{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:14:41Z","timestamp":1773724481599,"version":"3.50.1"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["1802"],"award-info":[{"award-number":["1802"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s00394-017-1387-1","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T12:20:01Z","timestamp":1487766001000},"page":"1025-1044","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Chlorella vulgaris on tumor growth in mammary tumor-bearing Balb\/c mice: discussing association of an immune-suppressed protumor microenvironment with serum IFN\u03b3 and IgG decrease and spleen IgG potentiation"],"prefix":"10.1007","volume":"57","author":[{"given":"Ahad","family":"Khalilnezhad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Mahmoudian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nariman","family":"Mosaffa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Anissian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Rashidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davar","family":"Amani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"issue":"5","key":"1387_CR1","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u2013674. doi: 10.1016\/j.cell.2011.02.013","journal-title":"Cell"},{"issue":"3","key":"1387_CR2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.chom.2014.02.003","volume":"15","author":"RS Goldszmid","year":"2014","unstructured":"Goldszmid RS, Dzutsev A, Trinchieri G (2014) Host immune response to infection and cancer: unexpected commonalities. Cell Host Microbe 15(3):295\u2013305. doi: 10.1016\/j.chom.2014.02.003","journal-title":"Cell Host Microbe"},{"issue":"9","key":"1387_CR3","doi-asserted-by":"publisher","first-page":"5487","DOI":"10.1128\/IAI.72.9.5487-5492.2004","volume":"72","author":"MB Voisin","year":"2004","unstructured":"Voisin MB, Buzoni-Gatel D, Bout D, Velge-Roussel F (2004) Both expansion of regulatory GR1 + CD11b + myeloid cells and anergy of T lymphocytes participate in hyporesponsiveness of the lung-associated immune system during acute toxoplasmosis. Infect Immun 72(9):5487\u20135492. doi: 10.1128\/IAI.72.9.5487-5492.2004","journal-title":"Infect Immun"},{"issue":"12","key":"1387_CR4","doi-asserted-by":"publisher","first-page":"8200","DOI":"10.4049\/jimmunol.175.12.8200","volume":"175","author":"X Song","year":"2005","unstructured":"Song X, Krelin Y, Dvorkin T, Bjorkdahl O, Segal S, Dinarello CA, Voronov E, Apte RN (2005) CD11b+\/Gr-1 + immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cells. J Immunol 175(12):8200\u20138208. doi: 10.4049\/jimmunol.175.12.8200","journal-title":"J Immunol"},{"issue":"12","key":"1387_CR5","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/j.procbio.2010.05.023","volume":"45","author":"H-M Wang","year":"2010","unstructured":"Wang H-M, Pan J-L, Chen C-Y, Chiu C-C, Yang M-H, Chang H-W, Chang J-S (2010) Identification of anti-lung cancer extract from Chlorella vulgaris C-C by antioxidant property using supercritical carbon dioxide extraction. Process Biochem 45(12):1865\u20131872. doi: 10.1016\/j.procbio.2010.05.023","journal-title":"Process Biochem"},{"key":"1387_CR6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.bbi.2012.12.001","volume":"29","author":"S Queiroz Jde","year":"2013","unstructured":"Queiroz Jde S, Barbosa CM, Rocha MC, Bincoletto C, Paredes-Gamero EJ, Queiroz ML, Palermo Neto J (2013) Chlorella vulgaris treatment ameliorates the suppressive effects of single and repeated stressors on hematopoiesis. Brain Behav Immun 29:39\u201350. doi: 10.1016\/j.bbi.2012.12.001","journal-title":"Brain Behav Immun"},{"issue":"9","key":"1387_CR7","doi-asserted-by":"publisher","first-page":"21021","DOI":"10.3390\/ijms160921021","volume":"16","author":"H Kang","year":"2015","unstructured":"Kang H, Lee CH, Kim JR, Kwon JY, Seo SG, Han JG, Kim BG, Kim JE, Lee KW (2015) Chlorella vulgaris attenuates dermatophagoides farinae-induced atopic dermatitis-like symptoms in NC\/Nga mice. Int J Mol Sci 16(9):21021\u201321034. doi: 