{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T18:00:06Z","timestamp":1785261606940,"version":"3.55.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s00394-016-1357-z","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T09:07:55Z","timestamp":1482570475000},"page":"703-711","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study"],"prefix":"10.1007","volume":"57","author":[{"given":"Deepa","family":"Haldar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj Ramrao","family":"Kambale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchan","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Batra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar C.","family":"Kabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"key":"1357_CR1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/adc.77.1.89","volume":"77","author":"S Franks","year":"1997","unstructured":"Franks S (1997) Polycystic ovary syndrome. Arch Dis Child 77:89\u201390","journal-title":"Arch Dis Child"},{"key":"1357_CR2","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","volume":"352","author":"DA Ehrmann","year":"2005","unstructured":"Ehrmann DA (2005) Polycystic ovary syndrome. N Engl J Med 352:1223\u20131236","journal-title":"N Engl J Med"},{"key":"1357_CR3","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1530\/eje.0.1450619","volume":"145","author":"HF Escobar-Morreale","year":"2001","unstructured":"Escobar-Morreale HF, Asunci\u00f3n M, Calvo RM, Sancho J, San Mill\u00e1n JL (2001) Receiver operating characteristic analysis of the performance of basal serum hormone profiles for the diagnosis of polycystic ovary syndrome in epidemiological studies. Eur J Endocrinol 145:619\u2013624","journal-title":"Eur J Endocrinol"},{"key":"1357_CR4","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00108-006-1776-7","volume":"48","author":"D Heutling","year":"2007","unstructured":"Heutling D, Schulz H, Randeva H, Dodt C, Lehnert H (2007) Polycystic ovary syndrome. Prototype of a cardio-metabolic syndrome. Internist 48:144\u2013153","journal-title":"Internist"},{"key":"1357_CR5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mce.2010.08.002","volume":"335","author":"A Repaci","year":"2011","unstructured":"Repaci A, Gambineri A, Pasquali R (2011) The role of low-grade inflammation in the polycystic ovary syndrome. Mol Cell Endocrinol 335:30\u201341","journal-title":"Mol Cell Endocrinol"},{"key":"1357_CR6","first-page":"47","volume":"1","author":"KG Seshadri","year":"2011","unstructured":"Seshadri KG, Tamilselvan B, Rajendran A (2011) Role of vitamin D in diabetes. J Endocrinol Metab 1:47\u201356","journal-title":"J Endocrinol Metab"},{"issue":"5","key":"1357_CR7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3109\/09513590.2015.1124260","volume":"32","author":"E Kiyak Caglayan","year":"2016","unstructured":"Kiyak Caglayan E, Engin-\u00dcstun Y, Sari N, G\u00f6\u00e7men AY, Seckin L, Kara M et al (2016) Is there association between vitamin D levels, apelin 36, and visfatin in PCOS? Gynecol Endocrinol 32(5):386\u2013389","journal-title":"Gynecol Endocrinol"},{"issue":"455","key":"1357_CR8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2015.12.040","volume":"1","author":"SZ Shahrokhi","year":"2016","unstructured":"Shahrokhi SZ, Ghaffari F, Kazerouni F (2016) Role of vitamin D in female reproduction. Clin Chim Acta 1(455):33\u201338","journal-title":"Clin Chim Acta"},{"issue":"1","key":"1357_CR9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/mnfr.201500259","volume":"60","author":"AE Joham","year":"2016","unstructured":"Joham AE, Teede HJ, Cassar S, Stepto NK, Strauss BJ, Harrison CL et al (2016) Vitamin D in polycystic ovary syndrome: relationship to obesity and insulin resistance. Mol Nutr Food Res 60(1):110\u2013118","journal-title":"Mol Nutr Food Res"},{"key":"1357_CR10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S1028-4559(09)60275-8","volume":"48","author":"B Rashidi","year":"2009","unstructured":"Rashidi B, Haghollahi F, Shariat M, Zayerii F (2009) The effects of calcium\u2013vitamin D and metformin on polycystic ovary syndrome: a pilot study. Taiwan J