{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:36:11Z","timestamp":1791329771169,"version":"4.3.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T00:00:00Z","timestamp":1456358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"ASDIA"},{"name":"Vaincre le Diab\u00e8te"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s00394-016-1192-2","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T13:31:39Z","timestamp":1456407099000},"page":"1467-1475","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Beneficial effects of a red wine polyphenol extract on high-fat diet-induced metabolic syndrome in rats"],"prefix":"10.1007","volume":"56","author":[{"given":"Nathalie","family":"Auberval","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Dal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Maillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Bietiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Peronet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Pinget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Schini-Kerth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Sigrist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,25]]},"reference":[{"key":"1192_CR1","unstructured":"World Health Organization (1999) Definition, diagnosis and classification of diabetes mellitus and its complications. WHO\/NCD\/NCS\/99.2"},{"key":"1192_CR2","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","volume":"285","author":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults","year":"2001","unstructured":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults (Adults Treatment panel III). JAMA 285:2486\u20132497","journal-title":"JAMA"},{"key":"1192_CR3","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2337\/diacare.25.5.829","volume":"25","author":"DW Dunstan","year":"2002","unstructured":"Dunstan DW, Zimmet PZ, Welborn TA, De Courten MP, Cameron AJ, Sicree RA, Dwyer T, Colagiuri S, Jolley D, Knuiman M, Atkins R, Shaw JE (2002) The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care 25:829\u2013834","journal-title":"Diabetes Care"},{"key":"1192_CR4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2337\/diacare.24.4.683","volume":"24","author":"B Isomaa","year":"2001","unstructured":"Isomaa B, Almgren P, Tuomi T, Fors\u00e9n B, Lahti K, Niss\u00e9n M, Taskinen MR, Groop L (2001) Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24:683\u2013689","journal-title":"Diabetes Care"},{"key":"1192_CR5","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/sj.ijo.0802277","volume":"27","author":"M Liebman","year":"2003","unstructured":"Liebman M, Pelican S, Moore SA, Holmes B, Wardlaw MK, Melcher LM, Liddil AC, Paul LC, Dunnagan T, Haynes GW (2003) Dietary intake, eating behavior, and physical activity-related determinants of high body mass index in rural communities in Wyoming, Montana, and Idaho. Int J Obes Relat Metab Disord 27:684\u2013692","journal-title":"Int J Obes Relat Metab Disord"},{"key":"1192_CR6","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1136\/bmj.39024.568738.43","volume":"333","author":"SH Wild","year":"2006","unstructured":"Wild SH, Byrne CD (2006) ABC of obesity. Risk factors for diabetes and coronary heart disease. BMJ 333:1009\u20131011","journal-title":"BMJ"},{"key":"1192_CR7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0021-9150(94)05558-Z","volume":"117","author":"FB Araujo","year":"1995","unstructured":"Araujo FB, Barbosa DS, Hsin CY, Maranh\u00e3o RC, Abdalla DS (1995) Evaluation of oxidative stress in patients with hyperlipidemia. Atherosclerosis 117:61\u201371","journal-title":"Atherosclerosis"},{"key":"1192_CR8","doi-asserted-by":"crossref","first-page":"591","DOI":"10.33549\/physiolres.930244","volume":"51","author":"P Kyselov\u00e1","year":"2002","unstructured":"Kyselov\u00e1 P, Zourek M, Rusav\u00fd Z, Trefil L, Racek J (2002) Hyperinsulinemia and oxidative stress. Physiol Res 51:591\u2013595","journal-title":"Physiol Res"},{"key":"1192_CR9","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3164\/jcbn.2008044","volume":"43","author":"RL Yang","year":"2008","unstructured":"Yang RL, Shi YH, Hao G, Li W, Le GW (2008) Increasing oxidative stress with progressive hyperlipidemia in human: relation between malondialdehyde and atherogenic index. J Clin Biochem Nutr 43:154\u2013158","journal-title":"J Clin Biochem Nutr"},{"key":"1192_CR10","doi-asserted-by":"crossref","first-page":"31S","DOI":"10.1016\/0002-9343(91)90281-2","volume":"91","author":"H