10.3390\/ijms160921021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1387_CR8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.lfs.2013.11.020","volume":"95","author":"JF Vecina","year":"2014","unstructured":"Vecina JF, Oliveira AG, Araujo TG, Baggio SR, Torello CO, Saad MJ, Queiroz ML (2014) Chlorella modulates insulin signaling pathway and prevents high-fat diet-induced insulin resistance in mice. Life Sci 95(1):45\u201352. doi: 10.1016\/j.lfs.2013.11.020","journal-title":"Life Sci"},{"issue":"1","key":"1387_CR9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1081\/IPH-100102573","volume":"23","author":"GZ Justo","year":"2001","unstructured":"Justo GZ, Silva MR, Queiroz ML (2001) Effects of the green algae Chlorella vulgaris on the response of the host hematopoietic system to intraperitoneal ehrlich ascites tumor transplantation in mice. Immunopharmacol Immunotoxicol 23(1):119\u2013132. doi: 10.1081\/IPH-100102573","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"8","key":"1387_CR10","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1080\/01635581.2010.513801","volume":"62","author":"AL Ramos","year":"2010","unstructured":"Ramos AL, Torello CO, Queiroz ML (2010) Chlorella vulgaris modulates immunomyelopoietic activity and enhances the resistance of tumor-bearing mice. Nutr Cancer 62(8):1170\u20131180. doi: 10.1080\/01635581.2010.513801","journal-title":"Nutr Cancer"},{"key":"1387_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.psyneuen.2015.12.002","volume":"65","author":"J Souza Queiroz","year":"2016","unstructured":"Souza Queiroz J, Marin Blasco I, Gagliano H, Daviu N, Gomez Roman A, Belda X, Carrasco J, Rocha MC, Palermo Neto J, Armario A (2016) Chlorella vulgaris reduces the impact of stress on hypothalamic-pituitary-adrenal axis and brain c-fos expression. Psychoneuroendocrinology 65:1\u20138. doi: 10.1016\/j.psyneuen.2015.12.002","journal-title":"Psychoneuroendocrinology"},{"key":"1387_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1475-2891-11-53","volume":"11","author":"JH Kwak","year":"2012","unstructured":"Kwak JH, Baek SH, Woo Y, Han JK, Kim BG, Kim OY, Lee JH (2012) Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of natural killer cell activity and early inflammatory response (randomized, double-blinded, placebo-controlled trial). Nutr J 11:53. doi: 10.1186\/1475-2891-11-53","journal-title":"Nutr J"},{"issue":"7","key":"1387_CR13","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.3748\/wjg.v19.i7.1085","volume":"19","author":"J Azocar","year":"2013","unstructured":"Azocar J, Diaz A (2013) Efficacy and safety of Chlorella supplementation in adults with chronic hepatitis C virus infection. World J Gastroenterol 19(7):1085\u20131090. doi: 10.3748\/wjg.v19.i7.1085","journal-title":"World J Gastroenterol"},{"key":"1387_CR14","doi-asserted-by":"publisher","first-page":"704619","DOI":"10.1155\/2014\/704619","volume":"2014","author":"N Noguchi","year":"2014","unstructured":"Noguchi N, Maruyama I, Yamada A (2014) The influence of chlorella and its hot water extract supplementation on quality of life in patients with breast cancer. Evid Based Complement Alternat Med 2014:704619. doi: 10.1155\/2014\/704619","journal-title":"Evid Based Complement Alternat Med"},{"issue":"2","key":"1387_CR15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2307\/1543397","volume":"203","author":"PB Armstrong","year":"2002","unstructured":"Armstrong PB, Armstrong MT, Pardy RL, Child A, Wainwright N (2002) Immunohistochemical demonstration of a lipopolysaccharide in the cell wall of a eukaryote, the green alga, Chlorella. Biol Bull 203(2):203\u2013204","journal-title":"Biol Bull"},{"issue":"9","key":"1387_CR16","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/j.carres.2010.04.004","volume":"345","author":"ER Suarez","year":"2010","unstructured":"Suarez ER, Kralovec JA, Grindley TB (2010) Isolation of phosphorylated polysaccharides from algae: the immunostimulatory principle of Chlorella pyrenoidosa. Carbohydr Res 345(9):1190\u20131204. doi: 10.1016\/j.carres.2010.04.004","journal-title":"Carbohydr