Obstet Gynecol 48:142\u2013147","journal-title":"Taiwan J Obstet Gynecol"},{"key":"1357_CR11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0140-6736(10)60588-0","volume":"376","author":"TJ Wang","year":"2010","unstructured":"Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D et al (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376:180\u2013188","journal-title":"Lancet"},{"key":"1357_CR12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jmb.2008.03.065","volume":"380","author":"N Strushkevich","year":"2008","unstructured":"Strushkevich N, Usanov SA, Plotnikov AN, Jones G, Park H-W (2008) Structural analysis of CYP2R1 in complex with vitamin D3. J Mol Biol 380:95\u2013106","journal-title":"J Mol Biol"},{"key":"1357_CR13","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.tibs.2004.10.005","volume":"29","author":"DE Prosser","year":"2004","unstructured":"Prosser DE, Jones G (2004) Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci 29:664\u2013673","journal-title":"Trends Biochem Sci"},{"key":"1357_CR14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3945\/jn.112.169482","volume":"143","author":"CD Engelman","year":"2013","unstructured":"Engelman CD, Meyers KJ, Iyengar SK, Liu Z, Karki CK, Igo RP et al (2013) Vitamin D intake and season modify the effects of the GC and CYP2R1 Genes on 25-hydroxyvitamin D concentrations. J Nutr 143:17\u201326","journal-title":"J Nutr"},{"key":"1357_CR15","first-page":"w13636","volume":"142","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Wang X, Liu Y, Qu H, Qu S, Wang W et al (2012) The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children. Swiss Med Wkly 142:w13636","journal-title":"Swiss Med Wkly"},{"key":"1357_CR16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2006.03.011","volume":"372","author":"M Speeckaert","year":"2006","unstructured":"Speeckaert M, Huang G, Delanghe JR, Taes YE (2006) Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta 372:33\u201342","journal-title":"Clin Chim Acta"},{"key":"1357_CR17","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S1043-2760(00)00317-9","volume":"11","author":"P White","year":"2000","unstructured":"White P, Cooke N (2000) The multifunctional properties and characteristics of vitamin D-binding protein. Trends Endocrinol Metab 11:320\u2013327","journal-title":"Trends Endocrinol Metab"},{"key":"1357_CR18","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1530\/EJE-11-0134","volume":"164","author":"E Wehr","year":"2011","unstructured":"Wehr E, Trummer O, Giuliani A, Gruber H-J, Pieber TR, Obermayer-Pietsch B (2011) Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome. Eur J Endocrinol 164:741\u2013749","journal-title":"Eur J Endocrinol"},{"key":"1357_CR19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","volume":"19","author":"Group TREP consensus workshop","year":"2004","unstructured":"Group TREP consensus workshop (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19:41\u201347","journal-title":"Hum Reprod"},{"key":"1357_CR20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0076-6879(96)72024-4","volume":"272","author":"AK Daly","year":"1996","unstructured":"Daly AK, Steen VM, Fairbrother KS, Idle JR (1996) CYP2D6 multiallelism. Meth Enzymol 272:199\u2013210","journal-title":"Meth Enzymol"},{"key":"1357_CR21","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/humupd\/dms030","volume":"18","author":"SS Lim","year":"2012","unstructured":"Lim SS, Davies MJ, Norman RJ, Moran LJ (2012) Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update 18:618\u2013637","journal-title":"Hum Reprod Update"},{"key":"1357_CR22","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S8756-3282(02)00692-0","volume":"30","author":"AC Looker","year":"2002","unstructured":"Looker AC, Dawson-Hughes B, Calvo MS, Gunter EW, Sahyoun NR (2002) Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone 30:771\u2013777","journal-title":"Bone"},{"key":"1357_CR23","first-page":"211","volume":"127","author":"CV Harinarayan","year":"2008","unstructured":"Harinarayan CV, Ramalakshmi T, Prasad UV, Sudhakar D (2008) Vitamin D status in Andhra Pradesh: a population