","year":"2007","unstructured":"Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S (2007) 2007 Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 28:1462\u20131536. doi: 10.1093\/eurheartj\/ehm236","journal-title":"Eur Heart J"},{"key":"895_CR10","doi-asserted-by":"crossref","first-page":"6156","DOI":"10.1021\/jf804045b","volume":"57","author":"E Cienfuegos-Jovellanos","year":"2009","unstructured":"Cienfuegos-Jovellanos E, Qui\u00f1ones M, Muguerza B, Moulay L, Miguel M, Aleixandre A (2009) Antihypertensive effect of a polyphenol-rich cocoa powder industrially processed to preserve the original flavonoids of the cocoa beans. J Agric Food Chem 57:6156\u20136162. doi: 10.1021\/jf804045b","journal-title":"J Agric Food Chem"},{"key":"895_CR11","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1039\/c1fo10119f","volume":"2","author":"M Qui\u00f1ones","year":"2011","unstructured":"Qui\u00f1ones M, Miguel M, Muguerza B, Aleixandre A (2011) Effect of a cocoa polyphenol extract in spontaneously hypertensive rats. Food Funct 2:649\u2013653. doi: 10.1039\/c1fo10119f","journal-title":"Food Funct"},{"key":"895_CR12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.foodres.2013.01.023","volume":"51","author":"M Qui\u00f1ones","year":"2013","unstructured":"Qui\u00f1ones M, Guerrero L, Suarez M, Pons Z, Aleixandre A, Arola L, Muguerza B (2013) Low-molecular procyanidin rich grape seed extract exerts antihypertensive effect in males spontaneously hypertensive rats. Food Res Int 51:587\u2013595. doi: 10.1016\/j.foores.2013.01.023","journal-title":"Food Res Int"},{"key":"895_CR13","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.phrs.2011.06.005","volume":"64","author":"M Qui\u00f1ones","year":"2011","unstructured":"Qui\u00f1ones M, Muguerza B, Miguel M, Aleixandre A (2011) Evidence that nitric oxide mediates the blood pressure lowering effect of a polyphenol-rich cocoa powder in spontaneously hypertensive rats. Pharmacol Res 64:478\u2013481. doi: 10.1016\/j.phrs.2011.06.005","journal-title":"Pharmacol Res"},{"key":"895_CR14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jff.2013.11.008","volume":"6","author":"M Qui\u00f1ones","year":"2014","unstructured":"Qui\u00f1ones M, Guerrero L, Fernandez-Vallinas S, Pons Z, Arola L, Aleixandre A, Muguerza B (2014) Involvement of nitric oxide and prostacyclin in the antihypertensive effect of low-molecular-weight procyanidin rich grape seed extract in male spontaneously hypertensive rats. J Funct Foods 6:419\u2013427. doi: 10.1016\/j.jff.2013.11.008","journal-title":"J Funct Foods"},{"key":"895_CR15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5344\/ajev.1965.16.3.144","volume":"16","author":"VL Singleton","year":"1965","unstructured":"Singleton VL, Rossi JA (1965) Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic 16:144\u2013158 citeulike-article-id:7170825","journal-title":"Am J Enol Vitic"},{"key":"895_CR16","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1016\/j.jchromb.2009.10.025","volume":"877","author":"M Su\u00e1rez","year":"2009","unstructured":"Su\u00e1rez M, Romero MP, Maci\u00e0 A, Valls RM, Fern\u00e1ndez S, Sol\u00e0 R, Motilva MJ (2009) Improved method for identifying and quantifying olive oil phenolic compounds and their metabolites in human plasma by microelution solid-phase extraction plate and liquid chromatography\u2013tandem mass spectrometry. J Chromatogr B 877:4097\u20134106. doi: 10.1016\/j.jchromb.2009.10.025","journal-title":"J Chromatogr B"},{"key":"895_CR17","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1152\/jappl.1973.34.2.279","volume":"34","author":"RD Bu\u00f1ag","year":"1973","unstructured":"Bu\u00f1ag RD (1973) Validation in awake rats of a tail-cuff method for measuring systolic pressure. J Appl Physiol 34:279\u2013282","journal-title":"J Appl