Res"},{"issue":"15","key":"1387_CR17","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1016\/j.carres.2008.07.009","volume":"343","author":"E Reyes Suarez","year":"2008","unstructured":"Reyes Suarez E, Bugden SM, Kai FB, Kralovec JA, Noseda MD, Barrow CJ, Grindley TB (2008) First isolation and structural determination of cyclic beta-(1\u2013>2)-glucans from an alga, Chlorella pyrenoidosa. Carbohydr Res 343(15):2623\u20132633. doi: 10.1016\/j.carres.2008.07.009","journal-title":"Carbohydr Res"},{"issue":"6","key":"1387_CR18","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1007\/s10068-015-0255-0","volume":"24","author":"M Tabarsa","year":"2015","unstructured":"Tabarsa M, Shin I-S, Lee JH, Surayot U, Park W, You S (2015) An immune-enhancing water-soluble \u03b1-glucan from Chlorella vulgaris and structural characteristics. Food Sci Biotechnol 24(6):1933\u20131941. doi: 10.1007\/s10068-015-0255-0","journal-title":"Food Sci Biotechnol"},{"issue":"4","key":"1387_CR19","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/S1567-5769(02)00002-4","volume":"2","author":"T Hasegawa","year":"2002","unstructured":"Hasegawa T, Matsuguchi T, Noda K, Tanaka K, Kumamoto S, Shoyama Y, Yoshikai Y (2002) Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris. Int Immunopharmacol 2(4):579\u2013589 doi: 10.1016\/S1567-5769(02)00002-4","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"1387_CR20","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1021\/jf902952z","volume":"58","author":"HY Hsu","year":"2010","unstructured":"Hsu HY, Jeyashoke N, Yeh CH, Song YJ, Hua KF, Chao LK (2010) Immunostimulatory bioactivity of algal polysaccharides from Chlorella pyrenoidosa activates macrophages via Toll-like receptor 4. J Agric Food Chem 58(2):927\u2013936. doi: 10.1021\/jf902952z","journal-title":"J Agric Food Chem"},{"issue":"3","key":"1387_CR21","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/mi.2012.4","volume":"5","author":"O Pabst","year":"2012","unstructured":"Pabst O, Mowat AM (2012) Oral tolerance to food protein. Mucosal Immunol 5(3):232\u2013239. doi: 10.1038\/mi.2012.4","journal-title":"Mucosal Immunol"},{"issue":"4","key":"1387_CR22","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1002\/eji.200838653","volume":"39","author":"L Eroukhmanoff","year":"2009","unstructured":"Eroukhmanoff L, Oderup C, Ivars F (2009) T-cell tolerance induced by repeated antigen stimulation: selective loss of Foxp3- conventional CD4 T cells and induction of CD4 T-cell anergy. Eur J Immunol 39(4):1078\u20131087. doi: 10.1002\/eji.200838653","journal-title":"Eur J Immunol"},{"issue":"7\u20138","key":"1387_CR23","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/j.molimm.2010.01.007","volume":"47","author":"S Noori","year":"2010","unstructured":"Noori S, Taghikhani M, Hassan ZM, Allameha A, Mostafaei A (2010) Tehranolide molecule modulates the immune response, reduce regulatory T cell and inhibits tumor growth in vivo. Mol Immunol 47(7\u20138):1579\u20131584. doi: 10.1016\/j.molimm.2010.01.007","journal-title":"Mol Immunol"},{"key":"1387_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im0301s39","volume-title":"Current protocols in immunology","author":"AM Kruisbeek","year":"2001","unstructured":"Kruisbeek AM (2001) Isolation of Mouse Mononuclear Cells. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W (eds) Current protocols in immunology. Wiley, New York. doi: 10.1002\/0471142735.im0301s39"},{"key":"1387_CR25","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254. doi: 10.1016\/0003-2697(76)90527-3","journal-title":"Anal Biochem"},{"issue":"10","key":"1387_CR26","doi-asserted-by":"publisher","first-page":"e76979","DOI":"10.1371\/journal.pone.0076979","volume":"8","author":"P Anderson","year":"2013","unstructured":"Anderson P, Carrillo-Galvez AB, Garcia-Perez A, Cobo M, Martin F (2013) CD105 (endoglin)-negative murine mesenchymal stromal cells define a new multipotent subpopulation with distinct differentiation and immunomodulatory capacities. PLoS One 8(10):e76979. doi: 10.1371\/journal.pone.0076979","journal-title":"PLoS