based study. Indian J Med Res 127:211\u2013218","journal-title":"Indian J Med Res"},{"key":"1357_CR24","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00198-005-1867-7","volume":"16","author":"B Dawson-Hughes","year":"2005","unstructured":"Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R (2005) Estimates of optimal vitamin D status. Osteoporos Int 16:713\u2013716","journal-title":"Osteoporos Int"},{"key":"1357_CR25","first-page":"94","volume":"10","author":"WB Grant","year":"2005","unstructured":"Grant WB, Holick MF (2005) Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev 10:94\u2013111","journal-title":"Altern Med Rev"},{"key":"1357_CR26","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/jn\/135.2.317","volume":"135","author":"BW Hollis","year":"2005","unstructured":"Hollis BW (2005) Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 135:317\u2013322","journal-title":"J Nutr"},{"key":"1357_CR27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1530\/EJE-09-0432","volume":"161","author":"E Wehr","year":"2009","unstructured":"Wehr E, Pilz S, Schweighofer N, Giuliani A, Kopera D, Pieber TR et al (2009) Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol 161:575\u2013582","journal-title":"Eur J Endocrinol"},{"key":"1357_CR28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00404-009-0958-7","volume":"280","author":"R Yildizhan","year":"2009","unstructured":"Yildizhan R, Kurdoglu M, Adali E, Kolusari A, Yildizhan B, Sahin HG et al (2009) Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome. Arch Gynecol Obstet 280:559\u2013563","journal-title":"Arch Gynecol Obstet"},{"key":"1357_CR29","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.metabol.2011.03.002","volume":"60","author":"HWR Li","year":"2011","unstructured":"Li HWR, Brereton RE, Anderson RA, Wallace AM, Ho CKM (2011) Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metab Clin Exp 60:1475\u20131481","journal-title":"Metab Clin Exp"},{"key":"1357_CR30","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1055\/s-2006-948308","volume":"114","author":"S Hahn","year":"2006","unstructured":"Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M, Roesler S et al (2006) Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 114:577\u2013583","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"1357_CR31","first-page":"229","volume":"127","author":"R Goswami","year":"2008","unstructured":"Goswami R, Mishra SK, Kochupillai N (2008) Prevalence & potential significance of vitamin D deficiency in Asian Indians. Indian J Med Res 127:229\u2013238","journal-title":"Indian J Med Res"},{"key":"1357_CR32","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/ajcn\/72.3.690","volume":"72","author":"J Wortsman","year":"2000","unstructured":"Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72:690\u2013693","journal-title":"Am J Clin Nutr"},{"key":"1357_CR33","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1093\/ajcn\/34.11.2359","volume":"34","author":"JE Compston","year":"1981","unstructured":"Compston JE, Vedi S, Ledger JE, Webb A, Gazet JC, Pilkington TR (1981) Vitamin D status and bone histomorphometry in gross obesity. Am J Clin Nutr 34:2359\u20132363","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"1357_CR34","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1530\/EJE-11-0984","volume":"166","author":"E Lerchbaum","year":"2012","unstructured":"Lerchbaum E, Obermayer-Pietsch B (2012) Mechanisms in endocrinology: vitamin D and fertility: a systematic review. Eur J Endocrinol 166(5):765\u2013778","journal-title":"Eur J Endocrinol"},{"key":"1357_CR35","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.fertnstert.2008.07.1757","volume":"92","author":"K Kotsa","year":"2009","unstructured":"Kotsa K, Yavropoulou MP, Anastasiou O, Yovos JG (2009) Role of vitamin D treatment in glucose metabolism in polycystic ovary syndrome. Fertil Steril 92:1053\u20131058","journal-title":"Fertil Steril"},{"key":"1357_CR36","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1210\/jc.2007-0298","volume":"92","author":"AG Pittas","year":"2007","unstructured":"Pittas AG, Lau J, Hu FB, Dawson-Hughes