Physiol"},{"key":"895_CR18","doi-asserted-by":"crossref","first-page":"38D","DOI":"10.1157\/13083447","volume":"5","author":"A Cordero","year":"2006","unstructured":"Cordero A, Moreno J, Alegr\u00eda E (2006) Hipertensi\u00f3n arterial y s\u00edndrome metab\u00f3lico. Rev Espa\u00f1ola Cardiol Supl 5:38D\u201345D. doi: 10.1016\/S1131-3587(05)74119-4","journal-title":"Rev Espa\u00f1ola Cardiol Supl"},{"key":"895_CR19","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.foodchem.2010.03.059","volume":"122","author":"M Qui\u00f1ones","year":"2010","unstructured":"Qui\u00f1ones M, S\u00e1nchez D, Muguerza B, Moulay L, Laghi S, Miguel M, Aleixandre A (2010) Long-term intake of CocoanOX attenuates the development of hypertension in spontaneously hypertensive rats. Food Chem 122:1013\u20131019. doi: 10.1016\/j.foodchem.2010.03.059","journal-title":"Food Chem"},{"key":"895_CR20","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/01.hjh.0000431740.32696.cc","volume":"31","author":"G Mancia","year":"2013","unstructured":"Mancia G, Fagard R, Narkiewicz K, Red\u00f3n J, Zanchetti A, B\u00f6hm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM et al (2013) 2013 ESH\/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 31:1281\u20131357. doi: 10.1097\/01.hjh.0000431740.32696.cc","journal-title":"J Hypertens"},{"key":"895_CR21","doi-asserted-by":"crossref","first-page":"875314","DOI":"10.1155\/2013\/875314","volume":"2013","author":"L Ced\u00f3","year":"2013","unstructured":"Ced\u00f3 L, Castell-Auv\u00ed A, Pallar\u00e8s V, Blay M, Ard\u00e9vol A, Pinent M (2013) Grape seed procyanidin extract improves insulin production but enhances Bax protein expression in cafeteria-treated male rats. Int J Food Sci 2013:875314. doi: 10.1155\/2013\/875314","journal-title":"Int J Food Sci"},{"key":"895_CR22","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.fitote.2011.01.018","volume":"82","author":"D Proch\u00e1zkov\u00e1","year":"2011","unstructured":"Proch\u00e1zkov\u00e1 D, Bousova I, Wilhelmov\u00e1 N (2011) Antioxidant and prooxidant properties of flavonoids. Fitoterapia 82:513\u2013523. doi: 10.1016\/j.fitote.2011.01.018","journal-title":"Fitoterapia"},{"key":"895_CR23","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1161\/01.HYP.0000138070.47616.9d","volume":"44","author":"RM Touyz","year":"2004","unstructured":"Touyz RM (2004) Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension what is the clinical significance? Hypertension 44:248\u2013252. doi: 10.1161\/01.HYP.0000138070.47616.9d","journal-title":"Hypertension"},{"key":"895_CR24","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0014-5793(03)01355-3","volume":"555","author":"L Actis-Goretta","year":"2003","unstructured":"Actis-Goretta L, Ottaviani JI, Keen CL, Fraga CG (2003) Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins. FEBS Lett 555:597\u2013600","journal-title":"FEBS Lett"},{"key":"895_CR25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1021\/jf052263o","volume":"54","author":"L Actis-Goretta","year":"2006","unstructured":"Actis-Goretta L, Ottaviani JI, Fraga CG (2006) Inhibition of angiotensin converting enzyme activity by flavanol-rich foods. J Agric Food Chem 54:229\u2013234","journal-title":"J Agric Food Chem"},{"key":"895_CR26","doi-asserted-by":"crossref","first-page":"e49493","DOI":"10.1371\/journal.pone.0049493","volume":"7","author":"L Guerrero","year":"2012","unstructured":"Guerrero L, Castillo J, Qui\u00f1ones M, Garcia-Vallv\u00e9 S, Arola L, Pujadas G, Muguerza B (2012) Inhibition of angiotensin-converting enzyme activity by flavonoids: structure\u2013activity relationship studies. PLoS One 7:e49493","journal-title":"PLoS One"},{"key":"895_CR27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.biochi.2005.10.001","volume":"88","author":"JI Ottaviani","year":"2006","unstructured":"Ottaviani JI, Actis-Goretta L, Villordo