One"},{"issue":"1\u20133","key":"1387_CR27","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ejphar.2012.11.033","volume":"701","author":"S-H Kim","year":"2013","unstructured":"Kim S-H, Hong J-H, Lee Y-C (2013) Ursolic acid, a potential PPAR\u03b3 agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma. Eur J Pharmacol 701(1\u20133):131\u2013143. doi: 10.1016\/j.ejphar.2012.11.033","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"1387_CR28","doi-asserted-by":"publisher","first-page":"e72772","DOI":"10.1371\/journal.pone.0072772","volume":"8","author":"W Xiong","year":"2013","unstructured":"Xiong W, Frasch SC, Thomas SM, Bratton DL, Henson PM (2013) Induction of TGF-beta1 synthesis by macrophages in response to apoptotic cells requires activation of the scavenger receptor CD36. PLoS One 8(8):e72772. doi: 10.1371\/journal.pone.0072772","journal-title":"PLoS One"},{"issue":"5","key":"1387_CR29","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.3892\/etm.2013.995","volume":"5","author":"Y Chen","year":"2013","unstructured":"Chen Y, Huang F, Wang D, Weng Z, Deng Z (2013) Upregulation of heme oxygenase-1 expression may facilitate memory and learning in mice. Exp Ther Med 5(5):1491\u20131495. doi: 10.3892\/etm.2013.995","journal-title":"Exp Ther Med"},{"issue":"8","key":"1387_CR30","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.1167\/iovs.07-1515","volume":"49","author":"K Patil","year":"2008","unstructured":"Patil K, Bellner L, Cullaro G, Gotlinger KH, Dunn MW, Schwartzman ML (2008) Heme oxygenase-1 induction attenuates corneal inflammation and accelerates wound healing after epithelial injury. Invest Ophthalmol Vis Sci 49(8):3379\u20133386. doi: 10.1167\/iovs.07-1515","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"27","key":"1387_CR31","doi-asserted-by":"publisher","first-page":"4450","DOI":"10.1038\/sj.onc.1208644","volume":"24","author":"E Perez-Gomez","year":"2005","unstructured":"Perez-Gomez E, Eleno N, Lopez-Novoa JM, Ramirez JR, Velasco B, Letarte M, Bernabeu C, Quintanilla M (2005) Characterization of murine S-endoglin isoform and its effects on tumor development. Oncogene 24(27):4450\u20134461 doi: 10.1038\/sj.onc.1208644","journal-title":"Oncogene"},{"issue":"4","key":"1387_CR32","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2013\u2206\u2206CT method. Methods 25(4):402\u2013408. doi: 10.1006\/meth.2001.1262","journal-title":"Methods"},{"issue":"4","key":"1387_CR33","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.nut.2014.08.010","volume":"31","author":"P Kubatka","year":"2015","unstructured":"Kubatka P, Kapinova A, Kruzliak P, Kello M, Vybohova D, Kajo K, Novak M, Chripkova M, Adamkov M, Pec M, Mojzis J, Bojkova B, Kassayova M, Stollarova N, Dobrota D (2015) Antineoplastic effects of Chlorella pyrenoidosa in the breast cancer model. Nutrition 31(4):560\u2013569. doi: 10.1016\/j.nut.2014.08.010","journal-title":"Nutrition"},{"issue":"Pt 23","key":"1387_CR34","doi-asserted-by":"publisher","first-page":"55915596","DOI":"10.1242\/jcs.116392","volume":"125","author":"FR Balkwill","year":"2012","unstructured":"Balkwill FR, Capasso M, Hagemann T (2012) The tumor microenvironment at a glance. J Cell Sci 125(Pt 23):5591\u20135596. doi: 10.1242\/jcs.116392","journal-title":"J Cell Sci"},{"issue":"4","key":"1387_CR35","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nrc3245","volume":"12","author":"WH Fridman","year":"2012","unstructured":"Fridman WH, Pages F, Sautes-Fridman C, Galon J (2012) The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 12(4):298\u2013306. doi: 10.1038\/nrc3245","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"1387_CR36","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.3892\/mmr.2012.1036","volume":"6","author":"JW Du","year":"2012","unstructured":"Du JW, Xu KY, Fang LY, Qi XL (2012) Interleukin-17, produced by lymphocytes, promotes tumor growth and angiogenesis in a mouse model of breast cancer. Mol Med Rep 6(5):1099\u20131102. doi: 10.3892\/mmr.2012.1036","journal-title":"Mol Med