{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:15:58Z","timestamp":1791670558959,"version":"4.3.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s00394-015-0911-4","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T12:56:55Z","timestamp":1430398615000},"page":"967-979","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Longitudinal associations of serum fatty acid composition with type 2 diabetes risk and markers of insulin secretion and sensitivity in the Finnish Diabetes Prevention Study"],"prefix":"10.1007","volume":"55","author":[{"name":"the DPS Study Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus J.","family":"Takkunen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula S.","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa D. F.","family":"de Mello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan G.","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Lindstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Tuomilehto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti I. J.","family":"Uusitupa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,1]]},"reference":[{"key":"911_CR1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1056\/NEJM200105033441801","volume":"344","author":"J Tuomilehto","year":"2001","unstructured":"Tuomilehto J, Lindstr\u00f6m J, Eriksson JG et al (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343\u20131350. doi: 10.1056\/NEJM200105033441801","journal-title":"N Engl J Med"},{"key":"911_CR2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","volume":"346","author":"WC Knowler","year":"2002","unstructured":"Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM, Diabetes Prevention Program Research Group (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393\u2013403. doi: 10.1056\/NEJMoa012512","journal-title":"N Engl J Med"},{"key":"911_CR3","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/S0140-6736(14)60613-9","volume":"383","author":"SH Ley","year":"2014","unstructured":"Ley SH, Hamdy O, Mohan V, Hu FB (2014) Prevention and management of type 2 diabetes: dietary components and nutritional strategies. Lancet 383:1999\u20132007","journal-title":"Lancet"},{"key":"911_CR4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0753-3322(03)00003-9","volume":"57","author":"AA Rivellese","year":"2003","unstructured":"Rivellese AA, Lilli S (2003) Quality of dietary fatty acids, insulin sensitivity and type 2 diabetes. Biomed Pharmacother 57:84\u201387","journal-title":"Biomed Pharmacother"},{"key":"911_CR5","first-page":"501015","volume":"2013","author":"M Zhang","year":"2013","unstructured":"Zhang M, Picard-Deland E, Marette A (2013) Fish and marine omega-3 polyunsaturated fatty acid consumption and incidence of type 2 diabetes: a systematic review and meta-analysis. Int J Endocrinol 2013:501015. doi: 10.1155\/2013\/501015","journal-title":"Int J Endocrinol"},{"key":"911_CR6","author":"U Schwab","year":"2014","unstructured":"Schwab U, Lauritzen L, Tholstrup T, Haldorssoni T, Riserus U, Uusitupa M, Becker W (2014) Effect of the amount and type of dietary fat on cardiometabolic risk factors and risk of developing type 2 diabetes, cardiovascular diseases, and cancer: a systematic review. Food Nutr Res. doi: 10.3402\/fnr.v58.25145 (eCollection 2014)","journal-title":"Food Nutr Res"},{"key":"911_CR7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.numecd.2007.04.005","volume":"18","author":"B Krachler","year":"2008","unstructured":"Krachler B, Norberg M, Eriksson JW, Hallmans G, Johansson I, Vessby B, Weinehall L, Lindahl B (2008) Fatty acid profile of the erythrocyte membrane preceding development of type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis 18:503\u2013510. doi: 10.1016\/j.numecd.2007.04.005","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"911_CR8","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2337\/dc10-1772","volume":"34","author":"F Fumeron","year":"2011","unstructured":"Fumeron F, Lamri A, Abi Khalil C et al (2011) Dairy consumption and the incidence of hyperglycemia and the metabolic syndrome: results from a French prospective study, Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Diabetes Care 34:813\u2013817. doi: 10.2337\/dc10-1772","journal-title":"Diabetes Care"},{"key":"911_CR9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.nutr.25.051804.101917","volume":"25","author":"H Sampath","year":"2005","unstructured":"Sampath H, Ntambi JM (2005) Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu Rev Nutr 25:317\u2013340. doi: 10.1146\/annurev.nutr.25.051804.101917","journal-title":"Annu Rev Nutr"},{"issue":"Suppl 2","key":"911_CR10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1463-1326.2010.01265.x","volume":"12","author":"W Gehrmann","year":"2010","unstructured":"Gehrmann W, Elsner M, Lenzen S (2010) Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic beta-cells. Diabetes Obes Metab 12(Suppl 2):149\u2013158. doi: 10.1111\/j.1463-1326.2010.01265.x","journal-title":"Diabetes Obes Metab"},{"key":"911_CR11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.plipres.2008.03.003","volume":"47","author":"L Hodson","year":"2008","unstructured":"Hodson L, Skeaff CM, Fielding BA (2008) Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res 