B (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92:2017\u20132029","journal-title":"J Clin Endocrinol Metab"},{"key":"1357_CR37","first-page":"E356","volume":"267","author":"JA Johnson","year":"1994","unstructured":"Johnson JA, Grande JP, Roche PC, Kumar R (1994) Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28\u00a0k in human and rat pancreas. Am J Physiol 267:E356\u2013E360","journal-title":"Am J Physiol"},{"key":"1357_CR38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF01269910","volume":"3","author":"RD Milner","year":"1967","unstructured":"Milner RD, Hales CN (1967) The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitro. Diabetologia 3:47\u201349","journal-title":"Diabetologia"},{"key":"1357_CR39","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1210\/jc.2008-1454","volume":"94","author":"D Bikle","year":"2009","unstructured":"Bikle D (2009) Nonclassic actions of vitamin D. J Clin Endocrinol Metab 94:26\u201334","journal-title":"J Clin Endocrinol Metab"},{"key":"1357_CR40","doi-asserted-by":"crossref","first-page":"8","DOI":"10.20452\/pamw.2636","volume":"125","author":"AE Grzegorzewska","year":"2015","unstructured":"Grzegorzewska AE, Ostromecki G, Mostowska A, Sowi\u0144ska A, Jagodzi\u0144ski PP (2015) Clinical aspects of vitamin D-binding protein gene polymorphisms in hemodialysis patients. Pol Arch Med Wewn 125:8\u201317","journal-title":"Pol Arch Med Wewn"},{"key":"1357_CR41","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3945\/ajcn.2008.26445","volume":"89","author":"M Sinotte","year":"2009","unstructured":"Sinotte M, Diorio C, B\u00e9rub\u00e9 S, Pollak M, Brisson J (2009) Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women. Am J Clin Nutr 89:634\u2013640","journal-title":"Am J Clin Nutr"},{"key":"1357_CR42","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1471-2350-14-101","volume":"14","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Yang S, Liu Y, Ren L (2013) Relationship between polymorphisms in vitamin D metabolism-related genes and the risk of rickets in Han Chinese children. BMC Med Genet 14:101","journal-title":"BMC Med Genet"},{"key":"1357_CR43","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1507\/endocrj.EJ12-0143","volume":"59","author":"S Kitanaka","year":"2012","unstructured":"Kitanaka S, Isojima T, Takaki M, NumakuraC HayasakaK, Igarashi T (2012) Association of vitamin D-related gene polymorphisms with manifestation of vitamin D deficiency in children. Endocr J 59:1007\u20131014","journal-title":"Endocr J"},{"key":"1357_CR44","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1210\/jc.2002-020978","volume":"88","author":"S Arunabh","year":"2003","unstructured":"Arunabh S, Pollack S, Yeh J, Aloia JF (2003) Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab 88:157\u2013161","journal-title":"J Clin Endocrinol Metab"},{"key":"1357_CR45","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/BF03345785","volume":"33","author":"H Selimoglu","year":"2009","unstructured":"Selimoglu H, Duran C, Kiyici S, Ersoy C, Guclu M, Ozkaya G et al (2009) The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome. J Endocrinol Invest 33:234\u2013238","journal-title":"J Endocrinol Invest"},{"issue":"4","key":"1357_CR46","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3945\/ajcn.112.050013","volume":"97","author":"AM Belenchia","year":"2013","unstructured":"Belenchia AM, Tosh AK, Hillman LS, Peterson CA (2013) Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J Clin Nutr 97(4):774\u2013781","journal-title":"Am J Clin Nutr"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-016-1357-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-016-1357-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-016-1357-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T21:16:39Z","timestamp":1749849399000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-016-1357-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,23]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["1357"],"URL":"https:\/\/doi.org\/10.1007\/s00394-016-1357-z","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,23]]}}}