Sies","year":"1991","unstructured":"Sies H (1991) Oxidative stress: from basic research to clinical application. Am J Med 91:31S\u201338S","journal-title":"Am J Med"},{"key":"1192_CR11","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1172\/JCI115641","volume":"89","author":"HI Krieger-Brauer","year":"1992","unstructured":"Krieger-Brauer HI, Kather H (1992) Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase. J Clin Invest 89:1006\u20131013","journal-title":"J Clin Invest"},{"key":"1192_CR12","first-page":"E976","volume":"277","author":"A Kashiwagi","year":"1999","unstructured":"Kashiwagi A, Shinozaki K, Nishio Y, Maegawa H, Maeno Y, Kanazawa A, Kojima H, Haneda M, Hidaka H, Yasuda H, Kikkawa R (1999) Endothelium-specific activation of NAD(P)H oxidase in aortas of exogenously hyperinsulinemic rats. Am J Physiol 277:E976\u2013E983","journal-title":"Am J Physiol"},{"key":"1192_CR13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1055\/s-2007-978733","volume":"31","author":"L Xu","year":"1999","unstructured":"Xu L, Badr MZ (1999) Enhanced potential for oxidative stress in hyperinsulinemic rats: imbalance between hepatic peroxisomal hydrogen peroxide production and decomposition due to hyperinsulinemia. Horm Metab Res 31:278\u2013282","journal-title":"Horm Metab Res"},{"issue":"Suppl 4","key":"1192_CR14","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1038\/sj.ijo.0802858","volume":"28","author":"JP Montani","year":"2004","unstructured":"Montani JP, Carroll JF, Dwyer TM, Antic V, Yang Z, Dulloo AG (2004) Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Disord 28(Suppl 4):S58\u2013S65","journal-title":"Int J Obes Relat Metab Disord"},{"key":"1192_CR15","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1042\/BST0360920","volume":"36","author":"C Guichard","year":"2008","unstructured":"Guichard C, Moreau R, Pessayre D, Epperson TK, Krause KH (2008) NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? Biochem Soc Trans 36:920\u2013929","journal-title":"Biochem Soc Trans"},{"key":"1192_CR16","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1161\/01.CIR.0000091257.27563.32","volume":"108","author":"MA Creager","year":"2003","unstructured":"Creager MA, L\u00fcscher TF, Cosentino F, Beckman JA (2003) Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Circulation 108:1527\u20131532","journal-title":"Circulation"},{"key":"1192_CR17","doi-asserted-by":"crossref","first-page":"32345","DOI":"10.1074\/jbc.M313478200","volume":"279","author":"VT Samuel","year":"2004","unstructured":"Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI (2004) Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 279:32345\u201332353","journal-title":"J Biol Chem"},{"key":"1192_CR18","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1007\/s00125-011-2157-x","volume":"54","author":"ME Visser","year":"2011","unstructured":"Visser ME, Lammers NM, Nederveen AJ, van der Graaf M, Heerschap A, Ackermans MT, Sauerwein HP, Stroes ES, Serlie MJ (2011) Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinaemia. Diabetologia 54:2113\u20132121","journal-title":"Diabetologia"},{"key":"1192_CR19","doi-asserted-by":"crossref","first-page":"722","DOI":"10.7326\/0003-4819-143-10-200511150-00009","volume":"143","author":"M Hamaguchi","year":"2005","unstructured":"Hamaguchi M, Kojima T, Takeda N, Nakagawa T, Taniguchi H, Fujii K, Omatsu T, Nakajima T, Sarui H, Shimazaki M, Kato T, Okuda J, Ida K (2005) The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 143:722\u2013728","journal-title":"Ann Intern Med"},{"key":"1192_CR20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00045.2011","volume":"93","author":"JM Forbes","year":"2013","unstructured":"Forbes JM, Cooper ME (2013) Mechanisms of diabetic complications. Physiol Rev 93:137\u2013188","journal-title":"Physiol Rev"},{"key":"1192_CR21","doi-asserted-by":"crossref","first-page":"820","DOI":"10.2337\/db08-0551","volume":"58","author":"O Escribano","year":"2009","unstructured":"Escribano O, Guill\u00e9n C, Nevado C, G\u00f3mez-Hern\u00e1ndez A, Kahn CR, Benito M (2009) Beta-cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform. Diabetes 58:820\u2013828","journal-title":"Diabetes"},{"key":"1192_CR22","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1055\/s-0030-1250737","volume":"77","author":"VB Schini-Kerth","year":"2011","unstructured":"Schini-Kerth VB, Etienne-Selloum N, Chataigneau T, Auger C (2011) Vascular protection by natural product-derived polyphenols: in vitro and