JJ, Fraga CG (2006) Procyanidin structure defines the extent and specificity of angiotensin I converting enzyme inhibition. Biochimie 88:359\u2013365","journal-title":"Biochimie"},{"key":"895_CR28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/FJC.0b013e3181fe62e3","volume":"57","author":"IAL Persson","year":"2011","unstructured":"Persson IAL, Persson K, H\u00e4gg S, Andersson RGG (2011) Effects of cocoa extract and dark chocolate on angiotensin-converting enzyme and nitric oxide in human endothelial cells and healthy volunteers\u2014a nutrigenomics perspective. J Cardiovasc Pharmacol 57:44\u201350","journal-title":"J Cardiovasc Pharmacol"},{"key":"895_CR29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1748-1716.2011.02290.x","volume":"203","author":"M Tesauro","year":"2011","unstructured":"Tesauro M, Cardillo C (2011) Obesity, blood vessels and metabolic syndrome. Acta Physiol 203:279\u2013286. doi: 10.1111\/j.1748-1716.2011.02290.x","journal-title":"Acta Physiol"},{"key":"895_CR30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1540\/jsmr.40.65","volume":"40","author":"F Sekiguchi","year":"2004","unstructured":"Sekiguchi F, Yanamoto A, Sunano S (2004) Superoxide dismutase reduces the impairment of endothelium-dependent relaxation in the spontaneously hypertensive rat aorta. J Smooth Muscle Res 40:65\u201374. doi: 10.1540\/jsmr.40.65","journal-title":"J Smooth Muscle Res"},{"key":"895_CR31","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/01.HYP.37.2.554","volume":"37","author":"AD Dobrian","year":"2001","unstructured":"Dobrian AD, Davies MJ, Schriver SD, Lauterio TJ, Prewitt RL (2001) Oxidative stress in a rat model of obesity-induced hypertension. Hypertension 37:554\u2013560. doi: 10.1161\/01.HYP.37.2.554","journal-title":"Hypertension"},{"key":"895_CR32","unstructured":"Rees DD, Schulz R, Hodson HF, Palmer RMJ, Moncada S (1990) Identification of some novel inhibitors of the vascular nitric oxide synthase in vivo and in vitro. Nitric oxide from l-arginine a bioregulatory Syst. In: Proceedings of a symposium held at the Royal Society of London, Elsevier, Amsterdam, pp 485\u2013487"},{"key":"895_CR33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0165-6147(87)90045-9","volume":"8","author":"JR Vane","year":"1987","unstructured":"Vane JR, Gryglewski RJ, Botting RM (1987) The endothelial cell as a metabolic and endocrine organ. Trends Pharmacol Sci 8:491\u2013496. doi: 10.1016\/0165-6147(87)90045-9","journal-title":"Trends Pharmacol Sci"},{"key":"895_CR34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/ajcn\/73.1.36","volume":"73","author":"DD Schramm","year":"2001","unstructured":"Schramm DD, Wang JF, Holt RR, Ensunsa JL, Gonsalves JL, Lazarus SA, Schmitz HH, German JB, Keen CL (2001) Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells. Am J Clin Nutr 73:36\u201340","journal-title":"Am J Clin Nutr"},{"key":"895_CR35","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0024-3205(98)00605-5","volume":"64","author":"R Maffei","year":"1999","unstructured":"Maffei R, Carini M, Aldini G, Berti F, Rossoni G, Bombardelli E, Morazzoni P (1999) Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in rats. Life Sci 64:627\u2013642. doi: 10.1016\/S0024-3205(98)00605-5","journal-title":"Life Sci"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-015-0895-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-015-0895-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-015-0895-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T10:40:57Z","timestamp":1691577657000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-015-0895-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,11]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["895"],"URL":"https:\/\/doi.org\/10.1007\/s00394-015-0895-0","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,11]]}}}