{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:13:19Z","timestamp":1778929999341,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002790","name":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["STPGP-397306"],"award-info":[{"award-number":["STPGP-397306"]}],"id":[{"id":"10.13039\/501100002790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002790","name":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["STPGP-397306"],"award-info":[{"award-number":["STPGP-397306"]}],"id":[{"id":"10.13039\/501100002790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002790","name":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["STPGP-397306"],"award-info":[{"award-number":["STPGP-397306"]}],"id":[{"id":"10.13039\/501100002790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["27059"],"award-info":[{"award-number":["27059"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00394-016-1319-5","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T11:13:20Z","timestamp":1477048400000},"page":"297-308","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Identification of urinary metabolites with potential blood pressure-lowering effects in lentil-fed spontaneously hypertensive rats"],"prefix":"10.1007","volume":"57","author":[{"given":"Matthew","family":"Hanson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Zahradka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla G.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Aliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,21]]},"reference":[{"key":"1319_CR1","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1001\/archinte.164.19.2126","volume":"164","author":"YF Wang","year":"2004","unstructured":"Wang YF, Wang QJ (2004) The prevalence of prehypertension and hypertension among US adults according to the new joint national committee guidelines. Arch Internal Med 164:2126\u20132134. doi: 10.1001\/archinte.164.19.2126","journal-title":"Arch Internal Med"},{"key":"1319_CR2","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.HYP.0000107251.49515.c2","volume":"42","author":"AV Chobanian","year":"2003","unstructured":"Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JLJ, Jones DW, Materson BJ, Oparil S, Wright JTJ, Roccella EJ (2003) Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 42:1206\u20131252","journal-title":"Hypertension"},{"key":"1319_CR3","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1080\/10408398.2010.550071","volume":"53","author":"WY Huang","year":"2013","unstructured":"Huang WY, Davidge ST, Wu JP (2013) Bioactive natural constituents from food sources\u2014potential use in hypertension prevention and treatment. Crit Rev Food Sci Nutr 53:615\u2013630. doi: 10.1080\/10408398.2010.550071","journal-title":"Crit Rev Food Sci Nutr"},{"key":"1319_CR4","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0007114512003534","volume":"108","author":"J Curran","year":"2012","unstructured":"Curran J (2012) The nutritional value and health benefits of pulses in relation to obesity, diabetes, heart disease and cancer. Br J Nutr 108:S1\u2013S2","journal-title":"Br J Nutr"},{"key":"1319_CR5","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.foodres.2009.09.002","volume":"43","author":"F Roy","year":"2010","unstructured":"Roy F, Boye JI, Simpson BK (2010) Bioactive proteins and peptides in pulse crops: pea, chickpea and lentil. Food Res Int 43:432\u2013442. doi: 10.1016\/j.foodres.2009.09.002","journal-title":"Food Res Int"},{"key":"1319_CR6","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/ajh\/hpt155","volume":"27","author":"VH Jayalath","year":"2014","unstructured":"Jayalath VH, de Souza RJ, Sievenpiper JL, Ha V, Chiavaroli L, Mirrahimi A, Di Buono M, Bernstein AM, Leiter LA, Kris-Etherton PM, Vuksan V, Beyene J, Kendall CW, Jenkins DJ (2014) Effect of dietary pulses on blood pressure: a systematic review and meta-analysis of controlled feeding trials. Am J Hypertens 27:56\u201364. doi: 10.1093\/ajh\/hpt155","journal-title":"Am J Hypertens"},{"key":"1319_CR7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.numecd.2008.09.007","volume":"19","author":"Y Mukai","year":"2009","unstructured":"Mukai Y, Sato S (2009) Polyphenol-containing azuki bean (Vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension. Nutr Metab Cardiovasc Dis 19:491\u2013497","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"1319_CR8","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1017\/S0007114513002997","volume":"111","author":"MG Hanson","year":"2014","unstructured":"Hanson MG, Zahradka P, Taylor CG (2014) Lentil-based diets attenuate hypertension and large-artery remodelling in spontaneously hypertensive rats. Br J Nutr 111:690\u2013698. doi: 10.1017\/S0007114513002997","journal-title":"Br