in vivo evidence. Planta Med 77:1161\u20131167","journal-title":"Planta Med"},{"key":"1192_CR23","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.cardiores.2006.05.022","volume":"71","author":"M Sarr","year":"2006","unstructured":"Sarr M, Chataigneau M, Martins S, Schott C, El Bedoui J, Oak MH, Muller B, Chataigneau T, Schini-Kerth VB (2006) Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase. Cardiovasc Res 71:794\u2013802","journal-title":"Cardiovasc Res"},{"key":"1192_CR24","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.bbrc.2012.02.031","volume":"419","author":"S Dal-Ros","year":"2012","unstructured":"Dal-Ros S, Bronner C, Auger C, Schini-Kerth VB (2012) Red wine polyphenols improve an established aging-related endothelial dysfunction in the mesenteric artery of middle-aged rats: role of oxidative stress. Biochem Biophys Res Commun 419:381\u2013387","journal-title":"Biochem Biophys Res Commun"},{"key":"1192_CR25","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.bbrc.2010.12.060","volume":"404","author":"S Dal-Ros","year":"2011","unstructured":"Dal-Ros S, Zoll J, Lang AL, Auger C, Keller N, Bronner C, Geny B, Schini-Kerth VB (2011) Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase. Biochem Biophys Res Commun 404:743\u2013749","journal-title":"Biochem Biophys Res Commun"},{"key":"1192_CR26","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1113\/expphysiol.2012.067496","volume":"98","author":"AL Charles","year":"2013","unstructured":"Charles AL, Meyer A, Dal-Ros S, Auger C, Keller N, Ramamoorthy TG, Zoll J, Metzger D, Schini-Kerth V, Geny B (2013) Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production. Exp Physiol 98:536\u2013545","journal-title":"Exp Physiol"},{"key":"1192_CR27","doi-asserted-by":"crossref","first-page":"e5557","DOI":"10.1371\/journal.pone.0005557","volume":"4","author":"A Agouni","year":"2009","unstructured":"Agouni A, Lagrue-Lak-Hal AH, Mostefai HA, Tesse A, Mulder P, Rouet P, Desmoulin F, Heymes C, Mart\u00ednez MC, Andriantsitohaina R (2009) Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa\/Fa). PLoS One 4:e5557","journal-title":"PLoS One"},{"key":"1192_CR28","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1758-5996-6-130","volume":"6","author":"N Auberval","year":"2014","unstructured":"Auberval N, Dal S, Bietiger W, Pinget M, Jeandidier N, Maillard-Pedracini E, Schini-Kerth V, Sigrist S (2014) Metabolic and oxidative stress markers in Wistar rats after 2\u00a0months on a high-fat diet. Diabetol Metab Syndr 6:130","journal-title":"Diabetol Metab Syndr"},{"key":"1192_CR29","doi-asserted-by":"crossref","first-page":"859048","DOI":"10.1155\/2015\/859048","volume":"2015","author":"N Auberval","year":"2015","unstructured":"Auberval N, Dal S, Bietiger W, Seyfritz E, Peluso J, Muller C, Zhao M, Marchioni E, Pinget M, Jeandidier N, Maillard E, Schini-Kerth V, Sigrist S (2015) Oxidative stress type influences the properties of antioxidants containing polyphenols in RINm5F beta cells. Evid Based Complement Altern Med 2015:859048","journal-title":"Evid Based Complement Altern Med"},{"key":"1192_CR30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"1192_CR31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2091-11-38","volume":"11","author":"C Gustavsson","year":"2010","unstructured":"Gustavsson C, Yassin K, Wahlstr\u00f6m E, Cheung L, Lindberg J, Brismar K, Ostenson CG, Norstedt G, Tollet-Egnell P (2010) Sex-different hepaticglycogen content and glucose output in rats. BMC Biochem 11:38","journal-title":"BMC Biochem"},{"key":"1192_CR32","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","volume":"41","author":"DE Kleiner","year":"2005","unstructured":"Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A, Yeh M, McCullough AJ, Sanyal AJ, Nonalcoholic Steatohepatitis Clinical Research Network (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41:1313\u20131321","journal-title":"Hepatology"},{"key":"1192_CR33","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.3390\/ijms13032965","volume":"13","author":"OO Erejuwa","year":"2012","unstructured":"Erejuwa OO (2012) Management of diabetes mellitus: could simultaneous targeting of hyperglycemia and oxidative stress be a better panacea? Int J Mol Sci 13:2965\u20132972","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1192_CR34","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"S Reagan-Shaw","year":"2008","unstructured":"Reagan-Shaw S, Nihal M, Ahmad N (2008) Dose translation from animal to human