Rep"},{"issue":"4","key":"1387_CR37","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.tcb.2014.11.001","volume":"25","author":"C Hagerling","year":"2015","unstructured":"Hagerling C, Casbon AJ, Werb Z (2015) Balancing the innate immune system in tumor development. Trends Cell Biol 25(4):214\u2013220. doi: 10.1016\/j.tcb.2014.11.001","journal-title":"Trends Cell Biol"},{"issue":"1","key":"1387_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/jir.2014.0026","volume":"35","author":"M Esquivel-Velazquez","year":"2015","unstructured":"Esquivel-Velazquez M, Ostoa-Saloma P, Palacios-Arreola MI, Nava-Castro KE, Castro JI, Morales-Montor J (2015) The role of cytokines in breast cancer development and progression. J Interferon Cytokine Res 35(1):1\u201316. doi: 10.1089\/jir.2014.0026","journal-title":"J Interferon Cytokine Res"},{"issue":"5","key":"1387_CR39","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.ccr.2008.10.011","volume":"14","author":"S Tu","year":"2008","unstructured":"Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B, Betz KS, Penz-Oesterreicher M, Bjorkdahl O, Fox JG, Wang TC (2008) Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell 14(5):408\u2013419. doi: 10.1016\/j.ccr.2008.10.011","journal-title":"Cancer Cell"},{"issue":"12","key":"1387_CR40","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.2174\/1389450111009011551","volume":"11","author":"H Was","year":"2010","unstructured":"Was H, Dulak J, Jozkowicz A (2010) Heme oxygenase-1 in tumor biology and therapy. Curr Drug Targets 11(12):1551\u20131570. doi: 10.2174\/1389450111009011551","journal-title":"Curr Drug Targets"},{"issue":"2","key":"1387_CR41","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1053\/j.seminoncol.2014.02.007","volume":"41","author":"K Mittal","year":"2014","unstructured":"Mittal K, Ebos J, Rini B (2014) Angiogenesis and the tumor microenvironment: vascular endothelial growth factor and beyond. Semin Oncol 41(2):235\u2013251. doi: 10.1053\/j.seminoncol.2014.02.007","journal-title":"Semin Oncol"},{"issue":"8","key":"1387_CR42","doi-asserted-by":"publisher","first-page":"4499","DOI":"10.4049\/jimmunol.0802740","volume":"182","author":"S Ostrand-Rosenberg","year":"2009","unstructured":"Ostrand-Rosenberg S, Sinha P (2009) Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol 182(8):4499\u20134506. doi: 10.4049\/jimmunol.0802740","journal-title":"J Immunol"},{"issue":"2","key":"1387_CR43","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/1096-9896(200106)194:2<254::AID-PATH880>3.0.CO;2-2","volume":"194","author":"A Sapino","year":"2001","unstructured":"Sapino A, Bongiovanni M, Cassoni P, Righi L, Arisio R, Deaglio S, Malavasi F (2001) Expression of CD31 by cells of extensive ductal in situ and invasive carcinomas of the breast. J Pathol 194(2):254\u2013261. doi: 10.1002\/1096-9896(200106)194:2<254::AID-PATH880>3.0.CO;2-2","journal-title":"J Pathol"},{"issue":"31","key":"1387_CR44","doi-asserted-by":"publisher","first-page":"4069","DOI":"10.1038\/onc.2015.509","volume":"35","author":"M Paauwe","year":"2016","unstructured":"Paauwe M, Heijkants RC, Oudt CH, van Pelt GW, Cui C, Theuer CP, Hardwick JC, Sier CF, Hawinkels LJ (2016) Endoglin targeting inhibits tumor angiogenesis and metastatic spread in breast cancer. Oncogene 35(31):4069\u20134079. doi: 10.1038\/onc.2015.509","journal-title":"Oncogene"},{"issue":"2","key":"1387_CR45","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nrc2780","volume":"10","author":"N Turner","year":"2010","unstructured":"Turner N, Grose R (2010) Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer 10(2):116\u2013129","journal-title":"Nat Rev Cancer"},{"key":"1387_CR46","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/1471-2407-9-188","volume":"9","author":"A Kohrmann","year":"2009","unstructured":"Kohrmann A, Kammerer U, Kapp M, Dietl J, Anacker J (2009) Expression of matrix metalloproteinases (MMPs) in primary human breast cancer and breast cancer cell lines: New findings and review of the literature. BMC Cancer 9:188. doi: 10.1186\/1471-2407-9-188","journal-title":"BMC