J Nutr"},{"key":"1319_CR9","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/hr.2011.182","volume":"35","author":"K Akira","year":"2012","unstructured":"Akira K, Masu S, Imachi M, Mitome H, Hashimoto T (2012) A metabonomic study of biochemical changes characteristic of genetically hypertensive rats based on 1H NMR spectroscopic urinalysis. Hypertens Res 35:404\u2013412","journal-title":"Hypertens Res"},{"key":"1319_CR10","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jff.2015.01.031","volume":"14","author":"JO Onuh","year":"2015","unstructured":"Onuh JO, Girgih AT, Ievari-Shariati S, Malomo SA, Aluko RE, Aliani M (2015) Kinetics of in vitro renin and angiotensin converting enzyme inhibition by chicken skin protein hydrolysates and their blood pressure lowering effects in spontaneously hypertensive rats. J Funct Foods 14:133\u2013143. doi: 10.1016\/j.jff.2015.01.031","journal-title":"J Funct Foods"},{"key":"1319_CR11","first-page":"015","volume":"1","author":"J Grant","year":"2015","unstructured":"Grant J, Whitehurst K, Taylor CG, Zahradka P, Aliani M (2015) Urinary metabolomics profile of genetically obese rats using liquid chromatography quadrupole time-of-flight mass spectrometry. Jacobs J Biomark 1:015","journal-title":"Jacobs J Biomark"},{"key":"1319_CR12","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/1541-4337.12051","volume":"13","author":"A Iwaniak","year":"2014","unstructured":"Iwaniak A, Minkiewicz P, Darewicz M (2014) Food-originating ACE inhibitors, including antihypertensive peptides, as preventive food components in blood pressure reduction. Compr Rev Food Sci Food Saf 13:114\u2013134","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"1319_CR13","doi-asserted-by":"crossref","first-page":"13946","DOI":"10.1021\/ja207142h","volume":"133","author":"J Xie","year":"2011","unstructured":"Xie J, Pierce JG, James RC, Okano A, Boger DL (2011) A redesigned Vancomycin engineered for dual D-Ala-D-Ala and D-Ala-D-Lac binding exhibits potent antimicrobial activity against Vancomycin-resistant bacteria. J Am Chem Soc 133:13946\u201313949","journal-title":"J Am Chem Soc"},{"key":"1319_CR14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00004872-199603000-00013","volume":"14","author":"KJ Lal","year":"1996","unstructured":"Lal KJ, Dakshinamurti K, Thliveris J (1996) The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens 14:355\u2013363","journal-title":"J Hypertens"},{"key":"1319_CR15","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/jn\/137.5.1183","volume":"137","author":"JA McMahon","year":"2007","unstructured":"McMahon JA, Skeaff CM, Williams SM, Green TJ (2007) Lowering homocysteine with B vitamins has no effect on blood pressure in older adults. J Nutr 137:1183\u20131187","journal-title":"J Nutr"},{"key":"1319_CR16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/jn\/85.2.207","volume":"85","author":"YO Chang","year":"1965","unstructured":"Chang YO (1965) Excretion of total nitrogen, lysine and methionine by rats as affected by the type of carbohydrate in the diet. J Nutr 85:207\u2013212","journal-title":"J Nutr"},{"key":"1319_CR17","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1097\/HJH.0000000000000460","volume":"33","author":"RD Semba","year":"2015","unstructured":"Semba RD, Sun K, Schwartz AV, Varadhan R, Harris TB, Satterfield S, Garcia M, Ferrucci L, Newman AB, Health ABCS (2015) Serum carboxymethyl-lysine, an advanced glycation end product, is associated with arterial stiffness in older adults. J Hypertens 33:797\u2013803. doi: 10.1097\/HJH.0000000000000460 (discussion 803)","journal-title":"J Hypertens"},{"key":"1319_CR18","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.bbagen.2013.03.025","volume":"1840","author":"PJ Thornalley","year":"2014","unstructured":"Thornalley PJ, Rabbani N (2014) Detection of oxidized and glycated proteins in clinical samples using mass spectrometry\u2013a user\u2019s perspective. Biochim Biophys Acta 1840:818\u2013829. doi: 10.1016\/j.bbagen.2013.03.025","journal-title":"Biochim Biophys Acta"},{"key":"1319_CR19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/ajcn\/85.1.167","volume":"85","author":"MCG Poll van de","year":"2007","unstructured":"van de Poll MCG, Siroen MPC, van Leeuwen PAM, Soeters PB, Melis GC, Boelens PG, Deutz NEP, Dejong CHC (2007) Interorgan amino acid exchange in humans: consequences for arginine and citrulline metabolism. Am J Clin Nutr 85:167\u2013172","journal-title":"Am J Clin Nutr"},{"key":"1319_CR20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1001\/jama.295.1.58","volume":"295","author":"SP Schulman","year":"2006","unstructured":"Schulman SP, Becker LC, Kass DA, Champion HC, Terrin ML, Forman S, Ernst KV, Kelemen