studies revisited. FASEB J 22(3):659\u2013661","journal-title":"FASEB J"},{"key":"1192_CR35","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.freeradbiomed.2008.11.020","volume":"46","author":"C Feillet-Coudray","year":"2009","unstructured":"Feillet-Coudray C, Sutra T, Fouret G, Ramos J, Wrutniak-Cabello C, Cabello G, Cristol JP, Coudray C (2009) Oxidative stress in rats fed a high-fat high-sucrose diet and preventive effect of polyphenols: involvement of mitochondrial and NAD(P)H oxidase systems. Free Radic Biol Med 46:624\u2013632","journal-title":"Free Radic Biol Med"},{"key":"1192_CR36","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4162\/nrp.2009.3.4.279","volume":"3","author":"SJ Lee","year":"2009","unstructured":"Lee SJ, Choi SK, Seo JS (2009) Grape skin improves antioxidant capacity in rats fed a high fat diet. Nutr Res Pract 3:279\u2013285","journal-title":"Nutr Res Pract"},{"key":"1192_CR37","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3390\/ijms11041365","volume":"11","author":"K Hanhineva","year":"2010","unstructured":"Hanhineva K, T\u00f6rr\u00f6nen R, Bondia-Pons I, Pekkinen J, Kolehmainen M, Mykk\u00e4nen H, Poutanen K (2010) Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci 11:1365\u20131402","journal-title":"Int J Mol Sci"},{"key":"1192_CR38","first-page":"303902","volume":"2013","author":"JM Li","year":"2013","unstructured":"Li JM, Wang W, Fan CY, Wang MX, Zhang X, Hu QH, Kong LD (2013) Quercetin preserves \u03b2-cell mass and function in fructose-induced hyperinsulinemia through modulating pancreatic Akt\/FoxO1 activation. Evid Based Complement Altern Med 2013:303902","journal-title":"Evid Based Complement Altern Med"},{"key":"1192_CR39","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1017\/S0007114510002850","volume":"104","author":"M Aoun","year":"2010","unstructured":"Aoun M, Michel F, Fouret G, Casas F, Jullien M, Wrutniak-Cabello C, Ramos J, Cristol JP, Coudray C, Carbonneau MA, Feillet-Coudray C (2010) A polyphenol extract modifies quantity but not quality of liver fatty acid content in high-fat-high-sucrose diet-fed rats: possible implication of the sirtuin pathway. Br J Nutr 104:1760\u20131770","journal-title":"Br J Nutr"},{"key":"1192_CR40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/2251-6581-12-43","volume":"12","author":"Z Bahadoran","year":"2013","unstructured":"Bahadoran Z, Mirmiran P, Azizi F (2013) Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. J Diabetes Metab Disord 12:43","journal-title":"J Diabetes Metab Disord"},{"key":"1192_CR41","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/ajcn\/66.2.447","volume":"66","author":"CJ Muller","year":"1997","unstructured":"Muller CJ, Fugelsang KC (1997) Red wine but not white: the importance of fully characterizing wines used in health studies. Am J Clin Nutr 66:447\u2013451","journal-title":"Am J Clin Nutr"},{"key":"1192_CR42","first-page":"421","volume-title":"Bioactive food as dietary interventions for arthritis and related inflammatory diseases, bioactive food in chronic disease states","author":"F Menaa","year":"2012","unstructured":"Menaa F, Badole S, Menaa B, Menaa A, Badhankar SL (2012) Polyphenols, promising therapeutics for inflammatory diseases? In: Watson RR, Preedy V (eds) Bioactive food as dietary interventions for arthritis and related inflammatory diseases, bioactive food in chronic disease states, 1st edn. Academic Press, Cambridge, pp 421\u2013428","edition":"1"},{"key":"1192_CR43","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/biof.1085","volume":"39","author":"M Ueda","year":"2013","unstructured":"Ueda M, Hayashibara K, Ashida H (2013) Propolis extract promotes translocation of glucose transporter 4 and glucose uptake through both PI3\u00a0K- and AMPK-dependent pathways in skeletal muscle. BioFactors 39:457\u2013466","journal-title":"BioFactors"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-016-1192-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-016-1192-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-016-1192-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-016-1192-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T16:11:37Z","timestamp":1718381497000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-016-1192-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,25]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["1192"],"URL":"https:\/\/doi.org\/10.1007\/s00394-016-1192-2","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,25]]}}}