47:348\u2013380. doi: 10.1016\/j.plipres.2008.03.003","journal-title":"Prog Lipid Res"},{"key":"911_CR12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1749-6632.2011.06303.x","volume":"1243","author":"H Sampath","year":"2011","unstructured":"Sampath H, Ntambi JM (2011) The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation. Ann N Y Acad Sci 1243:47\u201353. doi: 10.1111\/j.1749-6632.2011.06303.x","journal-title":"Ann N Y Acad Sci"},{"key":"911_CR13","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1038\/oby.2007.206","volume":"15","author":"E Warensjo","year":"2007","unstructured":"Warensjo E, Ingelsson E, Lundmark P, Lannfelt L, Syvanen AC, Vessby B, Riserus U (2007) Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity. Obesity (Silver Spring) 15:1732\u20131740","journal-title":"Obesity (Silver Spring)"},{"key":"911_CR14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/MOL.0b013e32834d2dc5","volume":"23","author":"J Kr\u00f6ger","year":"2012","unstructured":"Kr\u00f6ger J, Schulze MB (2012) Recent insights into the relation of Delta5 desaturase and Delta6 desaturase activity to the development of type 2 diabetes. Curr Opin Lipidol 23:4\u201310. doi: 10.1097\/MOL.0b013e32834d2dc5","journal-title":"Curr Opin Lipidol"},{"key":"911_CR15","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.2337\/diab.43.11.1353","volume":"43","author":"B Vessby","year":"1994","unstructured":"Vessby B, Aro A, Skarfors E, Berglund L, Salminen I, Lithell H (1994) The risk to develop NIDDM is related to the fatty acid composition of the serum cholesterol esters. Diabetes 43:1353\u20131357","journal-title":"Diabetes"},{"key":"911_CR16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/ajcn\/78.1.91","volume":"78","author":"Wang L, Folsom AR, Zheng ZJ, Pankow JS, Eckfeldt JH, ARIC Study Investigators","year":"2003","unstructured":"Wang L, Folsom AR, Zheng ZJ, Pankow JS, Eckfeldt JH, ARIC Study Investigators (2003) Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr 78:91\u201398","journal-title":"Am J Clin Nutr"},{"key":"911_CR17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3945\/ajcn.110.005447","volume":"93","author":"J Kr\u00f6ger","year":"2011","unstructured":"Kr\u00f6ger J, Zietemann V, Enzenbach C et al (2011) Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European prospective investigation into cancer and nutrition (EPIC)\u2013potsdam study. Am J Clin Nutr 93:127\u2013142. doi: 10.3945\/ajcn.110.005447","journal-title":"Am J Clin Nutr"},{"key":"911_CR18","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3945\/ajcn.111.013334","volume":"94","author":"L Djousse","year":"2011","unstructured":"Djousse L, Biggs ML, Lemaitre RN et al (2011) Plasma omega-3 fatty acids and incident diabetes in older adults. Am J Clin Nutr 94:527\u2013533. doi: 10.3945\/ajcn.111.013334","journal-title":"Am J Clin Nutr"},{"key":"911_CR19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3945\/ajcn.113.069740","volume":"99","author":"Y Mahendran","year":"2014","unstructured":"Mahendran Y, Agren J, Uusitupa M et al (2014) Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes. Am J Clin Nutr 99:79\u201385. doi: 10.3945\/ajcn.113.069740","journal-title":"Am J Clin Nutr"},{"key":"911_CR20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2337\/dc13-1504","volume":"37","author":"JK Virtanen","year":"2014","unstructured":"Virtanen JK, Mursu J, Voutilainen S, Uusitupa M, Tuomainen TP (2014) Serum omega-3 polyunsaturated fatty acids and risk of incident type 2 diabetes in men: the Kuopio ischemic heart disease risk factor study. Diabetes Care 37:189\u2013196. doi: 10.2337\/dc13-1504","journal-title":"Diabetes Care"},{"key":"911_CR21","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s001250051229","volume":"42","author":"J Eriksson","year":"1999","unstructured":"Eriksson J, Lindstr\u00f6m J, Valle T et al (1999) Prevention of Type II diabetes in subjects with impaired glucose tolerance: the diabetes prevention study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme. Diabetologia 42:793\u2013801","journal-title":"Diabetologia"},{"key":"911_CR22","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s00125-012-2752-5","volume":"56","author":"J Lindstr\u00f6m","year":"2013","unstructured":"Lindstr\u00f6m J, Peltonen M, Eriksson JG et al (2013) Improved lifestyle and decreased diabetes risk over 13\u00a0years: long-term follow-up of the randomised Finnish Diabetes Prevention Study (DPS). Diabetologia 56:284\u2013293. doi: 10.1007\/s00125-012-2752-5","journal-title":"Diabetologia"},{"key":"911_CR23","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.2337\/diacare.26.12.3230","volume":"26","author":"J Lindstr\u00f6m","year":"2003","unstructured":"Lindstr\u00f6m J, Louheranta A, Mannelin M et al (2003) The Finnish Diabetes Prevention Study (DPS): lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care 26:3230\u20133236","journal-title":"Diabetes Care"},{"key":"911_CR24","doi-asserted-by":"crossref","first-page":"e1002793","DOI":"10.1371\/journal.pgen.1002793","volume":"8","author":"BF Voight","year":"2012","unstructured":"Voight BF, Kang HM, Ding J et al (2012) The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet 8:e1002793. doi: 