MD, Townsend SN, Capriotti A, Hare JM, Gerstenblith G (2006) l-arginine therapy in acute myocardial infarction - The Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. Jama-J Am Med Assoc 295:58\u201364. doi: 10.1001\/jama.295.1.58","journal-title":"Jama-J Am Med Assoc"},{"key":"1319_CR21","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1159\/000327777","volume":"4","author":"FS Dioguardi","year":"2011","unstructured":"Dioguardi FS (2011) To give or not to give? lessons from the arginine paradox. J Nutrigenet Nutrigenom 4:90\u201398. doi: 10.1159\/000327777","journal-title":"J Nutrigenet Nutrigenom"},{"key":"1319_CR22","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1097\/HJH.0b013e32836037fb","volume":"6","author":"LP Zwan van der","year":"2013","unstructured":"van der Zwan LP, Davids M, Scheffer PG, Dekker JM, Stehouwer CD, Teerlink T (2013) L-Homoarginine and l-arginine are antagonistically related to blood pressure in an elderly population: the Hoorn study. J Hypertens 6:1114\u20131123","journal-title":"J Hypertens"},{"key":"1319_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellsig.2014.09.024","volume":"27","author":"D Feliers","year":"2015","unstructured":"Feliers D, Lee DY, Gorin Y, Kasinath BS (2015) Symmetric dimethylarginine alters endothelial nitric oxide activity in glomerular endothelial cells. Cell Signal 27:1\u20135. doi: 10.1016\/j.cellsig.2014.09.024","journal-title":"Cell Signal"},{"key":"1319_CR24","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/sj.bjp.0705027","volume":"138","author":"J Angulo","year":"2003","unstructured":"Angulo J, Cuevas P, Fernandez A, Gabancho S, Allona A, Martin-Morales A, Moncada I, de Tejada IS (2003) Activation and potentiation of the NO\/cGMP pathway by N-G-hydroxyl-l-arginine in rabbit corpus cavernosum under normoxic and hypoxic conditions and ageing. Br J Pharmacol 138:63\u201370. doi: 10.1038\/sj.bjp.0705027","journal-title":"Br J Pharmacol"},{"key":"1319_CR25","doi-asserted-by":"crossref","first-page":"17776","DOI":"10.1016\/S0021-9258(17)32375-X","volume":"269","author":"HG Korth","year":"1994","unstructured":"Korth HG, Sustmann R, Thater C, Butler AR, Ingold KU (1994) on the mechanism of the nitric-oxide synthase-catalyzed conversion of N-omega-hydroxy-l-arginine to citrulline and nitric-oxide. J Biol Chem 269:17776\u201317779","journal-title":"J Biol Chem"},{"key":"1319_CR26","doi-asserted-by":"publisher","first-page":"10453","DOI":"10.1021\/bi980742t","volume":"37","author":"C Moali","year":"1998","unstructured":"Moali C, Boucher JL, Sari MA, Stuehr DJ, Mansuy D (1998) Substrate specificity of NO synthases: detailed comparison of l-arginine, homo-l-arginine, their N-omega-hydroxy derivatives, and N-omega-hydroxynor-l-arginine. Biochemistry 37:10453\u201310460. doi: 10.1021\/bi980742t","journal-title":"Biochemistry"},{"key":"1319_CR27","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1124\/jpet.102.038612","volume":"303","author":"P Vetrovsky","year":"2002","unstructured":"Vetrovsky P, Boucher JL, Schott C, Beranova P, Chalupsky K, Callizot N, Muller B, Entlicher G, Mansuy D, Stoclet JC (2002) Involvement of NO in the endothelium-independent relaxing effects of N(omega)-hydroxy-l-arginine and other compounds bearing a C\u00a0=\u00a0NOH function in the rat aorta. J Pharmacol Exp Ther 303:823\u2013830. doi: 10.1124\/jpet.102.038612","journal-title":"J Pharmacol Exp Ther"},{"key":"1319_CR28","first-page":"2644","volume":"17","author":"CL Xuan","year":"2013","unstructured":"Xuan CL, Yao FR, Guo LR, Liu Q, Chang SK, Liu KX, Sun CW (2013) Comparison of extracts from cooked and raw lentil in antagonizing angiotensin II-induced hypertension and cardiac hypertrophy. Eur Rev Med Pharmacol Sci 17:2644\u20132653","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1319_CR29","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1039\/C1fo10142k","volume":"3","author":"FR Yao","year":"2012","unstructured":"Yao FR, Sun CW, Chang SKC (2012) Lentil polyphenol extract prevents angiotensin II-induced hypertension, vascular remodelling and perivascular fibrosis. Food Funct 3:127\u2013133. doi: 10.1039\/C1fo10142k","journal-title":"Food Funct"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-016-1319-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-016-1319-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-016-1319-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T22:53:19Z","timestamp":1657493599000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-016-1319-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,21]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["1319"],"URL":"https:\/\/doi.org\/10.1007\/s00394-016-1319-5","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,21]]}}}