Cancer"},{"issue":"15","key":"1387_CR47","doi-asserted-by":"publisher","first-page":"5390","DOI":"10.1158\/1078-0432.CCR-04-2391","volume":"11","author":"CA Fernandez","year":"2005","unstructured":"Fernandez CA, Yan L, Louis G, Yang J, Kutok JL, Moses MA (2005) The matrix metalloproteinase-9\/neutrophil gelatinase-associated lipocalin complex plays a role in breast tumor growth and is present in the urine of breast cancer patients. Clin Cancer Res 11(15):5390\u20135395. doi: 10.1158\/1078-0432.CCR-04-2391","journal-title":"Clin Cancer Res"},{"issue":"10","key":"1387_CR48","doi-asserted-by":"publisher","first-page":"3913","DOI":"10.1073\/pnas.0810617106","volume":"106","author":"J Yang","year":"2009","unstructured":"Yang J, Bielenberg DR, Rodig SJ, Doiron R, Clifton MC, Kung AL, Strong RK, Zurakowski D, Moses MA (2009) Lipocalin 2 promotes breast cancer progression. Proc Natl Acad Sci USA 106(10):3913\u20133918. doi: 10.1073\/pnas.0810617106","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"1387_CR49","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/path.4724","volume":"239","author":"B Oren","year":"2016","unstructured":"Oren B, Urosevic J, Mertens C, Mora J, Guiu M, Gomis RR, Weigert A, Schmid T, Grein S, Brune B, Jung M (2016) Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis. J Pathol 239(3):274\u2013285. doi: 10.1002\/path.4724","journal-title":"J Pathol"},{"issue":"12","key":"1387_CR50","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1158\/1535-7163.MCT-14-0522","volume":"13","author":"KL Dillehay","year":"2014","unstructured":"Dillehay KL, Lu S, Dong Z (2014) Anti-tumor effects of a novel small molecule targeting PCNA chromatin association in prostate cancer. Mol Cancer Ther 13(12):2817\u20132826 doi:molcanther.0522.2014","journal-title":"Mol Cancer Ther"},{"issue":"6024","key":"1387_CR51","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1126\/science.1203486","volume":"331","author":"RD Schreiber","year":"2011","unstructured":"Schreiber RD, Old LJ, Smyth MJ (2011) Cancer immunoediting: integrating immunity\u2019s roles in cancer suppression and promotion. Science 331(6024):1565\u20131570. doi: 10.1126\/science.1203486","journal-title":"Science"},{"issue":"19","key":"1387_CR52","doi-asserted-by":"publisher","first-page":"6118","DOI":"10.1158\/1078-0432.CCR-11-0482","volume":"17","author":"MR Zaidi","year":"2011","unstructured":"Zaidi MR, Merlino G (2011) The two faces of interferon-gamma in cancer. Clin Cancer Res 17(19):6118\u20136124. doi: 10.1158\/1078-0432.CCR-11-0482","journal-title":"Clin Cancer Res"},{"issue":"9","key":"1387_CR53","doi-asserted-by":"publisher","first-page":"5173","DOI":"10.4049\/jimmunol.1002050","volume":"186","author":"P Hemon","year":"2011","unstructured":"Hemon P, Jean-Louis F, Ramgolam K, Brignone C, Viguier M, Bachelez H, Triebel F, Charron D, Aoudjit F, Al-Daccak R, Michel L (2011) MHC class II engagement by its ligand LAG-3 (CD223) contributes to melanoma resistance to apoptosis. J Immunol 186(9):5173\u20135183. doi: 10.4049\/jimmunol.1002050","journal-title":"J Immunol"},{"issue":"6","key":"1387_CR54","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1189\/jlb.70.6.950","volume":"70","author":"P Bernabei","year":"2001","unstructured":"Bernabei P, Coccia EM, Rigamonti L, Bosticardo M, Forni G, Pestka S, Krause CD, Battistini A, Novelli F (2001) Interferon-gamma receptor 2 expression as the deciding factor in human T, B, and myeloid cell proliferation or death. J Leukoc Biol 70(6):950\u2013960","journal-title":"J Leukoc Biol"},{"issue":"6","key":"1387_CR55","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/cmi.2009.53","volume":"6","author":"Z Li","year":"2009","unstructured":"Li Z, Chen L, Qin Z (2009) Paradoxical roles of IL-4 in tumor immunity. Cell Mol Immunol 6(6):415\u2013422. doi: 10.1038\/cmi.2009.53","journal-title":"Cell Mol Immunol"},{"issue":"11","key":"1387_CR56","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.1016\/j.fct.2011.06.056","volume":"49","author":"ML Queiroz","year":"2011","unstructured":"Queiroz ML, da Rocha MC, Torello