10.1371\/journal.pgen.1002793","journal-title":"PLoS Genet"},{"key":"911_CR25","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"J Folch","year":"1957","unstructured":"Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497\u2013509","journal-title":"J Biol Chem"},{"key":"911_CR26","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2337\/dc11-1272","volume":"35","author":"VD Mello de","year":"2012","unstructured":"de Mello VD, Lindstr\u00f6m J, Eriksson J et al (2012) Insulin secretion and its determinants in the progression of impaired glucose tolerance to type 2 diabetes in impaired glucose-tolerant individuals: the Finnish Diabetes Prevention Study. Diabetes Care 35:211\u2013217. doi: 10.2337\/dc11-1272","journal-title":"Diabetes Care"},{"key":"911_CR27","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","volume":"22","author":"M Matsuda","year":"1999","unstructured":"Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462\u20131470","journal-title":"Diabetes Care"},{"key":"911_CR28","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.2337\/db08-1607","volume":"58","author":"A Stancakova","year":"2009","unstructured":"Stancakova A, Javorsky M, Kuulasmaa T, Haffner SM, Kuusisto J, Laakso M (2009) Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. Diabetes 58:1212\u20131221. doi: 10.2337\/db08-1607","journal-title":"Diabetes"},{"key":"911_CR29","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1194\/jlr.P027516","volume":"54","author":"J Zhu","year":"2013","unstructured":"Zhu J, Sun Q, Zong G et al (2013) Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans. J Lipid Res 54:1477\u20131483. doi: 10.1194\/jlr.P027516","journal-title":"J Lipid Res"},{"key":"911_CR30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/ng.520","volume":"42","author":"J Dupuis","year":"2010","unstructured":"Dupuis J, Langenberg C, Prokopenko I et al (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42:105\u2013116. doi: 10.1038\/ng.520","journal-title":"Nat Genet"},{"issue":"Suppl 2","key":"911_CR31","first-page":"S214","volume":"107","author":"JH Wu","year":"2012","unstructured":"Wu JH, Micha R, Imamura F et al (2012) Omega-3 fatty acids and incident type 2 diabetes: a systematic review and meta-analysis. Br J Nutr 107(Suppl 2):S214\u2013S227. doi: 10.1017\/S0007114512001602","journal-title":"Br J Nutr"},{"key":"911_CR32","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1056\/NEJMoa1205409","volume":"368","author":"MC Roncaglioni","year":"2013","unstructured":"Risk and Prevention Study Collaborative Group, Roncaglioni MC, Tombesi M et al (2013) N-3 fatty acids in patients with multiple cardiovascular risk factors. N Engl J Med 368:1800\u20131808. doi: 10.1056\/NEJMoa1205409","journal-title":"N Engl J Med"},{"key":"911_CR33","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1056\/NEJMoa1203859","volume":"367","author":"J Bosch","year":"2012","unstructured":"ORIGIN Trial Investigators, Bosch J, Gerstein HC et al (2012) N-3 fatty acids and cardiovascular outcomes in patients with dysglycemia. N Engl J Med 367:309\u2013318. doi: 10.1056\/NEJMoa1203859","journal-title":"N Engl J Med"},{"key":"911_CR34","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.clnu.2011.08.013","volume":"30","author":"AO Akinkuolie","year":"2011","unstructured":"Akinkuolie AO, Ngwa JS, Meigs JB, Djousse L (2011) Omega-3 polyunsaturated fatty acid and insulin sensitivity: a meta-analysis of randomized controlled trials. Clin Nutr 30:702\u2013707. doi: 10.1016\/j.clnu.2011.08.013","journal-title":"Clin Nutr"},{"key":"911_CR35","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S2213-8587(14)70146-9","volume":"2","author":"NG Forouhi","year":"2014","unstructured":"Forouhi NG, Koulman A, Sharp SJ et al (2014) Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-interact case\u2013cohort study. Lancet Diabetes Endocrinol 2:810\u2013818. doi: 10.1016\/S2213-8587(14)70146-9","journal-title":"Lancet Diabetes Endocrinol"},{"key":"911_CR36","doi-asserted-by":"crossref","first-page":"E321","DOI":"10.1152\/ajpendo.00306.2010","volume":"300","author":"A Peter","year":"2011","unstructured":"Peter A, Cegan A, Wagner S et al (2011) Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans. Am J Physiol Endocrinol Metab 300:E321\u2013E326. doi: 10.1152\/ajpendo.00306.2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"911_CR37","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s001250051620","volume":"44","author":"B Vessby","year":"2001","unstructured":"Vessby B, Uusitupa M, Hermansen K et al (2001) Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU study. Diabetologia 44:312\u2013319","journal-title":"Diabetologia"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-015-0911-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-015-0911-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-015-0911-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T17:07:19Z","timestamp":1651856839000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-015-0911-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,1]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["911"],"URL":"https:\/\/doi.org\/10.1007\/s00394-015-0911-4","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,1]]}}}