CO, de Souza Queiroz J, Bincoletto C, Morgano MA, Romano MR, Paredes-Gamero EJ, Barbosa CM, Calgarotto AK (2011) Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice. Food Chem Toxicol 49(11):2934\u20132941. doi: 10.1016\/j.fct.2011.06.056","journal-title":"Food Chem Toxicol"},{"issue":"6","key":"1387_CR57","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1189\/jlb.0708446","volume":"85","author":"SK Bunt","year":"2009","unstructured":"Bunt SK, Clements VK, Hanson EM, Sinha P, Ostrand-Rosenberg S (2009) Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4. J Leukoc Biol 85(6):996\u20131004. doi: 10.1189\/jlb.0708446","journal-title":"J Leukoc Biol"},{"key":"1387_CR58","doi-asserted-by":"publisher","DOI":"10.1080\/15321819.2016.1266499","author":"A Khalilnezhad","year":"2016","unstructured":"Khalilnezhad A, Mahmoudian E, Mosaffa N, Mohsenifar J, Amani D (2016) Spontaneous mouse mammary tumor cell lysates induce IgG production in spleen mononuclear cells of healthy and tumor-bearing mice. J Immunoassay Immunochem. doi: 10.1080\/15321819.2016.1266499","journal-title":"J Immunoassay Immunochem"},{"issue":"4","key":"1387_CR59","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/bjc.1980.272","volume":"42","author":"JM MacSween","year":"1980","unstructured":"MacSween JM, Eastwood SL (1980) Immunoglobulins associated with human tumours in vivo: IgG concentrations in eluates of colonic carcinomas. Br J Cancer 42(4):503\u2013509","journal-title":"Br J Cancer"},{"issue":"10","key":"1387_CR60","first-page":"3477","volume":"40","author":"SA Huber","year":"1980","unstructured":"Huber SA, Bigi G, Lucas ZJ (1980) Tumor-specific suppressor cells induced by immunization with spleen cells from tumor-bearing animals. Cancer Res 40(10):3477\u20133483","journal-title":"Cancer Res"},{"issue":"5","key":"1387_CR61","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/bf02470555","volume":"16","author":"T Toge","year":"1986","unstructured":"Toge T, Kameda A, Yamada H, Seto Y, Aratani K, Fujita T, Hattori T (1986) Role of the spleen on immunosuppression in esophageal and gastric cancer. The Japanese journal of surgery 16(5):330\u2013335. doi: 10.1007\/bf02470555","journal-title":"The Japanese journal of surgery"},{"issue":"7","key":"1387_CR62","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s002620100206","volume":"50","author":"JK Nyhus","year":"2001","unstructured":"Nyhus JK, Wolford CC, Friece CR, Nelson MB, Sampsel JW, Barbera-Guillem E (2001) IgG-recognizing shed tumor-associated antigens can promote tumor invasion and metastasis. Cancer Immunol Immunother 50(7):361\u2013372","journal-title":"Cancer Immunol Immunother"},{"issue":"23","key":"1387_CR63","first-page":"7042","volume":"62","author":"E Barbera-Guillem","year":"2002","unstructured":"Barbera-Guillem E, Nyhus JK, Wolford CC, Friece CR, Sampsel JW (2002) Vascular endothelial growth factor secretion by tumor-infiltrating macrophages essentially supports tumor angiogenesis, and IgG immune complexes potentiate the process. Cancer Res 62(23):7042\u20137049","journal-title":"Cancer Res"},{"issue":"6","key":"1387_CR64","doi-asserted-by":"publisher","first-page":"2827","DOI":"10.3892\/mmr.2014.2606","volume":"10","author":"B Dong","year":"2014","unstructured":"Dong B, Dai G, Xu L, Zhang Y, Ling L, Sun L, Lv J (2014) Tumor cell lysate induces the immunosuppression and apoptosis of mouse immunocytes. Mol Med Rep 10 (6):2827\u20132834. doi: 10.3892\/mmr.2014.2606","journal-title":"Mol Med Rep"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-017-1387-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-017-1387-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-017-1387-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T16:29:06Z","timestamp":1719073746000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-017-1387-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,22]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["1387"],"URL":"https:\/\/doi.org\/10.1007\/s00394-017-1387-1","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,22]]}}}